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Introduction: Coronavirus Disease-2019 (COVID-19) affects mental health, causing various psychiatric symptoms, including cognitive impairment, which may persist for a long time. To develop effective strategies for combating this global health burden, it is necessary to ascertain whether COVID-19 itself causes cognitive decline or whether other factors also play any role. Aim: To determine the prevalence of cognitive impairment in long COVID patients who present with post-COVID-19 psychiatric sequelae, and to investigate its association with socio-demographic factors, depression, anxiety, and stress. Materials and Methods: A cross-sectional study was conducted from July 2022 to June 2023 at a ‘Post-COVID Mental Health Clinic’ in a tertiary care medical college in Kolkata, India. A total of 204 subjects were selected through simple random sampling, aged between 18 and 65 years, of both sexes, who had recovered from COVID-19 more than three months but less than six months prior, and who presented with post-COVID-19 psychiatric sequelae, excluding those with a history of psychiatric disease before contracting COVID-19. The dependent variable, cognition, was measured using the Montreal Cognitive Assessment (MoCA) score, while independent variables included socio-demographic factors, depression, anxiety, and stress, measured by the Depression Anxiety Stress Scale -21 (DASS-21) scores. The Chi-square test was used to find the association between cognition and socio-demographic variables and Pearson’s correlation test was applied to measure the association of cognition with depression, anxiety, and stress scores. Results: The prevalence of cognitive impairment was found to be 86.8%. Chi-square tests of association showed no significant association with socio-demographic factors. However, there was a significant correlation between the severity of depression (r-value=-0.337, p-value

Abstract Novel therapeutic agents in clinical trials offer a paradigm shift in the approach to battling this prevalent and destructive disease, and the area of cancer therapy is on the precipice of a trans formative revolution. Despite the importance of tried-and-true cancer treatments like surgery, radiation, and chemotherapy, the disease continues to evolve and adapt, making new, more potent methods necessary. The field of cancer therapy is currently witnessing the emergence of a wide range of innovative approaches. Immunotherapy, including checkpoint inhibitors, CAR-T cell treatment, and cancer vaccines, utilizes the host’s immune system to selectively target and eradicate malignant cells while minimizing harm to normal tissue. The development of targeted medicines like kinase inhibitors and monoclonal antibodies has allowed for more targeted and less harmful approaches to treating cancer. With the help of genomics and molecular profiling, “precision medicine” customizes therapies to each patient’s unique genetic makeup to maximize therapeutic efficacy while minimizing unwanted side effects. Epigenetic therapies, metabolic interventions, radio-pharmaceuticals, and an increasing emphasis on combination therapy with synergistic effects further broaden the therapeutic landscape. Multiple-stage clinical trials are essential for determining the safety and efficacy of these novel drugs, allowing patients to gain access to novel treatments while also furthering scientific understanding. The future of cancer therapy is rife with promise, as the integration of artificial intelligence and big data has the potential to revolutionize early detection and prevention. Collaboration among researchers, and healthcare providers, and the active involvement of patients remain the bedrock of the ongoing battle against cancer. In conclusion, the dynamic and evolving landscape of cancer therapy provides hope for improved treatment outcomes, emphasizing a patient-centered, data-driven, and ethically grounded approach as we collectively strive towards a cancer-free world.

Background: Platelet-rich plasma (PRP) helps in the treatment of various insertion tendinitis, and the recurrence rate will be low. In this study, we used intralesional injections of autologous PRP for the treatment of insertion tendinitis. Aims and Objectives: Assessment of pain relief following PRP treatment for insertion tendinitis and ascertaining the efficacy of PRP as a treatment option for insertion tendinitis. Materials and Methods: The study was done at Maharani Laxmi Bai Medical College, Jhansi, between January 2021 and June 2022, including 100 patients were applied for the treatment of PRP. We assessed patients before treatment and at three follow-up time points: 2, 4, and 6 months after the end of treatment. During each evaluation, three parameters were noted: Victorian Institute of Sports Assessment- Achilles (VISA-A) score, the Visual Analog Scale, and patient satisfaction according to the roles and Maudsley score. Results: This was a prospective trial by study design conducted on 100 patients, which included 44 patients with plantar fasciitis and 56 patients with tennis elbow. The response to PRP injection in patients with plantar fasciitis was assessed by the VISA-A score. The pre-injection VISA-A score of patients with plantar fasciitis was 56.82 (mean with SD of 18.015), which improved to 65.45 in the 2nd month (mean with SD −18.857), 4th month with 69.77 (mean with SD–19.823), and at 6 months 71.82 (mean with SD–20.829). Statistical analysis with an analysis of variance test gave a P=0.001. In our study, the patients had gradual sequential improvement in VISA-A score throughout the follow-up, with maximum improvement from the pre-injection score were observed in 2 months (65.45 with SD 18.85). Conclusion: Autologous PRP injection is a safe and useful modality of treatment in the treatment of insertion tendinitis.

An efficient face recognition system is essential for security and authentication-based applications. However, real-time face recognition systems have a few significant concerns, including face pose orientations. In the last decade, numerous solutions have been introduced to estimate distinct face pose orientations. Nevertheless, these solutions must be adequately addressed for the three main face pose orientations: Yaw, Pitch, and Roll. This paper proposed a novel deep transfer learning-based multitasking approach for solving three integrated tasks, i.e., face detection, landmarks detection, and face pose estimation. The face pose variation vulnerability has been intensely investigated here underlying three modules: image preprocessing, feature extraction module through deep transfer learning, and regression module for estimating the face poses. The experiments are performed on the well-known benchmark dataset Annotated Faces in the Wild (AFW). We evaluate the outcomes of the experiments to reveal that our proposed approach is superior to other recently available solutions.

Purpose: To compare occlusal schemes with condylar inclination and anterior guidance in dentate individuals. Materials and Methods: A total of 26 dentate patients of Indian origin between the ages of 18 and 30 with canine-guided occlusion and 26 patients with group function occlusion were included in the study. The School of Articulator Munich (SAM) Axioquick system was used to assess the condylar guidance and eccentric tracings of the patients. For analyses, Student t test was used. For quantitative data, the means and SDs were calculated. For statistical analyses, the probability of type-I error of .05 was considered statistically significant. Results: The mean condylar guidance for canine-guided and group function occlusion was 38.4 ± 12.7 degrees and 30.5 ± 12.5 degrees on the right side, respectively. On the left side it was 36.5 ± 13.0 degrees and 27.5 ± 12.0 degrees for canine-guided and group function occlusion, respectively, with a statistically significant difference (P = .01). The condylar guidance, incisal guidance, Bennett angle, protrusion, left lateral and right lateral movement, and left and right lateral angles were analyzed statistically between the two types of occlusions. The results showed a statistically significant difference between the two groups for all parameters except right condylar guidance. Furthermore, all parameters were higher in the canine-guided occlusion group over group function occlusion. Conclusions: Within the study limitations, it was concluded that the condylar guidance was steeper in canine-guided occlusion than in group function occlusion. The eccentric parameters were steeper in canine-guided occlusion than in group function occlusion. This study showcases that the condylar guidance might not play a major role in determining the occlusal scheme but that the incisal guidance determines the occlusal scheme predominantly in Class 1 occlusion patients. [ABSTRACT FROM AUTHOR]

Abstract Climate change and increasing population pressure have put the agriculture sector in an arduous situation. With increasing demand for agricultural production overuse of inputs have accentuated the negative impact on environment. Hence, sustainable agriculture is gaining prominence in recent times with an emphasis on judicious and optimum use of resources. The field of nanotechnology can immensely help in achieving sustainability in agriculture at various levels. Use of nutrients and plant protection chemicals in nano-form can increase their efficacy even at reduced doses thus decreasing their pernicious impact. Seed priming is one of the important agronomic practices with widely reported positive impacts on germination, seedling growth and pathogen resistance. In the current study, the effect and efficacy of selenium nanoparticles synthesized using phyto-extracts as a seed priming agent is studied. This nanopriming enhanced the germination, hastened the seedling emergence and growth with an increase in seedling vigour and nutrient status. This eco-friendly and economical method of synthesizing nanoparticles of various nutrient minerals can optimize the resource use thus helping in sustainable agriculture by reducing environment damage without compromising on efficacy.

Chemically modified mandua starch was successfully synthesized and applied to coat mesalamine-loaded matrix tablets. The coating material was an aqueous dispersion of mandua starch modified by sodium trimetaphosphate and sodium tripolyphosphate. To investigate the colon-targeting release competence, chemically modified mandua starch film-coated mesalamine tablets were produced using the wet granulation method followed by dip coating. The effect of the coating on the colon-targeted release of the resultant delivery system was inspected in healthy human volunteers and rabbits using roentgenography. The results show that drug release was controlled when the coating level was 10% w/w. The release percentage in the upper gastric phase (pH 1.2, simulated gastric fluid) was less than 6% and reached up to 59.51% w/w after 14 h in simulated colonic fluid. In addition to in vivo roentgenographic studies in healthy rabbits, human volunteer studies proved the colon targeting efficiency of the formulation. These results clearly demonstrated that chemically modified mandua starch has high effectiveness as a novel aqueous coating material for controlled release or colon targeting.