829 results on '"Mazar, A. P."'
Search Results
2. Targeted inhibition of glycogen synthase kinase-3 using 9-ING-41 (elraglusib) enhances CD8 T-cell-reactivity against neuroblastoma cells
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Markovska, A., Somers, K., Guillaume, J., Melief, J., Mazar, A. P., Schmitt, D. M., Schipper, H. S., and Boes, M.
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- 2024
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3. Assessment of the importance of sleep quality and the effects of deprivation on Sudanese healthcare professionals amidst conflict in Sudan
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Amin, Mohammed Hammad Jaber, Elmahi, Musab Awadalla Mohamed Elhassan, Fadlalmoula, Gasm Alseed Abdelmonim Gasm Alseed, Amin, Jaber Hammad Jaber, Alrabee, Noon Hatim Khalid, Awad, Mohammed Haydar, Omer, Zuhal Yahya Mohamed, Dayyeh, Nuha Tayseer Ibrahim Abu, Abdalkareem, Nada Abdalla Hassan, Ahmed, Esra Mohammed Osman Meisara Seed, Osman, Hadia Abdelrahman Hassan, Mohamed, Hiba A. O., Othman, Dania Ibrahim Taha, Badawe, Tagwa Saeed Ibrahim, Mustafa, Eyha Abdulaziz, Hagar, Ehtida Abdelmonem, Babiker, Aya Elshaikh Mohamedtoum, Alnour, Ammar Alemam Diab, Ahmed, Estbrg Alsafi Mohamed, Garban, Eithar Hussein Elamin, Mohammed, Noura Satti Ali, Ahmed, Khabab Abbasher Hussien Mohamed, Beig, Mirza Adil, Shafique, Muhammad Ashir, Ali, Shahad Azhari Mohmed, Elhag, Mazar Gamal Mohamed, Omer, Mojtaba Majdy Elfakey, Mohamed, Asma Eltayeb Abdalla, Ali, Amna Alrasheed Abuzaid, Elhassan, Hiba Osman Ali Mohamed, Saleh, Khlood Hamdi Ahmed Bin, Ali, Maria Badraldin, Abdalla, Sahar Suliman Elzber, Alhaj, Waleed Mohammed, Mergani, Elaf Sabri Khalil, Hassan, Hazim Hassan Mohammed, Ahmed, Hind Mohamed Elfatih Fadl Elmula, and Subahi, Razan Abuelgasim Musa
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- 2024
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4. Investigating neighborhood adaptability using mobility networks: a case study of the COVID-19 pandemic
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Boz, Hasan Alp, Bahrami, Mohsen, Balcisoy, Selim, Bozkaya, Burcin, Mazar, Nina, Nichols, Aaron, and Pentland, Alex
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- 2024
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5. Targeted inhibition of glycogen synthase kinase-3 using 9-ING-41 (elraglusib) enhances CD8 T-cell-reactivity against neuroblastoma cells
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A. Markovska, K. Somers, J. Guillaume, J. Melief, A. P. Mazar, D. M. Schmitt, H. S. Schipper, and M. Boes
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Neuroblastoma ,GSK-3β ,Immunomodulation ,MHC-I ,Medicine ,Science - Abstract
Abstract The prognosis of patients with high-risk neuroblastoma remains poor, partly due to inadequate immune recognition of the tumor. Neuroblastomas display extremely low surface MHC-I, preventing recognition by cytotoxic T lymphocytes (CTLs) and contributing to an immunosuppressive tumor microenvironment. Glycogen synthase kinase-3 beta (GSK-3β) is involved in pathways that may affect the MHC-I antigen processing and presentation pathway. We proposed that therapeutic inhibition of GSK-3β might improve the surface display of MHC-I molecules on neuroblastoma cells, and therefore tested if targeting of GSK-3β using the inhibitor 9-ING-41 (Elraglusib) improves MHC-I-mediated CTL recognition. We analyzed mRNA expression data of neuroblastoma tumor datasets and found that non-MYCN-amplified neuroblastomas express higher GSK-3β levels than MYCN-amplified tumors. In non-MYCN-amplified cells SH-SY5Y, SK-N-AS and SK-N-SH 9-ING-41 treatment enhanced MHC-I surface display and the expression levels of a subset of genes involved in MHC-I antigen processing and presentation. Further, 9-ING-41 treatment triggered increased STAT1 pathway activation, upstream of antigen presentation pathways in two of the three non-MYCN-amplified cell lines. Finally, in co-culture experiments with CD8 + T cells, 9-ING-41 improved immune recognition of the neuroblastoma cells, as evidenced by augmented T-cell activation marker levels and T-cell proliferation, which was further enhanced by PD-1 immune checkpoint inhibition. Our preclinical study provides experimental support to further explore the GSK-3β inhibitor 9-ING-41 as an immunomodulatory agent to increase tumor immune recognition in neuroblastoma.
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- 2024
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6. Assessment of the importance of sleep quality and the effects of deprivation on Sudanese healthcare professionals amidst conflict in Sudan
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Mohammed Hammad Jaber Amin, Musab Awadalla Mohamed Elhassan Elmahi, Gasm Alseed Abdelmonim Gasm Alseed Fadlalmoula, Jaber Hammad Jaber Amin, Noon Hatim Khalid Alrabee, Mohammed Haydar Awad, Zuhal Yahya Mohamed Omer, Nuha Tayseer Ibrahim Abu Dayyeh, Nada Abdalla Hassan Abdalkareem, Esra Mohammed Osman Meisara Seed Ahmed, Hadia Abdelrahman Hassan Osman, Hiba A. O. Mohamed, Dania Ibrahim Taha Othman, Tagwa Saeed Ibrahim Badawe, Eyha Abdulaziz Mustafa, Ehtida Abdelmonem Hagar, Aya Elshaikh Mohamedtoum Babiker, Ammar Alemam Diab Alnour, Estbrg Alsafi Mohamed Ahmed, Eithar Hussein Elamin Garban, Noura Satti Ali Mohammed, Khabab Abbasher Hussien Mohamed Ahmed, Mirza Adil Beig, Muhammad Ashir Shafique, Shahad Azhari Mohmed Ali, Mazar Gamal Mohamed Elhag, Mojtaba Majdy Elfakey Omer, Asma Eltayeb Abdalla Mohamed, Amna Alrasheed Abuzaid Ali, Hiba Osman Ali Mohamed Elhassan, Khlood Hamdi Ahmed Bin Saleh, Maria Badraldin Ali, Sahar Suliman Elzber Abdalla, Waleed Mohammed Alhaj, Elaf Sabri Khalil Mergani, Hazim Hassan Mohammed Hassan, Hind Mohamed Elfatih Fadl Elmula Ahmed, and Razan Abuelgasim Musa Subahi
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Sleep ,Quality ,Deprivation ,Healthcare ,Professionals ,Sudan ,Medicine - Abstract
Abstract Background Quality sleep is vital for well-being, especially for healthcare workers facing high risks of fatigue and burnout. Sleep deprivation impairs cognitive and motor functions, contributing to medical errors. Addressing sleep disorders among healthcare professionals is crucial for enhancing patient care. Tailored interventions are needed to support their well-being and improve healthcare outcomes. Objective To evaluate the effect of Sleep Quality and its Deprivation on Sudanese Healthcare Professionals amidst conflict in Sudan. Methods A cross-sectional online survey of Sudanese doctors was conducted using convenience sampling. The questionnaire covered sleep quality, daytime sleepiness, and psychological well-being. Pilot testing ensured questionnaire clarity. Data collection utilized Google Forms distributed through social media and professional networks. A minimum sample size of 384 was calculated. Statistical analysis included descriptive statistics and various tests for significance. Data were securely stored and analyzed using SPSS and R software. Results Among 649 participants, 404 (62.2%) were women, with a mean age of 30.34 years. Most were single (434, 66.9%). General practitioners constituted the largest professional group (267, 41.1%), followed by registrars/residents (142, 21.9%). Participants took an average of 43.70 minutes to fall asleep and slept an average of 5.90 hours per night. According to the PSQI, 300 (46.2%) reported mild sleep disturbance, 287 (44.2%) moderate, 42 (6.5%) severe, and only 20 (3.1%) normal sleep. The ESS revealed 285 (43.9%) with lower normal daytime sleepiness, 188 (29.0%) with higher normal, and various levels of excessive daytime sleepiness. Stress levels varied, with 398 (61.3%) reporting normal stress, while anxiety ranged from 248 (38.2%) normal to 148 (22.8%) extremely severe. Conclusion This study emphasizes the importance of addressing sleep quality, mental health, and performance challenges among Sudanese healthcare professionals. It highlights the need for hospitals to implement measures enabling more time off, adequate sleep, and reduced on-call service days. Healthcare workers must recognize the significance of these factors for their well-being and patient care quality. The research outcomes can raise awareness about the necessity of regulating healthcare practitioners' working hours and ensuring adequate sleep.
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- 2024
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7. One City, Two Tales: Using Mobility Networks to Understand Neighborhood Resilience and Fragility during the COVID-19 Pandemic
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Boz, Hasan Alp, Bahrami, Mohsen, Balcisoy, Selim, Bozkaya, Burcin, Mazar, Nina, Nichols, Aaron, and Pentland, Alex
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Physics - Physics and Society - Abstract
What predicts a neighborhood's resilience and adaptability to essential public health policies and shelter-in-place regulations that prevent the harmful spread of COVID-19? To answer this question, in this paper we present a novel application of human mobility patterns and human behavior in a network setting. We analyze mobility data in New York City over two years, from January 2019 to December 2020, and create weekly mobility networks between Census Block Groups by aggregating Point of Interest level visit patterns. Our results suggest that both the socioeconomic and geographic attributes of neighborhoods significantly predict neighborhood adaptability to the shelter-in-place policies active at that time. That is, our findings and simulation results reveal that in addition to factors such as race, education, and income, geographical attributes such as access to amenities in a neighborhood that satisfy community needs were equally important factors for predicting neighborhood adaptability and the spread of COVID-19. The results of our study provide insights that can enhance urban planning strategies that contribute to pandemic alleviation efforts, which in turn may help urban areas become more resilient to exogenous shocks such as the COVID-19 pandemic.
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- 2022
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8. Susceptibilidad a deslizamientos de tierra en la zona costera y cuencas hidrográficas de la Sierra Maestra
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Leonor Villalón-Poulut, Sandra Yanetsy Rosabal-Domínguez, Alberto de las Mercedes Beyris-Mazar, and Elianne Calderón-Montoya
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riesgo geológico ,sismicidad ,vulnerabilidad costera. ,Mining engineering. Metallurgy ,TN1-997 ,Geology ,QE1-996.5 ,Mineralogy ,QE351-399.2 - Abstract
Se realizó una evaluación de las áreas susceptibles a la ocurrencia de deslizamientos en la zona costera y cuencas hidrográficas representativas del municipio Guamá. Se empleó, a través de un Sistema de Información Geográfica, el método Mora-Vahrson, con modificaciones de la propuesta original de acuerdo con las características del área. Se obtuvo el mapa de susceptibilidad, categorizado en: Baja, Moderada, Alta y Muy Alta. Como resultado de la zonificación se obtuvo que la susceptibilidad alta es la de mayor representatividad (52%); en ella se ubican localidades como El Macho, La Plata, Uvero, Montompolo y El Francés. El resultado constituye una actualización del peligro para el municipio Guamá y crea las bases para el desarrollo de estrategias locales de gestión y mitigación de los impactos.
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- 2024
9. Comparing antioxidant and cytoprotective effects: Quercetin glycoside vs. aglycone from Ephedra alata
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Ezzouhra El Maaiden, Najeeb Ullah, Amine Ezzariai, Adil Mazar, Hassan Boukcim, Abdelaziz Hirich, Boubker Nasser, Nagib Qarah, Lamfeddal Kouisni, and Youssef El Kharrassi
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Apoptosis ,Bioavailability ,Ephedra alata ,Hyperin ,Quercetin ,Oxidative stress ,Other systems of medicine ,RZ201-999 - Abstract
Background: A wide range of chronic diseases is associated with ROS-mediated oxidative stress. Quercetin glycoside (QG) is reported to be a powerful antioxidant with extremely high bioavailability and structural stability compared to quercetin aglycone. Hypothesis/Purpose: In this study, the antioxidant potential and cytoprotective effects of quercetin, and its glycosides isolated from Ephedra alata against oxidative damage induced by hydrogen peroxide in the cells of tetrahymena pyriformis (TEP) were evaluated and compared. Study design: Quercetin and its O-glycosides were isolated from Ephedra alata, and their chemical structures were elucidated using advanced spectroscopic techniques. The antioxidant and cytoprotective effects were evaluated using TEP cells exposed to hydrogen peroxide-induced oxidative stress. Methods: TEP cells were pretreated with quercetin aglycone (Q), isoquercetin (ISQ), or hyperin (HYP) before exposure to hydrogen peroxide (H2O2). Cell viability, lactate dehydrogenase (LDH) release, intracellular ROS levels, malondialdehyde (MDA levels, lipoperoxidation, antioxidant enzyme activity, and cleaved caspase-3 levels were measured. Results: ISQ pretreatment significantly enhanced cell survival and reduced H2O2-induced LDH release compared to Q. ISQ also decreased intracellular ROS levels, MDA levels, and lipoperoxidation, surpassing the effects of Q. Additionally, ISQ and HYP pretreatment notably increased antioxidant enzyme activity, outperforming Q. Furthermore, ISQ pretreatment significantly diminished cleaved caspase-3 levels compared to Q, indicating a potential role in preventing oxidative stress-induced apoptosis in TEP cells. Conclusion: Quercetin O-glycosides, particularly isoquercetin, from Ephedra alata exhibit superior antioxidant and cytoprotective effects compared to quercetin aglycone. These findings highlight the potential of these compounds as natural alternatives for mitigating oxidative damage and promoting cellular health. Future research should focus on elucidating the precise molecular pathways involved and evaluating their efficacy in animal models and clinical settings.
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- 2024
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10. Guidance on mucositis assessment from the MASCC Mucositis Study Group and ISOO: an international Delphi studyResearch in context
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Ragda Abdalla-Aslan, Pierluigi Bonomo, Dorothy Keefe, Nicole Blijlevens, Katrina Cao, Yin Ting Cheung, Eduardo Rodrigues Fregnani, Robert Miller, Judith Raber-Durlacher, Joel Epstein, Ysabella Van Sebille, Elisa Kauark-Fontes, Abhishek Kandwal, Emma McCurdy-Franks, Joel Finkelstein, Victoria McCarvell, Yehuda Zadik, Giulia Ottaviani, Rui Amaral Mendes, Caroline Margina Speksnijder, Hannah Rose Wardill, Paolo Bossi, Alexa Laheij, Arghavan Tonkaboni, Jacqui Scott, Rania Abasaeed, Adel Kauzman, Adriana Do Socorro Lima Flato, Adwaita Gore, Anne-Marie Hardman, Agnes Horvath, Allan Hovan, Aisha Al-Jamaei, Aya koizumi, Alan Santos-Silva, Alessandra Majorana, Alexandre Giannini, Aléxia Teixeira, Muhammad Ali Shazib, Alison Melvin, Aluísio Miranda Filho, Amanda Gruza, Amber Brown-Dahl, Amit Harilall, Amr El Maghrabi, Ana Andabak Rogulj, Ana Raphaela Curvo, Ana Laura Soares, Andrea Stringer, Andréa Moreira, Andy Kurtzweil, Angelyn Salaberry, Anne Blazy, Anne Margrete Gussgard, Anne Marie Lynge Pedersen, Annette Freidank, Anura Ariyawardana, Adrian Ramseier, Jann Arends, Ariel Blanchard, Adriana Sesti Paz, Angela Thermann, Augusto Poropat, Azael Freites-Martinez, Abdul Rahman Al-Azri, Bente Brokstad Herlofson, Sitaraman BalajiSubramanian, Barbara Ballantyne, Kivanc Bektas-Kayhan, Bengt Hasséus, Benjamin Kaffenberger, Bernar Benites, Bernice Kwong, Beth Test, Fernando Chiantia, Bo Pettersson, Bomi Framroze, Božana Lončar Brzak, Brittany Dulmage, Sorin Buga, Caroline Spekssnijder, Carlton Brown, Antonio Carlos Moura de Melo, Ana Carolina Ribeiro, Caroline Silva, Caroline Fulop, Carryn Anderson, Catherine Flaitz, Cathy Massoud, Cesar Migliorati, Callie Gross, Chiara Gandini, Charles Loprinzi, Charlotte de Mooij, Catherine Hong, Ying Chu Choi, Maria Choy, Christine Boers-Doets, Leonard Schmeel, Cibele Nagano, Maria Coeli Franco, Courtney Subramaniam, Carolyn Patrick, Catherine Poh, Cristina Neuenschwander, Cesar Virgen, Dorothea Riesenbeck, Dale Weaver, Daniel Cohen Goldemberg, Daniel Sundaresan, Daniela Nunes, Danyel Perez, Daphine Travassos, David Yang, Daniela Ribeiro, Dean Kolbinson, Deborah Buick, Deborah Saunders, Juliane De Bortolli, Deepika Chugh, Denise Markstrom, Denise Travassos, Dianna Weikel, Dimitra Galiti, Dinusha Peiris, Fedja Djordjevic, Pankaj Singhai, Douglas Peterson, Douglas Fonseca, Doreen Pon, Iuliia Kovalenko, Aleksandra Polonskaia, Rogério Caldas, Kevin Saganski, Julia Néri, Dennis Abbott, Abhijna Vithal Yergolkar, Cristina Del Conte, Januaria Passos, Katia Uezu, Paula Silva, Steven Gilbert, Keng Yeoh, Kunal Jain, Madhup Rastogi, Satheeshkumar Poolakkad Sankaran, Deborah Manne, Evgeniya Shatokhina, Esther Adebayo-Olojo, Eszter Somogyi-Ganss, Eli Ehrenpreis, Wilber Bernaola-Paredes, Eduardo Fregnani, Elaci Cardoso, Elena Bardellini, Eleni Arvanitou, Elisa Kauark Fontes, Elise Bruning, Eloise Neumann, Elsa Madureira, Marcia Ramires, Erofili Papadopoulou, Etiene Munhoz, Fred Spijkervet, Fabiana Granzotto, Fabiana Martins, Fabio Alves, Farah Mougeot, Federica Aielli, Fernanda Pigatti, Fernanda Fonseca, Firoozeh Samim, Flavia Carvalho, Florence Cuadra Zelaya, Cesar Freytes, Gabriela da Silveira, Gabriela Torino, Gabriela Martins, Geisa Silva, Gemma Caro, Gemma Bryan, Georgette Radford, Ghanyah Al-Qadami, Giorgia Albini, Gisele Mainville, Georgios Gkardiakos, Gleidston Potter, Gulbin Hoeberechts, Gordon Howarth, Grace Bradley, Gunjan Verma, Gustavo dos Santos, Margaret Randles-Guzzardi, Hanlie Engelbrecht, Hannah Wardill, Heidi Hansen, Iquebal Hasan, Hironobu Hata, Helena Ullgren, Heliton Spindola Antunes, Heloísa Laís dos Santos, Howard Weld, Helen McInnes, Hans Peter Jungbluth, Hsiaofen Weng, Ian Hewson, Ingrid Santos, Jorge Illarramendi, Ines Semendric, Rol Menge, Inger Von Bultzingslowen, Maria da Gloria de Melo, Iona Leong, Isabella Fonseca, Isadora Kalif, James Carroll, Janet Coller, Johann Beck-Mannagetta, Joanne Bowen, Jose Meurer, Ricky McCullough, Jennifer Powers, Jesus Gomez, Jimma Lenjisa, jaya Vangara, Jasna Leko, Jane Fall-Dickson, Jean-Luc Mougeot, Joan Fox, Jolien Robijns, Jonn Wu, Patricio Palma, Jaya Amaram-Davila, Jim Siderov, Juliana Dantas, Juliana Jasper, Juliana Monteiro, Julia Bruno, julie pfeffer, Julija Jovanovic Ristivojevic, Juliana Brito, Jyothsna Kuriakose, Yuji Kabasawa, Kanan Dave, Karin Barczyszyn, Karol Sartori Lima, Kate Secombe, Kate White, Kate Cooper, Kouji Katsura, Karen Biggs, Katharine Ciarrocca, Kristopher Dennis, Ken Tomizuka, Kevin Hendler, Ikuko Komo, Kristina Skallsjö, Kristy Hodgins, Katia Rupel, Keiko Tanaka, Seema Kurup, Luiz Gueiros, Larissa Agatti, Laura Garzona-Navas, Letícia Guerra, Leila Portela, Leilani Iossi, Linda Elting, Lene Baad-Hansen, Leslie Reeder, Leticia Lang, Liciane Menezes, Liliana Braun, Liliane Grando, Mathew Lim, Lina Fernandez, Lucy McKeage, Luana Campos, Luciana Simonato, Luciana Muniz, Leah van Draanen, Mieko Mizutani, Tsai-Wei Huang, Mahfujul Riad, Mahnoor Nazar, Maíra Souza, Mariana Minamisako, Manoela Pereira, Carlos Mantelato, Márcio Diniz-Freitas, Marco Montezuma, Marco Andrade, Marcos Santos, Margherita Gobbo, Maria Caterina Fortuna, Mariana Vitor, Joana Marinho, Alina Markova, Marlyse Knuchel, Marta Carlesimo, Marta Neves, Andrew Mazar, Maria Cristina Gomez Amarilla, Mark Chambers, Melissa de Araujo, Alexandre Melo, Melody Cole, Mohamed Elsayed, Monica Fliedner, Martin Hauer-Jensen, Micaela Bouchacourt, Michael Brennan, Michael Thirlwell, Michio Nakamura, Midori Nakagaki, Camila Rossi, Mireille Kaprilian, Michael Kase, Michael Dougan, Monique Stokman, Ragnhild Monsen, Alisha Morgan, Jocelyn Harding, Maryam Taleghani, Marie-Therese Genot, Mukund Seshadri, Brian Muzyka, Nancy Batista, Nancy Gadd, Naoko Tanda, Narmin Nasr, Natália Garcia, Nathan Lee, Natalia Palmier, Norman Brito-Dellan, Nancy Corbitt, Neli Pieralisi, Verônica Serrano, Nicola Alessandro Iacovelli, Norma Lúcia Sampaio, Nour Karra, Niveditha Venkatesh, Noam Yarom, Renata Cristina Borin, Olivia Lemenchick, Ondina Mendes, Ourania Nicolatou-Galitis, Vasiliy Shchitka, Paula Reis, Paulo Sérgio Santos, Paz Fernandez-Ortega, Ira Parker, Raquel García, Peter Fritz, Edmund Peters, Pamela Gardner, Pierre Saint Girons, Priya Tiwari, Pravin Chaturvedi, Tais de Moraes, Priscila Andrade, Raj Nair, Rachel Gibson, Rachita Gururaj, Raghu Thota, Rajesh Lalla, Raquel Almeida Prado, Ravikiran Ongole, George Taybos, Regina Mackey, Renata Rego, Renata Camilotti, Renata Ferrari, Renato Junior, Rene-Jean Bensadoun, Richard Logan, Roberta Sales, Roberta Zanicotti, Roberta Tunes, Rodolfo Mauceri, Rosiene Feitoza, Kathryn Ruddy, Cynthia Rybczyk, Stephanie Trager, Sachiyo Mitsunaga, Sahani Gunathilake, Rajan Saini, Viola Salvestrini, Sandip Mukhopadhyay, Sandrina Angeloz, Pramod Sankar S, Luciana S Barbosa Barbosa, Elena Volkova, Sharon Elad, Sergio Cantoreggi, Sharon Gordon, Shelly Brown, Shu Yie Janine Tam, Sibelle Faleiro, Silmara da Silva, Silvia de Oliveira, Siri Beier Jensen, Ivana Skrinjar, Sophie Beaumont, Felipe Sperandio, Sandra Reese, Steven Roser, Sachiko Seo, Stephanie van Leeuwen, Stephen Sonis, Stephen Bernard, Stephen Rajan Samuel, Stuart Taylor, Suranjan Maitra, Susanne Skulski, Suzanne Carlisle, Sylvie Louise Avon, Tomoya Yokota, Takashi Yurikusa, Tabata Santos Polvora, Tabitha Kelock, Tauana Fernandes, Taylor Wain, Timothy Brown, Tetsuhito konishi, Thalyta Amanda Ferreira, Tomoko Kataoka, Thomas Kelly, Takehiko Mori, Tomoko Higuchi, Toshiaki Saeki, Nikolaos Tsoukalas, Typhaine Maupoint De Vandeul, Masatoshi Usubuchi, Vanessa Lacerda, Vanessa Tilly, Emmanuelle Vigarios, Alessandro Villa, Vinicius Torregrossa, Vinodh Kumar Selvaraj, Viviane Sarmento, Vivien Heng, Wagner Gomes-Silva, Petter Wilberg, Wanessa Miranda e Silva, Wan Nor I'zzah Wan Mohamad Zain, Wonse Park, Wim Tissing, Yoshihiko Soga, Bella Van Sebille, and Yuhei Matsuda
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Oral mucositis ,Gastrointestinal mucositis ,Mucositis assessment tools ,Patient-reported outcome measures ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Mucositis is a common and highly impactful side effect of conventional and emerging cancer therapy and thus the subject of intense investigation. Although common practice, mucositis assessment is heterogeneously adopted and poorly guided, impacting evidence synthesis and translation. The Multinational Association of Supportive Care in Cancer (MASCC) Mucositis Study Group (MSG) therefore aimed to establish expert recommendations for how existing mucositis assessment tools should be used, in clinical care and trials contexts, to improve the consistency of mucositis assessment. Methods: This study was conducted over two stages (January 2022–July 2023). The first phase involved a survey to MASCC-MSG members (January 2022–May 2022), capturing current practices, challenges and preferences. These then informed the second phase, in which a set of initial recommendations were prepared and refined using the Delphi method (February 2023–May 2023). Consensus was defined as agreement on a parameter by >80% of respondents. Findings: Seventy-two MASCC-MSG members completed the first phase of the study (37 females, 34 males, mainly oral care specialists). High variability was noted in the use of mucositis assessment tools, with a high reliance on clinician assessment compared to patient reported outcome measures (PROMs, 47% vs 3%, 37% used a combination). The World Health Organization (WHO) and Common Terminology Criteria for Adverse Events (CTCAE) scales were most commonly used to assess mucositis across multiple settings. Initial recommendations were reviewed by experienced MSG members and following two rounds of Delphi survey consensus was achieved in 91 of 100 recommendations. For example, in patients receiving chemotherapy, the recommended tool for clinician assessment in clinical practice is WHO for oral mucositis (89.5% consensus), and WHO or CTCAE for gastrointestinal mucositis (85.7% consensus). The recommended PROM in clinical trials is OMD/WQ for oral mucositis (93.3% consensus), and PRO-CTCAE for gastrointestinal mucositis (83.3% consensus). Interpretation: These new recommendations provide much needed guidance on mucositis assessment and may be applied in both clinical practice and research to streamline comparison and synthesis of global data sets, thus accelerating translation of new knowledge into clinical practice. Funding: No funding was received.
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- 2024
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11. Investigating neighborhood adaptability using mobility networks: a case study of the COVID-19 pandemic
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Hasan Alp Boz, Mohsen Bahrami, Selim Balcisoy, Burcin Bozkaya, Nina Mazar, Aaron Nichols, and Alex Pentland
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History of scholarship and learning. The humanities ,AZ20-999 ,Social Sciences - Abstract
Abstract What predicts a neighborhood’s adaptability to essential public health policies and shelter-in-place regulations that prevent the harmful spread of COVID-19? To answer this question, we present a novel application of human mobility patterns and human behavior in a network setting. We analyze 2 years of mobility data (January 2019 to December 2020) from New York City and construct weekly mobility networks between census block groups based on aggregated point-of-interest visit patterns. Our results indicate that neighborhoods’ socioeconomic and geographic characteristics play a significant role in predicting their adaptability to active shelter-in-place policies. Our simulation outcomes reveal that, alongside factors such as race, education, and income, the geographical attributes of neighborhoods, such as access to amenities that satisfy community needs are equally important factors in predicting neighborhood adaptability to public health policies. These findings offer valuable insights that can enhance urban planning strategies, thereby aiding pandemic mitigation efforts and fostering increased adaptability of urban areas in the face of exogenous shocks like the COVID-19 pandemic.
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- 2024
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12. Fasciola Infection Unexpectedly Found During Cholecystectomy: Review on How to Avoid Increasing Surgery Interventions in Non-human Endemic Areas
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Mowlavi, Gholamreza, Bargues, María Dolores, Najafi, Faezeh, Naddaf, Saied Reza, Salehabadi, Alireza, Vejdan, Amir Kazem, Salimi, Mahboobeh, Fadavi, Arezoo, Arab-Mazar, Zahra, and Mas-Coma, Santiago
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- 2023
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13. Risk of breakthrough COVID-19 after vaccination among people with multiple sclerosis on disease-modifying therapies
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Spierer, Ronen, Lavi, Idit, Bloch, Sivan, Mazar, Marianna, and Golan, Daniel
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- 2023
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14. Diversidad briológica en las Reservas Florísticas Manejadas La Caoba y Charrascales de Mícara (Santiago de Cuba, Cuba)
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Yoira Rivera Queralta, Ángel E. Motito Marín, and Alberto M. Beyris Mazar
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Caribe insular ,conservación vegetal ,isla de Cuba ,planta no vascular ,Sierra Cristal. ,Science ,Botany ,QK1-989 - Abstract
Introducción y Objetivos: Los inventarios briológicos en los espacios protegidos cubanos apoyan la actualización de los planes de manejos al inventariar las especies, detectar sus amenazas y diseñar acciones para su conservación. El objetivo de esta investigación es caracterizar la brioflora presente en las Reservas Florísticas Manejadas La Caoba y Charrascales de Mícara, Santiago de Cuba, Cuba. M&M: En la recolecta de los especímenes se exploraron los hábitats adecuados para la instalación de los briófitos siguiendo el método del Muestro Florístico del Hábitat. En la determinación de los taxones se consultó la bibliografía especializada y las bases de datos. Todo el material colectado fue depositado en la colección Bryophyta del herbario BSC. Resultados: Se registraron para las Reservas Florísticas Manejadas La Caoba y Charrascales de Mícara 49 taxones infragenéricos de antocerotas, hepáticas y musgos. La reserva La Caoba fue la más diversa (73,5% del total) y los musgos la división mejor representada (55,1%). El sustrato epífito es el más diverso y el Bosque semideciduo mesófilo la formación vegetal mejor representada (83,3%). La totalidad de los taxones amenazados se registraron en la Reserva Florística Manejada La Caoba. Conclusiones: En las Reservas Florísticas Manejadas La Caoba y Charrascales de Mícara la brioflora se caracteriza por la presencia de taxones de amplia plasticidad ecológica y distribución geográfica. Las condiciones presentes en la reserva Charrascales de Mícara limitan el desarrollo de los briófitos. La diversidad briológica en La Caoba está amenazada por la fragmentación del hábitat debido a las alteraciones del paisaje.
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- 2024
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15. Glycogen synthase kinase 3 activity enhances liver inflammation in MASH
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Mireille Khoury, Qianqian Guo, Kunimaro Furuta, Cristina Correia, Chady Meroueh, Hyun Se Kim Lee, Khaled Warasnhe, Lucía Valenzuela-Pérez, Andrew P. Mazar, Iljung Kim, Yung-Kyun Noh, Heather Holmes, Michael F. Romero, Caroline R. Sussman, Kevin D. Pavelko, Shahidul Islam, Adebowale O. Bamidele, Petra Hirsova, Hu Li, and Samar H. Ibrahim
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Glycogen synthase kinase 3 (GSK3) ,Non-alcoholic steatohepatitis (NASH) ,Metabolic dysfunction associated steatohepatitis (MASH) ,Liver sinusoidal endothelial cells (LSEC) ,Myeloid cells ,Inflammation ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by excessive circulating toxic lipids, hepatic steatosis, and liver inflammation. Monocyte adhesion to liver sinusoidal endothelial cells (LSECs) and transendothelial migration (TEM) are crucial in the inflammatory process. Under lipotoxic stress, LSECs develop a proinflammatory phenotype known as endotheliopathy. However, mediators of endotheliopathy remain unclear. Methods: Primary mouse LSECs isolated from C57BL/6J mice fed chow or MASH-inducing diets rich in fat, fructose, and cholesterol (FFC) were subjected to multi-omics profiling. Mice with established MASH resulting from a choline-deficient high-fat diet (CDHFD) or FFC diet were also treated with two structurally distinct GSK3 inhibitors (LY2090314 and elraglusib [9-ING-41]). Results: Integrated pathway analysis of the mouse LSEC proteome and transcriptome indicated that leukocyte TEM and focal adhesion were the major pathways altered in MASH. Kinome profiling of the LSEC phosphoproteome identified glycogen synthase kinase (GSK)-3β as the major kinase hub in MASH. GSK3β-activating phosphorylation was increased in primary human LSECs treated with the toxic lipid palmitate and in human MASH. Palmitate upregulated the expression of C-X-C motif chemokine ligand 2, intracellular adhesion molecule 1, and phosphorylated focal adhesion kinase, via a GSK3-dependent mechanism. Congruently, the adhesive and transendothelial migratory capacities of primary human neutrophils and THP-1 monocytes through the LSEC monolayer under lipotoxic stress were reduced by GSK3 inhibition. Treatment with the GSK3 inhibitors LY2090314 and elraglusib ameliorated liver inflammation, injury, and fibrosis in FFC- and CDHFD-fed mice, respectively. Immunophenotyping using cytometry by mass cytometry by time of flight of intrahepatic leukocytes from CDHFD-fed mice treated with elraglusib showed reduced infiltration of proinflammatory monocyte-derived macrophages and monocyte-derived dendritic cells. Conclusion: GSK3 inhibition attenuates lipotoxicity-induced LSEC endotheliopathy and could serve as a potential therapeutic strategy for treating human MASH. Impact and Implications: LSECs under lipotoxic stress in MASH develop a proinflammatory phenotype known as endotheliopathy, with obscure mediators and functional outcomes. The current study identified GSK3 as the major driver of LSEC endotheliopathy, examined its pathogenic role in myeloid cell-associated liver inflammation, and defined the therapeutic efficacy of pharmacological GSK3 inhibitors in murine MASH. This study provides preclinical data for the future investigation of GSK3 pharmacological inhibitors in human MASH. The results of this study are important to hepatologists, vascular biologists, and investigators studying the mechanisms of inflammatory liver disease and MASH, as well as those interested in drug development.
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- 2024
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16. Lumbar Disc Prolapse: Microdiscectomy and its Clinical Outcomes
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Dr Shahbaz Khan Panhwar, Dr Saddam Mazar, Dr. Nida Hameed, Dr. Imtiaz A. Hashmi, and Dr. Muhammad Sohail Rafi
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Diskectomy, Intervertebral Disc Displacement, Radiculopathy ,Biochemistry ,QD415-436 ,Dentistry ,RK1-715 ,Therapeutics. Pharmacology ,RM1-950 ,Medicine (General) ,R5-920 - Abstract
Background: Prolapse lumbar intervertebral disc (PLID) is a localized disc displacement outside its margins is the most common source of sciatica pain, involving 1%-5% of the population annually. Standard management includes conservative management initially for a period of around 6 weeks. In general, microdiscectomy (MD) is considered a standard procedure for symptomatic cases, with approximately 60%-80% of satisfactory results. In this study, we aimed in describing experience of MD in patients diagnosed with PLID. Methods: This retrospective study has been conducted at Dr. Ziauddin University hospital, Karachi; Pakistan. The medical records from 2018 to 2020, of microdiscectomy for prolapsed intervertebral lumbar disc were studied. All patients of 18 years or more admitted with symptomatic PLID, and proceeded to single level MD have been included. The regular pre-operative work-up, surgical technique and post-operative management was followed. Data collection was performed using a standard proforma. Utilizing SPSS version 23.0, all statistical analyses were carried out a p
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- 2024
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17. Functional Outcomes of Close Reduction With K-wires Vs Open Reduction and Internal Fixation in Distal Radius Fractures
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Dr Saddam Mazar, Dr M. Idrees Shah, Dr Shahbaz Khan Panhwar, Dr Syed Atta ur Rahman, and syeda Laibah ali
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Biochemistry ,QD415-436 ,Dentistry ,RK1-715 ,Therapeutics. Pharmacology ,RM1-950 ,Medicine (General) ,R5-920 - Abstract
Background: Radius and/or ulna fractures are frequent which encounter higher emergency room visits. Despite high incidence, proper management between closed reduction and internal fixation (CRIF) with K-wires and open reduction and internal fixation (ORIF) with anatomical Volar locking plate, remains debatable. This study aimed to compare the functional outcomes between the two management protocols. Methods: A total of 118 patients with distal radius fractures were treated operatively, at Dr. Ziauddin University Hospital Karachi, from January 2017 to October 2020. Out of these, 29 patients (24.6%) were treated with CRIF and 89 patients (75.4%) with ORIF. The functional outcomes of both groups were assessed through disabilities of arm, shoulder and hand (DASH) scores at 3 and 6 months. functional outcomes were assessed through a t-test, p-value
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- 2024
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18. Prediction of Scoliosis Curve Correction Using Apical Fulcrum Bending Radiographs in Adolescent Idiopathic Scoliosis (AIS)
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Javeria Junaid, Saddam Mazar, Shahzaib Riaz Baloch, Fatima Bashir, Mohammed Sohail Rafi, and Imtiaz Ahmed Hashmi
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Biochemistry ,QD415-436 ,Dentistry ,RK1-715 ,Therapeutics. Pharmacology ,RM1-950 ,Medicine (General) ,R5-920 - Abstract
Background: Scoliosis is defined as a three-dimensional deformity of spine. Surgical treatment is indicated for curves equal to/or more than 40 degrees in magnitude. Curve flexibility is determined preoperatively through bending films, which help in the selection of fusion levels. Surgical treatment for fully-grown spine is a spinal fusion use to inhibit the progress of deformity which further helps in balancing of both sagittal and coronal planes. Therefore, this study aimed to find out the association between predicted via bending films after correction and final surgical correction of skeletally mature patients with Adolescent Idiopathic Scoliosis (AIS). Methods: Thirty-three patients with Adolescent Idiopathic Scoliosis (AIS) were recruited for the study. Those patients were operated at Dr. Ziauddin University Hospital, Karachi from June 2016 to June 2020. Using Pre- and post-operative radiographs of the spine, Cobb values were used to calculate the percentage of correction achieved. Percentage correction (surgical) was then compared to correction possible (predicted) to find association via an independent t-test with p
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- 2024
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19. Effectiveness of acupuncture for the relief of lumbar pain in the emergency room
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Liliset Rodríguez Domínguez, Marilú Ferrer Ramírez, Caridad Celeste Jacas García, Aylen Uriarte Nápoles, and Vivian de la Concepción Queralta Mazar
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dolor ,lumbalgia ,acupuntura ,atención secundaria de salud ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
Introduction: Low back pain is presented in approximately 9.4% of the world population. Acupuncture is used by Chinese traditional medicine to stimulate certain points of the body with different types of needles. Among its beneficial effects the pain remission is described. Objective: To evaluate the effectiveness of the acupuntural treatment in patients with lumbar pain assisted in the emergency room. Methods: A quasi-experiment of therapeutic intervention study (without control group) was carried out in 35 patients with lumbar pain, who were assisted in the Natural and Traditional Medicine Emergency Room of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba, from July to December, 2021. Results: In the investigation there was a prevalence the 40-49 age group (31.4%), female sex (57.1%), housewives, serious and moderate pain at the beginning of the treatment, as well as patients without pain one hour after the therapy. As for the final clinical course, the total of the sample classified in the relieved and improved categories. Conclusions: The effectiveness of acupuncture was demonstrated in patients with acute lumbar pain.
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- 2024
20. Influence of Gd and Li additions on the microstructural evolution and mechanical properties of hot-rolled AZ31 alloy
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M. Abbasi Mazar, F. Bayat, A. Farkas, K. Fekete, J. Mola, and M. Sabbaghian
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AZ31 alloy ,Basal texture ,Formability ,Grain refinement ,Shear punch test ,Strength ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Thermomechanical processing and alloying are two common approaches to enhance the mechanical properties of Mg. Thus, the effects of Gd and Li elements, as two elements with various properties, on the microstructure and mechanical properties of a hot-rolled and consequently annealed AZ31 alloy were analyzed. The microstructure and texture was analyzed by scanning electron microscopy and electron back scattered diffraction. Accordingly, the mean grain size of 46 μm in the AZ31 alloy was reduced to 41 and 26 μm in the AZ31–2.9Gd and AZ31–2.3Li alloys, respectively. Grain refinement occurred due to continuous dynamic recrystallization and twinning-induced recrystallization in all of the alloys. Textural evolution showed that neither Gd nor Li could inhibit the occurrence of basal texture. Room temperature mechanical properties were assessed by using the shear punch test (SPT) method. The results exhibited that the strength of the AZ31 alloy was improved from 116 MPa to 139 MPa and 141 MPa by respective additions of Gd and Li. Strength enhancement was mainly attributed to the grain boundary strengthening and second-phase particles hardening. One promising observation was the simultaneous enhancement of shear strength and ductility by the addition of Gd and Li. This observation was ascribed to the more uniform distribution of second-phase particles and lower volume fraction of twins as potential sites for crack initiation. As long as mechanical strength is concerned, results favor the use of Li as alloying element in Mg, especially due to the more noticeable lightweighting potential compared to Gd.
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- 2023
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21. Glycogen synthase kinase 3 activity enhances liver inflammation in MASH
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Khoury, Mireille, Guo, Qianqian, Furuta, Kunimaro, Correia, Cristina, Meroueh, Chady, Kim Lee, Hyun Se, Warasnhe, Khaled, Valenzuela-Pérez, Lucía, Mazar, Andrew P., Kim, Iljung, Noh, Yung-Kyun, Holmes, Heather, Romero, Michael F., Sussman, Caroline R., Pavelko, Kevin D., Islam, Shahidul, Bamidele, Adebowale O., Hirsova, Petra, Li, Hu, and Ibrahim, Samar H.
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- 2024
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22. Enriquecimiento de metales en las colas del proceso Caron aplicando intensidad variable del campo magnético
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Orleidy Loyola-Breffe, Pedro Enrique Beyris-Mazar, Amaury De los Milagros Palacios-Rodríguez, and Yunior Correa-Cala
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colas negras ,concentración de metales ,separación magnética ,tecnología caron ,tratamento de colas ,Mining engineering. Metallurgy ,TN1-997 ,Geology ,QE1-996.5 ,Mineralogy ,QE351-399.2 - Abstract
La producción de Ni y Co mediante la tecnología CARON en Moa, Cuba, vierte anualmente millones de toneladas de colas, que afectan al medio ambiente, con contenidos de elementos metálicos valiosos que pueden ser recuperados por diversas vías. El propósito de este trabajo es evaluar la concentración de tales elementos para diferentes clases de tamaño e intensidades del campo magnético. Para ello, se separó mediante tamizado tres clases de tamaño (gruesa +0,200 mm, media -0,200 +0,045 mm y fina -0,045 mm), a las cuales se les aplicó tres intesidades de campo magnético (0,05 A, 0,10 A y 0,15 A). Se obtuvo como resultado que en el producto no magnético para una intensidad del campo de 0,15 A, el cinc, cromo y aluminio se concentran en la clase de tamaño media y el níquel, magnesio y sílice en la clase gruesa. El hierro se concentra en el producto magnético de las clases media y gruesa para una intensidad de 0,05 A hasta aproximadamente 50 %. En la clase fina la aplicación de un campo magnético no ejerce ningún efecto. Finalmente, es posible concentrar el níquel hasta 1,23 %, en el producto no magnético de las partículas mayores de 0,045 mm, con posibilidad de incorporar este elemento valioso a la tecnología de extracción existente.
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- 2023
23. Pregnancy-related sensory deficits might impair foraging in echolocating bats
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Taub, Mor, Mazar, Omer, and Yovel, Yossi
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- 2023
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24. Management of tracheo-innominate artery fistula in the challenging environment of an improvised COVID-19 intensive care unit
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Kristina Krzelj, Zeljko Duric, Ivan Situm, Dora Karmelic, Ante Erceg, Kristina Kljajic, Mirabel Mazar, Hrvoje Gasparovic, and Daniel Lovric
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Anesthesiology ,RD78.3-87.3 ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Published
- 2023
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25. Etiological Spectrum of Obstructive Jaundice in Tertiary Hospital of Quetta
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Shakeel Akbar, Saleem Mustafa, Mazar Taj, Khadijah Abid, Alamgir Khan, and Muhammad Zakaryya Bashir
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etiological spectrum ,choledocholithiasis ,carcinoma head of pancreas ,obstructive jaundice ,Medicine - Abstract
Objective: To identify the etiological spectrum of obstructive jaundice in patients presenting in Bolan Medical Complex Hospital Quetta.Study type,settings& duration:This descriptive cross-sectional study was conducted at Department of General Surgery, Bolan Medical Complex Hospital, Quettafrom December 2017to June 2018.Methodology:A total number of 211 patients having age 15 to 65 years with diagnosis of obstructive jaundice were included. All radiological tests like ultrasound, CT scan and Magnetic Resonance Cholangio-pancreatography of the patients was done to determine the etiology of obstructive jaundice. After surgery,the histopathological examination of the biopsy was also done. Data analysis was done through SPSS v23 software.Results:Mean age of study patients was 47.86±12.40 years. There were 131 (62.09%) female patients and only 80 (37.91%) male patients. There were 87 (41.23%) patients who presented with benign causes while remaining 124 (58.77%) patients who presented with malignant causes. Among the benign causes, stone in common bile duct (CBD) were most common presented in 51 (24.2%) patients while 36 (17.1%) patients presented with stricture. Although pancreatic head carcinoma was the most prevalent disease diagnosed in 69 (32.7%) patients with malignant conditions, peri-ampular carcinoma in 24 (11.4%) patients, gallbladder carcinoma in 22 (10.4%), and cholangio-carcinoma in just 9 (4.3%) patients.Conclusion:As compared to benign causes, malignant causes of obstructive jaundice are more frequent. The highest prevalent tumour among malignant causes is pancreatic head carcinoma, while stones inthe common bile duct are highly prevalent among benign causes of obstruction in our population.
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- 2023
26. Reaching for rigor and relevance: better marketing research for a better world
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Madan, Shilpa, Johar, Gita Venkataramani, Berger, Jonah, Chandon, Pierre, Chandy, Rajesh, Hamilton, Rebecca, John, Leslie K., Labroo, Aparna A., Liu, Peggy J., Lynch, Jr., John G., Mazar, Nina, Mead, Nicole L., Mittal, Vikas, Moorman, Christine, Norton, Michael I., Roberts, John, Soman, Dilip, Viswanathan, Madhu, and White, Katherine
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- 2023
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27. Toxoplasma gondii vaccine candidates: a concise review
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Mamaghani, Amirreza Javadi, Fathollahi, Anwar, Arab-Mazar, Zahra, kohansal, Kobra, Fathollahi, Matin, Spotin, Adel, Bashiri, Homayoon, and Bozorgomid, Arezoo
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- 2023
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28. Side-by-Side Comparison of uPAR-Targeting Optical Imaging Antibodies and Antibody Fragments for Fluorescence-Guided Surgery of Solid Tumors
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Baart, Victor M., van Manen, Labrinus, Bhairosingh, Shadhvi S., Vuijk, Floris A., Iamele, Luisa, de Jonge, Hugo, Scotti, Claudia, Resnati, Massimo, Cordfunke, Robert A., Kuppen, Peter J. K., Mazar, Andrew P., Burggraaf, Jacobus, Vahrmeijer, Alexander L., and Sier, Cornelis F. M.
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- 2023
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29. Faculty and Staff Reporting & Disclosure of Sexual Harassment in Higher Education
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Kirkner, Anne Catherine, Lorenz, Katherine, and Mazar, Laurel
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Sexual harassment in the workplace is an overt form of sexism that reinscribes patriarchal power relations within the university. Despite the perception that many people are reporting their harassment in academia thanks to the MeToo movement, we found the problem largely unreported in our sample of faculty and staff at US universities. Little is known about what drives reporting and disclosure behaviors of faculty and staff within institutions of higher education (IHEs). The present study was designed to examine disclosing and reporting sexual harassment in academia, using a sample of (N = 88) faculty and staff from IHEs who experienced some form of unwanted sexual attention. Approximately 40% did not report or disclose to anyone, and among those who did disclose the harassment they overwhelmingly chose people outside the workplace. The most common reasons for not reporting included not interpreting the event as serious enough, concerns of not being taken seriously, and thinking that nothing would be done. Regression analysis showed that experiencing electronic harassment, but not other forms of harassment, predicted reporting and disclosure. This finding reveals the stereotypes behind 'the perfect victim' are alive and well, continuing to limit the ability of victims to come forward with claims of harassment.
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- 2022
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30. The role of manufacturing on Iran's economic growth: Divisa’s Logarithmic Index Method
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Esfandiar Jahangard, Ali Arab Mazar Yazdi, and Fateme Zahiri
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"structural change ," industrialization ," economic growth ," kaldor first law ,Economic growth, development, planning ,HD72-88 - Abstract
This article discusses the role of manufacturing in the economic growth of Iran using the logarithmic mean Divisia index (LMDI) method. The study identifies various drivers of industrialization and their impact on growth, including structural changes (productivity of labor and employment share in industrial factories) and employment scale. The LMDI method is used to analyze with a dataset from Iranian provinces between 1381 and 1399. The results show that industrialization has a positive and significant effect on economic growth, with structural changes having a greater impact than employment scale. The study highlights the importance of sustainable industrial development for economic growth in Iran.
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- 2023
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31. Values of abdominal perimeter and waist-hip ratio in patients with hypertension
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Ángel Alfonso Ximelis Morales, Vivian Queralta Mazar, Marilú Ferrer Ramírez, Aileen Vega Riveri, and Carlos Ernesto Quintana Batista
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hipertensión ,circunferencia de la cintura ,índice cintura-cadera ,atención secundaria de salud. ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
Introduction: Hypertension constitutes a problem of public health in almost all over the world. Among the risk factors associated with it, the accumulation of fat is notable, which can, in turn, establish risks and determine comorbidities and mortality associated with this nosological entity. Objective: To determine the variations in the values of the abdominal perimeter and waist-hip ratio in patients with hypertension, according to selected epidemiological and clinical variables. Methods: A descriptive, prospective and cross-sectional study was carried out on 221 patients with hypertension, belonging to doctor's office 19 of Josué País García Teaching Polyclinic in Santiago de Cuba municipality, from June, 2019 to December, 2020. Results: There was a prevalence of the female sex and the 65-74 age group (28.5%). The anthropometric indicators, abdominal perimeter and waist-hip ratio, had values that exceeded the established normal parameters for both sexes. The calculation of the abdominal perimeter revealed a predominance of obesity in the female sex, while it was classified as increased in the male sex. Conclusions: The values of the waist-hip ratio and abdominal perimeter exceeded those classified by the World Health Organization as high risk of presenting the disease in both sexes.
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- 2023
32. Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity
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Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, and Ian Sayers
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asthma ,barrier ,bronchial epithelial cells ,urokinase plasminogen receptor ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Objectives To determine (i) the expression profile of uPAR in cultured human bronchial epithelial cells (HBEC) from asthma patients, (ii) the relationship between uPAR and the epithelial barrier, including blocking uPAR functions and (iii) the function of different uPAR isoforms. Methods uPAR levels in HBECs isolated from asthma patients and cells at air liquid interface (ALI) during differentiation were quantified. Transepithelial electrical resistance or electrical cell impedance sensing was used to relate uPAR levels to barrier properties, including effects of uPAR blocking antibodies. The functional effects of gain of function was determined using transcriptomics, in cells over‐expressing membrane (muPAR), soluble cleaved (scuPAR) or soluble spliced (ssuPAR) isoforms. Results Elevated expression of uPAR was a feature of cultured HBECs from asthma patients, suggesting intrinsic alterations in asthma patient cells. Soluble uPAR levels inversely correlated with barrier properties of the HBEC layer in 2D and ALI. Blocking uPAR‐integrin interactions enhanced barrier formation. The gain of function cells showed limited transcriptomic changes. Conclusion This study provides a significant advance in our understanding of the relationship between asthma, uPAR and the epithelial barrier, where elevated circulating uPAR results in a reduced cell barrier, a phenotype prevalent in asthma.
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- 2023
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33. Pregnancy-related sensory deficits might impair foraging in echolocating bats
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Mor Taub, Omer Mazar, and Yossi Yovel
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Echolocation ,Sensing ,Pregnancy ,Reproduction ,Movement ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Reproduction entails substantial demands throughout its distinct stages. The mammalian gestation period imposes various energetic costs and movement deficits, but its effects on the sensory system are poorly understood. Bats rely heavily on active sensing, using echolocation to forage in complete darkness, or when lighting is uncertain. We examined the effects of pregnancy on bat echolocation. Results We show that pregnant Kuhl’s pipistrelles (Pipistrellus kuhlii) altered their echolocation and flight behavior. Specifically, pregnant bats emitted longer echolocation signals at an ~ 15% lower rate, while flying more slowly and at a lower altitude compared to post-lactating females. A sensorimotor foraging model suggests that these changes could lead to an ~ 15% reduction in hunting performance during pregnancy. Conclusions Sensory deficits related to pregnancy could impair foraging in echolocating bats. Our study demonstrates an additional cost of reproduction of possible relevance to other sensory modalities and organisms.
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- 2023
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34. Anti-bacterial Property and Cytotoxicity of Allium sativum and Myrtus communis Extracts Against Nosocomial Bacterial Infections
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Somayeh Soleymanzadeh Moghadam, Samaneh Mazar Atabaki, Pedram Ebrahimnejad, Zahra Mohammadi, and Maliheh Nobakht
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allium sativum ,toxicity ,nosocomial infections ,Toxicology. Poisons ,RA1190-1270 - Abstract
Background: Microbial infections and the resistance to antibacterial drugs are on the rise, and scientists are in search of the safest and most effective approach to overcome them. Medicinal plants are potentially effective against many microorganisms. Therefore, this study was planned to examine the antibacterial properties and cytotoxicity of the extracts of Allium sativum and Myrtus communis against bacteria that cause nosocomial infections. Methods: A. sativum and M. communis were collected from the northern regions of Iran during the spring. After preparing the hydroalcoholic extracts of A. sativum and M. communis, the minimum inhibitory and bactericidal concentrations (MIC & MBC) were determined. The cytotoxicity of the extracts was asseyed in normal cells and Hu02 fibroblast cell line. Results: The MIC and MBC of A. sativum (62.5 mg/mL) against Salmonella enterica were similar. Also, the MIC of A. sativum and M. communis against Acinetobacter baumannii and Pseudomonas aeruginosa were similar (62.5 & 15.6 mg/mL), respectively. The viability percentage of skin fibroblasts after treatment for 48 hours with the extract of A. sativum was significantly higher than that of M. communis. Conclusion: Both extracts from A. sativum and M. communis demonstrated good antimicrobial properties. Based on the results, the safe antibacterial potential of the extracts may be used as alternative agents to fight against nosocomial bacterial infections.
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- 2023
35. Investigating the Attitude and Behavior of Rafsanjan University of Medical Sciences Students Regarding Prayer in 2020-2021
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Leili Mazar, Mostafa Nasirzadeh, Abbas Sadeghi Hasan Abadi, and Yaser Salim Abadi
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prayer ,attitude ,behavior ,students ,Medical philosophy. Medical ethics ,R723-726 - Abstract
Background and Objectives: The three main elements of the home, study environment, and mass media have a fundamental role in the tendency and attitude of adolescents and young people to pray. This study was conducted to determine students’ attitudes toward prayer, the causes of their tendency toward it, and its impact on various aspects of their lives. Methods: This descriptive study was performed among 192 students of Rafsanjan University of Medical Sciences, Rafsanjan City, Iran. Data were collected by a researcher-made questionnaire through the press line system. Data were analyzed by SPSS software, version 18 using an independent t-test and One-way analysis of variance (ANOVA) at a significance level of less than 0.05. Results: A total of 60.9% of students reported that they perform daily prayers. The Mean±SD score of students’ attitude about praying is 121.99±199.97 out of 165. A significant correlation was observed between the mean score of attitude and behavior. A significant relationship was also found between the mean score of students’ attitudes and the variables of father’s education, father’s and mother’s occupation (P
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- 2022
36. Psychometric performance of the Primary Mitochondrial Myopathy Symptom Assessment (PMMSA) in a randomized, double-blind, placebo-controlled crossover study in subjects with mitochondrial disease
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Chad Gwaltney, Jonathan Stokes, Anthony Aiudi, Iyar Mazar, Sarah Ollis, Emily Love, Amel Karaa, Carrie R. Houts, R. J. Wirth, and Alan L. Shields
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Psychometric evaluation ,Patient-reported outcomes ,Mitochondrial disease ,Primary Mitochondrial Myopathy ,Primary Mitochondrial Myopathy Symptom Assessment ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The Primary Mitochondrial Myopathy Symptom Assessment (PMMSA) is a 10-item patient-reported outcome (PRO) measure designed to assess the severity of mitochondrial disease symptoms. Analyses of data from a clinical trial with PMM patients were conducted to evaluate the psychometric properties of the PMMSA and to provide score interpretation guidelines for the measure. Methods The PMMSA was completed as a daily diary for approximately 14 weeks by individuals in a Phase 2 randomized, placebo-controlled crossover trial evaluating the safety, tolerability, and efficacy of subcutaneous injections of elamipretide in patents with mitochondrial disease. In addition to the PMMSA, performance-based assessments, clinician ratings, and other PRO measures were also completed. Descriptive statistics, psychometric analyses, and score interpretation guidelines were evaluated for the PMMSA. Results Participants (N = 30) had a mean age of 45.3 years, with the majority of the sample being female (n = 25, 83.3%) and non-Hispanic white (n = 29, 96.6%). The 10 PMMSA items assessing a diverse symptomology were not found to form a single underlying construct. However, four items assessing tiredness and muscle weakness were grouped into a “general fatigue” domain score. The PMMSA Fatigue 4 summary score (4FS) demonstrated stable test–retest scores, internal consistency, correlations with the scores produced by reference measures, and the ability to differentiate between different global health levels. Changes on the PMMSA 4FS were also related to change scores produced by the reference measures. PMMSA severity scores were higher for the symptom rated as “most bothersome” by each subject relative to the remaining nine PMMSA items (most bothersome symptom mean = 2.88 vs. 2.18 for other items). Distribution- and anchor-based evaluations suggested that reduction in weekly scores between 0.79 and 2.14 (scale range: 4–16) may represent a meaningful change on the PMMSA 4FS and reduction in weekly scores between 0.03 and 0.61 may represent a responder for each of the remaining six non-fatigue items, scored independently. Conclusions Upon evaluation of its psychometric properties, the PMMSA, specifically the 4FS domain, demonstrated strong reliability and construct-related validity. The PMMSA can be used to evaluate treatment benefit in clinical trials with individuals with PMM. Trial registration ClinicalTrials.gov identifier, NCT02805790; registered June 20, 2016; https://clinicaltrials.gov/ct2/show/NCT02805790 .
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- 2022
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37. Seasonal challenges of tropical bats in temperate zones
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Maya Weinberg, Omer Mazar, Adi Rachum, Xing Chen, Sophia Goutink, Nora Lifshitz, Rona Winter-Livneh, Gábor Á. Czirják, and Yossi Yovel
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Medicine ,Science - Abstract
Abstract To examine the challenges faced by free-ranging Rousettus aegyptiacus living at the northern edge of their distribution, we performed a retrospective analysis of 2196 clinical cases reported by a bat rescue NGO over a period of 36 months, from throughout Israel. All cases of injured bats were evaluated and categorized according to date, place, sex, age, and etiology of the morbidity. The data analysis revealed an increase in all types of morbidity during the wintertime, with more than two-fold the number of cases per week compared to in the summer, over three consecutive years. Moreover, we found that the number of abandoned pups peaked during spring and summer, when adult morbidity is minimal. We characterized two prominent types of previously undescribed morbidities in R. aegyptiacus. We also employed GPS tracking to monitor the movement and foraging of dozens of bats, and to examine the potential correlates of elevated winter morbidity. Our results suggest that it is mainly harsh weather that drives the observed winter morbidity, with food limitations playing a minor-role. We hypothesize that R. aegyptiacus, of tropical origin, is facing major seasonal survival difficulties near the northern edge of its distribution, probably limiting its spread further northwards still.
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- 2022
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38. Pituitary metastasis from renal cell carcinoma presenting with significant hyperprolactinemia, case report
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Ali Mazar‐Atabaki, Omid Mohamadzadeh, Seyed Mousa Sadrehosseini, Azin Tabari, and Mehdi Zeinalizadeh
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endonasal approach ,hyperprolactinemia ,pituitary metastasis ,renal cell carcinoma ,Medicine ,Medicine (General) ,R5-920 - Abstract
Key Clinical Message Kidney metastasis to the pituitary gland can cause hyperprolactinemia even above 250 ng/mL. Although the treatment of metastasis is palliative, surgical decompression could play a major role in the recovery of symptoms and improve quality of life. Pituitary metastasis should be considered in the evaluation of an unusual pituitary mass. Abstract Pituitary tumors are frequently encountered in the neurosurgical setting. Although the majority of them are pituitary adenomas, rare entities encompass pituitary metastasis. They should be differentiated from pituitary adenomas because their management and prognosis are different. We report a 53‐year‐old female who complained of headache and had remarkable hyperprolactinemia (271.1 ng/mL). Having considered macroprolactinoma as the initial diagnosis, medical treatment was initiated with Cabergoline. Subsequently, the patient's vision deteriorated which prompted us to perform endoscopic endonasal transsphenoidal surgery. Histologic examination of the resected tumor revealed metastatic renal cell carcinoma. Main treatment for these subjects is palliative; and unlike the pituitary adenoma, the prognosis is unfortunately poor. Pituitary metastasis should be considered in the evaluation of an unusual pituitary mass associated with hyperprolactinemia.
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- 2023
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39. Vaccination is the most effective and best way to avoid the disease of COVID‐19
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Hadi Lotfi, Mina G. Mazar, Negar M. H. Ei, Mostafa Fahim, and Nafiseh S. Yazdi
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COVID‐19 ,vaccines ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Most of the vaccines that are effective against SARS‐CoV‐2 have used the following functional strategies: inactivated viruses, live attenuated viruses, viral vector‐based vaccines, subunit vaccines, recombinant proteins, and DNA/RNA vaccines. Among the vaccines that stimulate the host's immune system with the help of DNA are: undergoing Phase 2/3 trials including INO‐4800 (International Vaccine Institute; Inovio Pharmaceuticals), Symvivo, Canada‐COVID19 (AnGes, Inc.); GX‐19 (Genexine, Inc.). BNT162b2 and mRNA‐1273 vaccines were made by BioNTech/Pfizer/Fosun Pharma group and Moderna/NIAID group, respectively, which are considered as types of RNA vaccines. Vaccines that are based on the viral vector are AstraZeneca, Sputonium, and Johnson‐Jensen. Among the inactive viral vaccines, the following can be mentioned: CoronaVac (Sinovac) WIBP vaccine (Wuhan Institute of Biological Products, Sinopharm), BBIBPCorV (Beijing Institute of Biological Products, Sinopharm), BBV152/Covaxin (Bharat Biotech, ICMR, National Institute of Virology) And among the protein‐based/subunit vaccines, the following can be counted: NVX‐CoV2373: (Novavax); SCB‐2019 vaccine (Clover Biopharmaceuticals AUS Pty Ltd.); Covax‐19 (GeneCure Biotechnologies; Vaxine Pty Ltd.) mRNA vaccines, viral vector vaccines, and protein subunit vaccines cannot cause disease because these vaccines stimulate the immune system to produce antibodies against virus proteins instead of the virus itself (or its antigen). MRNA vaccines increase SARS‐CoV‐2 proteins and ultimately stimulate the production of T and B lymphocytes. The epidemic of HCoVs and their destructive and harmful effects on life has caused the scientific community to seek the production of an effective and efficient vaccine before its catastrophic release. We all need to know that none of us will be healed until the other is healed. The purpose of this review article is to present a selection of existing knowledge in the field of fighting and preventing the coronavirus.
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- 2023
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40. Implantable vagus nerve stimulation system performance is not affected by internal or external defibrillation shocks
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Libbus, Imad, Stubbs, Scott R., Mazar, Scott T., Mindrebo, Scott, KenKnight, Bruce H., and DiCarlo, Lorenzo A.
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- 2022
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41. Effect of cinnamon supplementation on blood pressure, oxidative stress, and inflammatory biomarkers in adults: An umbrella review of the meta-analyses of randomized controlled trials.
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Zhang, Kaitian, Li, Yang, Lin, Xuefeng, Daneshar, Mazar, Karamian, Fatemeh, and Li, Mingzhu
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Cinnamon has positive effects on markers of cardiometabolic health, including blood pressure (BP), oxidative stress, and inflammation. Despite the evidence accumulated from meta-analysis studies on the effects of cinnamon on these markers, the reported findings are still controversial. This umbrella review was conducted to evaluate the evidence and provide a definitive clarification. We conducted a systematic search in four scientific databases, including PubMed, Scopus, Web of Science, and Embase electronic databases, up to March 2024 to identify systematic reviews and meta-analyses of randomized clinical trials investigating the impact of cinnamon on blood pressure, oxidative stress, and inflammation. The findings revealed that cinnamon might exert favorable effects on systolic blood pressure (SBP) (ES = −2.36 mmHg; 95% CI: 3.86, −1.40), diastolic blood pressure (DBP) (ES = −1.65 mmHg; 95% CI: 2.41, −0.90), total antioxidant capacity (TAC) (WMD = 0.34; 95% CI: 0.04, 0.64), and interleukin-6 (IL-6) (WMD = −1.48; 95% CI: 2.96, −0.01). However, the results did not show any significant effect of cinnamon on malondialdehyde (MDA) (WMD = −0.47; 95% CI: 0.99, 0.05), C-reactive protein (CRP) (WMD = −1.33; 95% CI: 2.66, 0.00), and intercellular adhesion molecule 1 (ICAM-1) (WMD= 1.53, 95% CI: 12.03, 15.10). The results of the studies included in this umbrella review support the usefulness of cinnamon consumption in modulating BP as well as improving TAC and IL-6 in metabolic disorders. Due to the limited number of studies, clinical diversity, and other limitations, more high-quality studies must be conducted to provide more precise and comprehensive recommendations. PROSPERO, CRD42023487350. • 11 meta-analyses were included in this umbrella review. • Cinnamon supplementation had a statistically significant reduction in SBP, DBP, and IL-6. • Cinnamon had no significant effect on CRP or MDA levels. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Mesenchymal stromal cells enhance self-assembly of a HUVEC tubular network through uPA-uPAR/VEGFR2/integrin/NOTCH crosstalk
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Beloglazova, Irina, Stepanova, Victoria, Zubkova, Ekaterina, Dergilev, Konstantin, Koptelova, Natalia, Tyurin-Kuzmin, Pyotr A., Dyikanov, Daniyar, Plekhanova, Olga, Cines, Douglas B., Mazar, Andrew P., and Parfyonova, Yelena
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- 2022
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43. Simulation and optimization of robotic tasks for UV treatment of diseases in horticulture
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Mazar, Merouane, Sahnoun, M’hammed, Bettayeb, Belgacem, Klement, Nathalie, and Louis, Anne
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- 2022
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44. PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe
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G. W. Severin, J. Fonslet, L. K. Kristensen, C. H. Nielsen, A. I. Jensen, A. Kjær, A. P. Mazar, K. Johnston, and U. Köster
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Medicine ,Science - Abstract
Abstract The in vivo-generator radionuclides 140Nd (t1/2 = 3.4 d) and 134Ce (t1/2 = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides 134La and 140Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides 134Ce and 140Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like 177Lu, 161Tb and 225Ac when internalizing bioconjugates are employed.
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- 2022
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45. The Association between Mood, Inhibitory Control and Depressive Symptoms: An Ecological Momentary Assessment Study
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M. Nahum, N. Yitzhak, O. Shimony-Mazar, N. Oved, and O. Bonne
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Psychiatry ,RC435-571 - Abstract
Introduction Cognitive models of depression highlight the role of inhibitory control - the cognitive control ability which supports our goal directed behavior – as key and even causal feature of the disorder. According to these models, deficits in inhibitory control prevent the exclusion of irrelevant negative information, leading to rumination and sustained negative mood which result in depressive episodes. However, the scientific evidence linking deficits in inhibitory control to depression is thus far mixed. Moreover, although one’s inhibitory control ability may fluctuate, it is often assessed using a single-time measurement in the lab. Objectives Here we aimed to assess the association between intra-individual fluctuations in inhibitory control measured in ecological settings, daily mood states, and depressive symptoms. Methods N=106 participants (Mean age: 38 ± 10 years; range: 19-62 years; 68% female) reported their depressive symptoms (using the PHQ-9 scale) and completed a mobile version of the Go-NoGo inhibition task at baseline. They then completed a 5-day ecological-momentary-assessment (EMA) protocol, in which they reported their current mood (using the IMS-12 scale) and performed a shortened version of the Go-NoGo task twice/day using a mobile application. Depressive symptoms were assessed again following the 5-day EMA. Hierarchical-linear-modeling (HLM) was applied to examine the association between momentary IC and mood, with post-EMA depressive symptoms as a moderator. Inhibitory control was included as a time-varying predictor for mood in the 1st step, and depressive symptoms post-EMA and their interaction with inhibition were included in the 2nd step. Results At baseline, there were no correlations between depressive symptoms and inhibitory control (rp = .035, n.s). However, individuals with elevated depressive symptoms demonstrated worse and more variable inhibition performance over time (rp = .29, p = .002), as captured in the EMA measures. In addition, participants with more variable inhibitory control performance over time also reported more depressive symptoms at the end of the 5-day period (rp = .27, p = .006). Finally, post-EMA depressive symptoms moderated the association between momentary inhibitory control and daily mood, such that reduced inhibition was associated with more negative mood only for those with lower, but not with higher, depressive symptoms (Figure 1). Image: Conclusions Variable, rather than mere reduced inhibitory control is related to depressive symptoms. Moreover, the role of inhibition in modulating mood differs in non-depressed vs. depressed individuals. These findings contribute to our understanding of inhibition and mood in real life and help account for some of the discrepant findings related to cognitive control models of depression. Future investigations should examine the validity of these outcomes in other, clinical samples. Disclosure of Interest None Declared
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- 2023
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46. Seasonal challenges of tropical bats in temperate zones
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Weinberg, Maya, Mazar, Omer, Rachum, Adi, Chen, Xing, Goutink, Sophia, Lifshitz, Nora, Winter-Livneh, Rona, Czirják, Gábor Á., and Yovel, Yossi
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- 2022
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47. PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe
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Severin, G. W., Fonslet, J., Kristensen, L. K., Nielsen, C. H., Jensen, A. I., Kjær, A., Mazar, A. P., Johnston, K., and Köster, U.
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- 2022
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48. Psychometric performance of the Primary Mitochondrial Myopathy Symptom Assessment (PMMSA) in a randomized, double-blind, placebo-controlled crossover study in subjects with mitochondrial disease
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Gwaltney, Chad, Stokes, Jonathan, Aiudi, Anthony, Mazar, Iyar, Ollis, Sarah, Love, Emily, Karaa, Amel, Houts, Carrie R., Wirth, R. J., and Shields, Alan L.
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- 2022
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49. Development of symptom-focused outcome measures for advanced and indolent systemic mastocytosis: the AdvSM-SAF and ISM-SAF©
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Fiona Taylor, Cem Akin, Roger E. Lamoureux, Brad Padilla, Tanya Green, Anthony L. Boral, Iyar Mazar, Brenton Mar, Alan L. Shields, and Frank Siebenhaar
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Content validity ,Instrument development ,Patient-reported outcomes ,Advanced systemic mastocytosis ,Indolent systemic mastocytosis ,Medicine - Abstract
Abstract Background Advanced systemic mastocytosis (AdvSM), indolent systemic mastocytosis (ISM), and smoldering systemic mastocytosis (SSM) are rare diseases characterized by neoplastic mast cell infiltration of more than one organ. A content-valid patient-reported outcome (PRO) questionnaire that assesses relevant signs and symptoms that are important and understandable to individuals with a condition is critical for assessing new treatment benefit as well as supporting product labeling claims. Notably, no such PRO questionnaire has been developed in accordance with regulatory and scientific guidelines for use in AdvSM, ISM, and SSM patient populations. To fill that gap, this study documents the development and content validity of instruments evaluating signs and symptoms of systemic mastocytosis. Methods A review of peer-reviewed literature, advice meetings with clinical therapeutic area experts, patient concept elicitation interviews, concept selection and questionnaire construction meetings, and patient cognitive debriefing interviews were conducted, and regulatory feedback was incorporated. Results For AdvSM, 26 sign- and symptom-level concepts were identified in literature, 39 by clinicians, and 33 by patients. For ISM/SSM, 38 sign- and symptom-level concepts were identified in the literature, 39 by clinicians, and 57 by patients. Two patient-reported instruments, the Advanced Systemic Mastocytosis Symptom Assessment Form (AdvSM-SAF) and Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF)(©Blueprint Medicines Corporation), were developed based on consolidated findings. Cognitive debriefing interviews with AdvSM and ISM patients showed the AdvSM-SAF and ISM-SAF were understood and interpreted as intended by the majority of patients. Conclusion The AdvSM-SAF and ISM-SAF are content-valid tools measuring symptoms from AdvSM and ISM patients’ perspective.
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- 2021
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50. Design, implementation, and evaluation of a PRECEDE-PROCEED model-based intervention for oral and dental health among primary school students of Rafsanjan city: a mixed method study
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Mohtasham Ghaffari, Sakineh Rakhshanderou, Mohammad Asadpour, Mostafa Nasirzadeh, and Leili Mazar
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Oral and dental health ,Brushing ,PRECEDE-PROCEED model ,Intervention ,Primary schools’ students ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Oral and dental health has a significant impact on public health as well as the quality of life among individuals and families. This study aims to design, implement, and evaluate an intervention based on the PRECEDE-PROCEED model for oral and dental health among primary school students in Rafsanjan city, Southern Iran. Methods According to the nature of the model and with the focus group discussion and interview methods, in phases 1 to 4 (PRECEDE), predisposing, enabling, and reinforcing factors related to oral health were identified. The training program was designed and consisted of six sessions for students (250 students) with a brushing session, three sessions for parents, and two sessions for teachers. Process evaluation and the effect of the program on behavioral and factors affecting oral health were evaluated (PROCEED). Results In the qualitative section, seven predisposing factors, five enabling factors, and two reinforcing factors were identified. A training program based on the PRECEDE-PROCEED model was found to be effective in increasing the mean scores of the above constructs and the students’ brushing behavior (P
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- 2021
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