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1. Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer

Author

Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., and Dunne, Philip D.

Published
2024
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2. Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors

Author

Blake, Andrew, Buffa, Francesca, Domingo, Enric, Higgins, Geoffrey, Holmes, Christopher, Koelzer, Viktor, Leedham, Simon, Maughan, Timothy, McKenna, Gillies, Robineau, James, Tomlinson, Ian, Youdell, Michael, Quirke, Philip, Richman, Susan, Sebag-Montefiore, David, Seymour, Matthew, West, Nicholas, Dunne, Philip, Kennedy, Richard, Lawler, Mark, Redmond, Keara, Salto-Tellez, Manuel, Campbell, Peter, Chatzipli, Aikaterini, Hardy, Claire, McDermott, Ultan, Bach, Simon, Beggs, Andrew, Cazier, Jean-Baptiste, Middleton, Gary, Morton, Dion, Whalley, Celina, Brown, Louise, Kaplan, Richard, Murray, Graeme, Wilson, Richard, Adams, Richard, Sullivan, Richard, Samuel, Leslie, Harkin, Paul, Walker, Steven, Hill, Jim, Wu, Chieh-Hsi, Horgan, Dennis, Rathee, Sanjay, Gollins, Simon, Begum, Rubina, Quirke, Phil, Barberis, Alessandro, Hassanieh, Sylvana, Mahmood, Umair, Buffa, Francesca M., and Maughan, Timothy S.

Published
2024
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3. Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer

Author

Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., and Dunne, Philip D.

Published
2024
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4. Prognostic value of liver metastases in colorectal cancer treated by systemic therapy: An ARCAD pooled analysis

Author

Cohen, Romain, Raeisi, Morteza, Chibaudel, Benoist, Shi, Qian, Yoshino, Takayuki, Zalcberg, John R., Adams, Richard, Cremolini, Chiara, Van Cutsem, Eric, Heinemann, Volker, Tabernero, Josep, Punt, Cornelis J.A., Arnold, Dirk, Hurwitz, Herbert I., Douillard, Jean-Yves, Venook, Alan P., Saltz, Leonard B., Maughan, Timothy S., Kabbinavar, Fairooz, Bokemeyer, Carsten, Grothey, Axel, Mayer, Robert J., Kaplan, Richard, Tebbutt, Niall C., Randolph Hecht, J., Giantonio, Bruce J., Díaz-Rubio, Eduardo, Sobrero, Alberto F., Peeters, Marc, Koopman, Miriam, Goldberg, Richard M., Andre, Thierry, and de Gramont, Aimery

Published
2024
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6. Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Author

Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., and Sansom, Owen J.

Published
2023
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7. Joint Prediction of Response to Therapy, Molecular Traits, and Spatial Organisation in Colorectal Cancer Biopsies

Author

Wood, Ruby, Domingo, Enric, Sirinukunwattana, Korsuk, Lafarge, Maxime W., Koelzer, Viktor H., Maughan, Timothy S., Rittscher, Jens, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Greenspan, Hayit, editor, Madabhushi, Anant, editor, Mousavi, Parvin, editor, Salcudean, Septimiu, editor, Duncan, James, editor, Syeda-Mahmood, Tanveer, editor, and Taylor, Russell, editor

Published
2023
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8. Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Author

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Potter, John, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David, Joshi, Amit, Schafmayer, Clemens, Scacheri, Peter, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Haiman, Christopher, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Gruber, Stephen, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, and Peters, Ulrike

Published
2023
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9. Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Responsep53 Pathway SNPs and Mutations Interact to Affect Cancer

Author

Zhang, Ping, Kitchen-Smith, Isaac, Xiong, Lingyun, Stracquadanio, Giovanni, Brown, Katherine, Richter, Philipp H, Wallace, Marsha D, Bond, Elisabeth, Sahgal, Natasha, Moore, Samantha, Nornes, Svanhild, De Val, Sarah, Surakhy, Mirvat, Sims, David, Wang, Xuting, Bell, Douglas A, Zeron-Medina, Jorge, Jiang, Yanyan, Ryan, Anderson J, Selfe, Joanna L, Shipley, Janet, Kar, Siddhartha, Pharoah, Paul D, Loveday, Chey, Jansen, Rick, Grochola, Lukasz F, Palles, Claire, Protheroe, Andrew, Millar, Val, Ebner, Daniel V, Pagadala, Meghana, Blagden, Sarah P, Maughan, Timothy S, Domingo, Enric, Tomlinson, Ian, Turnbull, Clare, Carter, Hannah, and Bond, Gareth L

Subjects
Clinical Research, Cancer, Prevention, Human Genome, Patient Safety, Genetics, Biotechnology, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Animals, Antineoplastic Agents, Biomarkers, Pharmacological, Carcinogenesis, Case-Control Studies, Cell Line, Tumor, Disease Progression, Drug Resistance, Neoplasm, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Germ-Line Mutation, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Mutation, Missense, Neoplasms, Polymorphism, Single Nucleotide, Prognosis, Risk Factors, Signal Transduction, Treatment Outcome, Tumor Suppressor Protein p53, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Insights into oncogenesis derived from cancer susceptibility loci (SNP) hold the potential to facilitate better cancer management and treatment through precision oncology. However, therapeutic insights have thus far been limited by our current lack of understanding regarding both interactions of these loci with somatic cancer driver mutations and their influence on tumorigenesis. For example, although both germline and somatic genetic variation to the p53 tumor suppressor pathway are known to promote tumorigenesis, little is known about the extent to which such variants cooperate to alter pathway activity. Here we hypothesize that cancer risk-associated germline variants interact with somatic TP53 mutational status to modify cancer risk, progression, and response to therapy. Focusing on a cancer risk SNP (rs78378222) with a well-documented ability to directly influence p53 activity as well as integration of germline datasets relating to cancer susceptibility with tumor data capturing somatically-acquired genetic variation provided supportive evidence for this hypothesis. Integration of germline and somatic genetic data enabled identification of a novel entry point for therapeutic manipulation of p53 activities. A cluster of cancer risk SNPs resulted in increased expression of prosurvival p53 target gene KITLG and attenuation of p53-mediated responses to genotoxic therapies, which were reversed by pharmacologic inhibition of the prosurvival c-KIT signal. Together, our results offer evidence of how cancer susceptibility SNPs can interact with cancer driver genes to affect cancer progression and identify novel combinatorial therapies. SIGNIFICANCE: These results offer evidence of how cancer susceptibility SNPs can interact with cancer driver genes to affect cancer progression and present novel therapeutic targets.

Published
2021

11. Enhancing Local Context of Histology Features in Vision Transformers

Author

Wood, Ruby, Sirinukunwattana, Korsuk, Domingo, Enric, Sauer, Alexander, Lafarge, Maxime W., Koelzer, Viktor H., Maughan, Timothy S., Rittscher, Jens, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kakileti, Siva Teja, editor, Gabrani, Maria, editor, Manjunath, Geetha, editor, Rosen-Zvi, Michal, editor, Braman, Nathaniel, editor, Schwartz, Robert G., editor, Frangi, Alejandro F., editor, Chung, Pau-Choo, editor, Weight, Christopher, editor, and Jagadish, Vekataraman, editor

Published
2022
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13. Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units

Author

Love, Sharon B., Cafferty, Fay, Snowdon, Claire, Carty, Karen, Savage, Joshua, Pallmann, Philip, McParland, Lucy, Brown, Louise, Masters, Lindsey, Schiavone, Francesca, Hague, Dominic, Townsend, Stephen, Amos, Claire, South, Annabelle, Sturgeon, Kate, Langley, Ruth, Maughan, Timothy, James, Nicholas, Hall, Emma, Kernaghan, Sarah, Bliss, Judith, Turner, Nick, Tutt, Andrew, Yap, Christina, Firth, Charlotte, Kong, Anthony, Mehanna, Hisham, Watts, Colin, Hills, Robert, Thomas, Ian, Copland, Mhairi, Bell, Sue, Sebag-Montefiore, David, Jones, Robert, Parmar, Mahesh K. B., and Sydes, Matthew R.

Published
2022
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15. Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Author

Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gundaz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., and Sansom, Owen J.

Published
2022
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16. Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Author

Fernandez-Rozadilla, Ceres, Timofeeva, Maria, Chen, Zhishan, Law, Philip, Thomas, Minta, Schmit, Stephanie, Díez-Obrero, Virginia, Hsu, Li, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah, Svinti, Victoria, Donnelly, Kevin, Farrington, Susan, Blackmur, James, Vaughan-Shaw, Peter, Shu, Xiao-ou, Long, Jirong, Cai, Qiuyin, Guo, Xingyi, Lu, Yingchang, Broderick, Peter, Studd, James, Huyghe, Jeroen, Harrison, Tabitha, Conti, David, Dampier, Christopher, Devall, Mathew, Schumacher, Fredrick, Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Moratalla-Navarro, Ferran, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John, Jenkins, Mark, Win, Aung Ko, Pai, Rish, Figueiredo, Jane, Haile, Robert, Gallinger, Steven, Woods, Michael, Newcomb, Polly, Duggan, David, Cheadle, Jeremy, Kaplan, Richard, Maughan, Timothy, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Lukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri, Rissanen, Harri, Pukkala, Eero, Eriksson, Johan, Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Zanke, Brent, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie, Ruiz-Narvaez, Edward, Palmer, Julie, Buchanan, Daniel, Platz, Elizabeth, Visvanathan, Kala, Ulrich, Cornelia, Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha, Potter, John, Tsilidis, Konstantinos, Schulze, Matthias, Gunter, Marc, Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Stern, Mariana, Pardamean, Bens, Bishop, Timothy, Giles, Graham, Southey, Melissa, Idos, Gregory, McDonnell, Kevin, Abu-Ful, Zomoroda, Greenson, Joel, Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope, van Guelpen, Bethany, Hudson, Thomas, Hampel, Heather, Pearlman, Rachel, Berndt, Sonja, Hayes, Richard, Martinez, Marie Elena, Thomas, Sushma, Corley, Douglas, Pharoah, Paul, Larsson, Susanna, Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly, Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew, Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David, Joshi, Amit, Schafmayer, Clemens, Scacheri, Peter, Kundaje, Anshul, Nickerson, Deborah, Schoen, Robert, Hampe, Jochen, Stadler, Zsofia, Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Papadopoulos, Nickolas, Edlund, Chistopher, Gauderman, William, Thomas, Duncan, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen, van Duijnhoven, Franzel, Feskens, Edith, Sakoda, Lori, Gago-Dominguez, Manuela, Wolk, Alicja, Naccarati, Alessio, Pardini, Barbara, FitzGerald, Liesel, Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie, Kooperberg, Charles, Li, Christopher, Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Tangen, Catherine, Mardis, Elaine, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Haiman, Christopher, Le Marchand, Loic, Wu, Anna, Qu, Chenxu, McNeil, Caroline, Coetzee, Gerhard, Hayward, Caroline, Deary, Ian, Harris, Sarah, Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Moreno, Victor, Casey, Graham, Gruber, Stephen, Tomlinson, Ian, Zheng, Wei, Dunlop, Malcolm, Houlston, Richard, and Peters, Ulrike

Published
2023
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17. Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project

Author

Sjoquist, Katrin M, Renfro, Lindsay A, Simes, R John, Tebbutt, Niall C, Clarke, Stephen, Seymour, Matthew T, Adams, Richard, Maughan, Timothy S, Saltz, Leonard, Goldberg, Richard M, Schmoll, Hans-Joachim, Van Cutsem, Eric, Douillard, Jean-Yves, Hoff, Paulo M, Hecht, Joel Randolph, Tournigand, Christophe, Punt, Cornelis JA, Koopman, Miriam, Hurwitz, Herbert, Heinemann, Volker, Falcone, Alfredo, Porschen, Rainer, Fuchs, Charles, Diaz-Rubio, Eduardo, Aranda, Enrique, Bokemeyer, Carsten, Souglakos, Ioannis, Kabbinavar, Fairooz F, Chibaudel, Benoist, Meyers, Jeffrey P, Sargent, Daniel J, de Gramont, Aimery, and Zalcberg, John R

Subjects
Patient Safety, Colo-Rectal Cancer, Digestive Diseases, Prevention, Clinical Research, Cancer, Aged, Colorectal Neoplasms, Disease Progression, Female, Humans, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Metastasis, Nomograms, Precision Medicine, Prognosis, Progression-Free Survival, Survival Analysis, Fondation Aide et Recherche en Cancerologie Digestive Group, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundEstimating prognosis on the basis of clinicopathologic factors can inform clinical practice and improve risk stratification for clinical trials. We constructed prognostic nomograms for one-year overall survival and six-month progression-free survival in metastatic colorectal carcinoma by using the ARCAD database.MethodsData from 22 674 patients in 26 randomized phase III clinical trials since 1997 were used to construct and validate Cox models, stratified by treatment arm within each study. Candidate variables included baseline age, sex, body mass index, performance status, colon vs rectal cancer, prior chemotherapy, number and location of metastatic sites, tumor mutation status (BRAF, KRAS), bilirubin, albumin, white blood cell count, hemoglobin, platelets, absolute neutrophil count, and derived neutrophil-to-lymphocyte ratio. Missing data (50% vs 50% vs

Published
2018

20. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial

Author

Shablack, Alaaeldin, O'Callaghan, Ann, Moody, (Margaret) Anne, Allen, Alex, Brewster, Alison, Brown, Alison, Mayer, Astrid, Davidson, Brian, Ton, Chan, Wilson, Charles, Lowdell, Charles, Rees, Charlotte, Baughan, Christopher, Barlow, Clare, Purcell, Colin, Smith, David, Tsang, David, Brown, Ewan, Walker, Georgina, Malik, Hassan, Cameron, Iain, Nolan, Luke, Hall, Marcia, Tomlinson, Marjorie, Hill, Mark, Peterson, Mark, Finch-Jones, Meg, Kumar, Nagappan, Karanjia, Nariman, Ali, Nasim, Heaton, Nigel, Ton, Nua Chan, Ross, Paul, Praseedom, Raaj, Thomas, Robert, Clive, Sally, Slater, Sarah, Smith, Sarah, Mudan, Satvinder, Bhattacharya, Satya, Essapen, Sharadah, Raouf, Sherif, Fenwick, Stephen, Cleator, Susan, Diamond, Tom, Potter, Vanessa, Bridgewater, John A, Pugh, Siân A, Maishman, Tom, Eminton, Zina, Mellor, Jane, Whitehead, Amy, Stanton, Louise, Radford, Michael, Corkhill, Andrea, Griffiths, Gareth O, Falk, Stephen, Valle, Juan W, O'Reilly, Derek, Siriwardena, Ajith K, Hornbuckle, Joanne, Rees, Myrddin, Iveson, Timothy J, Hickish, Tamas, Garden, O James, Cunningham, David, Maughan, Timothy S, and Primrose, John N

Published
2020
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22. Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

Author

May-Wilson, Sebastian, Sud, Amit, Law, Philip J., Palin, Kimmo, Tuupanen, Sari, Gylfe, Alexandra, Hänninen, Ulrika A., Cajuso, Tatiana, Tanskanen, Tomas, Kondelin, Johanna, Kaasinen, Eevi, Sarin, Antti-Pekka, Eriksson, Johan G., Rissanen, Harri, Knekt, Paul, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka-Pekka, Al-Tassan, Nada A., Palles, Claire, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Timothy S., Fisher, David, Kerr, Rachel, Kerr, David, Passarelli, Michael N., Figueiredo, Jane C., Buchanan, Daniel D., Win, Aung K., Hopper, John L., Jenkins, Mark A., Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steven, Conti, David, Schumacher, Fred, Casey, Graham, Aaltonen, Lauri A., Cheadle, Jeremy P., Tomlinson, Ian P., Dunlop, Malcolm G., and Houlston, Richard S.

Published
2017
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23. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

Author

Houlston, Richard S, Cheadle, Jeremy, Dobbins, Sara E, Tenesa, Albert, Jones, Angela M, Howarth, Kimberley, Spain, Sarah L, Broderick, Peter, Domingo, Enric, Farrington, Susan, Prendergast, James GD, Pittman, Alan M, Theodoratou, Evi, Smith, Christopher G, Olver, Bianca, Walther, Axel, Barnetson, Rebecca A, Churchman, Michael, Jaeger, Emma EM, Penegar, Steven, Barclay, Ella, Martin, Lynn, Gorman, Maggie, Mager, Rachel, Johnstone, Elaine, Midgley, Rachel, Niittymäki, Iina, Tuupanen, Sari, Colley, James, Idziaszczyk, Shelley, Thomas, Huw JW, Lucassen, Anneke M, Evans, D Gareth R, Maher, Eamonn R, Maughan, Timothy, Dimas, Antigone, Dermitzakis, Emmanouil, Cazier, Jean-Baptiste, Aaltonen, Lauri A, Pharoah, Paul, Kerr, David J, Carvajal-Carmona, Luis G, Campbell, Harry, Dunlop, Malcolm G, and Tomlinson, Ian PM

Subjects
Prevention, Cancer, Genetics, Colo-Rectal Cancer, Human Genome, Digestive Diseases, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 13, Chromosomes, Human, Pair 3, Colorectal Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Meta-Analysis as Topic, Odds Ratio, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Risk Assessment, COGENT Consortium, CORGI Consortium, COIN Collaborative Group, COINB Collaborative Group, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 × 10⁻¹⁰ and rs6687758, OR = 1.09, P = 2.27 × 10⁻⁹, 3q26.2 (rs10936599, OR = 0.93, P = 3.39 × 10⁻⁸), 12q13.13 (rs11169552, OR = 0.92, P = 1.89 × 10⁻¹⁰ and rs7136702, OR = 1.06, P = 4.02 × 10⁻⁸) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 × 10⁻¹⁰). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered.

Published
2010

27. Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database

Author

Franko, Jan, Shi, Qian, Meyers, Jeffrey P, Maughan, Timothy S, Adams, Richard A, Seymour, Matthew T, Saltz, Leonard, Punt, Cornelis J A, Koopman, Miriam, Tournigand, Christophe, Tebbutt, Niall C, Diaz-Rubio, Eduardo, Souglakos, John, Falcone, Alfredo, Chibaudel, Benoist, Heinemann, Volker, Moen, Joseph, De Gramont, Aimery, Sargent, Daniel J, and Grothey, Axel

Published
2016
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28. supplementary figures, from In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer

Author

Malla, Sudhir B., primary, Fisher, David J., primary, Domingo, Enric, primary, Blake, Andrew, primary, Hassanieh, Sylvana, primary, Redmond, Keara L., primary, Richman, Susan D., primary, Youdell, Michael, primary, Walker, Steven M., primary, Logan, Gemma E., primary, Chatzipli, Aikaterina, primary, Amirkhah, Raheleh, primary, Humphries, Matthew P., primary, Craig, Stephanie G., primary, McDermott, Ultan, primary, Seymour, Matthew T., primary, Morton, Dion G., primary, Quirke, Philip, primary, West, Nicholas P., primary, Salto-Tellez, Manuel, primary, Kennedy, Richard D., primary, Johnston, Patrick G., primary, Tomlinson, Ian, primary, Koelzer, Viktor H., primary, Campo, Letitia, primary, Kaplan, Richard S., primary, Longley, Daniel B., primary, Lawler, Mark, primary, Maughan, Timothy S., primary, Brown, Louise C., primary, and Dunne, Philip D., primary

Published
2023
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29. Data from Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response

Author

Zhang, Ping, primary, Kitchen-Smith, Isaac, primary, Xiong, Lingyun, primary, Stracquadanio, Giovanni, primary, Brown, Katherine, primary, Richter, Philipp H., primary, Wallace, Marsha D., primary, Bond, Elisabeth, primary, Sahgal, Natasha, primary, Moore, Samantha, primary, Nornes, Svanhild, primary, De Val, Sarah, primary, Surakhy, Mirvat, primary, Sims, David, primary, Wang, Xuting, primary, Bell, Douglas A., primary, Zeron-Medina, Jorge, primary, Jiang, Yanyan, primary, Ryan, Anderson J., primary, Selfe, Joanna L., primary, Shipley, Janet, primary, Kar, Siddhartha, primary, Pharoah, Paul D., primary, Loveday, Chey, primary, Jansen, Rick, primary, Grochola, Lukasz F., primary, Palles, Claire, primary, Protheroe, Andrew, primary, Millar, Val, primary, Ebner, Daniel V., primary, Pagadala, Meghana, primary, Blagden, Sarah P., primary, Maughan, Timothy S., primary, Domingo, Enric, primary, Tomlinson, Ian, primary, Turnbull, Clare, primary, Carter, Hannah, primary, and Bond, Gareth L., primary

Published
2023
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30. Supplementary Results from In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer

Author

Malla, Sudhir B., primary, Fisher, David J., primary, Domingo, Enric, primary, Blake, Andrew, primary, Hassanieh, Sylvana, primary, Redmond, Keara L., primary, Richman, Susan D., primary, Youdell, Michael, primary, Walker, Steven M., primary, Logan, Gemma E., primary, Chatzipli, Aikaterina, primary, Amirkhah, Raheleh, primary, Humphries, Matthew P., primary, Craig, Stephanie G., primary, McDermott, Ultan, primary, Seymour, Matthew T., primary, Morton, Dion G., primary, Quirke, Philip, primary, West, Nicholas P., primary, Salto-Tellez, Manuel, primary, Kennedy, Richard D., primary, Johnston, Patrick G., primary, Tomlinson, Ian, primary, Koelzer, Viktor H., primary, Campo, Letitia, primary, Kaplan, Richard S., primary, Longley, Daniel B., primary, Lawler, Mark, primary, Maughan, Timothy S., primary, Brown, Louise C., primary, and Dunne, Philip D., primary

Published
2023
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31. Supplementary Tables S1-5 and Figure S1 from Analyses of 7,635 Patients with Colorectal Cancer Using Independent Training and Validation Cohorts Show That rs9929218 in CDH1 Is a Prognostic Marker of Survival

Author

Smith, Christopher G., primary, Fisher, David, primary, Harris, Rebecca, primary, Maughan, Timothy S., primary, Phipps, Amanda I., primary, Richman, Susan, primary, Seymour, Matthew, primary, Tomlinson, Ian, primary, Rosmarin, Dan, primary, Kerr, David, primary, Chan, Andrew T., primary, Peters, Ulrike, primary, Newcomb, Polly A., primary, Idziaszczyk, Shelley, primary, West, Hannah, primary, Meade, Angela, primary, Kaplan, Richard, primary, and Cheadle, Jeremy P., primary

Published
2023
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33. Supplementary Figure 2 from Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab

Author

Smith, Christopher G., primary, Fisher, David, primary, Claes, Bart, primary, Maughan, Timothy S., primary, Idziaszczyk, Shelley, primary, Peuteman, Gilian, primary, Harris, Rebecca, primary, James, Michelle D., primary, Meade, Angela, primary, Jasani, Bharat, primary, Adams, Richard A., primary, Kenny, Sarah, primary, Kaplan, Richard, primary, Lambrechts, Diether, primary, and Cheadle, Jeremy P., primary

Published
2023
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34. Supplementary Data from Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response

Author

Zhang, Ping, primary, Kitchen-Smith, Isaac, primary, Xiong, Lingyun, primary, Stracquadanio, Giovanni, primary, Brown, Katherine, primary, Richter, Philipp H., primary, Wallace, Marsha D., primary, Bond, Elisabeth, primary, Sahgal, Natasha, primary, Moore, Samantha, primary, Nornes, Svanhild, primary, De Val, Sarah, primary, Surakhy, Mirvat, primary, Sims, David, primary, Wang, Xuting, primary, Bell, Douglas A., primary, Zeron-Medina, Jorge, primary, Jiang, Yanyan, primary, Ryan, Anderson J., primary, Selfe, Joanna L., primary, Shipley, Janet, primary, Kar, Siddhartha, primary, Pharoah, Paul D., primary, Loveday, Chey, primary, Jansen, Rick, primary, Grochola, Lukasz F., primary, Palles, Claire, primary, Protheroe, Andrew, primary, Millar, Val, primary, Ebner, Daniel V., primary, Pagadala, Meghana, primary, Blagden, Sarah P., primary, Maughan, Timothy S., primary, Domingo, Enric, primary, Tomlinson, Ian, primary, Turnbull, Clare, primary, Carter, Hannah, primary, and Bond, Gareth L., primary

Published
2023
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35. Supplementary Figure 3 from Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab

Author

Smith, Christopher G., primary, Fisher, David, primary, Claes, Bart, primary, Maughan, Timothy S., primary, Idziaszczyk, Shelley, primary, Peuteman, Gilian, primary, Harris, Rebecca, primary, James, Michelle D., primary, Meade, Angela, primary, Jasani, Bharat, primary, Adams, Richard A., primary, Kenny, Sarah, primary, Kaplan, Richard, primary, Lambrechts, Diether, primary, and Cheadle, Jeremy P., primary

Published
2023
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36. Supplementary Figure Legends from Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab

Author

Smith, Christopher G., primary, Fisher, David, primary, Claes, Bart, primary, Maughan, Timothy S., primary, Idziaszczyk, Shelley, primary, Peuteman, Gilian, primary, Harris, Rebecca, primary, James, Michelle D., primary, Meade, Angela, primary, Jasani, Bharat, primary, Adams, Richard A., primary, Kenny, Sarah, primary, Kaplan, Richard, primary, Lambrechts, Diether, primary, and Cheadle, Jeremy P., primary

Published
2023
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37. Supplementary Figure 1 from Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab

Author

Smith, Christopher G., primary, Fisher, David, primary, Claes, Bart, primary, Maughan, Timothy S., primary, Idziaszczyk, Shelley, primary, Peuteman, Gilian, primary, Harris, Rebecca, primary, James, Michelle D., primary, Meade, Angela, primary, Jasani, Bharat, primary, Adams, Richard A., primary, Kenny, Sarah, primary, Kaplan, Richard, primary, Lambrechts, Diether, primary, and Cheadle, Jeremy P., primary

Published
2023
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38. Supplementary Materials and Methods and Tables 1-5 from Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab

Author

Smith, Christopher G., primary, Fisher, David, primary, Claes, Bart, primary, Maughan, Timothy S., primary, Idziaszczyk, Shelley, primary, Peuteman, Gilian, primary, Harris, Rebecca, primary, James, Michelle D., primary, Meade, Angela, primary, Jasani, Bharat, primary, Adams, Richard A., primary, Kenny, Sarah, primary, Kaplan, Richard, primary, Lambrechts, Diether, primary, and Cheadle, Jeremy P., primary

Published
2023
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39. Supplementary Data from In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer

Author

Malla, Sudhir B., primary, Fisher, David J., primary, Domingo, Enric, primary, Blake, Andrew, primary, Hassanieh, Sylvana, primary, Redmond, Keara L., primary, Richman, Susan D., primary, Youdell, Michael, primary, Walker, Steven M., primary, Logan, Gemma E., primary, Chatzipli, Aikaterina, primary, Amirkhah, Raheleh, primary, Humphries, Matthew P., primary, Craig, Stephanie G., primary, McDermott, Ultan, primary, Seymour, Matthew T., primary, Morton, Dion G., primary, Quirke, Philip, primary, West, Nicholas P., primary, Salto-Tellez, Manuel, primary, Kennedy, Richard D., primary, Johnston, Patrick G., primary, Tomlinson, Ian, primary, Koelzer, Viktor H., primary, Campo, Letitia, primary, Kaplan, Richard S., primary, Longley, Daniel B., primary, Lawler, Mark, primary, Maughan, Timothy S., primary, Brown, Louise C., primary, and Dunne, Philip D., primary

Published
2023
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41. Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer

Author

Brown, Louise C, Graham, Janet, Fisher, David, Adams, Richard, Seligmann, Jenny, Seymour, Matthew, Kaplan, Richard, Yates, Emma, Parmar, Mahesh, Richman, Susan D, Quirke, Philip, Butler, Rachel, Shiu, Kaikeen, Middleton, Gary, Samuel, Leslie, Wilson, Richard H., and Maughan, Timothy S

Subjects
Pharmacology, Class I Phosphatidylinositol 3-Kinases, Rectal Neoplasms, Colonic Neoplasms, Humans, General Medicine, Colorectal Neoplasms
Abstract

Background: Complex innovative design trials are becoming increasingly common and offer potential for improving patient outcomes in a faster time frame. FOCUS4 was the first molecularly stratified trial in metastatic colorectal cancer and it remains one of the first umbrella trial designs to be launched globally. Here, we aim to describe lessons learned from delivery of the trial over the last 10 years. Methods: FOCUS4 was a Phase II/III molecularly stratified umbrella trial testing the safety and efficacy of targeted therapies in metastatic colorectal cancer. It used adaptive statistical methodology to decide which sub-trial should close early, and new therapies were added as protocol amendments. Patients with newly diagnosed metastatic colorectal cancer were registered, and central laboratory testing was used to stratify their tumour into molecular subtypes. Following 16 weeks of first-line therapy, patients with stable or responding disease were eligible for randomisation into either a molecularly stratified sub-trial (FOCUS4-B, C or D) or non-stratified FOCUS4-N. The primary outcome for all studies was progression-free survival comparing the intervention with active monitoring/placebo. At the close of the trial, feedback was elicited from all investigators through surveys and interviews and consolidated into a series of recommendations and lessons learned for the delivery of similar future trials. Results: Between January 2014 and October 2020, 1434 patients were registered from 88 UK hospitals. Of the 20 drug combinations that were explored for inclusion in the platform trial, three molecularly targeted sub-trials were activated: FOCUS4-D (February 2014–March 2016) evaluated AZD8931 in the BRAF-PIK3CA-RAS wildtype subgroup; FOCUS4-B (February 2016–July 2018) evaluated aspirin in the PIK3CA mutant subgroup and FOCUS4-C (June 2017–October 2020) evaluated adavosertib in the RAS+TP53 double mutant subgroup. FOCUS4-N was active throughout and evaluated capecitabine monotherapy versus a treatment break. A total of 361 (25%) registered patients were randomised into a sub-trial. Feedback on the experiences of delivery of FOCUS4 could be grouped into three main areas of challenge: funding/infrastructure, biomarker testing procedures and trial design efficiencies within which 20 recommendations are summarised. Conclusion: Adaptive stratified medicine platform studies are feasible in common cancers but present challenges. Our stakeholder feedback has helped to inform how these trial designs can succeed and answer multiple questions efficiently, providing resource is adequate.

Published
2022

42. The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression

Author

Thomas, Rachael, Trapani, Davide, Goodyer-Sait, Lily, Tomkova, Marketa, Fernandez-Rozadilla, Ceres, Sahnane, Nora, Woolley, Connor, Davis, Hayley, Chegwidden, Laura, Kriaucionis, Skirmantas, Maughan, Timothy, Leedham, Simon, Palles, Claire, Furlan, Daniela, Tomlinson, Ian, and Lewis, Annabelle

Published
2019
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44. Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2)

Author

Strauss, Victoria Y., Shaw, Rachel, Virdee, Pradeep S., Hurt, Christopher N., Ward, Elizabeth, Tranter, Bethan, Patel, Neel, Bridgewater, John, Parsons, Philip, Radhakrishna, Ganesh, O’Neill, Eric, Sebag-Montefiore, David, Hawkins, Maria, Corrie, Pippa G., Maughan, Timothy, and Mukherjee, Somnath

Published
2019
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46. Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Author

Fernandez-Rozadilla, Ceres, primary, Timofeeva, Maria, additional, Chen, Zhishan, additional, Law, Philip, additional, Thomas, Minta, additional, Schmit, Stephanie, additional, Díez-Obrero, Virginia, additional, Hsu, Li, additional, Fernandez-Tajes, Juan, additional, Palles, Claire, additional, Sherwood, Kitty, additional, Briggs, Sarah, additional, Svinti, Victoria, additional, Donnelly, Kevin, additional, Farrington, Susan, additional, Blackmur, James, additional, Vaughan-Shaw, Peter, additional, Shu, Xiao-ou, additional, Long, Jirong, additional, Cai, Qiuyin, additional, Guo, Xingyi, additional, Lu, Yingchang, additional, Broderick, Peter, additional, Studd, James, additional, Huyghe, Jeroen, additional, Harrison, Tabitha, additional, Conti, David, additional, Dampier, Christopher, additional, Devall, Mathew, additional, Schumacher, Fredrick, additional, Melas, Marilena, additional, Rennert, Gad, additional, Obón-Santacana, Mireia, additional, Martín-Sánchez, Vicente, additional, Moratalla-Navarro, Ferran, additional, Oh, Jae Hwan, additional, Kim, Jeongseon, additional, Jee, Sun Ha, additional, Jung, Keum Ji, additional, Kweon, Sun-Seog, additional, Shin, Min-Ho, additional, Shin, Aesun, additional, Ahn, Yoon-Ok, additional, Kim, Dong-Hyun, additional, Oze, Isao, additional, Wen, Wanqing, additional, Matsuo, Keitaro, additional, Matsuda, Koichi, additional, Tanikawa, Chizu, additional, Ren, Zefang, additional, Gao, Yu-Tang, additional, Jia, Wei-Hua, additional, Hopper, John, additional, Jenkins, Mark, additional, Win, Aung Ko, additional, Pai, Rish, additional, Figueiredo, Jane, additional, Haile, Robert, additional, Gallinger, Steven, additional, Woods, Michael, additional, Newcomb, Polly, additional, Duggan, David, additional, Cheadle, Jeremy, additional, Kaplan, Richard, additional, Maughan, Timothy, additional, Kerr, Rachel, additional, Kerr, David, additional, Kirac, Iva, additional, Böhm, Jan, additional, Mecklin, Lukka-Pekka, additional, Jousilahti, Pekka, additional, Knekt, Paul, additional, Aaltonen, Lauri, additional, Rissanen, Harri, additional, Pukkala, Eero, additional, Eriksson, Johan, additional, Cajuso, Tatiana, additional, Hänninen, Ulrika, additional, Kondelin, Johanna, additional, Palin, Kimmo, additional, Tanskanen, Tomas, additional, Renkonen-Sinisalo, Laura, additional, Zanke, Brent, additional, Männistö, Satu, additional, Albanes, Demetrius, additional, Weinstein, Stephanie, additional, Ruiz-Narvaez, Edward, additional, Palmer, Julie, additional, Buchanan, Daniel, additional, Platz, Elizabeth, additional, Visvanathan, Kala, additional, Ulrich, Cornelia, additional, Siegel, Erin, additional, Brezina, Stefanie, additional, Gsur, Andrea, additional, Campbell, Peter, additional, Chang-Claude, Jenny, additional, Hoffmeister, Michael, additional, Brenner, Hermann, additional, Slattery, Martha, additional, Potter, John, additional, Tsilidis, Konstantinos, additional, Schulze, Matthias, additional, Gunter, Marc, additional, Murphy, Neil, additional, Castells, Antoni, additional, Castellví-Bel, Sergi, additional, Moreira, Leticia, additional, Arndt, Volker, additional, Shcherbina, Anna, additional, Stern, Mariana, additional, Pardamean, Bens, additional, Bishop, Timothy, additional, Giles, Graham, additional, Southey, Melissa, additional, Idos, Gregory, additional, McDonnell, Kevin, additional, Abu-Ful, Zomoroda, additional, Greenson, Joel, additional, Shulman, Katerina, additional, Lejbkowicz, Flavio, additional, Offit, Kenneth, additional, Su, Yu-Ru, additional, Steinfelder, Robert, additional, Keku, Temitope, additional, van Guelpen, Bethany, additional, Hudson, Thomas, additional, Hampel, Heather, additional, Pearlman, Rachel, additional, Berndt, Sonja, additional, Hayes, Richard, additional, Martinez, Marie Elena, additional, Thomas, Sushma, additional, Corley, Douglas, additional, Pharoah, Paul, additional, Larsson, Susanna, additional, Yen, Yun, additional, Lenz, Heinz-Josef, additional, White, Emily, additional, Li, Li, additional, Doheny, Kimberly, additional, Pugh, Elizabeth, additional, Shelford, Tameka, additional, Chan, Andrew, additional, Cruz-Correa, Marcia, additional, Lindblom, Annika, additional, Hunter, David, additional, Joshi, Amit, additional, Schafmayer, Clemens, additional, Scacheri, Peter, additional, Kundaje, Anshul, additional, Nickerson, Deborah, additional, Schoen, Robert, additional, Hampe, Jochen, additional, Stadler, Zsofia, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Vymetalkova, Veronika, additional, Papadopoulos, Nickolas, additional, Edlund, Chistopher, additional, Gauderman, William, additional, Thomas, Duncan, additional, Shibata, David, additional, Toland, Amanda, additional, Markowitz, Sanford, additional, Kim, Andre, additional, Chanock, Stephen, additional, van Duijnhoven, Franzel, additional, Feskens, Edith, additional, Sakoda, Lori, additional, Gago-Dominguez, Manuela, additional, Wolk, Alicja, additional, Naccarati, Alessio, additional, Pardini, Barbara, additional, FitzGerald, Liesel, additional, Lee, Soo Chin, additional, Ogino, Shuji, additional, Bien, Stephanie, additional, Kooperberg, Charles, additional, Li, Christopher, additional, Lin, Yi, additional, Prentice, Ross, additional, Qu, Conghui, additional, Bézieau, Stéphane, additional, Tangen, Catherine, additional, Mardis, Elaine, additional, Yamaji, Taiki, additional, Sawada, Norie, additional, Iwasaki, Motoki, additional, Haiman, Christopher, additional, Le Marchand, Loic, additional, Wu, Anna, additional, Qu, Chenxu, additional, McNeil, Caroline, additional, Coetzee, Gerhard, additional, Hayward, Caroline, additional, Deary, Ian, additional, Harris, Sarah, additional, Theodoratou, Evropi, additional, Reid, Stuart, additional, Walker, Marion, additional, Ooi, Li Yin, additional, Moreno, Victor, additional, Casey, Graham, additional, Gruber, Stephen, additional, Tomlinson, Ian, additional, Zheng, Wei, additional, Dunlop, Malcolm, additional, Houlston, Richard, additional, and Peters, Ulrike, additional

Published
2022
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47. Molecular selection of therapy in metastatic colorectal cancer: the FOCUS4 molecularly stratified RCT

Author

Brown, Louise C, primary, Fisher, David, additional, Adams, Richard, additional, Seligmann, Jenny, additional, Seymour, Matthew, additional, Kaplan, Richard, additional, Richman, Susan D, additional, Quirke, Philip, additional, Butler, Rachel, additional, Roberts, Helen, additional, Graham, Janet, additional, Wilson, Richard H, additional, and Maughan, Timothy S, additional

Published
2022
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48. Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

Author

Gil Vazquez, Ester, primary, Nasreddin, Nadia, additional, Valbuena, Gabriel N., additional, Mulholland, Eoghan J., additional, Belnoue-Davis, Hayley L., additional, Eggington, Holly R., additional, Schenck, Ryan O., additional, Wouters, Valérie M., additional, Wirapati, Pratyaksha, additional, Gilroy, Kathryn, additional, Lannagan, Tamsin R.M., additional, Flanagan, Dustin J., additional, Najumudeen, Arafath K., additional, Omwenga, Sulochana, additional, McCorry, Amy M.B., additional, Easton, Alistair, additional, Koelzer, Viktor H., additional, East, James E., additional, Morton, Dion, additional, Trusolino, Livio, additional, Maughan, Timothy, additional, Campbell, Andrew D., additional, Loughrey, Maurice B., additional, Dunne, Philip D., additional, Tsantoulis, Petros, additional, Huels, David J., additional, Tejpar, Sabine, additional, Sansom, Owen J., additional, and Leedham, Simon J., additional

Published
2022
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49. Erratum: Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia (Cell Stem Cell (2022) 29(8) (1213–1228.e8), (S1934590922003034), (10.1016/j.stem.2022.07.008))

Author

Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R. M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M. B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J., Center of Experimental and Molecular Medicine, CCA - Cancer biology and immunology, and CCA - Imaging and biomarkers

Abstract

(Cell Stem Cell 29, 1213–1228, August 4, 2022) In the version of our manuscript that was accepted by the Cell Press editorial office, we mistakenly included a misspelling of the first author's surname. We did not catch this unfortunate error during the production process, and the manuscript published with the error included. We have now corrected the spelling, and the correct author list appears here and in the online version of our article. We apologize for the oversight.

Published
2022

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