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4. Deleterious in late life mitochondrial alleles and aging: secrets of Japanese centenarians

Author

Mikhailova, Alina, Shamansky, Viktor, Bazykin, Georgii A., Mazunin, Ilia, Gunbin, Konstantin, Kunz, Wolfram, Reymond, Alexandre, Tanaka, Masashi, Khrapko, Konstantin, and Popadin, Konstantin

Abstract

Aging is associated with accumulation of somatic mutations. This process is especially pronounced in mitochondrial genomes of postmitotic cells, which accumulate large-scale somatic mitochondrial deletions with time, leading to neurodegeneration, muscular dystrophy and aging. Slowing down the rate of origin of these somatic deletions may benefit human lifespan and healthy aging. The main factors determining breakpoints of somatic mitochondrial deletions are direct nucleotide repeats, which might be considered as Deleterious In Late Life (DILL) alleles. Correspondingly, the decreased amount of these DILL alleles might lead to low production of somatic deletions and increased lifespan. Intriguingly, in the Japanese D4a haplogroup, which is famous for an excess of centenarians and supercentenarians, we found that the longest direct repeat (“common repeat”) in the human mitochondrial genome has been disrupted by a point synonymous mutation. Thus we hypothesize that the disruption of the common repeat annuls common deletion (which is the most frequent among all somatic deletions) and at least partially may contribute to the extreme longevity of the D4a Japanese haplogroup. Here, to better understand the mitochondrial components of longevity and potential causative links between repeats, deletions and longevity we discuss molecular, population and evolutionary factors affecting dynamics of mitochondrial direct repeats.

Published
2019
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6. Additional file 3: of Prevalence and genetic diversity of Wolbachia endosymbiont and mtDNA in Palearctic populations of Drosophila melanogaster

Author

Bykov, Roman, Yudina, Maria, Gruntenko, Nataly, Zakharov, Ilya, Voloshina, Marina, Melashchenko, Elena, Danilova, Maria, Mazunin, Ilia, and Ilinsky, Yury

Subjects
parasitic diseases, bacteria, biochemical phenomena, metabolism, and nutrition, reproductive and urinary physiology
Abstract

Haplotypes of Wolbachia from CS-group genotypes. GenBank accession numbers are indicated in brackets where available. (DOC 74 kb)

Published
2019
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10. Risk of mitochondrial deletions is affected by the global secondary structure of the mitochondrial genome

Author

Mikhailova, Alina A., primary, Shamanskiy, Viktor, additional, Ushakova, Kristina, additional, Mikhailova, Alina G., additional, Oreshkov, Sergei, additional, Knorre, Dmitry, additional, Tretiakov, Evgenii O., additional, Zazhytska, Marianna, additional, Lukowski, Samuel W., additional, Liou, Chia-Wei, additional, Lin, Tsu-Kung, additional, Kunz, Wolfram S., additional, Reymond, Alexandre, additional, Mazunin, Ilia, additional, Bazykin, Georgii A., additional, Gunbin, Konstantin, additional, Fellay, Jacques, additional, Tanaka, Masashi, additional, Khrapko, Konstantin, additional, and Popadin, Konstantin, additional

Published
2019
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16. Complete genome sequence of and proposal of Thermofilum uzonense sp. nov. a novel hyperthermophilic crenarchaeon and emended description of the genus Thermofilum

Author

Toshchakov, Stepan V., primary, Korzhenkov, Aleksei A., additional, Samarov, Nazar I., additional, Mazunin, Ilia O., additional, Mozhey, Oleg I., additional, Shmyr, Ilya S., additional, Derbikova, Ksenia S., additional, Taranov, Evgeny A., additional, Dominova, Irina N., additional, Bonch-Osmolovskaya, Elizaveta A., additional, Patrushev, Maxim V., additional, Podosokorskaya, Olga A., additional, and Kublanov, Ilya V., additional

Published
2015
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18. Risk of mitochondrial deletions is affected by the global secondary structure of the mitochondrial genome

Author

Shamanskiy, Victor, Mikhailova, Alina A., Ushakova, Kristina, Mikhailova, Alina G., Oreshkov, Sergei, Knorre, Dmitry, Tretiakov, Evgenii O., Zazhytska, Marianna, Lukowski, Samuel W., Liou, Chia-Wei, Lin, Tsu-Kung, Kunz, Wolfram S., Reymond, Alexandre, Mazunin, Ilia, Bazykin, Georgii A., Gunbin, Konstantin, Jacques Fellay, Tanaka, Masashi, Khrapko, Konstantin, and Popadin, Konstantin

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