1. A multicenter epidemiological study on second malignancy in non-syndromic pheochromocytoma/paraganglioma patients in Italy
- Author
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Luigi Petramala, Tonino Ercolino, Valentina Morelli, Marialuisa Appetecchia, Antongiulio Faggiano, Francesca Schiavi, P. Razzore, Uberta Verga, Anna Pia, Barbara Altieri, Francesca Brignardello, Massimo Terzolo, Antonio Concistrè, Antonio Stigliano, Soraya Puglisi, Micaela Pellegrino, Mario Maggi, Michaela Luconi, Giuseppe Opocher, Paola Berchialla, Massimo Mannelli, Emanuela Arvat, Mauro Maccario, Mirko Parasiliti-Caprino, Giuseppina De Filpo, Jacopo Burrello, Roberta Modica, Letizia Canu, Stefania Zovato, Alfonso Massimiliano Ferrara, Maura Arosio, Giuseppe Reimondo, Claudio Letizia, Elena Rapizzi, Canu, Letizia, Puglisi, Soraya, Berchialla, Paola, DE FILPO, Giuseppina, Brignardello, Francesca, Schiavi, Francesca, Ferrara, ALFONSO MASSIMILIANO, Zovato, Stefania, Luconi, Michaela, Anna, Pia, Appetecchia, Marialuisa, Arvat, Emanuela, Letizia, Claudio, Maccario, Mauro, Parasiliti-Caprino, Mirko, Altieri, Barbara, Faggiano, Antongiulio, Modica, Roberta, Morelli, Valentina, Arosio, Maura, Verga, Uberta, Pellegrino, Micaela, Petramala, Luigi, Concistrè, Antonio, Razzore, Paola, Ercolino, Tonino, Rapizzi, Elena, Maggi, Mario, Stigliano, Antonio, Burrello, Jacopo, Terzolo, Massimo, Opocher, Giuseppe, Mannelli, Massimo, and Matteo REIMONDO, Giuseppe
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Population ,genetic analysis ,Malignancy ,Mortality surveillance ,Article ,Pheochromocytoma ,paraganglioma ,Breast cancer ,Paraganglioma ,Internal medicine ,medicine ,ddc:610 ,education ,Thyroid cancer ,RC254-282 ,epidemiology ,mortality surveillance ,pheochromocytoma ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,mortality ,Standardized mortality ratio ,surveillance ,business - Abstract
No studies have carried out an extensive analysis of the possible association between non-syndromic pheochromocytomas and paragangliomas (PPGLs) and other malignancies. To assess the risk of additional malignancy in PPGL, we retrospectively evaluated 741 patients with PPGLs followed-up in twelve referral centers in Italy. Incidence of second malignant tumors was compared between this cohort and Italian patients with two subsequent malignancies. Among our patients, 95 (12.8%) developed a second malignant tumor, which were mainly prostate, colorectal and lung/bronchial cancers in males, breast cancer, differentiated thyroid cancer and melanoma in females. The standardized incidence ratio was 9.59 (95% CI 5.46–15.71) in males and 13.21 (95% CI 7.52–21.63) in females. At multivariable analysis, the risk of developing a second malignant tumor increased with age at diagnosis (HR 2.50, 95% CI 1.15–5.44, p = 0.021 for 50–59 vs. <, 50-year category, HR 3.46, 95% CI 1.67–7.15, p <, 0.001 for >, 60- vs. <, 50-year). In patients with available genetic evaluation, a positive genetic test was inversely associated with the risk of developing a second tumor (HR 0.25, 95% CI 0.10–0.63, p = 0.003). In conclusion, PPGLs patients have higher incidence of additional malignant tumors compared to the general population who had a first malignancy, which could have an impact on the surveillance strategy.
- Published
- 2021