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Background and Objective:Consanguinity increases the incidence of genetic disorders.The frequency ofconsanguinityvaries in different societies. There was no data regarding the frequency of consanguinity in Zanjan province. This study aimed to describe the prevalence of consanguineous unions in the parents of children with genetic disorders and its related factors in Zanjan, Iran. Materials and Methods:This cross-sectional study included children with genetic diseases referring to the medical genetics clinic in Zanjan's Musavi Hospital during 2014-2018. Data including consanguineous unions in families (up to three previous generations), types of genetic illnesses, child and parents' age, parental educational level, and occupation were collected and analyzed using descriptive statistics, independent t-test, and chi-square test. Results:Of the 87 children, 41 (47.7%) were male, and 50 (59.5%) resided in urban areas. The mean age of the children was 6.5 years. The educational level of56.6%of fathers and50.6%of mothers were highschool diplomaor higher.The parents of 44 children (51.8%) had consanguineous unions. The most common type of consanguineous union was between first cousins. The nature of the genetic disorders in 63 (72.4%) of children was molecular.The proportion ofconsanguinitywas significantly higher in parents of children with molecular than chromosomal disorder(P Conclusion:This study's outcomes illustrate that parents of more than half of children with genetic disorders had consanguinity and the frequency of consanguinity was more common in parents of children with molecular disease than chromosomal disorder. Given that, it is necessary to avoid consanguineous marriage as much as possible, and families with a history of molecular genetic disease, should be informed of the possible consequences. Keywords:Consanguinity,Genetic disorders,Children

Background and Objective:Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants are utilized for treatment of post stroke depression, reduced quality of life and poor compliance. This study compared the effects of sertraline and nortriptyline on the quality of life and depression in post-stroke patients. Materials and Methods:This randomized double-blind trial was conducted on 56 stroke patients admitted to Valiasr Hospital in Zanjan, Iran, 2016. Patients were randomly allocated in two groups by simple randomization and received sertraline in one group, nortriptyline in the other and nobody received placebo.Patients were screened for depression using BDI (II) questionnaire andthose withoutdepression were entered into study. During follow-up, patients completed a quality of life questionnaire named Nottingham Health Profile (NHP). Data were analysed using repeated measure and Bonferroni tests in SPSS22. P Results:The mean age of patients in sertraline and nortriptyline groups were61.7and63.6, respectively (P=0.194).No significant differences were observed for sex, marital status and education between two groups. The mean score of total quality of life and its dimensions decreased significantly during 6 months for both groups (P=0.001). The effect of sertraline in these reductions was not different from nortriptyline (P=0.60). The proportions of moderate or severe depression were 17.9% and 37.0% in sertraline and nortriptyline groups, respectively (P=0.24). Conclusion:Both sertraline and nortriptyline improved all aspects of quality of life and their effect on prevention of depression was similar. Therefore, the administration of sertraline or nortriptyline could be beneficial in post-stroke patients. Keywords:Sertraline,Nortriptyline,Stroke,Depression,Quality of life

Background and Purpose: With regards to the importance of women's beliefs in improving pregnancy outcomes, this study was performed to determine the perceived internal control on future pregnancy outcomes and its related factors in women who participated in pre-marital counseling. Materials and Methods: In a cross-sectional study, women's perceived internal control was investigated. The study population comprised the women in reproductive age of whom 400 were selected by random sampling. Data collection instrument was a questionnaire consisting of demographic, pre-conceptional care, and internal control questions. Two categories of favorite and not favorite levels of internal control were defined based on the total score. The validity of the questionnaire was determined via content validity method by use of experts’ opinion and its reliability was evaluated through the calculation of Cronbach's alpha coefficient which was 0.76. Data were analyzed through frequency tables, correlation coefficient, and Chi-square test at the confidence level of 0.95. Results: Two hundred sixty-five (65%) women had a good perceived internal control and it was significantly associated with the age, educational level, and hearing about pre-conceptional care. The internal control score also showed a positive and significant correlation with both age and the subject knowledge about folic acid (r = 0.19 and r = 0.15, respectively). Conclusion: The majority of women had a favorite perceived internal control. Since age and educational level were the affecting factors on the perceived internal control of women, promoting the level of internal control in young women and those with low education in pre-marital counseling classes seems necessary.