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2. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.

Author

Schijven, Dick, Postema, M.C., Fukunaga, M., Matsumoto, J., Miura, K., Zwarte, S.M.C. de, Haren, N.E.M. van, Cahn, W., Hulshoff Pol, H.E., Kahn, R.S., Ayesa-Arriola, R., Ortoz-García de la Foz, V., Tordesillas-Gutierrez, D., Vázquez-Bourgon, J., Crespo-Facorro, B., Alnæs, D., Dahl, A., Westlye, L.T., Agartz, I., Andreassen, O.A., Jönsson, E.G., Kochunov, P., Bruggemann, J.M., Catts, S.V., Michie, P.T., Mowry, B.J., Quidé, Y., Rasser, P.E., Schall, U., Scott, R.J., Carr, V.J., Green, M.J., Henskens, F.A., Loughland, C.M., Pantelis, C., Weickert, C.S., Weickert, T.W., Haan, L. de, Brosch, K., Pfarr, J.K., Ringwald, K.G., Stein, F., Jansen, Andreas, Kircher, T.T.J., Nenadić, I., Krämer, Bernd, Gruber, O., Satterthwaite, T.D., Bustillo, J., Mathalon, D.H., Preda, A., Calhoun, V.D., Ford, J.M., Potkin, S.G., Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, F., Ehrlich, S., Fuentes-Claramonte, P., Garcia-Leon, M.A., Guerrero-Pedraza, A., Salvador, R., Sarró, S., Pomarol-Clotet, E., Ciullo, V., Piras, F., Vecchio, D., Banaj, N., Spalletta, G., Michielse, S., Amelsvoort, T. van, Dickie, E.W., Voineskos, A.N., Sim, K., Ciufolini, S., Dazzan, P., Murray, R.M., Kim, W.S., Chung, Y.C., Andreou, C., Schmidt, A, Borgwardt, S., McIntosh, A.M., Whalley, H.C., Lawrie, S.M., Plessis, S. du, Luckhoff, H.K., Scheffler, F., Emsley, R., Grotegerd, D., Lencer, R., Dannlowski, U., Edmond, J.T., Rootes-Murdy, K., Stephen, J.M., Mayer, A.R., Antonucci, L.A., Fazio, L., Pergola, G., Bertolino, A., Díaz-Caneja, C.M., Janssen, J, Lois, N.G., Arango, C., Tomyshev, A.S., Lebedeva, I., Cervenka, S., Sellgren, C.M., Georgiadis, F., Kirschner, M., Kaiser, S., Hajek, T., Skoch, A., Spaniel, F., Kim, M., Kwak, Y.B., Oh, S., Kwon, J.S., James, A., Bakker, G., Knöchel, C., Stäblein, M., Oertel, V., Uhlmann, A., Howells, F.M., Stein, D.J., Temmingh, H.S., Diaz-Zuluaga, A.M., Pineda-Zapata, J.A., López-Jaramillo, C., Homan, S., Ji, E., Surbeck, W., Homan, P., Fisher, S.E., Franke, B., Glahn, D.C., Gur, R.C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S.E., Thompson, P.M., Turner, J.A., Erp, T.G. van, Francks, C., Schijven, Dick, Postema, M.C., Fukunaga, M., Matsumoto, J., Miura, K., Zwarte, S.M.C. de, Haren, N.E.M. van, Cahn, W., Hulshoff Pol, H.E., Kahn, R.S., Ayesa-Arriola, R., Ortoz-García de la Foz, V., Tordesillas-Gutierrez, D., Vázquez-Bourgon, J., Crespo-Facorro, B., Alnæs, D., Dahl, A., Westlye, L.T., Agartz, I., Andreassen, O.A., Jönsson, E.G., Kochunov, P., Bruggemann, J.M., Catts, S.V., Michie, P.T., Mowry, B.J., Quidé, Y., Rasser, P.E., Schall, U., Scott, R.J., Carr, V.J., Green, M.J., Henskens, F.A., Loughland, C.M., Pantelis, C., Weickert, C.S., Weickert, T.W., Haan, L. de, Brosch, K., Pfarr, J.K., Ringwald, K.G., Stein, F., Jansen, Andreas, Kircher, T.T.J., Nenadić, I., Krämer, Bernd, Gruber, O., Satterthwaite, T.D., Bustillo, J., Mathalon, D.H., Preda, A., Calhoun, V.D., Ford, J.M., Potkin, S.G., Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, F., Ehrlich, S., Fuentes-Claramonte, P., Garcia-Leon, M.A., Guerrero-Pedraza, A., Salvador, R., Sarró, S., Pomarol-Clotet, E., Ciullo, V., Piras, F., Vecchio, D., Banaj, N., Spalletta, G., Michielse, S., Amelsvoort, T. van, Dickie, E.W., Voineskos, A.N., Sim, K., Ciufolini, S., Dazzan, P., Murray, R.M., Kim, W.S., Chung, Y.C., Andreou, C., Schmidt, A, Borgwardt, S., McIntosh, A.M., Whalley, H.C., Lawrie, S.M., Plessis, S. du, Luckhoff, H.K., Scheffler, F., Emsley, R., Grotegerd, D., Lencer, R., Dannlowski, U., Edmond, J.T., Rootes-Murdy, K., Stephen, J.M., Mayer, A.R., Antonucci, L.A., Fazio, L., Pergola, G., Bertolino, A., Díaz-Caneja, C.M., Janssen, J, Lois, N.G., Arango, C., Tomyshev, A.S., Lebedeva, I., Cervenka, S., Sellgren, C.M., Georgiadis, F., Kirschner, M., Kaiser, S., Hajek, T., Skoch, A., Spaniel, F., Kim, M., Kwak, Y.B., Oh, S., Kwon, J.S., James, A., Bakker, G., Knöchel, C., Stäblein, M., Oertel, V., Uhlmann, A., Howells, F.M., Stein, D.J., Temmingh, H.S., Diaz-Zuluaga, A.M., Pineda-Zapata, J.A., López-Jaramillo, C., Homan, S., Ji, E., Surbeck, W., Homan, P., Fisher, S.E., Franke, B., Glahn, D.C., Gur, R.C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S.E., Thompson, P.M., Turner, J.A., Erp, T.G. van, and Francks, C.

Abstract

Item does not contain fulltext, Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

Published
2023

5. Carcass characteristics of immunocastrated steers finished on diets with different energy patterns

Author

de Moura, A.F., Filho, D.C.A., Brondani, I.L., Pereira, L.B., Joner, G., Martini, A.P.M., Pacheco, R.F., Mayer, A.R., da Silva, M.B., and Borchate, D.

Subjects
beef cattle, Nellore, Charolais, forage to concentrate ratio, feedlot
Abstract

The aim of this study was to evaluate the effects of various dietary energy levels on the carcass and meat characteristics of feedlot-finished steers. A total of 27 purebred and crossbred Charolais and Nellore steers were used, with a mean initial age of 22 months and weight of 253 kg. The animals were allotted to a completely randomized design with three treatments and nine replicates each. Dietary treatments were arranged so that the average forage to concentrate ratio (FCR) was equivalent to that of a constant FCR treatment. The treatments consisted of CT (constant FCR at 60 to 40), CT5 (starting with 70: 30 FCR and finishing with 50: 50 FCR, that is, a mean overall FCR of 60: 40), and CT10 (starting with 80: 20 FCR and finishing with 40: 60, that is, a mean overall FCR of 60: 40). The dietary treatments did not affect slaughter weight, carcass weight, carcass conformation, physiological maturity, subcutaneous fat thickness, ribeye area, marbling score, and carcass measurements or the yield of commercial cuts. Chilling loss was higher in CT10 steers (2.41%) than in CT (2.26%) and CT5 (2.15%).

Published
2021

7. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Author

Thompson, P.M. (Paul), Jahanshad, N. (Neda), Ching, C.R.K. (Christopher), Salminen, L.E. (Lauren E.), Thomopoulos, S.I. (Sophia I.), Bright, J. (Joanna), Baune, B.T., Bertolín, S. (Sara), Bralten, L.B.C. (Linda), Bruin, W.B. (Willem B.), Bülow, R. (Robin), Chen, J. (Jian), Chye, Y. (Yann), Dannlowski, U. (Udo), de Kovel, C.G.F. (Carolien G F), Donohoe, D.J. (Dennis), Eyler, L.T. (Lisa T.), Faraone, S.V. (Stephen), Favre, P. (Pauline), Filippi, C.A. (Courtney A.), Frodl, T. (Thomas), Garijo, D. (Daniel), Gil, Y. (Yolanda), Grabe, H.J. (Hans Jörgen), Grasby, K.L. (Katrina L.), Hajek, T. (Tomas), Han, L.K.M. (Laura K M), Hatton, W., Hilbert, K. (Kevin), Ho, T.C. (Tiffany C.), Holleran, L. (Laurena), Homuth, G. (Georg), Hosten, N. (Norbert), Houenou, J. (Josselin), Ivanov, I. (Iliyan), Jia, T. (Tianye), Kelly, S. (Sinead), Klein, M. (Marieke), Kwon, J.S. (Jun Soo), Laansma, M.A. (Max A.), Leerssen, J. (Jeanne), Lueken, U. (Ulrike), Nunes, A. (Abraham), Neill, J.O. (Joseph O'), Opel, N. (Nils), Piras, F. (Fabrizio), Piras, F. (Federica), Postema, M.C. (Merel C.), Pozzi, E. (Elena), Shatokhina, N. (Natalia), Soriano-Mas, C. (Carles), Spalletta, G. (Gianfranco), Sun, D. (Daqiang), Teumer, A. (Alexander), Tilot, A.K. (Amanda K.), Tozzi, L. (Leonardo), van der Merwe, C. (Celia), Someren, E.J.W. (Eus) van, van Wingen, G.A. (Guido A.), Völzke, H. (Henry), Walton, E. (Esther), Wang, L. (Lei), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Wright, M.J. (Margaret), Yun, J.-Y. (Je-Yeon), Zhang, G. (Guohao), Zhang-James, Y. (Yanli), Adhikari, B.M. (Bhim M.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Aleman, A. (André), Althoff, R.R. (Robert R.), Altmann, A. (A.), Andreassen, O.A. (Ole), Baron, D.A. (David A.), Bartnik-Olson, B.L. (Brenda L.), Marie Bas-Hoogendam, J. (Janna), Baskin-Sommers, A.R. (Arielle R.), Bearden, C.E. (Carrie), Berner, L.A. (Laura A.), Boedhoe, P.S.W. (Premika S W), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan), Caeyenberghs, K. (Karen), Cecil, C.A.M. (Charlotte), Cohen, R.A. (Ronald A.), Cole, J.H. (James H.), Conrod, P. (Patricia), De Brito, S.A. (Stephane A.), de Zwarte, S.M.C. (Sonja M C), Dennis, E.L. (Emily L.), Desrivieres, S. (Sylvane), Dima, D. (Danai), Ehrlich, S.M. (Stefan), Esopenko, C. (Carrie), Fairchild, G. (Graeme), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Francks, C. (Clyde), Frangou, S. (Sophia), Franke, B. (Barbara), Garavan, H.P. (Hugh P.), Glahn, D.C. (David), Groenewold, N.A. (Nynke A.), Gurholt, T.P. (Tiril P.), Gutman, B.A. (Boris A.), Hahn, T. (Tim), Harding, I.H. (Ian H.), Hernaus, D. (Dennis), Hibar, D.P. (Derrek P.), Hillary, F.G. (Frank G.), Hoogman, M. (Martine), Hulshoff Pol, H.E. (Hilleke E.), Jalbrzikowski, M. (Maria), Karkashadze, G.A. (George A.), Klapwijk, E.T. (Eduard T.), Knickmeyer, R.C. (Rebecca C.), Kochunov, P. (Peter), Koerte, I.K. (Inga K.), Kong, X.-Z. (Xiang-Zhen), Liew, S.-L. (Sook-Lei), Lin, A.P. (Alexander P.), Logue, M.W. (Mark W.), Luders, E. (Eileen), Macciardi, F. (Fabio), Mackey, S. (Scott), Mayer, A.R. (Andrew R.), McDonald, C.R. (Carrie R.), McMahon, A.B. (Agnes B.), Medland, S.E. (Sarah), Modinos, G. (Gemma), Morey, R.A. (Rajendra A.), Mueller, S.C. (Sven C.), Mukherjee, P. (Pratik), Namazova-Baranova, L. (L.), Nir, T.M. (Talia M.), Olsen, A. (Alexander), Paschou, P. (Peristera), Pine, D.S. (Daniel S.), Pizzagalli, F. (Fabrizio), Rentería, M.E. (Miguel), Rohrer, J.D. (Jonathan D.), Sämann, P.G. (Philipp), Schmaal, L. (Lianne), Schumann, G. (Gunter), Shiroishi, M.S. (Mark S.), Sisodiya, S.M. (Sanjay), Smit, D.J.A. (Dirk J A), Sønderby, I.E. (Ida E.), Stein, D.J. (Dan J.), Stein, J.L., Tahmasian, M. (Masoud), Tate, D.F. (David F.), Turner, J. (Jessica), Heuvel, O.A. (Odile A.), Wee, N.J. (Nic) van der, van der Werf, Y.D. (Ysbrand), Erp, T.G.M. (Theo G.) van, van Haren, N.E.M. (Neeltje E M), van Rooij, D. (Daan), Van Velzen, L.S., Veer, I.M. (Ilya), Veltman, D.J. (Dick), Villalon-Reina, J.E. (Julio E.), Walter, H.J. (Henrik), Whelan, C.D. (Christopher), Wilde, E.A. (Elisabeth A.), Zarei, M. (Mojtaba), Zelman, V. (Vladimir), Thompson, P.M. (Paul), Jahanshad, N. (Neda), Ching, C.R.K. (Christopher), Salminen, L.E. (Lauren E.), Thomopoulos, S.I. (Sophia I.), Bright, J. (Joanna), Baune, B.T., Bertolín, S. (Sara), Bralten, L.B.C. (Linda), Bruin, W.B. (Willem B.), Bülow, R. (Robin), Chen, J. (Jian), Chye, Y. (Yann), Dannlowski, U. (Udo), de Kovel, C.G.F. (Carolien G F), Donohoe, D.J. (Dennis), Eyler, L.T. (Lisa T.), Faraone, S.V. (Stephen), Favre, P. (Pauline), Filippi, C.A. (Courtney A.), Frodl, T. (Thomas), Garijo, D. (Daniel), Gil, Y. (Yolanda), Grabe, H.J. (Hans Jörgen), Grasby, K.L. (Katrina L.), Hajek, T. (Tomas), Han, L.K.M. (Laura K M), Hatton, W., Hilbert, K. (Kevin), Ho, T.C. (Tiffany C.), Holleran, L. (Laurena), Homuth, G. (Georg), Hosten, N. (Norbert), Houenou, J. (Josselin), Ivanov, I. (Iliyan), Jia, T. (Tianye), Kelly, S. (Sinead), Klein, M. (Marieke), Kwon, J.S. (Jun Soo), Laansma, M.A. (Max A.), Leerssen, J. (Jeanne), Lueken, U. (Ulrike), Nunes, A. (Abraham), Neill, J.O. (Joseph O'), Opel, N. (Nils), Piras, F. (Fabrizio), Piras, F. (Federica), Postema, M.C. (Merel C.), Pozzi, E. (Elena), Shatokhina, N. (Natalia), Soriano-Mas, C. (Carles), Spalletta, G. (Gianfranco), Sun, D. (Daqiang), Teumer, A. (Alexander), Tilot, A.K. (Amanda K.), Tozzi, L. (Leonardo), van der Merwe, C. (Celia), Someren, E.J.W. (Eus) van, van Wingen, G.A. (Guido A.), Völzke, H. (Henry), Walton, E. (Esther), Wang, L. (Lei), Winkler, A.M. (Anderson), Wittfeld, K. (Katharina), Wright, M.J. (Margaret), Yun, J.-Y. (Je-Yeon), Zhang, G. (Guohao), Zhang-James, Y. (Yanli), Adhikari, B.M. (Bhim M.), Agartz, I. (Ingrid), Aghajani, M. (Moji), Aleman, A. (André), Althoff, R.R. (Robert R.), Altmann, A. (A.), Andreassen, O.A. (Ole), Baron, D.A. (David A.), Bartnik-Olson, B.L. (Brenda L.), Marie Bas-Hoogendam, J. (Janna), Baskin-Sommers, A.R. (Arielle R.), Bearden, C.E. (Carrie), Berner, L.A. (Laura A.), Boedhoe, P.S.W. (Premika S W), Brouwer, R.M. (Rachel), Buitelaar, J.K. (Jan), Caeyenberghs, K. (Karen), Cecil, C.A.M. (Charlotte), Cohen, R.A. (Ronald A.), Cole, J.H. (James H.), Conrod, P. (Patricia), De Brito, S.A. (Stephane A.), de Zwarte, S.M.C. (Sonja M C), Dennis, E.L. (Emily L.), Desrivieres, S. (Sylvane), Dima, D. (Danai), Ehrlich, S.M. (Stefan), Esopenko, C. (Carrie), Fairchild, G. (Graeme), Fisher, S.E. (Simon), Fouche, J.-P. (Jean-Paul), Francks, C. (Clyde), Frangou, S. (Sophia), Franke, B. (Barbara), Garavan, H.P. (Hugh P.), Glahn, D.C. (David), Groenewold, N.A. (Nynke A.), Gurholt, T.P. (Tiril P.), Gutman, B.A. (Boris A.), Hahn, T. (Tim), Harding, I.H. (Ian H.), Hernaus, D. (Dennis), Hibar, D.P. (Derrek P.), Hillary, F.G. (Frank G.), Hoogman, M. (Martine), Hulshoff Pol, H.E. (Hilleke E.), Jalbrzikowski, M. (Maria), Karkashadze, G.A. (George A.), Klapwijk, E.T. (Eduard T.), Knickmeyer, R.C. (Rebecca C.), Kochunov, P. (Peter), Koerte, I.K. (Inga K.), Kong, X.-Z. (Xiang-Zhen), Liew, S.-L. (Sook-Lei), Lin, A.P. (Alexander P.), Logue, M.W. (Mark W.), Luders, E. (Eileen), Macciardi, F. (Fabio), Mackey, S. (Scott), Mayer, A.R. (Andrew R.), McDonald, C.R. (Carrie R.), McMahon, A.B. (Agnes B.), Medland, S.E. (Sarah), Modinos, G. (Gemma), Morey, R.A. (Rajendra A.), Mueller, S.C. (Sven C.), Mukherjee, P. (Pratik), Namazova-Baranova, L. (L.), Nir, T.M. (Talia M.), Olsen, A. (Alexander), Paschou, P. (Peristera), Pine, D.S. (Daniel S.), Pizzagalli, F. (Fabrizio), Rentería, M.E. (Miguel), Rohrer, J.D. (Jonathan D.), Sämann, P.G. (Philipp), Schmaal, L. (Lianne), Schumann, G. (Gunter), Shiroishi, M.S. (Mark S.), Sisodiya, S.M. (Sanjay), Smit, D.J.A. (Dirk J A), Sønderby, I.E. (Ida E.), Stein, D.J. (Dan J.), Stein, J.L., Tahmasian, M. (Masoud), Tate, D.F. (David F.), Turner, J. (Jessica), Heuvel, O.A. (Odile A.), Wee, N.J. (Nic) van der, van der Werf, Y.D. (Ysbrand), Erp, T.G.M. (Theo G.) van, van Haren, N.E.M. (Neeltje E M), van Rooij, D. (Daan), Van Velzen, L.S., Veer, I.M. (Ilya), Veltman, D.J. (Dick), Villalon-Reina, J.E. (Julio E.), Walter, H.J. (Henrik), Whelan, C.D. (Christopher), Wilde, E.A. (Elisabeth A.), Zarei, M. (Mojtaba), and Zelman, V. (Vladimir)

Abstract

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

Published
2020
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9. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Author

Erp, T.G.M. (Theo G.) van, Walton, E. (Esther), Hibar, D.P. (Derrek P.), Schmaal, L. (Lianne), Jiang, W. (Wenhao), Glahn, D.C. (David), Pearlson, G. (Godfrey), Yao, N. (Nailin), Fukunaga, M. (Masaki), Hashimoto, R. (Ryota), Okada, N. (Naohiro), Yamamori, H. (Hidenaga), Bustillo, J., Clark, V.P., Agartz, I. (Ingrid), Mueller, B.A. (Bryon ), Cahn, W. (Wiepke), de Zwarte, S.M.C. (Sonja M.C.), Hulshoff Pol, H.E. (Hilleke), Kahn, R. (René), Ophoff, R.A. (Roel), van Haren, N.E.M. (Neeltje E.M.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), Doan, N.T. (Nhat Trung), Gurholt, T.P. (Tiril P.), Hartberg, C.B. (Cecilie B.), Haukvik, U.K. (Unn), Jørgensen, K.N. (Kjetil N.), Lagerberg, T.V. (Trine V.), Melle, I. (Ingrid), Westlye, L.T. (Lars), Gruber, O. (Oliver), Kraemer, B. (Bernd), Richter, A. (Anja), Zilles, D. (David), Calhoun, V.D. (Vince), Crespo-Facorro, B. (Benedicto), Roiz-Santiañez, R. (Roberto), Tordesillas-Gutierrez, D. (Diana), Loughland, C.M. (Carmel), Carr, V.J. (Vaughan J.), Catts, S.V. (Stanley), Cropley, V.L. (Vanessa L.), Fullerton, J.M. (Janice M.), Green, M.J. (Melissa J.), Henskens, F.A. (Frans), Jablensky, A. (Assen), Lenroot, R.K. (Rhoshel), Mowry, B.J. (Bryan J), Michie, P.T. (Patricia), Pantelis, C. (Christos), Quidé, Y. (Yann), Schall, J.D. (Jeffrey), Scott, R.J. (Rodney J.), Cairns, M.J. (Murray J.), Seal, M. (Marc), Tooney, P.A. (Paul A.), Rasser, P.E. (Paul E.), Cooper, G. (Gavin), Shannon Weickert, C. (Cynthia), Weickert, T.W. (Thomas W.), Morris, D.W. (Derek W), Hong, E. (Elliot), Kochunov, P. (Peter), Beard, L.M. (Lauren M.), Gur, R.E. (Raquel), Gur, R.C. (Ruben C.), Satterthwaite, T.D. (Theodore), Wolf, D.H. (Daniel H.), Belger, A. (Aysenil), Brown, G.G. (Gregory G.), Ford, J.M. (Judith M.), Macciardi, F. (Fabio), Mathalon, D.H. (Daniel H.), O'Leary, D.S. (Daniel S.), Potkin, S.G. (Steven), Preda, A. (Adrian), Voyvodic, J. (James), Lim, K.O. (Kelvin), McEwen, S. (Sarah), Yang, F. (Fude), Tan, Y. (Yunlong), Tan, S. (Shuping), Wang, Z. (Zhiren), Fan, F. (Fengmei), Chen, J. (Jingxu), Xiang, H. (Hong), Tang, S. (Shiyou), Guo, H. (Hua), Wan, P. (Ping), Wei, D. (Dong), Bockholt, H.J., Ehrlich, S.M. (Stefan), Wolthusen, R.P.F. (Rick P.F.), King, M.D. (Margaret D.), Shoemaker, J.M. (Jody M.), Sponheim, S.R. (Scott), Haan, L. (Lieuwe) de, Koenders, L. (Laura), Machielsen, M.W.J. (Marise), Amelsvoort, T.A.M.J. (Therese) van, Veltman, D.J. (Dick), Assogna, F. (Francesca), Banaj, N. (Nerisa), de Rossi, P. (Pietro), Iorio, M. (Mariangela), Piras, F. (Fabrizio), Spalletta, G. (Gianfranco), McKenna, P.J. (Peter J.), Pomarol-Clotet, E. (Edith), Salvador, R. (Raymond), Corvin, A. (Aiden), Donohoe, D.J. (Dennis), Kelly, S. (Sinead), Whelan, C.D. (Christopher), Dickie, E.W. (Erin W.), Rotenberg, D. (David), Voineskos, A.N. (Aristotle N.), Ciufolini, S. (Simone), Radua, J. (Joaquim), Dazzan, P. (Paola), Murray, R. (Robin), Reis Marques, T. (Tiago), Simmons, A. (Andrew), Borgwardt, S. (Stefan), Egloff, L. (Laura), Harrisberger, F. (Fabienne), Riecher-Rössler, A. (Anita), Smieskova, R. (Renata), Alpert, K. (Kathryn), Wang, L. (Lei), Jönsson, E.G. (Erik), Koops, S. (Sanne), Sommer, I.E.C. (Iris E.C.), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Di Giorgio, A. (Annabella), Neilson, E. (Emma), Mayer, A.R. (Andrew R.), Stephen, J.M. (Julia M.), Kwon, J.S. (Jun Soo), Yun, J.-Y. (Je-Yeon), Cannon, D.M. (Dara), McDonald, C. (Colm), Lebedeva, I. (Irina), Tomyshev, A.S. (Alexander S.), Akhadov, T. (Tolibjohn), Kaleda, V. (Vasily), Fatouros-Bergman, H. (Helena), Flyckt, L. (Lena), Farde, L. (Lars), Engberg, G. (Göran), Erhardt, S. (Sophie), Cervenka, S. (Simon), Schwieler, L. (Lilly), Piehl, F. (Fredrik), Collste, K. (Karin), Victorsson, P. (Pauliina), Malmqvist, A. (Anna), Hedberg, M. (Mikael), Orhan, F. (Funda), Busatto, G.F. (Geraldo F.), Rosa, P.G.P. (Pedro G.P.), Serpa, M.H. (Mauricio H.), Zanetti, M.V. (Marcus V.), Hoschl, C. (Cyril), Skoch, A. (Antonin), Spaniel, F. (Filip), Tomecek, D. (David), Hagenaars, S. (Saskia), McIntosh, A.M. (Andrew), Whalley, H.C. (Heather C.), Lawrie, S. (Stephen), Knöchel, C. (Christian), Oertel-Knöchel, V. (Viola), Stäblein, M. (Michael), Howells, F.M. (Fleur M.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Uhlmann, A. (Anne), Lopez-Jaramillo, C. (Carlos), Dima, D. (Danai), McMahon, A. (Agnes), Faskowitz, J.I. (Joshua I.), Gutman, B.A. (Boris A.), Jahanshad, N. (Neda), Thompson, P.M. (Paul), Turner, J. (Jessica), Erp, T.G.M. (Theo G.) van, Walton, E. (Esther), Hibar, D.P. (Derrek P.), Schmaal, L. (Lianne), Jiang, W. (Wenhao), Glahn, D.C. (David), Pearlson, G. (Godfrey), Yao, N. (Nailin), Fukunaga, M. (Masaki), Hashimoto, R. (Ryota), Okada, N. (Naohiro), Yamamori, H. (Hidenaga), Bustillo, J., Clark, V.P., Agartz, I. (Ingrid), Mueller, B.A. (Bryon ), Cahn, W. (Wiepke), de Zwarte, S.M.C. (Sonja M.C.), Hulshoff Pol, H.E. (Hilleke), Kahn, R. (René), Ophoff, R.A. (Roel), van Haren, N.E.M. (Neeltje E.M.), Andreassen, O.A. (Ole), Dale, A.M. (Anders), Doan, N.T. (Nhat Trung), Gurholt, T.P. (Tiril P.), Hartberg, C.B. (Cecilie B.), Haukvik, U.K. (Unn), Jørgensen, K.N. (Kjetil N.), Lagerberg, T.V. (Trine V.), Melle, I. (Ingrid), Westlye, L.T. (Lars), Gruber, O. (Oliver), Kraemer, B. (Bernd), Richter, A. (Anja), Zilles, D. (David), Calhoun, V.D. (Vince), Crespo-Facorro, B. (Benedicto), Roiz-Santiañez, R. (Roberto), Tordesillas-Gutierrez, D. (Diana), Loughland, C.M. (Carmel), Carr, V.J. (Vaughan J.), Catts, S.V. (Stanley), Cropley, V.L. (Vanessa L.), Fullerton, J.M. (Janice M.), Green, M.J. (Melissa J.), Henskens, F.A. (Frans), Jablensky, A. (Assen), Lenroot, R.K. (Rhoshel), Mowry, B.J. (Bryan J), Michie, P.T. (Patricia), Pantelis, C. (Christos), Quidé, Y. (Yann), Schall, J.D. (Jeffrey), Scott, R.J. (Rodney J.), Cairns, M.J. (Murray J.), Seal, M. (Marc), Tooney, P.A. (Paul A.), Rasser, P.E. (Paul E.), Cooper, G. (Gavin), Shannon Weickert, C. (Cynthia), Weickert, T.W. (Thomas W.), Morris, D.W. (Derek W), Hong, E. (Elliot), Kochunov, P. (Peter), Beard, L.M. (Lauren M.), Gur, R.E. (Raquel), Gur, R.C. (Ruben C.), Satterthwaite, T.D. (Theodore), Wolf, D.H. (Daniel H.), Belger, A. (Aysenil), Brown, G.G. (Gregory G.), Ford, J.M. (Judith M.), Macciardi, F. (Fabio), Mathalon, D.H. (Daniel H.), O'Leary, D.S. (Daniel S.), Potkin, S.G. (Steven), Preda, A. (Adrian), Voyvodic, J. (James), Lim, K.O. (Kelvin), McEwen, S. (Sarah), Yang, F. (Fude), Tan, Y. (Yunlong), Tan, S. (Shuping), Wang, Z. (Zhiren), Fan, F. (Fengmei), Chen, J. (Jingxu), Xiang, H. (Hong), Tang, S. (Shiyou), Guo, H. (Hua), Wan, P. (Ping), Wei, D. (Dong), Bockholt, H.J., Ehrlich, S.M. (Stefan), Wolthusen, R.P.F. (Rick P.F.), King, M.D. (Margaret D.), Shoemaker, J.M. (Jody M.), Sponheim, S.R. (Scott), Haan, L. (Lieuwe) de, Koenders, L. (Laura), Machielsen, M.W.J. (Marise), Amelsvoort, T.A.M.J. (Therese) van, Veltman, D.J. (Dick), Assogna, F. (Francesca), Banaj, N. (Nerisa), de Rossi, P. (Pietro), Iorio, M. (Mariangela), Piras, F. (Fabrizio), Spalletta, G. (Gianfranco), McKenna, P.J. (Peter J.), Pomarol-Clotet, E. (Edith), Salvador, R. (Raymond), Corvin, A. (Aiden), Donohoe, D.J. (Dennis), Kelly, S. (Sinead), Whelan, C.D. (Christopher), Dickie, E.W. (Erin W.), Rotenberg, D. (David), Voineskos, A.N. (Aristotle N.), Ciufolini, S. (Simone), Radua, J. (Joaquim), Dazzan, P. (Paola), Murray, R. (Robin), Reis Marques, T. (Tiago), Simmons, A. (Andrew), Borgwardt, S. (Stefan), Egloff, L. (Laura), Harrisberger, F. (Fabienne), Riecher-Rössler, A. (Anita), Smieskova, R. (Renata), Alpert, K. (Kathryn), Wang, L. (Lei), Jönsson, E.G. (Erik), Koops, S. (Sanne), Sommer, I.E.C. (Iris E.C.), Bertolino, A. (Alessandro), Bonvino, A. (Aurora), Di Giorgio, A. (Annabella), Neilson, E. (Emma), Mayer, A.R. (Andrew R.), Stephen, J.M. (Julia M.), Kwon, J.S. (Jun Soo), Yun, J.-Y. (Je-Yeon), Cannon, D.M. (Dara), McDonald, C. (Colm), Lebedeva, I. (Irina), Tomyshev, A.S. (Alexander S.), Akhadov, T. (Tolibjohn), Kaleda, V. (Vasily), Fatouros-Bergman, H. (Helena), Flyckt, L. (Lena), Farde, L. (Lars), Engberg, G. (Göran), Erhardt, S. (Sophie), Cervenka, S. (Simon), Schwieler, L. (Lilly), Piehl, F. (Fredrik), Collste, K. (Karin), Victorsson, P. (Pauliina), Malmqvist, A. (Anna), Hedberg, M. (Mikael), Orhan, F. (Funda), Busatto, G.F. (Geraldo F.), Rosa, P.G.P. (Pedro G.P.), Serpa, M.H. (Mauricio H.), Zanetti, M.V. (Marcus V.), Hoschl, C. (Cyril), Skoch, A. (Antonin), Spaniel, F. (Filip), Tomecek, D. (David), Hagenaars, S. (Saskia), McIntosh, A.M. (Andrew), Whalley, H.C. (Heather C.), Lawrie, S. (Stephen), Knöchel, C. (Christian), Oertel-Knöchel, V. (Viola), Stäblein, M. (Michael), Howells, F.M. (Fleur M.), Stein, D.J. (Dan), Temmingh, H.S. (Henk S.), Uhlmann, A. (Anne), Lopez-Jaramillo, C. (Carlos), Dima, D. (Danai), McMahon, A. (Agnes), Faskowitz, J.I. (Joshua I.), Gutman, B.A. (Boris A.), Jahanshad, N. (Neda), Thompson, P.M. (Paul), and Turner, J. (Jessica)

Abstract

Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This

Published
2018
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12. Patterns of Gray Matter Abnormalities in Schizophrenia Based on an International Mega-analysis

Author

Gupta, C.N., Calhoun, V.D., Rachakonda, S., Chen, J., Patel, V., Liu, J., Segall, J., Franke, B., Zwiers, M.P., Arias-Vasquez, A., Buitelaar, J.K., Fisher, S.E., Fernandez, G.S.E., Erp, T.G. van, Potkin, S., Ford, J., Mathalon, D., McEwen, S., Lee, H.J., Mueller, B.A., Greve, D.N., Andreassen, O., Agartz, I., Gollub, R.L., Sponheim, S.R., Ehrlich, S., Wang, L., Pearlson, G., Glahn, D.C., Sprooten, E., Mayer, A.R., Stephen, J., Jung, R.E., Canive, J., Bustillo, J., Turner, J.A., Gupta, C.N., Calhoun, V.D., Rachakonda, S., Chen, J., Patel, V., Liu, J., Segall, J., Franke, B., Zwiers, M.P., Arias-Vasquez, A., Buitelaar, J.K., Fisher, S.E., Fernandez, G.S.E., Erp, T.G. van, Potkin, S., Ford, J., Mathalon, D., McEwen, S., Lee, H.J., Mueller, B.A., Greve, D.N., Andreassen, O., Agartz, I., Gollub, R.L., Sponheim, S.R., Ehrlich, S., Wang, L., Pearlson, G., Glahn, D.C., Sprooten, E., Mayer, A.R., Stephen, J., Jung, R.E., Canive, J., Bustillo, J., and Turner, J.A.

Abstract

Contains fulltext : 153613.pdf (publisher's version ) (Closed access), Analyses of gray matter concentration (GMC) deficits in patients with schizophrenia (Sz) have identified robust changes throughout the cortex. We assessed the relationships between diagnosis, overall symptom severity, and patterns of gray matter in the largest aggregated structural imaging dataset to date. We performed both source-based morphometry (SBM) and voxel-based morphometry (VBM) analyses on GMC images from 784 Sz and 936 controls (Ct) across 23 scanning sites in Europe and the United States. After correcting for age, gender, site, and diagnosis by site interactions, SBM analyses showed 9 patterns of diagnostic differences. They comprised separate cortical, subcortical, and cerebellar regions. Seven patterns showed greater GMC in Ct than Sz, while 2 (brainstem and cerebellum) showed greater GMC for Sz. The greatest GMC deficit was in a single pattern comprising regions in the superior temporal gyrus, inferior frontal gyrus, and medial frontal cortex, which replicated over analyses of data subsets. VBM analyses identified overall cortical GMC loss and one small cluster of increased GMC in Sz, which overlapped with the SBM brainstem component. We found no significant association between the component loadings and symptom severity in either analysis. This mega-analysis confirms that the commonly found GMC loss in Sz in the anterior temporal lobe, insula, and medial frontal lobe form a single, consistent spatial pattern even in such a diverse dataset. The separation of GMC loss into robust, repeatable spatial patterns across multiple datasets paves the way for the application of these methods to identify subtle genetic and clinical cohort effects.

Published
2015

20. Multimodal and Multi-Tissue Measures of Connectivity Revealed by Joint Independent Component Analysis.

Author

Franco, A.R., Josef Ling, Caprihan, A., Calhoun, V.D., Jung, R.E., Heileman, G.L., and Mayer, A.R.

Abstract

The human brain functions as an efficient system where signals arising from gray matter are transported via white matter tracts to other regions of the brain to facilitate human behavior. However, with a few exceptions, functional and structural neuroimaging data are typically optimized to maximize the quantification of signals arising from a single source. For example, functional magnetic resonance imaging (FMRI) is typically used as an index of gray matter functioning whereas diffusion tensor imaging (DTI) is typically used to determine white matter properties. While it is likely that these signals arising from different tissue sources contain complementary information, the signal processing algorithms necessary for the fusion of neuroimaging data across imaging modalities are still in a nascent stage. In the current paper we present a data-driven method for combining measures of functional connectivity arising from gray matter sources (FMRI resting state data) with different measures of white matter connectivity (DTI). Specifically, a joint independent component analysis (J-ICA) was used to combine these measures of functional connectivity following intensive signal processing and feature extraction within each of the individual modalities. Our results indicate that one of the most predominantly used measures of functional connectivity (activity in the default mode network) is highly dependent on the integrity of white matter connections between the two hemispheres (corpus callosum) and within the cingulate bundles. Importantly, the discovery of this complex relationship of connectivity was entirely facilitated by the signal processing and fusion techniques presented herein and could not have been revealed through separate analyses of both data types as is typically performed in the majority of neuroimaging experiments. We conclude by discussing future applications of this technique to other areas of neuroimaging and examining potential limitations of the methods- - . [ABSTRACT FROM PUBLISHER]

Published
2008
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21. A practical approach to incidental findings in neuroimaging research

Author

Shoemaker, J.M., Holdsworth, M.T., Aine, C., Calhoun, V.D., de La Garza, R., Feldstein Ewing, S.W., Hayek, R., Mayer, A.R., Kiehl, K.A., Petree, L.E., Sanjuan, P., Scott, A., Stephen, J., and Phillips, J.P.

Abstract

We describe the systematic approach to incidental findings (IFs) used at the Mind Research Network (MRN) where all MRI scans receive neuroradiologist interpretation and participants are provided results.

Published
2011
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