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Introduction: The COVID-19 pandemic has affected millions worldwide, causing mortality and multi-organ morbidity. Neurological complications have been recognized. This study aimed to assess brain structural, microstructural, and connectivity alterations in patients with COVID-19-related olfactory or cognitive impairment using post-acute (time from onset: 264[208–313] days) multi-directional diffusion-weighted MRI (DW-MRI). Methods: The study included 16 COVID-19 patients with cognitive impairment (COVID-CM), 35 COVID-19 patients with olfactory disorder (COVID-OD), and 14 controls. A state-of-the-art processing pipeline was developed for DW-MRI pre-processing, mean diffusivity and fractional anisotropy computation, fiber density and cross-section analysis, and tractography of white-matter bundles. Brain parcellation required for probing network connectivity, region-specific microstructure and volume, and cortical thickness was based on T1-weighted scans and anatomical atlases. Results: Compared to controls, COVID-CM patients showed overall gray matter atrophy (age and sex corrected p = 0.004), and both COVID-19 patient groups showed regional atrophy and cortical thinning. Both groups presented an increase in gray matter mean diffusivity (corrected p = 0.001), decrease in white matter fiber density and cross-section (corrected p

This paper illustrates and discusses a novel method for the digital documentation of human remains in narrow spaces. A 360° borescope prototype made up of a panoramic camera and a lighting LED system was designed and assembled to acquire data in confined spaces for photogrammetric processing. A series of laboratory experiments were planned to assess the method’s validity. A modern concrete tunnel and a mock grave were surveyed using surveying instruments and a laser scanner, comparing the results with the borescope prototype. Then, data acquisition was moved to the field, i.e., in a real case study. Two burial vaults in a church containing human remains were selected and surveyed. The remains were accessible only from small breaches. The results show that using the 360° borescope is suitable for documenting narrow/confined spaces with minimum alteration of the scene. This result can be of interest for archaeological and forensic purposes, especially when the context is hardly accessible, with minimal intervention on the scene.

This paper describes the case study of the damaged church of St. Francesco in the hamlet of Arquata del Tronto (Italy) that was struck by the earthquake in 2016. The municipality commissioned the research to support the preliminary design of the preservation plan. The first digitisation level has been started from the richness of surveying data acquired from static and dynamic terrestrial laser scanning (TLS), and photogrammetry, overcoming challenging constraints due to the scaffolding covering the surfaces. The geometric survey allowed authors to acquire massively geometric and material information supporting the three-dimensional (3D) volume stratigraphic and the creation of the Heritage Building Information Modelling (HBIM). The paper proposes a shift from the Geographic Information System (GIS)-based analysis of the materials toward spatial HBIM management. Building Archaeology is turned into HBIM 3D volume stratigraphy, overcoming the bidimensional (2D) surface mapping, in favour of a 3D understanding of direct and indirect sources. Material mapping is added to HBIM 3D volume stratigraphy, and each stratigraphic unit (SU) has its proprieties. The 3D volume stratigraphic database has been designed to collect the data on the unit detection at three levels (direct sources data collection, indirect data documentation, the relation among the BIM object elements). A common data environment (CDE) has been set up to share the 3D volume informative models that can be accessed, and all the information gathered. The knowledge transfer using the eXtended reality (XR) has been devoted to the citizen and tourist fruition, enhancing the comprehension of difficult concepts like the SUs to support a better critical 3D reconstruction. It includes the phases of construction across time-lapse documentation that validates related information within the building archaeology informative models leaving spaces to the uncertainty and documenting the relationship established so far thanks to the direct and indirect sources. The result obtained is a live digital twin that can be continuously updated, which justifies the costs and time demanding of HBIM despite 2D drawings. Highlights: • 3D survey and scan-to-HBIM process for the creation of a digital twin were oriented to the preliminary design of the preservation plan of the church of St. Francesco in Arquata del Tronto (Italy). • Stratigraphy is investigated and oriented towards a digitisation process to share different levels of knowledge through new forms of digital-sharing such as Common Data Environment (CDE) and cloud-based BIM platform. • eXtended reality (XR) is the final tool to reach new levels of communication and a wider audience characterised by experts in the construction sector and virtual and non-expert tourists.

Background and objective: COVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity in COVID-19 patients, as assessed by morphologic evaluation of brain DWI scans only. The aim of this study was to assess and quantify brain diffusion alterations in COVID-19 patients with neurological manifestations. Methods: 215 COVID-19 patients with neurological manifestations (olfactory and/or other neurological disorders) and 36 normal controls were compared and studied with DWI and T1-weighted MRI scans. MRI scans were processed by a semi-automatic processing procedure specifically developed for the purpose of this study, and the Apparent Diffusion Coefficient (ADC) was quantified in different brain tissues and individual white matter (WM) and gray matter (GM) regions. Differences in ADC values were assessed between COVID-19 patients and normal controls, as well as in the COVID-19 patient population grouped by hospitalization and neurological symptoms. Results: Among COVID-19 patients (median [IQR] = 52 [42 – 60] years of age, 58 % females), 91 were hospitalized and 26 needed intensive care. 84 patients had hyposmia/ageusia only, while 131 ones showed other neurological disorders. COVID-19 patients showed significantly increased ADC values in the WM and in several GM regions (p

The article provides an overview of the digitisation project conducted by the Parco Archeologico dell’Appia Antica (PAAA) in Rome, focusing on an 11.7 km section of the Appian Way. This effort is part of the “Appia Regina Viarum” project, supporting the UNESCO heritage site candidacy of the Appian Way. Advanced sensor technologies, including the Mobile Mapping System (MMS), 360° Cameras, Terrestrial Laser Scanner (TLS), digital cameras, and drones, are employed to collect extensive data sets. The primary goal is to create highly accurate three-dimensional (3D) models for knowledge enhancement, conservation, and communication purposes. Innovative tools are introduced to manage High Resolution 3D textured models, improving maintenance, management, and design processes over traditional CAD methods. The project aims to develop multi-temporal Digital Twins integrated with historical documentation, such as Piranesi’s imaginary views and architect Canina’s monument reconstructions. These informative models function as nodes within the DT, serving the PAAA’s geographic hub by means of an eXtended Reality (XR) platform: the paper proposes bridging the physical object and virtual models, contributing to supporting the operators in the maintenance planning as well as information dissemination and public awareness, offering an immersive experience beyond conventional reality.

Digital recording of historic buildings and sites in mountainous areas could be challenging. The paper considers and discusses the case of historical defensive structures in the Italian Alps, designed and built to be not accessible. Drone images and photogrammetric techniques for 3D modeling play a fundamental role in the digital documentation of fortified constructions with non-contact techniques. This manuscript describes the use of drones for reconstructing the external surfaces of some fortified structures using traditional photogrammetric/SfM solutions and novel methods based on NeRFs. The case of direct orientation based on PPK and traditional GCPs placed on the ground is also discussed, considering the difficulties in placing and measuring control points in such environments.

Cultural and built heritage is nowadays recognized as a value not only in the socio-cultural field but also as an important economic driver. However, this non-renewable resource is more and more threatened by both external and internal factors and only by raising awareness on the vulnerability of cultural heritage we can lead to a real involvement of citizen to heritage site protection. In this sense, Virtual Museums (VMs), and more in general virtual technologies, can have a primary role to attract tourists and citizens. Indeed, VMs by presenting cultural concepts by using amusing and engaging techniques may reach younger generations in an easier way. In this paper, the specific case of the San Clemente archaeological site (Albenga, Italy) is addressed. Being the site in the riverbed of the Centa, it undergoes frequent flooding events causing continuously new damages to the archaeological site. The development of a virtual logbook of the site is presented along with the pre-processing steps that are necessary for the preparation of the published material. The logbook is addressed on one side to professionals (i.e. archaeologists and practitioners in cultural heritage) with the main aim of providing a tool for quick damage assessment. On the other side, a mobile app is on development for tourists and citizens allowing virtual exportation of the site and providing informative contents about it. Highlights: • Virtual museums and virtual environments are fundamental tools to raise awareness about the vulnerability of archaeological sites. • This paper presents the development of a virtual logbook, that can be used by experts and tourists, for the archaeological site of San Clemente (Albenga). • Integration of data coming from different sources is rendered into a web environment that can be easily accessed from both desktop and mobile devices.

This study summarises research progress to identify appropriate quality methodologies for representing, interpreting, and modelling complex contexts such as the Claudian Aqueduct in the Appian Way Archaeological Park. The goal is to intrinsically integrate (embed) geometric survey (Laser scanning and photogrammetric) with the materials and construction techniques (Stratigraphic Units—SU), semantic models in order to support the design with a better understanding of the artefact considered, and also to give indications that can be implemented in the future in a continuous cognitive process. Volume stratigraphic units in the form of architectural drawings, heritage building information modelling (HBIM) and extended reality (XR) environments have been oriented to comparative analyses based on the research case study’s complex morphology. Analysis of geometries’ intersection, construction techniques and materials open up new cognitive scenarios, self-feeding a progressive knowledge and making different studies correlatable, avoiding diaspora or incommunicability. Finally, an extended reality (XR) platform aims to enhance tangible and intangible values through new human-computer interaction and information sharing levels.

Digital twins (DTs) and building information modelling (BIM) are proving to be valuable tools for managing the entire life cycle of a building (LCB), from the early design stages to management and maintenance over time. On the other hand, BIM platforms cannot manage the geometric complexities of existing buildings and the large amount of information that sensors can collect. For this reason, this research proposes a scan-to-BIM process capable of managing high levels of detail (LODs) and information (LOIs) during the design, construction site management, and construction phases. Specific grades of generation (GOGs) were applied to create as-found, as-designed, and as-built models that interact with and support the rehabilitation project of a multi-level residential building. Furthermore, thanks to the sharing of specific APIs (Revit and Autodesk Forge APIs), it was possible to switch from static representations to novel levels of interoperability and interactivity for the user and more advanced forms of building management such as a DT, a BIM cloud, and an extended reality (XR) web platform. Finally, the development of a live app shows how different types of users (professionals and non-expert) can interact with the DT, in order to know the characteristics with which the environments have been designed, as well as the environmental parameters, increasing their degree of control, from the point of view of improving comfort, use, costs, behaviour, and good practices. Finally, the overall approach was verified through a real case study where the BIM-XR platform was built for energy improvements to existing buildings and façade renovations.

The objective of the applied research is the construction of a crossmedia map to discover the agricultural landscape, through the digitization and geo-referencing on Google maps of historical maps and photos of the Cà Granda Foundation Archive. It allows the visualization and immediate accessibility of landscape transformations, in a sort of multimedia journey through time.

The open data paradigm is changing the research approach in many fields such as remote sensing and the social sciences. This is supported by governmental decisions and policies that are boosting the open data wave, and in this context archaeology is also affected by this new trend. In many countries, archaeological data are still protected or only limited access is allowed. However, the strong political and economic support for the publication of government data as open data will change the accessibility and disciplinary expertise in the archaeological field too. In order to maximize the impact of data, their technical openness is of primary importance. Indeed, since a spreadsheet is more usable than a PDF of a table, the availability of digital archaeological data, which is structured using standardised approaches, is of primary importance for the real usability of published data. In this context, the main aim of this paper is to present a workflow for archaeological data sharing as open data with a large level of technical usability and interoperability. Primary data is mainly acquired through the use of digital techniques (e.g. digital cameras and terrestrial laser scanning). The processing of this raw data is performed with commercial software for scan registration and image processing, allowing for a simple and semi-automated workflow. Outputs obtained from this step are then processed in modelling and drawing environments to generate digital models, both 2D and 3D. These crude geometrical data are then enriched with further information to generate a Geographic Information System (GIS) which is finally published as open data using Open Geospatial Consortium (OGC) standards to maximise interoperability. Highlights: • Open data will change the accessibility and disciplinary expertise in the archaeological field. • The main aim of this paper is to present a workflow for archaeological data sharing as open data with a large level of interoperability. • Digital acquisition techniques are used to document archaeological excavations and a Geographic Information System (GIS) is generated that is published as open data.

Our built environment is nowadays considered as a dynamic complex, stretching and transforming across space and time, with the interaction of human, social and economic dimensions. It needs to be safeguarded as living places for the future taking into account such complexity. The general aim of this work is to contribute to the comprehension of landscape values, enhancing participation processes by tourists and local communities, considering the built environment as a system: the sum of natural transformation, ancient artefacts stratification and human activities, partially covering the tangible traces, and functioning as a vehicle for the comprehension of intangible values. Multi-temporal, multi-scale and geospatial datasets can play an important role in such knowledge transfer processes by means of narratives and immersive experiences in a multimedia museum approach. In particular, the cartographic heritage, in the form of metric and non-metric maps, can be progressively used as a source of information for innovative narratives. Virtual Museums (VMs)are additional "channels" to disseminate content and to provide knowledge about cultural heritage; they have emerged from the crossbreeding process between museums and digital technologies. Investigating how digital storytelling may support communication and understanding of complex systems, such as the built environment and landscape, it is relevant because cultural awareness may foster the sense of belonging and identity construction of which Europe is thirsty, contributing to the safeguarding of fragile sites. The paper provides useful information for museums that would like to follow this pathway. It retraces the main steps of storytelling production and presents interesting examples of immersive narrative models based on geospatial data and a virtual hub, helping people to retrieve and access information and to recognize places of memory mostly unknown. Moreover, it offers an evaluation of existing tools that can be adopted for this purpose. Eventually, by virtue of the research carried out for the case study of the Virtual Museum of Como Lake Landscape, the paper aims at ascertaining which kind of stories and experiences can be designed, the potential of these tools and possible weaknesses or constraints that deserve future researches. Highlights: • Investigation of a narrative approach to develop a theoretical model of virtual museums that can support communication and understanding of built environment and landscape. • Integration of multi-temporal, multi-scale cartography and geospatial datasets, as a narrative base and information to facilitate the landscape values comprehension by non-expert users. • Use of low-cost techniques (panoramic photos, 360° videos, 3D models) to design immersive experiences that can increase the interest of people in discovering the built environment.

In recent years, the advent of the latest-generation technologies and methods have made it possible to survey, digitise and represent complex scenarios such as archaeological sites and historic buildings. Thanks to computer languages based on Visual Programming Language (VPL) and advanced real-time 3D creation platform, this study shows the results obtained in eXtended Reality (XR) oriented to archaeological sites and heritage buildings. In particular, the scan-to-BIM process, digital photogrammetry (terrestrial and aerial) were oriented towards a digitisation process able to tell and share tangible and intangible values through the latest generation techniques, methods and devices. The paradigm of the geometric complexity of the built heritage and new levels of interactivity between users and digital worlds were investigated and developed to favour the transmissibility of information at different levels of virtual experience and digital sharing with the aim to archive, tell and implement historical and cultural baggage that over the years risks being lost and not told to future generations.

Building Information Modeling (BIM) has a crucial role in smart road applications, not only limited to the design and construction stages, but also to traffic monitoring, autonomous vehicle navigation, road condition assessment, and real-time data delivery to drivers, among others. Point clouds collected through LiDAR are a powerful solution to capture as-built conditions, notwithstanding the lack of commercial tools able to automatically reconstruct road geometry in a BIM environment. This paper illustrates a two-step procedure in which roads are automatically detected and classified, providing GIS layers with basic road geometry that are turned into parametric BIM objects. The proposed system is an integrated BIM-GIS with a structure based on multiple proposals, in which a single project file can handle different versions of the model using a variable level of detail. The model is also refined by adding parametric elements for buildings and vegetation. Input data for the integrated BIM-GIS can also be existing cartographic layers or outputs generated with algorithms able to handle LiDAR data. This makes the generation of the BIM-GIS more flexible and not limited to the use of specific algorithms for point cloud processing.

In recent years, many efforts have been invested in the cultural heritage digitization: surveying, modelling, diagnostic analysis and historic data collection. Nowadays, this effort is finalized in many cases towards historical building information modelling (HBIM). However, the architecture, engineering, construction and facility management (AEC-FM) domain is very fragmented and many experts operating with different data types and models are involved in HBIM projects. This prevents effective communication and sharing of the results not only among different professionals but also among different projects. Semantic web tools may significantly contribute in facilitating sharing, connection and integration of data provided in different domains and projects. The paper describes this aspect specifically focusing on managing the information and models acquired on the case of vaulted systems. Information is collected within a semantic based hub platform to perform cross correlation. Such functionality allows the reconstructing of the rich history of the construction techniques and skilled workers across Europe. To this purpose an ontology-based vaults database has been undertaken and an example of its implementation is presented. The developed ontology-based vaults database is a database that makes uses of a set of ontologies to effectively combine data and information from multiple heterogeneous sources. The defined ontologies provide a high-level schema of a data source and provides a vocabulary for user queries.

The identification of deterioration mechanisms and their monitoring over time is an essential phase for conservation. This work aimed at developing a novel approach for deterioration mapping and monitoring based on 360° images, which allows for simple and rapid data collection. The opportunity to capture the whole scene around a 360° camera reduces the number of images needed in a condition mapping project, resulting in a powerful solution to document small and narrow spaces. The paper will describe the implemented workflow for deterioration mapping based on 360° images, which highlights pathologies on surfaces and quantitatively measures their extension. Such a result will be available as standard outputs as well as an innovative virtual environment for immersive visualization. The case of multi-temporal data acquisition will be considered and discussed as well. Multiple 360° images acquired at different epochs from slightly different points are co-registered to obtain pixel-to-pixel correspondence, providing a solution to quantify and track deterioration effects.

A new 3D acquisition and processing procedure to map RGB, thermal IR and near infrared images (NIR) on a detailed 3D model of a building is presented. The combination and fusion of different data sources allows the generation of 3D thermal data useful for different purposes such as localization, visualization, and analysis of anomalies in contemporary architecture. The classic approach, which is currently used to map IR images on 3D models, is based on the direct registration of each single image by using space resection or homography. This approach is largely time consuming and in many cases suffers from poor object texture. To overcome these drawbacks, a “bi-camera” system coupling a thermal IR camera to a RGB camera has been setup. The second sensor is used to orient the “bi-camera” through a photogrammetric network also including free-handled camera stations to strengthen the block geometry. In many cases the bundle adjustment can be executed through a procedure for automatic extraction of tie points. Terrestrial laser scanning is adopted to retrieve the 3D model building. The integration of a low-cost NIR camera accumulates further radiometric information on the final 3D model. The use of such a sensor has not been exploited until now to assess the conservation state of buildings. Here some interesting findings from this kind of analysis are reported. The paper shows the methodology and its experimental application to a couple of buildings in the main Campus of Politecnico di Milano University, where IR thermography has previously been carried out for conservation and maintenance purposes.

Despite the increasing demand of updated and detailed indoor models, indoor reconstruction from point clouds is still in an early stage in comparison with the reconstruction of outdoor scenes. Specific challenges are related to the complex building layouts and the high presence of elements such as pieces of furniture causing clutter and occlusions. This work proposes an automatic method for modelling Manhattan-World indoors acquired with a mobile laser scanner in the presence of highly occluded walls. The core of the methodology is the transformation of indoor reconstruction into a labelling problem of structural cells in a 2D floor plan. Assuming the prevalence of orthogonal intersections between walls, indoor completion is formulated as an energy minimization problem using graph cuts. Doors and windows are detected from occlusions by implementing a ray-tracing algorithm. The methodology is tested in a real case study. Except for one window partially covered by a curtain, all building elements were successfully reconstructed.