Search

Your search keyword '"Matsumoto, Yoshiaki"' showing total 569 results
Start Over Author "Matsumoto, Yoshiaki"
569 results on '"Matsumoto, Yoshiaki"'

2. TP53 signature predicts pathological complete response after neoadjuvant chemotherapy for breast cancer: Observational and confirmational study using prospective study cohorts

Author

Takahashi, Shin, Sato, Nobuaki, Kaneko, Kouji, Masuda, Norikazu, Kawai, Masaaki, Hirakawa, Hisashi, Nomizu, Tadashi, Iwata, Hiroji, Ueda, Ai, Ishikawa, Takashi, Bando, Hiroko, Inoue, Yuka, Ueno, Takayuki, Ohno, Shinji, Kubo, Makoto, Yamauchi, Hideko, Okamoto, Masahiro, Tokunaga, Eriko, Kamigaki, Shunji, Aogi, Kenjiro, Komatsu, Hideaki, Kitada, Masahiro, Uemoto, Yasuaki, Toyama, Tatsuya, Yamamoto, Yutaka, Yamashita, Toshinari, Yanagawa, Takehiro, Yamashita, Hiroko, Matsumoto, Yoshiaki, Toi, Masakazu, Miyashita, Minoru, Ishida, Takanori, Fujishima, Fumiyoshi, Sato, Satoko, Yamaguchi, Takuhiro, Takahashi, Fumiaki, and Ishioka, Chikashi

Published
2024
Full Text
View/download PDF

10. The Ganymede Laser Altimeter (GALA) for the Jupiter Icy Moons Explorer (JUICE): Mission, science, and instrumentation of its receiver modules

Author

Enya, Keigo, Kobayashi, Masanori, Kimura, Jun, Araki, Hiroshi, Namiki, Noriyuki, Noda, Hirotomo, Kashima, Shingo, Oshigami, Shoko, Ishibashi, Ko, Yamawaki, T., Tohara, Kazuyuki, Saito, Yoshifumi, Ozaki, Masanobu, Mizuno, Takahide, Kamata, Shunichi, Matsumoto, Koji, Sasaki, Sho, Kuramoto, Kiyoshi, Sato, Yuki, Yokozawa, Takeshi, Numata, Tsutomu, Mizumoto, Satoko, Mizuno, Hiroyuki, Nagamine, Kenta, Sawamura, Akihiko, Tanimoto, Kazuo, Imai, Hisato, Nakagawa, Hiroyuki, Kirino, Okiharu, Green, David, Fujii, Masayuki, Iwamura, Satoru, Fujishiro, Naofumi, Matsumoto, Yoshiaki, Lingenauber, Kay, Kallenbach, Reinald, Althaus, Christian, Behnke, Thomas, Binger, Jan, Daurskikh, Anna, Eisenmenger, Henri, Heer, Ulrich, Hüttig, Christian, Lara, Luisa M., Lichopoj, Alexander, Lötzke, Horst-Georg, Lüdicke, Fabian, Michaelis, Harald, Pablo Rodriguez Garcia, Juan, Rösner, Kerstin, Stark, Alexander, Steinbrügge, Gregor, Thabaut, Pascal, Thomas, Nicolas, del Togno, Simone, Wahl, Daniel, Wendler, Belinda, Wickhusen, Kai, Willner, Konrad, and Hussmann, Hauke

Published
2022
Full Text
View/download PDF

14. Kinetic–pharmacodynamic model of warfarin for prothrombin time–international normalized ratio in Japanese patients.

Author

Hirai, Toshinori, Aoyama, Takahiko, Tsuji, Yasuhiro, Itoh, Toshimasa, Matsumoto, Yoshiaki, and Iwamoto, Takuya

Subjects
JAPANESE people, WARFARIN, PROTHROMBIN, MONTE Carlo method, BODY surface area
Abstract

Aims: Genotype‐guided dosing algorithms can explain about half of the interindividual variability in prothrombin time–international normalized ratio (PT‐INR) under warfarin treatment. This study aimed to refine a published kinetic–pharmacodynamic model and guide warfarin dosage for an optimal PT‐INR based on renal function. Methods: Using a retrospective cohort of adult patients (>20 years) who were administered warfarin and underwent PT‐INR measurements, we refined the kinetic–pharmacodynamic model with age and the genotypes of cytochrome P450 2C9 and vitamin K epoxide reductase complex subunit 1 using the PRIOR subroutine in the nonlinear‐mixed‐effect modelling programme. We searched the significant covariates for parameters, such as the dose rate for 50% inhibition of coagulation (EDR50), using a stepwise forward and backward method. Monte Carlo simulation determined a required daily dose of warfarin with a target range of PT‐INR (2.0–3.0 or 1.6–2.6) based on the significant covariates. Results: A total of 350 patients with 2762 PT‐INR measurements were enrolled (estimated glomerular filtration rate [eGFR]: 47.5 [range: 2.6–199.0] mL/min/1.73 m2). The final kinetic–pharmacodynamic model showed that the EDR50 changed power functionally with body surface area, serum albumin level and eGFR. Monte Carlo simulation revealed that a lower daily dose of warfarin was required to attain the target PT‐INR range as eGFR decreased. Conclusions: Model‐informed precision dosing of warfarin is a valuable approach for estimating its dosage in patients with renal impairment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Vascular branching point counts using photoacoustic imaging in the superficial layer of the breast: A potential biomarker for breast cancer

Author

Yamaga, Iku, Kawaguchi-Sakita, Nobuko, Asao, Yasufumi, Matsumoto, Yoshiaki, Yoshikawa, Aya, Fukui, Toshifumi, Takada, Masahiro, Kataoka, Masako, Kawashima, Masahiro, Fakhrejahani, Elham, Kanao, Shotaro, Nakayama, Yoshie, Tokiwa, Mariko, Torii, Masae, Yagi, Takayuki, Sakurai, Takaki, Haga, Hironori, Togashi, Kaori, Shiina, Tsuyoshi, and Toi, Masakazu

Published
2018
Full Text
View/download PDF

19. Updip Fluid Flow in the Crust of the Northeastern Noto Peninsula, Japan, Triggered the 2023 Mw 6.2 Suzu Earthquake During Swarm Activity.

Author

Yoshida, Keisuke, Uchida, Naoki, Matsumoto, Yoshiaki, Orimo, Masaki, Okada, Tomomi, Hirahara, Satoshi, Kimura, Shuutoku, and Hino, Ryota

Subjects
EARTHQUAKE swarms, FLUID flow, TSUNAMIS, SUBDUCTION zones, EARTHQUAKES, EARTHQUAKE aftershocks
Abstract

An Mw 6.2 earthquake occurred in Suzu, northeastern Noto Peninsula, Japan, on 5 May 2023, followed by many aftershocks. Before this mainshock‐aftershock sequence, an intense earthquake swarm lasted in the vicinity for 2.5 years. Here, we estimated the rupture process of the Mw 6.2 mainshock and relocated >20,000 surrounding small earthquakes. The results show that systematic upward migration occurred via a complex network of faults in the preceding swarm period and that the mainshock rupture was initiated near the shallow end of the swarm earthquakes. The mainshock rupture propagated farther updip, followed by many aftershocks in the shallow extension. Upward fluid movement likely caused systematic upward earthquake migration from a depth of 18–5 km. The present results indicate the importance of monitoring swarm events since large (M > 6) and dangerous earthquakes can occur during such swarms. Plain Language Summary: Growing evidence suggests that fluid movements at depth can cause earthquake swarms in the overriding plates of subduction zones. However, there is less evidence of fluid involvement in the occurrence of large (M > 6) earthquakes, and it has been reported that the generation environments of large earthquakes and swarm earthquakes tend to be different. During intense swarm activity in the northeastern Noto Peninsula, Japan, starting at the end of 2020, an M6.2 earthquake occurred on 5 May 2023, followed by many aftershocks. To clarify the occurrence mechanism of the M6.2 mainshock, we relocated >20,000 small earthquakes and estimated the rupture process. The results showed a systematic upward migration of earthquakes in the preceding swarm period on the deep side of the mainshock fault (depth from 20 to 12 km). The mainshock rupture initiated near the shallow end of the swarm activity and propagated updip (depth from 12 to 9 km). Many aftershocks followed in shallower part of the same fault (depth from 10 to 5 km). Upward fluid migration likely caused the observed systematic upward earthquake migration throughout the sequence. The results indicate that earthquakes as large as M > 6 can be triggered by fluid migration during enhanced seismicity in swarms. Key Points: An Mw 6.2 event initiated near the shallow end of a fault where the preceding earthquake swarm showed systematic upward migrationThe Mw 6.2 rupture propagated farther updip, followed by many shallow aftershocks on the faultUpward fluid migration can trigger earthquakes as large as Mw > 6 [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. The Ganymede Laser Altimeter (GALA) for the Jupiter Icy Moons Explorer (JUICE): Mission, science, and instrumentation of its receiver modules

Author

Enya, Keigo, Kobayashi, Masanori, Kimura, Jun, Araki, Hiroshi, Namiki, Noriyuki, Noda, Hirotomo, Kashima, Shingo, Oshigami, Shoko, Ishibashi, Ko, Yamawaki, T., Tohara, Kazuyuki, Saito, Yoshifumi, Ozaki, Masanobu, Mizuno, Takahide, Kamata, Shunichi, Matsumoto, Koji, Sasaki, Sho, Kuramoto, Kiyoshi, Sato, Yuki, Yokozawa, Takeshi, Numata, Tsutomu, Mizumoto, Satoko, Mizuno, Hiroyuki, Nagamine, Kenta, Sawamura, Akihiko, Tanimoto, Kazuo, Imai, Hisato, Nakagawa, Hiroyuki, Kirino, Okiharu, Green, David, Fujii, Masayuki, Iwamura, Satoru, Fujishiro, Naofumi, Matsumoto, Yoshiaki, Lingenauber, Kay, Kallenbach, Reinald, Althaus, Christian, Behnke, Thomas, Binger, Jan, Daurskikh, Anna, Eisenmenger, Henri, Heer, Ulrich, Hüttig, Christian, Lara, Luisa M., Lichopoj, Alexander, Lötzke, Horst-Georg, Lüdicke, Fabian, Michaelis, Harald, Pablo Rodriguez Garcia, Juan, Rösner, Kerstin, Stark, Alexander, Steinbrügge, Gregor, Thabaut, Pascal, Thomas, Nicolas, Del Togno, Simone, Wahl, Daniel, Wendler, Belinda, Wickhusen, Kai, Willner, Konrad, Hussmann, Hauke, Ministerio de Ciencia e Innovación (España), European Commission, National Natural Science Foundation of China, and Chinese Academy of Sciences

Subjects
Atmospheric Science, Finite element method, Binary asteroids, 520 Astronomy, GPU, Aerospace Engineering, Laser Altimeter, Astronomy and Astrophysics, CUDA, Full 2-body, 620 Engineering, Receiver, Geophysics, Space and Planetary Science, Ganymede, General Earth and Planetary Sciences, JUICE
Abstract

Full list of authors: Enya, Keigo; Kobayashi, Masanori; Kimura, Jun; Araki, Hiroshi; Namiki, Noriyuki; Noda, Hirotomo; Kashima, Shingo; Oshigami, Shoko; Ishibashi, Ko; Yamawaki, T.; Tohara, Kazuyuki; Saito, Yoshifumi; Ozaki, Masanobu; Mizuno, Takahide; Kamata, Shunichi; Matsumoto, Koji; Sasaki, Sho; Kuramoto, Kiyoshi; Sato, Yuki; Yokozawa, Takeshi; Numata, Tsutomu; Mizumoto, Satoko; Mizuno, Hiroyuki; Nagamine, Kenta; Sawamura, Akihiko; Tanimoto, Kazuo; Imai, Hisato; Nakagawa, Hiroyuki; Kirino, Okiharu; Green, David; Fujii, Masayuki; Iwamura, Satoru; Fujishiro, Naofumi; Matsumoto, Yoshiaki; Lingenauber, Kay; Kallenbach, Reinald; Althaus, Christian; Behnke, Thomas; Binger, Jan; Daurskikh, Anna; Eisenmenger, Henri; Heer, Ulrich; Hüttig, Christian; Lara, Luisa M.; Lichopoj, Alexander; Lötzke, Horst-Georg; Lüdicke, Fabian; Michaelis, Harald; Pablo Rodriguez Garcia, Juan; Rösner, Kerstin; Stark, Alexander; Steinbrügge, Gregor; Thabaut, Pascal; Thomas, Nicolas; del Togno, Simone; Wahl, Daniel; Wendler, Belinda; Wickhusen, Kai; Willner, Konrad; Hussmann, Hauke.--This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/)., The Jupiter Icy Moons Explorer (JUICE) is a science mission led by the European Space Agency, being developed for launch in 2023. The Ganymede Laser Altimeter (GALA) is an instrument onboard JUICE, whose main scientific goals are to understand ice tectonics based on topographic data, the subsurface structure by measuring tidal response, and small-scale roughness and albedo of the surface. In addition, from the perspective of astrobiology, it is imperative to study the subsurface ocean scientifically. The development of GALA has proceeded through an international collaboration between Germany (the lead), Japan, Switzerland, and Spain. Within this framework, the Japanese team (GALA-J) is responsible for developing three receiver modules: the Backend Optics (BEO), the Focal Plane Assembly (FPA), and the Analog Electronics Module (AEM). Like the German team, GALA-J also developed software to simulate the performance of the entire GALA system (performance model). In July 2020, the Proto-Flight Models of BEO, FPA, and AEM were delivered from Japan to Germany. This paper presents an overview of JUICE/GALA and its scientific objectives and describes the instrumentation, mainly focusing on Japan's contribution. © 2021 COSPAR., NSO/Kitt Peak data (synoptic maps of He I Å intensity) used here are produced cooperatively by NSF/NOAO, NASA/GSFC, and NOAA/SEL. Sunspot number (version 2) comes from the Sunspot Index and Long-term Solar Observations at Royal Observatory of Belgium, Brussels. All used data are courtesy to be downloaded from their web sites. The authors would like to express their deep thanks to the staffs of these web sites. This work is supported by the National Natural Science Foundation of China (11973085, 11903077, 11803086, and 11633008), the Yunnan Ten-Thousand Talents Plan (the Yunling-Scholar Project), the national project for large scale scientific facilities (2019YFA0405001), and the Chinese Academy of Sciences., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.

Published
2021

32. A Proposed Dedicated Breast PET Lexicon: Standardization of Description and Reporting of Radiotracer Uptake in the Breast

Author

Miyake, Kanae K., primary, Kataoka, Masako, additional, Ishimori, Takayoshi, additional, Matsumoto, Yoshiaki, additional, Torii, Masae, additional, Takada, Masahiro, additional, Satoh, Yoko, additional, Kubota, Kazunori, additional, Satake, Hiroko, additional, Yakami, Masahiro, additional, Isoda, Hiroyoshi, additional, Ikeda, Debra M., additional, Toi, Masakazu, additional, and Nakamoto, Yuji, additional

Published
2021
Full Text
View/download PDF

33. Optimization of prediction methods for risk assessment of pathogenic germline variants in the Japanese population

Author

Senda, Noriko, primary, Kawaguchi‐Sakita, Nobuko, additional, Kawashima, Masahiro, additional, Inagaki‐Kawata, Yukiko, additional, Yoshida, Kenichi, additional, Takada, Masahiro, additional, Kataoka, Masako, additional, Torii, Masae, additional, Nishimura, Tomomi, additional, Kawaguchi, Kosuke, additional, Suzuki, Eiji, additional, Kataoka, Yuki, additional, Matsumoto, Yoshiaki, additional, Yoshibayashi, Hiroshi, additional, Yamagami, Kazuhiko, additional, Tsuyuki, Shigeru, additional, Takahara, Sachiko, additional, Yamauchi, Akira, additional, Shinkura, Nobuhiko, additional, Kato, Hironori, additional, Moriguchi, Yoshio, additional, Okamura, Ryuji, additional, Kan, Norimichi, additional, Suwa, Hirofumi, additional, Sakata, Shingo, additional, Mashima, Susumu, additional, Yotsumoto, Fumiaki, additional, Tachibana, Tsuyoshi, additional, Tanaka, Mitsuru, additional, Togashi, Kaori, additional, Haga, Hironori, additional, Yamada, Takahiro, additional, Kosugi, Shinji, additional, Inamoto, Takashi, additional, Sugimoto, Masahiro, additional, Ogawa, Seishi, additional, and Toi, Masakazu, additional

Published
2021
Full Text
View/download PDF

34. Optimization of prediction methods for risk assessment of pathogenic germline variants in the Japanese population

Author

80766676, 50452363, 10611577, 30516927, 80760769, 50252432, 10207516, Senda, Noriko, Kawaguchi‐Sakita, Nobuko, Kawashima, Masahiro, Inagaki‐Kawata, Yukiko, Yoshida, Kenichi, Takada, Masahiro, Kataoka, Masako, Torii, Masae, Nishimura, Tomomi, Kawaguchi, Kosuke, Suzuki, Eiji, Kataoka, Yuki, Matsumoto, Yoshiaki, Yoshibayashi, Hiroshi, Yamagami, Kazuhiko, Tsuyuki, Shigeru, Takahara, Sachiko, Yamauchi, Akira, Shinkura, Nobuhiko, Kato, Hironori, Moriguchi, Yoshio, Okamura, Ryuji, Kan, Norimichi, Suwa, Hirofumi, Sakata, Shingo, Mashima, Susumu, Yotsumoto, Fumiaki, Tachibana, Tsuyoshi, Tanaka, Mitsuru, Togashi, Kaori, Haga, Hironori, Yamada, Takahiro, Kosugi, Shinji, Inamoto, Takashi, Sugimoto, Masahiro, Ogawa, Seishi, Toi, Masakazu, 80766676, 50452363, 10611577, 30516927, 80760769, 50252432, 10207516, Senda, Noriko, Kawaguchi‐Sakita, Nobuko, Kawashima, Masahiro, Inagaki‐Kawata, Yukiko, Yoshida, Kenichi, Takada, Masahiro, Kataoka, Masako, Torii, Masae, Nishimura, Tomomi, Kawaguchi, Kosuke, Suzuki, Eiji, Kataoka, Yuki, Matsumoto, Yoshiaki, Yoshibayashi, Hiroshi, Yamagami, Kazuhiko, Tsuyuki, Shigeru, Takahara, Sachiko, Yamauchi, Akira, Shinkura, Nobuhiko, Kato, Hironori, Moriguchi, Yoshio, Okamura, Ryuji, Kan, Norimichi, Suwa, Hirofumi, Sakata, Shingo, Mashima, Susumu, Yotsumoto, Fumiaki, Tachibana, Tsuyoshi, Tanaka, Mitsuru, Togashi, Kaori, Haga, Hironori, Yamada, Takahiro, Kosugi, Shinji, Inamoto, Takashi, Sugimoto, Masahiro, Ogawa, Seishi, and Toi, Masakazu

Abstract

Predicting pathogenic germline variants (PGVs) in breast cancer patients is important for selecting optimal therapeutics and implementing risk reduction strategies. However, PGV risk factors and the performance of prediction methods in the Japanese population remain unclear. We investigated clinicopathological risk factors using the Tyrer-Cuzick (TC) breast cancer risk evaluation tool to predict BRCA PGVs in unselected Japanese breast cancer patients (n = 1, 995). Eleven breast cancer susceptibility genes were analyzed using target-capture sequencing in a previous study; the PGV prevalence in BRCA1, BRCA2, and PALB2 was 0.75%, 3.1%, and 0.45%, respectively. Significant associations were found between the presence of BRCA PGVs and early disease onset, number of familial cancer cases (up to third-degree relatives), triple-negative breast cancer patients under the age of 60, and ovarian cancer history (all P < .0001). In total, 816 patients (40.9%) satisfied the National Comprehensive Cancer Network (NCCN) guidelines for recommending multigene testing. The sensitivity and specificity of the NCCN criteria for discriminating PGV carriers from noncarriers were 71.3% and 60.7%, respectively. The TC model showed good discrimination for predicting BRCA PGVs (area under the curve, 0.75; 95% confidence interval, 0.69-0.81). Furthermore, use of the TC model with an optimized cutoff of TC score ≥0.16% in addition to the NCCN guidelines improved the predictive efficiency for high-risk groups (sensitivity, 77.2%; specificity, 54.8%; about 11 genes). Given the influence of ethnic differences on prediction, we consider that further studies are warranted to elucidate the role of environmental and genetic factors for realizing precise prediction.

Published
2021

41. Usefulness and Prospects of Sentinel Lymph Node Biopsy for Patients With Breast Cancer Using the Medical Imaging Projection System

Author

Nakamura, Yuki, primary, Takada, Masahiro, additional, Imamura, Michiko, additional, Higami, Akane, additional, Jiaxi, He, additional, Fujino, Makoto, additional, Nakagawa, Rie, additional, Inagaki, Yukiko, additional, Matsumoto, Yoshiaki, additional, Kawaguchi, Kosuke, additional, Kawashima, Masahiro, additional, Suzuki, Eiji, additional, and Toi, Masakazu, additional

Published
2021
Full Text
View/download PDF

44. TP53signature predicts pathological complete response after neoadjuvant chemotherapy for breast cancer: Observational and confirmational study using prospective study cohorts

Author

Takahashi, Shin, Sato, Nobuaki, Kaneko, Kouji, Masuda, Norikazu, Kawai, Masaaki, Hirakawa, Hisashi, Nomizu, Tadashi, Iwata, Hiroji, Ueda, Ai, Ishikawa, Takashi, Bando, Hiroko, Inoue, Yuka, Ueno, Takayuki, Ohno, Shinji, Kubo, Makoto, Yamauchi, Hideko, Okamoto, Masahiro, Tokunaga, Eriko, Kamigaki, Shunji, Aogi, Kenjiro, Komatsu, Hideaki, Kitada, Masahiro, Uemoto, Yasuaki, Toyama, Tatsuya, Yamamoto, Yutaka, Yamashita, Toshinari, Yanagawa, Takehiro, Yamashita, Hiroko, Matsumoto, Yoshiaki, Toi, Masakazu, Miyashita, Minoru, Ishida, Takanori, Fujishima, Fumiyoshi, Sato, Satoko, Yamaguchi, Takuhiro, Takahashi, Fumiaki, and Ishioka, Chikashi

Abstract

•TP53signature can predict the pathological complete response in breast cancer.•TP53signature is a predictor for survival benefit from neoadjuvant chemotherapy.•Benefit from chemotherapy is grater in mutant than in wild-type signature group.

Published
2024
Full Text
View/download PDF

45. Estrogen Induces Mammary Ductal Dysplasia via the Upregulation of Myc Expression in a DNA-Repair-Deficient Condition

Author

80760769, 10207516, Itou, Junji, Takahashi, Rei, Sasanuma, Hiroyuki, Tsuda, Masataka, Morimoto, Suguru, Matsumoto, Yoshiaki, Ishii, Tomoko, Sato, Fumiaki, Takeda, Shunichi, Toi, Masakazu, 80760769, 10207516, Itou, Junji, Takahashi, Rei, Sasanuma, Hiroyuki, Tsuda, Masataka, Morimoto, Suguru, Matsumoto, Yoshiaki, Ishii, Tomoko, Sato, Fumiaki, Takeda, Shunichi, and Toi, Masakazu

Abstract

Mammary ductal dysplasia is a phenotype observed in precancerous lesions and early-stage breast cancer. However, the mechanism of dysplasia formation remains elusive. Here we show, by establishing a novel dysplasia model system, that estrogen, a female hormone, has the potential to cause mammary ductal dysplasia. We injected estradiol (E2), the most active form of estrogen, daily into scid mice with a defect in non-homologous end joining repair and observed dysplasia formation with cell proliferation at day 30. The protooncogene Myc is a downstream target of estrogen signaling, and we found that its expression is augmented in mammary epithelial cells in this dysplasia model. Treatment with a Myc inhibitor reduced E2-induced dysplasia formation. Moreover, we found that isoflavones inhibited E2-induced dysplasia formation. Our dysplasia model system provides insights into the mechanistic understanding of breast tumorigenesis and the development of breast cancer prevention.

Published
2020

47. Comparison of maximum drug concentration and area under the time-concentration curve between humans and animals for oral and intravenous investigational drugs

Author

Fujita, Tomoe, Matsumoto, Yoshiaki, Ozaki, Machiko, Majima, Masataka, Kumagai, Yuji, and Ohtani, Yoshio

Subjects
Body weight -- Health aspects -- Research, Pharmacokinetics -- Research -- Health aspects, Drugs -- Dosage and administration, Dose-response relationship (Biochemistry) -- Research -- Health aspects, Health, Research, Health aspects
Abstract

The study compared maximum drug concentration ([C.sub.max]) and area under the time-concentration curve (AUC) after normalization of doses to body weight and to body surface area and developed relationships for [...]

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results