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46 results on '"Matsunaga, Masaji"'

1. Functional Materials Derived from DNA

Author

Dong Liu, Xiang, Yamada, Masanori, Matsunaga, Masaji, Nishi, Norio, Dong Liu, Xiang, Esker, Alan R., Häußler, Matthias, Kim, Chanjoong, Lucas, Patrice, Matsunaga, Masaji, Nishi, Norio, Robin, Jean-Jacques, Tang, Ben Zhong, Wang, Dong-An, Yamada, Masanori, and Yu, Hyuk

Published
2007
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8. Functional Materials and Biomaterials

Author

Dong Liu, Xiang, primary, Esker, Alan R., additional, Häußler, Matthias, additional, Kim, Chanjoong, additional, Lucas, Patrice, additional, Matsunaga, Masaji, additional, Nishi, Norio, additional, Robin, Jean-Jacques, additional, Tang, Ben Zhong, additional, Wang, Dong-An, additional, Yamada, Masanori, additional, and Yu, Hyuk, additional

Published
2007
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10. Physiological Effects of Salmon Milt Nucleoprotein on Movement, Stress Tolerance and Lifespan of C. elegans

Author

Matsunaga Masaji, Shintani Hiroaki, Sakamoto Kazuichi, Hano Hiroyuki, Usumi Koji, Furuhashi Tsubasa, and Shudo Norimasa

Subjects
Milt, Strain (chemistry), Ecology, Period (gene), Wild type, Biology, medicine.disease_cause, biology.organism_classification, Protamine, Andrology, Nematode, Nucleic acid, medicine, biology.protein, Oxidative stress
Abstract

In recent years, various physiological functions of salmon milt extract, which consists of nucleic acid and nucleoprotein, have been reported. The objective of this study is to analyze the physiological function and its mechanism of salmon milt extract (NG) on nematodes (C. elegans). The wild type nematode N2 strain was bred on the plate containing of NG for four days, and its body length increased depending on NG concentration. When nematodes were bred with NG for a longer period, average lifespan was increased, and survival rate was increased by up to 20%. Generally, the movement of nematodes decreases with longer breeding period (i.e. aging). Analysis of movement (both gross thrashing movement and local pumping movement) showed that NG suppressed this decrease f movement with aging. Furthermore, the deease of survival rate by heat stress and oxidative stress was suppressed by NG administration. Nile Red staining analysis showed that fat accumulation varied depending on the concentration of NG. RT-PCR analysis revealed that the mRNA expression levels of the stress resistance genes sod-3 and sod-4 were increased. These results indicated that NG administration increased the expression of stress-tolerance-related genes, promoted stress tolerance, increased movement and prolonged lifespan in nematode.

Published
2012

16. Accumulation of autofluorescent storage material in brain is accelerated by ischemia in chloride channel 3 gene‐deficient mice

Author

Ohtaki, Hirokazu, primary, Ohara, Kenji, additional, Song, Dandan, additional, Miyamoto, Kazuyuki, additional, Tsumuraya, Tomomi, additional, Yofu, Sachiko, additional, Dohi, Kenji, additional, Tanabe, Shigeru, additional, Sasaki, Sei, additional, Uchida, Shinichi, additional, Matsunaga, Masaji, additional, and Shioda, Seiji, additional

Published
2012
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19. Preferential Blockade of Dioxin-Induced Activation of the Aryl Hydrocarbon Receptor by Antrodia camphorata

Author

Mukai, Mai, primary, Hayakawa, Kunihiro, additional, Okamura, Maro, additional, Tagawa, Yasuhiro, additional, Nakajima, Shotaro, additional, Saito, Yukinori, additional, Takahashi, Shuhei, additional, Yao, Jian, additional, Nishimura, Daisuke, additional, Sugi, Masahito, additional, Matsunaga, Masaji, additional, and Kitamura, Masanori, additional

Published
2009
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27. Does PACAP have therapeutic potential in the field of neuroregenerative medicine?

Author

Kusano, Mitsuo, Ohtaki, Hirokazu, Nakamachi, Tomoya, Watanabe, Jun, Yofu, Sachiko, Matsunaga, Masaji, Matsuno, Ryosuke, Dohi, Kenji, and Shioda, Seiji

Abstract

The incidence of stroke is gradually increasing in the industrialized world, and is a major cause of long-lasting disability. Several different strategies have been investigated as a means of either preventing the occurrence of stroke or suppressing the subsequent enlargement of the in-farct volume. However, due to the narrowness of the therapeutic time window, we are still far from achieving an effective response. One finding that has offered new hope is the discovery that neurogenesis, long regarded as an impossibility in the adult brain, does indeed occur. This raises the possibility that the damaged brain might in fact be able to recover as well as other tissues and organs. In this paper, we will review both existing and potential strategies for the treatment of cerebrovascular disease. In particular, we will focus on the prospects of pituitary adenylate cyclase-activating polypeptide (PACAP), a neuropeptide that has been shown to exert both neuroprotective and neurogenic effects. [ABSTRACT FROM AUTHOR]

Published
2007
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28. Engagement of Proinflammatory Cytokines after Cerebral Ischemia.

Author

Homma, Ikuo, Shioda, Seiji, Ohtaki, Hirokazu, Yin, Li, Dohi, Kenji, Yofu, Sachiko, Nakamachi, Tomoya, and Matsunaga, Masaji

Abstract

The incidence of stroke is gradually increasing in the industrialized world and a major cause of long-lasting disability. To determine the mechanism of neuronal cell death after stroke and develop the new strategy of therapy, several studies had been performed during the past decade and some proinflammatory cytokines were identified as the therapeutic candidate. However, the critical actions of proinflammatory cytokines are still largely unknown in detail because the cytokines play a role on small amount, show the short half-life, and have multiple functions for depending on the amount and time of expression. We present here the pathophysiological events of cerebral ischemia and the action and possibility of proinflammatory cytokines from the recent results. [ABSTRACT FROM AUTHOR]

Published
2006
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29. Functional Materials Derived from DNA.

Author

Xiang Dong Liu, Yamada, Masanori, Matsunaga, Masaji, and Nishi, Norio

Subjects
GENES, MOLECULAR genetics, POLYMERS, DNA, BIOMEDICAL materials
Abstract

DNA has special properties and its unique double-helical structure offers excellent prospects for creating novel DNA-based materials. In recent years, DNA has been shown to be an ideal molecule in the material world. This review is intended to provide an overview of functional materials derived from DNA based on the double-helical structure. Various DNA-based materials are reviewed according to the basic DNA structural properties, including the electrostatic properties of DNA as a highly charged polyelectrolyte, complementary base pairing, and intercalation and groove binding interaction with small molecules. Finally, attempts to produce biomaterials based on DNA are also summarized. [ABSTRACT FROM AUTHOR]

Published
2007
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30. Ultrastructural Study on the Demyelination of the White Matter in the Rat Spinal Cord after Cardiac Arrest and Massive Hemorrhagic Shock.

Author

Homma, Ikuo, Shioda, Seiji, Yin, Li, Kudo, Yoshifumi, Ohtaki, Hirokazu, Yofu, Sachiko, and Matsunaga, Masaji

Abstract

Neuronal damages in lumbar spinal cord are known to induce the motor deficit after systemic ischemia including cardiac arrest and heart attack. Recently we reported that the neuronal damages in the hippocampus and lumbar spinal cord were induced after the combination of cardiac arrest and massive hemorrhagic shock. In the model, the neurons in intermediate gray matter were showed necrotic neuronal cell death at 1 d after ischemia. However, the damages of white matter did not understood well. Therefore, we focused on the white matter damages and have checked on the processes of the demyelination in limber spinal cord after severe systemic ischemia using electron microscopy. At 1 d, the myelin sheaths was collapsed and dissociated from axon although the axons seemed relatively intact. At 7 d, many shrank axons were observed and some of axons were disappeared. This result suggested the progressively demyelination was observed in ventral white matter in lumber spinal cord prior to axonal degeneration after severe systemic ischemia. [ABSTRACT FROM AUTHOR]

Published
2006
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31. CORRELATIONS BETWEEN LONG-RANGE COUPLINGS IN ELECTRON SPIN RESONANCE AND NUCLEAR MAGNETIC RESONANCE

Author

Kawamura, Takashi, Matsunaga, Masaji, and Yonezawa, Teijiro

Abstract

Correlations between coupling constants in electron spin resonance and nuclear magnetic resonance are examined. Plots of proton hyper-fine splitting constants of HR·against the corresponding proton–proton coupling constants of the parent hydrocarbons HRH are shown to fit one curve.

Published
1975
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44. Polymer Monolayer Dynamics

Author

Esker, Alan R., Kim, Chanjoong, Yu, Hyuk, Dong Liu, Xiang, Esker, Alan R., Häußler, Matthias, Kim, Chanjoong, Lucas, Patrice, Matsunaga, Masaji, Nishi, Norio, Robin, Jean-Jacques, Tang, Ben Zhong, Wang, Dong-An, Yamada, Masanori, and Yu, Hyuk

Published
2007
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