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14 results on '"Mazuecos Blanca, Auxiliadora"'

1. Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study

Author

Eugenia García Montemayor, Victoria, Salgueira Lazo, Mercedes, Mazuecos Blanca, Auxiliadora, Jiménez Salcedo, Tamara, José Espigares Huete, María, Araceli Jiménez Vibora, Elena, Álamo Caballero, Concepción, Banegas Deras, Eduardo J., Alonso Bethencourt, Alejandro, Rodríguez García, Alejandra, Fernández Granados, Saulo, Fernández Fresnedo, Gema, Calle García, Leonardo, Martín García, Jesús, Estifan Kasabji, Jorge, Jesús Izquierdo, María, Mouzo Mirco, Ricardo, García Agudo, Rebeca, de Arriba de la Fuente, Gabriel, Facundo Molas, Carme, Xipell Font, Marc, Yugueros González, Alejandra, Antóns, Paula, Ibernon Vilaro, Meritxell, de la Fuente Fernández, Vanessa, González Galván, Yussel, Cabezas, Antonio, Castro Alonso, Cristina, Juan García, Isabel, Garín Cascales, Eduardo, Sebastiá Morant, Josepa, Luna Complejo, Enrique, María Díaz Campillejo, Rosa, González Sanchidrián, Silvia, Cao Vilariño Complejo, Mercedes, Sierra Carpio, Milagros, Ortega Díaz, Mayra, Sánchez Hernández, Rosa, Ossorio González, Marta, Vega Martínez, Almudena, Teresa López Picasso, María, Goma, Elena, Giorgi, Martín, Martínez Miguel, Patricia, Gutiérrez Martínez, Eduardo, Paraíso Cuevas, Vicente, Echarri, Rocío, Martínez, Víctor, Pérez Arnedo, Mario, Juliana Castañeda Infante, Laura, Antonio Menacho Miguel, Jose, Blasco, Miquel, Quiroga, Borja, García-Aznar, José M., Castro-Alonso, Cristina, Fernández-Granados, Saulo J., Luna, Enrique, Ossorio, Marta, Izquierdo, María Jesús, Sanchez-Ospina, Didier, Castañeda-Infante, Laura, Mouzo, Ricardo, Cao, Mercedes, Besada-Cerecedo, María L., Pan-Lizcano, Ricardo, Torra, Roser, Ortiz, Alberto, and de Sequera, Patricia

Published
2024
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4. ¿Predice el Kidney Donor Profile Index (KDPI) la supervivencia del injerto y del paciente en una población española?

Author

Calvillo-Arbizu, Jorge, Pérez-Valdivia, Miguel A., Gentil-Govantes, Miguel A., Castro-de-la-Nuez, Pablo, Mazuecos-Blanca, Auxiliadora, Rodríguez-Benot, Alberto, Gracia-Guindo, María C., Borrego-Utiel, Francisco, Cabello-Díaz, Mercedes, Bedoya-Pérez, Rafael, Alonso-Gil, Manuel, Salgueira-Lazo, Mercedes, and Roa-Romero, Laura M.

Published
2018
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5. Predicting Kidney Transplantation Outcomes from Donor and Recipient Characteristics at Time Zero: Development of a Mobile Application for Nephrologists.

Author

Pérez Valdivia, Miguel Ángel, Calvillo Arbizu, Jorge, Portero Barreña, Daniel, Castro de la Nuez, Pablo, López Jiménez, Verónica, Rodríguez Benot, Alberto, Mazuecos Blanca, Auxiliadora, de Gracia Guindo, Mª Carmen, Bernal Blanco, Gabriel, Gentil Govantes, Miguel Ángel, Bedoya Pérez, Rafael, and Rocha Castilla, José Luis

Subjects
KIDNEY transplantation, TREATMENT effectiveness, MOBILE apps, NEPHROLOGISTS, OVERALL survival
Abstract

(1) Background: We report on the development of a predictive tool that can estimate kidney transplant survival at time zero. (2) Methods: This was an observational, retrospective study including 5078 transplants. Death-censored graft and patient survivals were calculated. (3) Results: Graft loss was associated with donor age (hazard ratio [HR], 1.021, 95% confidence interval [CI] 1.018–1.024, p < 0.001), uncontrolled donation after circulatory death (DCD) (HR 1.576, 95% CI 1.241–2.047, p < 0.001) and controlled DCD (HR 1.567, 95% CI 1.372–1.812, p < 0.001), panel reactive antibody percentage (HR 1.009, 95% CI 1.007–1.011, p < 0.001), and previous transplants (HR 1.494, 95% CI 1.367–1.634, p < 0.001). Patient survival was associated with recipient age (> 60 years, HR 5.507, 95% CI 4.524–6.704, p < 0.001 vs. < 40 years), donor age (HR 1.019, 95% CI 1.016–1.023, p < 0.001), dialysis vintage (HR 1.0000263, 95% CI 1.000225–1.000301, p < 0.01), and male sex (HR 1.229, 95% CI 1.135–1.332, p < 0.001). The C-statistics for graft and patient survival were 0.666 (95% CI: 0.646, 0.686) and 0.726 (95% CI: 0.710–0.742), respectively. (4) Conclusions: We developed a mobile app to estimate survival at time zero, which can guide decisions for organ allocation. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Clinical evolution of chronic renal patients with HIV infection in replacement therapy

Author

Saracho, Ramón, Martín Escobar, Eduardo, Comas Farnés, Jordi, Arcos, Emma, Mazuecos Blanca, Auxiliadora, Gentil Govantes, Miguel Ángel, Castro de la Nuez, Pablo, Zurriaga, Óscar, Ferrer Alamar, Manuel, Bouzas Caamaño, Encarnación, García Falcón, Teresa, Portolés Pérez, José, Herrero Calvo, José A., Chamorro Jambrina, Carlos, Moina Eguren, Íñigo, Rodrigo de Tomás, María Teresa, Abad Díez, José María, Sánchez Miret, José I., Alvarez Lipe, Rafael, Díaz Tejeiro, Rafael, Moreno Alía, Inmaculada, Torres Guinea, Marta, Huarte Loza, Enma, Artamendi Larrañaga, Marta, Fernández Renedo, Carlos, González Fernández, Raquel, Sánchez Álvarez, Emilio, and Alonso de la Torre, Ramón

Published
2015
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7. Evolución clínica de los enfermos renales crónicos en tratamiento sustitutivo con infección por VIH

Author

Saracho, Ramón, Martín Escobar, Eduardo, Comas Farnés, Jordi, Arcos, Emma, Mazuecos Blanca, Auxiliadora, Gentil Govantes, Miguel Ángel, Castro de la Nuez, Pablo, Zurriaga, Óscar, Ferrer Alamar, Manuel, Bouzas Caamaño, Encarnación, García Falcón, Teresa, Portolés Pérez, José, Herrero Calvo, José A., Chamorro Jambrina, Carlos, Moina Eguren, Íñigo, Rodrigo de Tomás, María Teresa, Abad Díez, José María, Sánchez Miret, José I., Alvarez Lipe, Rafael, Díaz Tejeiro, Rafael, Moreno Alía, Inmaculada, Torres Guinea, Marta, Huarte Loza, Enma, Artamendi Larrañaga, Marta, Fernández Renedo, Carlos, González Fernández, Raquel, Sánchez Álvarez, Emilio, and Alonso de la Torre, Ramón

Published
2015
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9. Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study

Author

Blasco, Miquel, Quiroga, Borja, García-Aznar, José M., Castro-Alonso, Cristina, Fernández-Granados, Saulo J., Luna, Enrique, Fernández Fresnedo, Gema, Ossorio, Marta, Izquierdo, María Jesús, Sanchez-Ospina, Didier, Castañeda-Infante, Laura, Mouzo, Ricardo, Cao, Mercedes, Besada-Cerecedo, María L., Pan-Lizcano, Ricardo, Torra, Roser, Ortiz, Alberto, de Sequera, Patricia, Eugenia García Montemayor, Victoria, Salgueira Lazo, Mercedes, Mazuecos Blanca, Auxiliadora, Jiménez Salcedo, Tamara, José Espigares Huete, María, Araceli Jiménez Vibora, Elena, Álamo Caballero, Concepción, Banegas Deras, Eduardo J., Alonso Bethencourt, Alejandro, Rodríguez García, Alejandra, Fernández Granados, Saulo, Fernández Fresnedo, Gema, Calle García, Leonardo, Martín García, Jesús, Estifan Kasabji, Jorge, Jesús Izquierdo, María, Mouzo Mirco, Ricardo, García Agudo, Rebeca, de Arriba de la Fuente, Gabriel, Facundo Molas, Carme, Xipell Font, Marc, Yugueros González, Alejandra, Antóns, Paula, Ibernon Vilaro, Meritxell, de la Fuente Fernández, Vanessa, González Galván, Yussel, Cabezas, Antonio, Castro Alonso, Cristina, Juan García, Isabel, Garín Cascales, Eduardo, Sebastiá Morant, Josepa, Luna Complejo, Enrique, María Díaz Campillejo, Rosa, González Sanchidrián, Silvia, Cao Vilariño Complejo, Mercedes, Sierra Carpio, Milagros, Ortega Díaz, Mayra, Sánchez Hernández, Rosa, Ossorio González, Marta, Vega Martínez, Almudena, Teresa López Picasso, María, Goma, Elena, Giorgi, Martín, Martínez Miguel, Patricia, Gutiérrez Martínez, Eduardo, Paraíso Cuevas, Vicente, Echarri, Rocío, Martínez, Víctor, Pérez Arnedo, Mario, Juliana Castañeda Infante, Laura, and Antonio Menacho Miguel, Jose

Abstract

Chronic kidney disease of unknown etiology (CKDUE) is one of the main global causes of kidney failure. Genetic studies may identify an etiology in these patients, but few studies have implemented genetic testing of CKDUE in a population-based series of patients, which was the focus of the GENSEN Study.

Published
2024
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10. Does the Kidney Donor Profile Index (KDPI) predict graft and patient survival in a Spanish population?

Author

Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Universidad de Sevilla. Departamento de Ingeniería Telemática, Universidad de Sevilla. TIC203: Ingenieria Biomedica, Fondo de Investigación Sanitaria, Calvillo Arbizu, Jorge, Pérez Valdivia, Miguel Angel, Gentil Govantes, Miguel Ángel, Castro de la Nuez, Pablo, Mazuecos Blanca, Auxiliadora, Rodríguez Benot, Alberto, Gracia Guindo, María, Borrego Utiel, Francisco, Cabello Díaz, Mercedes, Bedoya Pérez, Rafael, Alonso Gil, Manuel, Salgueira Lazo, Mercedes, Roa Romero, Laura Maria, Universidad de Sevilla. Departamento de Ingeniería de Sistemas y Automática, Universidad de Sevilla. Departamento de Ingeniería Telemática, Universidad de Sevilla. TIC203: Ingenieria Biomedica, Fondo de Investigación Sanitaria, Calvillo Arbizu, Jorge, Pérez Valdivia, Miguel Angel, Gentil Govantes, Miguel Ángel, Castro de la Nuez, Pablo, Mazuecos Blanca, Auxiliadora, Rodríguez Benot, Alberto, Gracia Guindo, María, Borrego Utiel, Francisco, Cabello Díaz, Mercedes, Bedoya Pérez, Rafael, Alonso Gil, Manuel, Salgueira Lazo, Mercedes, and Roa Romero, Laura Maria

Abstract

Background and objective: The Kidney Donor Profile Index (KDPI), together with other donor and recipient variables, can optimise the organ allocation process. This study aims to check the feasibility of the KDPI for a Spanish population and its predictive ability of graft and patient survival. Materials and methods: Data from 2734 kidney transplants carried out in Andalusia between January 2006 and December 2015 were studied. Cases were grouped by recipient age, categorised by KDPI quartile and both graft and patient survival were compared among groups. Results: The KDPI accurately discriminated optimal organs from suboptimal or marginal ones. For adult recipients (aged: 18–59 years) it presents a hazard ratio of 1.013 (P < 0.001) for death-censored graft survival and of 1.013 (P = 0.007) for patient survival. For elderly recipients (aged: 60+ years), KDPI presented a hazard ratio of 1.016 (P = 0.001) for death-censored graft survival and of 1.011 (P = 0.0007) for patient survival. A multivariate analysis identified the KDPI, donor age, donation after circulatory death, recipient age and gender as predictive factors of graft survival. Conclusions: The results obtained show that the KDPI makes it possible to relate the donor’s characteristics with the greater or lesser survival of the graft and the patient in the Spanish population. However, due to certain limitations, a new index for Spain based on Spanish or European data should be created. In this study, some predictive factors of graft survival are identified that may serve as a first step in this path., Antecedentes y objetivo: El Kidney Donor Profile Index (KDPI), junto a otras variables del donante y receptor, puede optimizar el proceso de asignación de órganos. Este estudio tiene como objetivo comprobar la aplicabilidad del KDPI en una población espanola, ˜ así como su capacidad de predicción de la supervivencia del injerto y del paciente. Materiales y métodos: Se estudiaron 2.734 trasplantes renales llevados a cabo en Andalucía entre enero de 2006 y diciembre de 2015. Los casos se agruparon por edad del receptor y cuartil del KDPI y se compararon entre grupos tanto la supervivencia del injerto como la del paciente. Resultados: El KDPI discrimina con precisión los órganos óptimos de los subóptimos o marginales. Para receptores entre 18 y 59 anos ˜ presenta un hazard ratio de 1,013 (p < 0,001) para supervivencia de injerto censurada para muerte y de 1,013 (p = 0,007) para supervivencia del paciente. Para receptores mayores de 60 anos ˜ el hazard ratio es de 1,016 (p = 0,001) para supervivencia del injerto censurada para muerte y de 1,011 (p = 0,007) para supervivencia del paciente. Un análisis multivariante identificó como factores predictivos de la supervivencia del injerto el KDPI, la edad del donante, la donación tras muerte circulatoria, la edad y el sexo del receptor. Conclusiones: El KDPI permite relacionar, a grandes rasgos, las características del donante con la mayor o menor supervivencia del injerto y del paciente en la población espanola. ˜ No obstante, debido a ciertas limitaciones, convendría elaborar un índice propio a partir de los datos espanoles ˜ o europeos. En este trabajo se identifican algunos factores predictivos de la supervivencia del injerto que pueden servir como primer paso en esa línea.

Published
2018

12. ¿Predice el Kidney Donor Profile Index(KDPI) la supervivencia del injerto y del paciente en una población española?

Author

Calvillo-Arbizu, Jorge, Pérez-Valdivia, Miguel A., Gentil-Govantes, Miguel A., Castro-de-la-Nuez, Pablo, Mazuecos-Blanca, Auxiliadora, Rodríguez-Benot, Alberto, Gracia-Guindo, María C., Borrego-Utiel, Francisco, Cabello-Díaz, Mercedes, Bedoya-Pérez, Rafael, Alonso-Gil, Manuel, Salgueira-Lazo, Mercedes, and Roa-Romero, Laura M.

Abstract

El Kidney Donor Profile Index(KDPI), junto a otras variables del donante y receptor, puede optimizar el proceso de asignación de órganos. Este estudio tiene como objetivo comprobar la aplicabilidad del KDPI en una población española, así como su capacidad de predicción de la supervivencia del injerto y del paciente.

Published
2018
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13. Passenger lymphocyte syndrome: an uncommon form of anaemia in renal transplantation.

Author

Pascual-Pérez, Verónica, Gómez-Larrambe, Nerea, Collantes-Mateos, Rocío, de Manzanos, Teresa Visus-Fernández, Urbizu-Gallardo, José M., and Mazuecos-Blanca, Auxiliadora

Abstract

A letter to the editor is presented in response to the article "Passenger lymphocyte syndrome: an uncommon form of anaemia in renal transplantation," that was published in a previous issue.

Published
2013
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14. Sodium-glucose cotransporter-2 inhibitor therapy in kidney transplant patients with type 2 or post-transplant diabetes: an observational multicentre study.

Author

Sánchez Fructuoso AI, Bedia Raba A, Banegas Deras E, Vigara Sánchez LA, Valero San Cecilio R, Franco Esteve A, Cruzado Vega L, Gavela Martínez E, González Garcia ME, Saurdy Coronado P, Morales NDV, Zarraga Larrondo S, Ridao Cano N, Mazuecos Blanca A, Hernández Marrero D, Beneyto Castello I, Paul Ramos J, Sierra Ochoa A, Facundo Molas C, González Roncero F, Torres Ramírez A, Cigarrán Guldris S, and Pérez Flores I

Abstract

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have cardioprotective and renoprotective effects. However, experience with SGLT2is in diabetic kidney transplant recipients (DKTRs) is limited., Methods: This observational multicentre study was designed to examine the efficacy and safety of SGLT2is in DKTRs. The primary outcome was adverse effects within 6 months of SGLT2i treatment., Results: Among 339 treated DKTRs, adverse effects were recorded in 26%, the most frequent (14%) being urinary tract infection (UTI). In 10%, SGLT2is were suspended mostly because of UTI. Risk factors for developing a UTI were a prior episode of UTI in the 6 months leading up to SGLT2i use {odds ratio [OR] 7.90 [confidence interval (CI) 3.63-17.21]} and female sex [OR 2.46 (CI 1.19-5.03)]. In a post hoc subgroup analysis, the incidence of UTI emerged as similar in DKTRs treated with SGLT2i for 12 months versus non-DKTRs (17.9% versus 16.7%). Between baseline and 6 months, significant reductions were observed in body weight [-2.22 kg (95% CI -2.79 to -1.65)], blood pressure, fasting glycaemia, haemoglobin A1c [-0.36% (95% CI -0.51 to -0.21)], serum uric acid [-0.44 mg/dl (95% CI -0.60 to -0.28)] and urinary protein:creatinine ratio, while serum magnesium [+0.15 mg/dl (95% CI 0.11-0.18)] and haemoglobin levels rose [+0.44 g/dl (95% CI 0.28-0.58]. These outcomes persisted in participants followed over 12 months of treatment., Conclusions: SGLT2is in kidney transplant offer benefits in terms of controlling glycaemia, weight, blood pressure, anaemia, proteinuria and serum uric acid and magnesium. UTI was the most frequent adverse effect. According to our findings, these agents should be prescribed with caution in female DKTRs and those with a history of UTI., Competing Interests: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the ERA.)

Published
2023
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