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2,504 results on '"Matsuo, Koji"'

3. Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.

Author

Okada, Naohiro, Fukunaga, Masaki, Miura, Kenichiro, Nemoto, Kiyotaka, Matsumoto, Junya, Hashimoto, Naoki, Kiyota, Masahiro, Morita, Kentaro, Koshiyama, Daisuke, Ohi, Kazutaka, Takahashi, Tsutomu, Koeda, Michihiko, Yamamori, Hidenaga, Fujimoto, Michiko, Yasuda, Yuka, Hasegawa, Naomi, Narita, Hisashi, Yokoyama, Satoshi, Mishima, Ryo, Kawashima, Takahiko, Kobayashi, Yuko, Sasabayashi, Daiki, Harada, Kenichiro, Yamamoto, Maeri, Hirano, Yoji, Itahashi, Takashi, Nakataki, Masahito, Hashimoto, Ryu-Ichiro, Tha, Khin, Koike, Shinsuke, Matsubara, Toshio, Okada, Go, Jahanshad, Neda, Yoshimura, Reiji, Abe, Osamu, Onitsuka, Toshiaki, Watanabe, Yoshiyuki, Matsuo, Koji, Yamasue, Hidenori, Okamoto, Yasumasa, Suzuki, Michio, Turner, Jessica, Thompson, Paul, Ozaki, Norio, Kasai, Kiyoto, Hashimoto, Ryota, and Van Erp, Theodorus

Subjects
Humans, Schizophrenia, Depressive Disorder, Major, Bipolar Disorder, Female, Male, Magnetic Resonance Imaging, Adult, Neuroimaging, Brain, Autism Spectrum Disorder, Middle Aged, Mental Disorders, Organ Size
Abstract

Differential diagnosis is sometimes difficult in practical psychiatric settings, in terms of using the current diagnostic system based on presenting symptoms and signs. The creation of a novel diagnostic system using objective biomarkers is expected to take place. Neuroimaging studies and others reported that subcortical brain structures are the hubs for various psycho-behavioral functions, while there are so far no neuroimaging data-driven clinical criteria overcoming limitations of the current diagnostic system, which would reflect cognitive/social functioning. Prior to the main analysis, we conducted a large-scale multisite study of subcortical volumetric and lateralization alterations in schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder using T1-weighted images of 5604 subjects (3078 controls and 2526 patients). We demonstrated larger lateral ventricles volume in schizophrenia, bipolar disorder, and major depressive disorder, smaller hippocampus volume in schizophrenia and bipolar disorder, and schizophrenia-specific smaller amygdala, thalamus, and accumbens volumes and larger caudate, putamen, and pallidum volumes. In addition, we observed a leftward alteration of lateralization for pallidum volume specifically in schizophrenia. Moreover, as our main objective, we clustered the 5,604 subjects based on subcortical volumes, and explored whether data-driven clustering results can explain cognitive/social functioning in the subcohorts. We showed a four-biotype classification, namely extremely (Brain Biotype [BB] 1) and moderately smaller limbic regions (BB2), larger basal ganglia (BB3), and normal volumes (BB4), being associated with cognitive/social functioning. Specifically, BB1 and BB2-3 were associated with severe and mild cognitive/social impairment, respectively, while BB4 was characterized by normal cognitive/social functioning. Our results may lead to the future creation of novel biological data-driven psychiatric diagnostic criteria, which may be expected to be useful for prediction or therapeutic selection.

Published
2023

4. Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals.

Author

Matsumoto, Junya, Fukunaga, Masaki, Miura, Kenichiro, Nemoto, Kiyotaka, Okada, Naohiro, Hashimoto, Naoki, Morita, Kentaro, Koshiyama, Daisuke, Ohi, Kazutaka, Takahashi, Tsutomu, Koeda, Michihiko, Yamamori, Hidenaga, Fujimoto, Michiko, Yasuda, Yuka, Ito, Satsuki, Yamazaki, Ryuichi, Hasegawa, Naomi, Narita, Hisashi, Yokoyama, Satoshi, Mishima, Ryo, Miyata, Jun, Kobayashi, Yuko, Sasabayashi, Daiki, Harada, Kenichiro, Yamamoto, Maeri, Hirano, Yoji, Itahashi, Takashi, Nakataki, Masahito, Hashimoto, Ryu-Ichiro, Tha, Khin, Koike, Shinsuke, Matsubara, Toshio, Okada, Go, Yoshimura, Reiji, Abe, Osamu, Turner, Jessica, Jahanshad, Neda, Thompson, Paul, Onitsuka, Toshiaki, Watanabe, Yoshiyuki, Matsuo, Koji, Yamasue, Hidenori, Okamoto, Yasumasa, Suzuki, Michio, Ozaki, Norio, Kasai, Kiyoto, Hashimoto, Ryota, and Van Erp, Theodorus

Subjects
Humans, Depressive Disorder, Major, Autism Spectrum Disorder, Bipolar Disorder, Mental Disorders, Cerebral Cortex, Magnetic Resonance Imaging
Abstract

According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites. Effect sizes were determined using a linear regression model within each protocol, and these effect sizes were meta-analyzed. The similarity of the differences in cortical thickness and surface area of each disorder group was calculated using cosine similarity, which was calculated from the effect sizes of each cortical regions. The thinnest cortex was found in SZ, followed by BD and MDD. The cosine similarity values between disorders were 0.943 for SZ and BD, 0.959 for SZ and MDD, and 0.943 for BD and MDD, which indicated that a common pattern of cortical thickness alterations was found among SZ, BD, and MDD. Additionally, a generally smaller cortical surface area was found in SZ and MDD than in BD, and the effect was larger in SZ. The cosine similarity values between disorders were 0.945 for SZ and MDD, 0.867 for SZ and ASD, and 0.811 for MDD and ASD, which indicated a common pattern of cortical surface area alterations among SZ, MDD, and ASD. Patterns of alterations in cortical thickness and surface area were revealed in the four major psychiatric disorders. To our knowledge, this is the first report of a cross-disorder analysis conducted on four major psychiatric disorders. Cross-disorder brain imaging research can help to advance our understanding of the pathogenesis of psychiatric disorders and common symptoms.

Published
2023

8. Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages

Author

Groeger, Marko, Matsuo, Koji, Heidary Arash, Emad, Pereira, Ashley, Le Guillou, Dounia, Pino, Cindy, Telles-Silva, Kayque A, Maher, Jacquelyn J, Hsiao, Edward C, and Willenbring, Holger

Subjects
Biochemistry and Cell Biology, Biological Sciences, Nutrition, Digestive Diseases, Liver Disease, Stem Cell Research, Stem Cell Research - Induced Pluripotent Stem Cell, Diabetes, Chronic Liver Disease and Cirrhosis, Stem Cell Research - Induced Pluripotent Stem Cell - Human, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Aetiology, Development of treatments and therapeutic interventions, Metabolic and endocrine, Humans, Induced Pluripotent Stem Cells, Insulin Resistance, Diabetes Mellitus, Type 2, Liver, Hepatocytes, Inflammation, Macrophages, Insulins
Abstract

Hepatic insulin resistance is recognized as a driver of type 2 diabetes and fatty liver disease but specific therapies are lacking. Here we explore the potential of human induced pluripotent stem cells (iPSCs) for modeling hepatic insulin resistance in vitro, with a focus on resolving the controversy about the impact of inflammation in the absence of steatosis. For this, we establish the complex insulin signaling cascade and the multiple inter-dependent functions constituting hepatic glucose metabolism in iPSC-derived hepatocytes (iPSC-Heps). Co-culture of these insulin-sensitive iPSC-Heps with isogenic iPSC-derived pro-inflammatory macrophages induces glucose output by preventing insulin from inhibiting gluconeogenesis and glycogenolysis and activating glycolysis. Screening identifies TNFα and IL1β as the mediators of insulin resistance in iPSC-Heps. Neutralizing these cytokines together restores insulin sensitivity in iPSC-Heps more effectively than individual inhibition, reflecting specific effects on insulin signaling and glucose metabolism mediated by NF-κB or JNK. These results show that inflammation is sufficient to induce hepatic insulin resistance and establish a human iPSC-based in vitro model to mechanistically dissect and therapeutically target this metabolic disease driver.

Published
2023

20. ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages

Author

Matsuo, Koji, Lepinski, Abigail, Chavez, Robert D, Barruet, Emilie, Pereira, Ashley, Moody, Tania A, Ton, Amy N, Sharma, Aditi, Hellman, Judith, Tomoda, Kiichiro, Nakamura, Mary C, and Hsiao, Edward C

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Rare Diseases, Stem Cell Research, Stem Cell Research - Induced Pluripotent Stem Cell, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Activin Receptors, Type I, Humans, Induced Pluripotent Stem Cells, Macrophages, Myositis Ossificans, Ossification, Heterotopic, Signal Transduction, Human induced pluripotent stem cells, Fibrodysplasia ossificans progressiva, Heterotopic ossification, Inflammation, Immune activation, Cytokines, Activin A, FOP, Biological Sciences, Engineering, Medical and Health Sciences, Endocrinology & Metabolism, Clinical sciences
Abstract

Macrophages play crucial roles in many human disease processes. However, obtaining large numbers of primary cells for study is often difficult. We describe 2D and 3D methods for directing human induced pluripotent stem cells (hiPSCs) into macrophages (iMACs). iMACs generated in 2D culture showed functional similarities to human primary monocyte-derived M2-like macrophages, and could be successfully polarized into a M1-like phenotype. Both M1- and M2-like iMACs showed phagocytic activity and reactivity to endogenous or exogenous stimuli. In contrast, iMACs generated by a 3D culture system showed mixed M1- and M2-like functional characteristics. 2D-iMACs from patients with fibrodysplasia ossificans progressiva (FOP), an inherited disease with progressive heterotopic ossification driven by inflammation, showed prolonged inflammatory cytokine production and higher Activin A production after M1-like polarization, resulting in dampened responses to additional LPS stimulation. These results demonstrate a simple and robust way of creating hiPSC-derived M1- and M2-like macrophage lineages, while identifying macrophages as a source of Activin A that may drive heterotopic ossification in FOP.

Published
2021

35. Radical hysterectomy case volume and cervical cancer treatment in the era of COVID-19: A multi-site analysis of National Cancer Institute-designated Comprehensive Cancer Centers

Author

Wickenheisser, Natalie E., Dillon, Mairead, Broadwater, Gloria, Zacherl, Kathleen, Bixel, Kristin, Levine, Monica, Newton, Meredith, Thel, Hannah, Tucker, Katherine, Gehrig, Paola, Khetan, Varun U., Brunette-Masi, Laurie L., Matsuo, Koji, Khouri, Olivia R., Duhon, Ashley, Gowthaman, Divya, Cowan, Matthew, Mojdehbakhsh, Rachel, Rose, Stephen, Olawaiye, Alexander, Davidson, Brittany A., Moss, Haley A., and Havrilesky, Laura J.

Published
2023
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