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Your search keyword '"Mattheij, Nadine J.A."' showing total 14 results
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14 results on '"Mattheij, Nadine J.A."'

2. A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

Author

Baaten, Constance C.F.M.J., Meacham, Stuart, de Witt, Susanne M., Feijge, Marion A.H., Adams, David J., Akkerman, Jan-Willem N., Cosemans, Judith M.E.M., Grassi, Luigi, Jupe, Steve, Kostadima, Myrto, Mattheij, Nadine J.A., Prins, Martin H., Ramirez-Solis, Ramiro, Soehnlein, Oliver, Swieringa, Frauke, Weber, Christian, White, Jacqueline K., Ouwehand, Willem H., and Heemskerk, Johan W.M.

Published
2018
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8. A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

Author

Circulatory Health, Centraal Diagnostisch Laboratorium, Baaten, Constance C.F.M.J., Meacham, Stuart, De Witt, Susanne M., Feijge, Marion A.H., Adams, David J., Akkerman, Jan Willem N., Cosemans, Judith M.E.M., Grassi, Luigi, Jupe, Steve, Kostadima, Myrto, Mattheij, Nadine J.A., Prins, Martin H., Ramirez-Solis, Ramiro, Soehnlein, Oliver, Swieringa, Frauke, Weber, Christian, White, Jacqueline K., Ouwehand, Willem H., Heemskerk, Johan W.M., Circulatory Health, Centraal Diagnostisch Laboratorium, Baaten, Constance C.F.M.J., Meacham, Stuart, De Witt, Susanne M., Feijge, Marion A.H., Adams, David J., Akkerman, Jan Willem N., Cosemans, Judith M.E.M., Grassi, Luigi, Jupe, Steve, Kostadima, Myrto, Mattheij, Nadine J.A., Prins, Martin H., Ramirez-Solis, Ramiro, Soehnlein, Oliver, Swieringa, Frauke, Weber, Christian, White, Jacqueline K., Ouwehand, Willem H., and Heemskerk, Johan W.M.

Published
2018

9. Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies

Author

Nagy, Magdolna, primary, Mastenbroek, Tom G., additional, Mattheij, Nadine J.A., additional, de Witt, Susanne, additional, Clemetson, Kenneth J., additional, Kirschner, Janbernd, additional, Schulz, Ansgar S., additional, Vraetz, Thomas, additional, Speckmann, Carsten, additional, Braun, Attila, additional, Cosemans, Judith M.E.M., additional, Zieger, Barbara, additional, and Heemskerk, Johan W.M., additional

Published
2017
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10. Coated platelets function in platelet-dependent fibrin formation via integrin α IIb β 3 and transglutaminase factor XIII

Author

Mattheij, Nadine J.A., primary, Swieringa, Frauke, additional, Mastenbroek, Tom G., additional, Berny-Lang, Michelle A., additional, May, Frauke, additional, Baaten, Constance C.F.M.J., additional, van der Meijden, Paola E.J., additional, Henskens, Yvonne M.C., additional, Beckers, Erik A.M., additional, Suylen, Dennis P.L., additional, Nolte, Marc W., additional, Hackeng, Tilman M., additional, McCarty, Owen J.T., additional, Heemskerk, Johan W.M., additional, and Cosemans, Judith M.E.M., additional

Published
2015
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11. Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α

Author

Kuijpers, Marijke J.E., primary, Mattheij, Nadine J.A., additional, Cipolla, Lina, additional, van Geffen, Johanna P., additional, Lawrence, Toby, additional, Donners, Marjo M.P.C., additional, Boon, Louis, additional, Lievens, Dirk, additional, Torti, Mauro, additional, Noels, Heidi, additional, Gerdes, Norbert, additional, Cosemans, Judith M.E.M., additional, Lutgens, Esther, additional, and Heemskerk, Johan W.M., additional

Published
2015
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14. The effects of arterial flow on platelet activation, thrombus growth, and stabilization

Author

Cosemans, Judith M.E.M., Angelillo-Scherrer, Anne, Mattheij, Nadine J.A., Heemskerk, Johan W.M., Cosemans, Judith M.E.M., Angelillo-Scherrer, Anne, Mattheij, Nadine J.A., and Heemskerk, Johan W.M.

Abstract

Injury of an arterial vessel wall acutely triggers a multifaceted process of thrombus formation, which is dictated by the high-shear flow conditions in the artery. In this overview, we describe how the classical concept of arterial thrombus formation and vascular occlusion, driven by platelet activation and fibrin formation, can be extended and fine-tuned. This has become possible because of recent insight into the mechanisms of: (i) platelet-vessel wall and platelet-platelet communication, (ii) autocrine platelet activation, and (iii) platelet-coagulation interactions, in relation to blood flow dynamics. We list over 40 studies with genetically modified mice showing a role of platelet and plasma proteins in the control of thrombus stability after vascular injury. These include multiple platelet adhesive receptors and other junctional molecules, components of the ADP receptor signalling cascade to integrin activation, proteins controlling platelet shape, and autocrine activation processes, as well as multiple plasma proteins binding to platelets and proteins of the intrinsic coagulation cascade. Regulatory roles herein of the endothelium and other blood cells are recapitulated as well. Patient studies support the contribution of platelet- and coagulation activation in the regulation of thrombus stability. Analysis of the factors determining flow-dependent thrombus stabilization and embolus formation in mice will help to understand the regulation of this process in human arterial disease

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