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Your search keyword '"Matsunaga, Tatsuya"' showing total 41 results
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41 results on '"Matsunaga, Tatsuya"'

5. Does the extension of the type of hysterectomy contribute to the local control of endometrial cancer?

Author

Hasegawa, Tetsuya, Furugori, Megumi, Kubota, Kazumi, Asai-Sato, Mikiko, Yashiro-Kawano, Aiko, Kato, Hisamori, Oi, Yuka, Shigeta, Hiroyuki, Segawa, Keiko, Kitagawa, Masakazu, Mine, Yuko, Saji, Haruya, Numazaki, Reiko, Maruyama, Yasuyo, Ohnuma, Emi, Taniguchi, Hanako, Sugiura, Ken, Miyagi, Etsuko, Matsunaga, Tatsuya, and Yokohama City University Gynecologic Oncology Research Group (YCUGO-ReG)

Published
2019
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8. Clinicopathological features and programmed death-ligand 1 immunohistochemical expression in a multicenter cohort of uterine and ovarian melanomas: a retrospective study in Japan (KCOG-G1701s)

Author

Yano, Mitsutake, primary, Nasu, Kaei, additional, Yasuda, Masanori, additional, Katoh, Tomomi, additional, Kagabu, Masahiro, additional, Kobara, Hisanori, additional, Matsuura, Motoki, additional, Tokuyama, Osamu, additional, Yamawaki, Takaharu, additional, Wakahashi, Senn, additional, Noguchi, Tomoko, additional, Mizuno, Kaoruko, additional, Shitsukawa, Keiji, additional, Onohara, Yoshimasa, additional, Nakabori, Takashi, additional, Miyasaka, Aki, additional, Nakao, Takehiro, additional, Matsunaga, Tatsuya, additional, Kunimi, Yusuke, additional, Sakurai, Manabu, additional, Uchiyama, Aya, additional, Itoh, Ryoji, additional, Ohike, Nobuyuki, additional, Hirakawa, Takashi, additional, Watanabe, Tadashi, additional, Nishino, Koji, additional, Motohashi, Takashi, additional, and Ito, Kimihiko, additional

Published
2022
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12. Detection of circulating tumor cells in patients with lung cancer using metallic micro-cavity array filter: A pilot study

Author

Nakamura Seita, Shinsuke Kitazawa, Hideo Ichimura, Katsuya Endo, Yukio Sato, Yusuke Yamamoto, Takeshi Nawa, Keisuke Kobayashi, Kei Shimizu, Matsunaga Tatsuya, Satomi Yagi, Hisashige Kanbara, and Taihei Odagiri

Subjects
Cancer Research, medicine.medical_specialty, Oncogene, business.industry, Cancer, Articles, medicine.disease, 03 medical and health sciences, Cytokeratin, 0302 clinical medicine, Circulating tumor cell, Oncology, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, Radiology, Sample collection, Stage (cooking), business, Lung cancer, Whole blood
Abstract

We have developed a metallic micro-cavity array filter and an automated detection system for capturing circulating tumor cells (CTCs). In this single institutional pilot study, we assessed the ability of this device to detect CTCs in patients with lung cancer at each stage. Patients diagnosed with lung cancer, undergoing planned surgery for lung cancer, or suspected of having lung cancer were recruited (40 recruited and 2 excluded). Blood samples were obtained from the patients and 3 ml whole blood was applied to the device without any preparation. The captured cells were stained to differentiate the nucleus, and determine cytokeratin and CD45 expression. Subsequently, two operators blinded to clinical information counted the number of CTCs. Sample collection was performed at the time of recruitment, before treatment and ~3 months after initial blood collection. CTC counts at recruitment were 1.4±0.4, 1.8±1.2, 1.3±0.6 and 7.4±5.1 (mean ± SE) in clinical stages I, II, III and IV, respectively. No significant difference was observed among the stages. These data indicated the ability of this device to detect CTCs at early or non-metastatic stages of lung cancer. Further research on a larger scale is needed for a more accurate assessment of the device, and research on the utility of captured cells remains a future challenge.

Published
2020

13. Design of IIR digital filters in the complex domain by transforming the desired response

Author

Matsunaga, Tatsuya, Yoshida, Masahiro, and Ikehara, Masaaki

Subjects
Digital filters -- Design and construction, Digital filters -- Usage, Signal processing -- Analysis, Error analysis (Mathematics), Digital signal processor, Business, Computers, Electronics, Electronics and electrical industries
Abstract

A new design method of infinite impulse response (IIR) digital filters with Quasi-equiripple absolute error in the complex domain is presented. By multiplying an arbitrary weighting function on the desired responses of passband and stopband, the error at the passband and stopband can be controlled.

Published
2004

15. Detection of circulating tumor cells in patients with lung cancer using metallic micro‑cavity array filter: A pilot study

Author

Ichimura, Hideo, primary, Nawa, Takeshi, additional, Yamamoto, Yusuke, additional, Shimizu, Kei, additional, Kobayashi, Keisuke, additional, Kitazawa, Shinsuke, additional, Kanbara, Hisashige, additional, Odagiri, Taihei, additional, Endo, Katsuya, additional, Matsunaga, Tatsuya, additional, Nakamura, Seita, additional, Yagi, Satomi, additional, and Sato, Yukio, additional

Published
2020
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17. Changes in the Clinicopathological Demographics of Vulvar Cancer in Japan: Increasing Oldest-Old, Stage Shifting, and Decreasing Cohort-Level Survival †

Author

Nishio, Shin, primary, Matsuo, Koji, additional, Shibata, Takeo, additional, Yamaguchi, Satoshi, additional, Kanao, Hiroyuki, additional, Takehara, Kazuhiro, additional, Kado, Nobuhiro, additional, Tozawa, Akiko, additional, Tokunaga, Hideki, additional, Matsunaga, Tatsuya, additional, Kato, Hisamori, additional, Horie, Koji, additional, Kikuchi, Akira, additional, Enomoto, Takayuki, additional, and Mikami, Mikio, additional

Published
2019
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19. Efficient solvent suppression with adiabatic inversion for 1H-detected solid-state NMR.

Author

Matsunaga, Tatsuya, Okabe, Ryotaro, and Ishii, Yoshitaka

Subjects
MAGIC angle spinning, SOLVENTS
Abstract

This study introduces a conceptually new solvent suppression scheme with adiabatic inversion pulses for 1H-detected multidimensional solid-state NMR (SSNMR) of biomolecules and other systems, which is termed "Solvent suppression of Liquid signal with Adiabatic Pulse" (SLAP). 1H-detected 2D 13C/1H SSNMR data of uniformly 13C- and 15N-labeled GB1 sample using ultra-fast magic angle spinning at a spinning rate of 60 kHz demonstrated that the SLAP scheme showed up to 3.5-fold better solvent suppression performance over a traditional solvent-suppression scheme for SSNMR, MISSISSIPPI (Zhou and Rienstra, J Magn Reson 192:167–172, 2008) with 2/3 of the average RF power. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Indicators of the need for insulin treatment and the effect of treatment for gestational diabetes on pregnancy outcomes in Japan

Author

Ito, Yuzuru, primary, Shibuya, Makoto, additional, Hosokawa, Saho, additional, Motoki, Yoko, additional, Nagata, Ryou, additional, Konishi, Hiromi, additional, Miyazaki, Takashi, additional, Matsunaga, Tatsuya, additional, Nomura, Yoshiyuki, additional, Mihara, Takashi, additional, Ito, Shihou, additional, Sugiura, Ken, additional, and Terauchi, Yasuo, additional

Published
2016
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34. Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo

Author

Niikura, Kenichi, primary, Matsunaga, Tatsuya, additional, Suzuki, Tadaki, additional, Kobayashi, Shintaro, additional, Yamaguchi, Hiroki, additional, Orba, Yasuko, additional, Kawaguchi, Akira, additional, Hasegawa, Hideki, additional, Kajino, Kiichi, additional, Ninomiya, Takafumi, additional, Ijiro, Kuniharu, additional, and Sawa, Hirofumi, additional

Published
2013
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40. Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitroand in Vivo

Author

Niikura, Kenichi, Matsunaga, Tatsuya, Suzuki, Tadaki, Kobayashi, Shintaro, Yamaguchi, Hiroki, Orba, Yasuko, Kawaguchi, Akira, Hasegawa, Hideki, Kajino, Kiichi, Ninomiya, Takafumi, Ijiro, Kuniharu, and Sawa, Hirofumi

Abstract

This paper demonstrates how the shape and size of gold nanoparticles (AuNPs) affect immunological responses in vivoand in vitrofor the production of antibodies for West Nile virus (WNV). We prepared spherical (20 and 40 nm in diameter), rod (40 × 10 nm), and cubic (40 × 40 × 40 nm) AuNPs as adjuvants and coated them with WNV envelope (E) protein. We measured anti-WNVE antibodies after inoculation of these WNVE-coated AuNPs (AuNP-Es) into mice. The 40 nm spherical AuNP-Es (Sphere40-Es) induced the highest level of WNVE-specific antibodies, while rod AuNP-Es (Rod-Es) induced only 50% of that of Sphere40-E. To examine the mechanisms of the shape-dependent WNVE antibody production, we next measured the efficiency of cellular uptake of AuNP-Es into RAW264.7 macrophage cells and bone-marrow-derived dendritic cells (BMDCs) and the subsequent cytokine secretion from BMDCs. The uptake of Rod-Es into the cells proceeded more efficiently than those of Sphere-Es or cubic WNVE-coated AuNPs (Cube-Es), suggesting that antibody production was not dependent on the uptake efficiency of the different AuNP-Es. Cytokine production from BMDCs treated with the AuNP-Es revealed that only Rod-E-treated cells produced significant levels of interleukin-1β (IL-1β) and interleukin-18 (IL-18), indicating that Rod-Es activated inflammasome-dependent cytokine secretion. Meanwhile, Sphere40-Es and Cube-Es both significantly induced inflammatory cytokine production, including tumor necrosis factor-α (TNF-α), IL-6, IL-12, and granulocyte macrophage colony-stimulating factor (GM-CSF). These results suggested that AuNPs are effective vaccine adjuvants and enhance the immune response viadifferent cytokine pathways depending on their sizes and shapes.

Published
2013
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41. Outcome of Radiation Therapy for Locally Advanced Vulvar Carcinoma: Analysis of Inguinal Lymph Node.

Author

Mukai Y, Koike I, Matsunaga T, Yokota NR, Kaizu H, Takano S, Sugiura M, Ito E, Miyagi E, and Hata M

Subjects
Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell radiotherapy, Female, Follow-Up Studies, Humans, Inguinal Canal radiation effects, Lymph Nodes radiation effects, Middle Aged, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local radiotherapy, Prognosis, Retrospective Studies, Survival Rate, Vulvar Neoplasms pathology, Vulvar Neoplasms radiotherapy, Carcinoma, Squamous Cell mortality, Inguinal Canal pathology, Lymph Nodes pathology, Neoplasm Recurrence, Local mortality, Radiotherapy mortality, Vulvar Neoplasms mortality
Abstract

Background/aim: The aim of this study was to define the outcome of radiation therapy for vulvar carcinoma, and to investigate the effectiveness of therapeutic and prophylactic inguinal lymph node (ILN) irradiation. Because reports about the treatment of ILN were limited., Patients and Methods: Thirty consecutive vulvar carcinoma patients were treated using external beam radiation therapy (EBRT) for definitive disease (n=25) or postoperatively (n=5). Twenty-four (80%) had squamous cell carcinoma (SCC). Tumor stages (2002 UICC) ranged from 0 to IVB, with no distant metastases., Results: The median total prescribed dose for primary tumor was 64.8 Gy. The 2-year overall survival rate was 25.3%. The outcome was significantly better in patients with ILNs<30 mm (p=0.005) and patients receiving prescribed doses >60 Gy (p=0.002)., Conclusions: ILN diameters ≤30 mm and prescribed doses over 60 Gy were associated with ILN control in patients with vulvar carcinoma., (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2020
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