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Background: The study of non-communicable diseases (NCDs) in a developing country like Thailand has rarely been conducted in long-term cohorts, especially among the working-age population. We aim to assess the prevalence and incidence of risk factors and their associations underlying NCDs, especially type-2 diabetes mellitus (T2DM) among healthcare workers enrolled in the Siriraj Health (SIH) study cohort. Methods: The SIH study was designed as a longitudinal cohort and conducted at Siriraj hospital, Thailand. A total of 5,011 participants (77% women) were recruited and follow-up. Physical examinations, blood biochemical analyses, family history assessments, behavior evaluations, and genetics factors were assessed. Results: The average age was 35.44±8.24 years and 51% of participants were overweight and obese. We observed that men were more likely to have a prevalence of T2DM and dyslipidemia (DLP) compared to women. Aging was significantly associated with pre-diabetes and T2DM (P<0.001). Additionally, aging, metabolic syndrome, and elevated triglycerides were associated with the development of pre-diabetes and T2DM. The minor T allele of the rs7903146(C/T) and rs4506565 (A/T) were associated with a high risk of developing pre-diabetes with odds ratios of 2.74 (95% confidence interval [CI]: 0.32–23.3) and 2.71 (95% CI: 0.32–23.07), respectively; however, these associations were statistically insignificant (P>0.05). Conclusion: The findings of the SIH study provide a comprehensive understanding of the health status, risk factors, and genetic factors related to T2DM in a specific working population and highlight areas for further research and intervention to address the growing burden of T2DM and NCDs. [ABSTRACT FROM AUTHOR]

Background: In December 2021, Omicron replaced Delta as the dominant coronavirus disease 2019 (COVID-19) variant in Thailand. Both variants embody diverse epidemiological trends and immunogenicity. We investigated whether Delta and Omicron patients' biological and clinical characteristics and immunogenicity differed post-COVID-19 infection. Methods: This retrospective cohort study investigated the clinical outcomes and laboratory data of 5181 patients with mild-to-moderate COVID-19 (Delta, 2704; Omicron, 2477) under home isolation. We evaluated anti-receptor-binding domain immunoglobulin G (anti-RBD IgG) and surrogate viral neutralizing (sVNT) activity in 495 individuals post-COVID-19 infection during the Delta pandemic. Results: Approximately 84% of all patients received favipiravir. The median cycle threshold (Ct) values were lower for Omicron patients than Delta patients (19 vs. 21; p < 0.001), regardless of vaccination status. Upper respiratory tract symptoms were more frequent with Omicron patients than Delta patients. There were no significant associations between Ct and Omicron symptoms (95% confidence interval 0.98–1.02). A two-dose vaccine regimen reduced hospital readmission by 10% to 30% and death by under 1%. Anti-RBD IgG and sVNT against Delta were higher among older individuals post-COVID-19 infection. Older individuals expressed anti-RBD IgG and sVNT for a more extended period after two-dose vaccination than other age groups. Conclusions: After a full vaccination course, breakthrough mild-to-moderate Delta and Omicron infections have limited immunogenicity. Prior infections exert reduced protection against later reinfection or infection from novel variants. However, this protection may be sufficient to prevent hospitalization and death, particularly in countries where vaccine supplies are limited. [ABSTRACT FROM AUTHOR]

Background: Increasing levels of poor glycaemic control among Thai patients with type 2 diabetes mellitus (T2DM) motivated us to compare T2DM care between urban and suburban primary care units (PCUs), to identify gaps in care, and to identify significant factors that may influence strategies to enhance the quality of care and clinical outcomes in this population., Methods: We conducted a cross-sectional study involving 2160 patients with T2DM treated at four Thai PCUs from 2019 to 2021, comprising one urban and three suburban facilities. Using mixed effects logistic regression, we compared care factors between urban and suburban PCUs., Results: Patients attending suburban PCUs were significantly more likely to undergo eye (adjusted OR (AOR): 1.83, 95% CI 1.35 to 1.72), foot (AOR: 1.61, 95% CI 0.65 to 4.59) and HbA 1c (AOR: 1.66, 95% CI 1.09 to 2.30) exams and achieved all ABC (HbA 1c , blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C)) goals (AOR: 2.23, 95% CI 1.30 to 3.83). Conversely, those at an urban PCU were more likely to undergo albuminuria exams. Variables significantly associated with good glycaemic control included age (AOR: 1.51, 95% CI 1.31 to 1.79), T2DM duration (AOR: 0.59, 95% CI 0.41 to 0.88), FAACE (foot, HbA 1c , albuminuria, LDL-C and eye) goals (AOR: 1.23, 95% CI 1.12 to 1.36) and All8Q (AOR: 1.20, 95% CI 1.05 to 1.41). Chronic kidney disease (CKD) was significantly linked with high triglyceride and HbA 1c levels (AOR: 5.23, 95% CI 1.21 to 7.61). Elevated HbA 1c levels, longer T2DM duration, insulin use, high systolic BP and high lipid profile levels correlated strongly with diabetic retinopathy (DR) and CKD progression., Conclusion: This highlights the necessity for targeted interventions to bridge urban-suburban care gaps, optimise drug prescriptions and implement comprehensive care strategies for improved glycaemic control, DR prevention and CKD progression mitigation among in Thai patients with T2DM. The value of the clinical target aggregate (ABC) and the process of care aggregate (FAACE) was also conclusively demonstrated., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Background: Protein Malnutrition is one of the most important health indexes that affect children's growth and development. In Thailand National Health Survey 2004, 21.5% of primary school students living in the rural area were below the 90th percentile of the standard weight for age., Objective: To compare nutritional status with serum proteins and lipids, and to determine the effect of egg supplement for primary school students aged 6-15 years., Material and Method: A randomized experimental study was performed in 417 participants received an addition of either three or ten eggs per week for 12 consecutive weeks to basal diet., Results: The anthropometric and biochemical indexes were measured, 29.1% and 20.8% of whom were Protein Malnutrition according to serum albumin and PreAlbumin's criteria, respectively. Albumin and PreAlbumin levels were positively correlated with Total Cholesterol and LDL-C levels. No difference in any biochemical index has been found between 3 eggs/wk group and 10 eggs/wk group. Besides, due to continuing egg supplement, Total Cholesterol, LDL and ratio of Total Cholesterol to HDL level have decreased (p < 0.001) but albumin, PreAlbumin and HDL levels have demonstrated significantly increasing levels (p < 0.001)., Conclusion: Nowadays in rural areas of Thailand there are still primary school students with protein malnutrition especially in rural area. An addition of at least 3 eggs/wk supplements can effectively correct the problem of protein malnutrition among primary school students at risk as shown by biochemical indices, and it benefits the blood cholesterol level as well.

Objective: To determine the status of disease control and to compare the prevalence of microvascular complications among type-2 diabetes in a primary care setting., Material and Method: The authors performed a cross-sectional study of 287 diabetic patients from 13 primary care units in urban areas of Thailand The status of diabetic control was dominantly defined by HbA(1C) (A1C), blood pressure (BP). Screening programs for microvascular complications included retinopathy and nephropathy. Retinopathy used a seven-field stereoscopic retinal photography while nephropathy was defined by a random urine albumin-to-creatinine ratio., Results: The AIC of 41.3% of the patients was lower than 7% however 80% of them used only low doses of anti-diabetic drugs. The prevalence of microalbuminuria was 28.7% and macroalbuminuria was 5.7%, whereas diabetic retinopathy was 15.1%. In multivariate analyses, nephropathy was significantly related to duration of diabetes > or =4 years (odds ratio 1.5, 95% CI 1.2-1.8, p < 0.001) and A1C > or =8% (odds ratio 2.2, 95% CI 1.3-3.8, p < 0.05), while retinopathy was related to duration of diabetes > or =4 years (odds ratio 9.5, 95% CI 1.17-77.8, p < 0.05)., Conclusion: The present study shows that primary care units provides patients with well-controlled diabetes. Nonetheless, those type 2 diabetes patients have significantly higher rates of microvascular complications, despite shorter diabetes duration and lower A1C. Type 2 diabetic patients in primary care unit should be screened for complications and efforts should be done to reach optimal glycemic level, especially for individuals with diabetes > or =4 years.