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6 results on '"Maurizio Toraldo, Domenico"'

1. Use of cluster analysis to describe desaturator phenotypes in COPD: correlations between pulmonary function tests and nocturnal oxygen desaturation

Author

Maurizio Toraldo,Domenico, De Nuccio,Francesco, Gaballo,Annarita, Nicolardi,Giuseppe, Maurizio Toraldo,Domenico, De Nuccio,Francesco, Gaballo,Annarita, and Nicolardi,Giuseppe

Abstract

Domenico Maurizio Toraldo1, Francesco De Nuccio2, Annarita Gaballo1, Giuseppe Nicolardi21A Galateo Lung Disease Hospital, Regional Service Puglia, San Cesario di Lecce, 2Laboratory of Human Anatomy, Department of Biological and Environmental Sciences and Technologies, University of Lecce, Lecce, ItalyBackground: Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD). Although forced expiratory volume in 1 second (FEV1) inadequately describes this heterogeneity, a clear alternative has not emerged. This article discusses and refines the concept of phenotyping desaturators in COPD and shows a possible pattern which could be used as a framework for future research.Recent findings: COPD is a complex condition with pulmonary and extrapulmonary manifestations. We suggest that COPD phenotypes should be associated with clinically meaningful outcomes. The innovation of COPD phenotyping is defined as COPD desaturators. Sleep-related hypoxemia and hypercapnia are well recognized in COPD and the development of systemic inflammation during sleep. These sleep-related changes predispose to nocturnal cardiac arrhythmias, pulmonary hypertension, and possibly death, particularly during acute exacerbations.Conclusion: A more focused definition makes possible a classification of patients into two distinct subgroups for both clinical and research purposes. Establishing a common language for future research will facilitate our understanding and management of such diseases. Even if different treatment strategies have different outcomes for these groups, we will have confirmation, or otherwise, of the clinical value of cluster analysis. This knowledge could lead to pharmacological treatment and other interventions directed to specific phenotypic groups.Keywords: phenotypes, chronic obstructive pulmonary disease, desaturator, nocturnal hypoxemia, systemic inflammation, intermittent hypoxia

Published
2011

5. Cognitive and socio–cognitive deficits in patients with Obstructive Sleep Apnea

Author

Luigi Macchitella, Daniele Luigi Romano, Chiara Valeria Marinelli, Domenico Maurizio Toraldo, Michele Arigliani, Michele De Benedetto, Paola Angelelli, Macchitella, Luigi, Romano, DANIELE LUIGI, Valeria Marinelli, Chiara, Maurizio Toraldo, Domenico, Arigliani, Michele, De Benedetto, Michele, and Angelelli, Paola

Abstract

Obstructive sleep apnea (OSA) is one of the most common sleep breathing disorders (SRBDs). It is associated with (under-recognized) cognitive impairment as well as with psychiatric disorders, motor vehicle accidents, low work performance, low social functioning and decrease in quality of life. As a result of the cognitive deficits that characterize patients with OSA, the syndrome has been included in the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders. However, it is not clear whether OSA causes an impairment in the majority cognitive processes or whether it affects only some and specific cognitive skills. In this study we assessed 29 previously untreated severe OSA patients (mean age of 55.6 ± 9.9 years) on wide range of cognitive skills as well as (for first time) on socio-cognitive skills. A control group was also enrolled. Data were analysed with a Bayesian approach. The final aim of the study was to address an open fundamental question in experimental psychology and socio-cognitive neuroscience literatures: is there a "social brain" specialized in the processing social stimuli? Results indicate that OSA does not affect all cognitive processes, but mainly executive and socio-cognitive skills. Finally, our results support a dissociation between socio-cognitive ability and other domain-general cognitive functions. OSA affect mainly (and independently of each other) executive and social brain.

Published
2021

6. Polygraphic findings in simplified Barbed Reposition Pharyngoplasty (BRP) as a treatment for OSA patient

Author

Caterina Arigliani, Michele Arigliani, Enrico Ciavolino, Luana Conte, Domenico Maurizio Toraldo, Silvia Passariello, Serena Arima, Paola Angelelli, Luigi Macchitella, Antonio Palumbo, Michele De Benedetto, Arigliani, Caterina, Arigliani, Michele, Ciavolino, Enrico, Conte, Luana, Maurizio Toraldo, Domenico, Passariello, Silvia, Arima, Serena, Angelelli, Paola, Macchitella, Luigi, Palumbo, Antonio, and De Benedetto, Michele

Subjects
Barbed reposition pharyngoplasty, Obstructive Sleep Apnea, polygraphy, Home Sleep Ap-nea Testing device, sleep surgery
Abstract

This study aims to compare polygraphic data in patients with OSA treated with Barbed Reposition Pharyn-goplasty (BRP) performed with a simplified technique compared to the standard method. Variations of tech-nique were performed and tested with the purpose of promoting tolerability and diffusion of this simplified technique. To evaluate the efficacy of the simplified BRP method, a sample of 99 patients was divided into two groups: Group A was treated with BRP (BRP group) and Group B was treated with simplified BRP (sBRP group). The results obtained on the two groups were compared with the two sample Bootstrap t-tests method, showing a substantial overlap in polygraphic results recorded 6 months after surgery.

Published
2021

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