1. A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
- Author
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Adhikari, Kaustubh, Fuentes-Guajardo, Macarena, Quinto-Sánchez, Mirsha, Mendoza-Revilla, Javier, Camilo Chacón-Duque, Juan, Acuña-Alonzo, Victor, Jaramillo, Claudia, Arias, William, Lozano, Rodrigo Barquera, Pérez, Gastón Macín, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Hunemeier, Tábita, Ramallo, Virginia, Silva de Cerqueira, Caio C., Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Gallo, Carla, Poletti, Giovanni, Schuler-Faccini, Lavinia, Salzano, Francisco M., Bortolini, Maria- Cátira, Canizales-Quinteros, Samuel, Cheeseman, Michael, Rosique, Javier, Bedoya, Gabriel, Rothhammer, Francisco, Headon, Denis, González-José, Rolando, Balding, David, and Ruiz-Linares, Andrés
- Subjects
Adult ,Population genetics ,Science ,purl.org/pe-repo/ocde/ford#1.06.03 [https] ,Otras Ciencias Biológicas ,purl.org/pe-repo/ocde/ford#1.03.00 [https] ,Cadherin Related Proteins ,morphogenesis ,Core Binding Factor Alpha 1 Subunit ,Nerve Tissue Proteins ,Paired Box Transcription Factors/genetics ,Polymorphism, Single Nucleotide ,Article ,purl.org/becyt/ford/1 [https] ,Core Binding Factor Alpha 1 Subunit/genetics ,Ciencias Biológicas ,Mice ,Young Adult ,Zinc Finger Protein Gli3 ,Paired Box Transcription Factors ,Animals ,Humans ,Nerve Tissue Proteins/genetics ,purl.org/becyt/ford/1.6 [https] ,Maxillofacial Development ,Edar Receptor ,Maxillofacial Development/genetics ,Anatomic Variation ,Zinc Finger Protein Gli3/genetics ,Edar Receptor/genetics ,stomatognathic diseases ,Latin America ,Cadherin Related Proteins/genetics ,Face ,genome-wide association studies ,purl.org/pe-repo/ocde/ford#1.04.00 [https] ,Face/anatomy & histology ,CIENCIAS NATURALES Y EXACTAS ,Genome-Wide Association Study - Abstract
We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values, Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology.
- Published
- 2016
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