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Background: Dentures play a crucial role in restoring oral function and aesthetics for individuals with missing teeth. However, the impact of partial versus complete dentures on oral health-related quality of life (OHRQoL) remains unclear. This study aimed to compare OHRQoL between partial and complete denture wearers. Materials and Methods: A cross-sectional survey was conducted among 200 denture wearers (100 partial, 100 complete) at a university dental clinic. Participants completed the Oral Health Impact Profile-14 (OHIP-14) questionnaire to assess OHRQoL. Demographic data and denture-related information were also collected. Statistical analysis included descriptive statistics, t-tests, and multiple regression analysis. Results: Complete denture wearers reported significantly lower OHRQoL scores (mean OHIP-14 score: 18.3 ± 7.2) compared to partial denture wearers (mean OHIP-14 score: 12.7 ± 6.5; p < 0.001). Functional limitation and physical pain domains showed the greatest differences between groups. Age, gender, and duration of denture use were significant predictors of OHRQoL (p < 0.05). Satisfaction with dentures was positively correlated with higher OHRQoL in both groups (r = 0.62, p < 0.001). Conclusion: Partial denture wearers reported better oral health-related quality of life compared to complete denture wearers. These findings highlight the need for tailored interventions and support for complete denture wearers to improve their oral health outcomes and overall well-being. [ABSTRACT FROM AUTHOR]