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2. Recurrence of membranous nephropathy after kidney transplantation: A multicenter retrospective cohort study

Author

Hullekes, Frank, Uffing, Audrey, Verhoeff, Rucháma, Seeger, Harald, von Moos, Seraina, Mansur, Juliana, Mastroianni-Kirsztajn, Gianna, Silva, Helio Tedesco, Buxeda, Anna, Pérez-Sáez, María José, Arias-Cabrales, Carlos, Collins, A. Bernard, Swett, Christie, Morená, Leela, Loucaidou, Marina, Kousios, Andreas, Malvezzi, Paolo, Bugnazet, Mathilde, Russo, Luis Sanchez, Muhsin, Saif A., Agrawal, Nikhil, Nissaisorakarn, Pitchaphon, Patel, Het, Al Jurdi, Ayman, Akalin, Enver, Neto, Elias David, Agena, Fabiana, Ventura, Carlucci, Manfro, Roberto C., Bauer, Andrea Carla, Mazzali, Marilda, de Sousa, Marcos Vinicius, La Manna, Gaetano, Bini, Claudia, Comai, Giorgia, Reindl-Schwaighofer, Roman, Berger, Stefan, Cravedi, Paolo, and Riella, Leonardo V.

Published
2024
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5. Abstract 12228: Prognostic Role of Renal Replacement Therapy Among Hospitalized Patients With Heart Failure in the Brazilian National Public Health System

Author

Coy-Cangucu, Andrea, M Antunes Correa, Lígia, Mazzali, Marilda, Abrao, Paula, Mendes, Fernanda M, TEIXEIRA, CINTHIA M, Viana, Karynna P, Cordeiro, Guilherme, Longato, Maurício, Coelho, Otávio R, Souza, Jos?, Nadruz, Wilson, Sposito, Andrei, Petersen, Steffen E, Jerosch-Herold, Michael, and Coelho-Filho, Otavio R

Published
2023
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9. 420.3: The Use of mTOR Inhibitors Is Associated With Reduced Mortality Among Kidney Transplant Patients Developing COVID-19

Author

Requião-Moura, Lúcio, de Andrade, Luís Gustavo Modelli, Sandes-Freitas, Tainá V, Cristelli, Marina P, Viana, Laila A, Nakamura, Mônica R, Garcia, Valter D, Manfro, Roberto C, Simão, Denise R, Barros Almeida, Ricardo Augusto M, Ferreira, Gustavo F, Henrique Costa, Kellen Micheline A, Lima, Paula R, Pacheco-Silva, Alvaro, Fernandes Charpiot, Ida Maria M, Deboni, Luciane M, Ferreira, Teresa Cristina A, Mazzali, Marilda, Calazans, Carlos Alberto C, Oriá, Reinaldo B, Tedesco-Silva, Hélio, and Medina-Pestana, José

Published
2022
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14. The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study.

Author

Sandes-Freitas, Tainá Veras de, Moura, Lucio Requião, Carvalho, Deise Rosa de Boni Monteiro de, Garcia, Valter Duro, Modelli de Andrade, Luis Gustavo, Mazzali, Marilda, Manfro, Roberto Ceratti, Deboni, Luciane Mônica, Davi-Neto, Elias, Oliveira, Claudia Maria Costa de, Cavalcanti, Frederico Castelo Branco, Madeira, Rafael Lage, Esmeraldo, Ronaldo de Matos, Simão, Denise Rodrigues, Meira, Ana Carolina Guedes, Ferreira, Gustavo Fernandes, Lasmar, Marcus, Bignelli, Alexandre Tortoza, Pacheco-Silva, Alvaro, and Medina Pestana, José

Subjects
COLD storage, KIDNEYS, KIDNEY transplantation, TREATMENT effectiveness, GRAFT survival, CONFOUNDING variables, TOTAL body irradiation
Abstract

This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Prognostic role of renal replacement therapy among hospitalized patients with heart failure in the Brazilian national public health system

Author

Coy-Canguçu, Andréa, primary, Antunes-Correa, Lígia M., additional, Mazzali, Marilda, additional, Abrão, Paula, additional, Ronco, Fernanda, additional, Teixeira, Cinthia Montenegro, additional, Viana, Karynna Pimentel, additional, Cordeiro, Guilherme, additional, Longato, Mauricio, additional, Coelho, Otávio Rizzi, additional, Matos-Souza, José Roberto, additional, Nadruz, Wilson, additional, Sposito, Andrei C., additional, Petersen, Steffen E., additional, Jerosch-Herold, Michael, additional, and Coelho-Filho, Otávio Rizzi, additional

Published
2023
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24. Sugar, salt, immunity and the cause of primary hypertension.

Author

Sánchez-Lozada, Laura G, Madero, Magdalena, Mazzali, Marilda, Feig, Daniel I, Nakagawa, Takahiko, Lanaspa, Miguel A, Kanbay, Mehmet, Kuwabara, Masanari, Rodriguez-Iturbe, Bernardo, and Johnson, Richard J

Subjects
ESSENTIAL hypertension, HIGH-fructose corn syrup, PROTEIN kinases, SYMPATHETIC nervous system, HIGH-salt diet, SUGAR alcohols, NADPH oxidase
Abstract

Despite its discovery more than 150 years ago, the cause of primary hypertension remains unknown. Most studies suggest that hypertension involves genetic, congenital or acquired risk factors that result in a relative inability of the kidney to excrete salt (sodium chloride) in the kidneys. Here we review recent studies that suggest there may be two phases, with an initial phase driven by renal vasoconstriction that causes low-grade ischemia to the kidney, followed by the infiltration of immune cells that leads to a local autoimmune reaction that maintains the renal vasoconstriction. Evidence suggests that multiple mechanisms could trigger the initial renal vasoconstriction, but one way may involve fructose that is provided in the diet (such as from table sugar or high fructose corn syrup) or produced endogenously. The fructose metabolism increases intracellular uric acid, which recruits NADPH oxidase to the mitochondria while inhibiting AMP-activated protein kinase. A drop in intracellular ATP level occurs, triggering a survival response. Leptin levels rise, triggering activation of the sympathetic central nervous system, while vasopressin levels rise, causing vasoconstriction in its own right and stimulating aldosterone production via the vasopressin 1b receptor. Low-grade renal injury and autoimmune-mediated inflammation occur. High-salt diets can amplify this process by raising osmolality and triggering more fructose production. Thus, primary hypertension may result from the overactivation of a survival response triggered by fructose metabolism. Restricting salt and sugar and hydrating with ample water may be helpful in the prevention of primary hypertension. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Development and validation of a simple web-based tool for early prediction of COVID-19-associated death in kidney transplant recipients

Author

Modelli de Andrade, Luis Gustavo [UNESP], de Sandes-Freitas, Tainá Veras, Requião-Moura, Lúcio R., Viana, Laila Almeida, Cristelli, Marina Pontello, Garcia, Valter Duro, Alcântara, Aline Lima Cunha, Esmeraldo, Ronaldo de Matos, Abbud Filho, Mario, Pacheco-Silva, Alvaro, de Lima Carneiro, Erika Cristina Ribeiro, Manfro, Roberto Ceratti, Costa, Kellen Micheline Alves Henrique, Simão, Denise Rodrigues, de Sousa, Marcos Vinicius, Santana, Viviane Brandão Bandeira de Mello, Noronha, Irene L., Romão, Elen Almeida, Zanocco, Juliana Aparecida, Arimatea, Gustavo Guilherme Queiroz, De Boni Monteiro de Carvalho, Deise, Tedesco-Silva, Helio, Medina-Pestana, José, Keitel, Elizete, Costa de Oliveira, Claudia Maria, Neri, Beatriz de Oliveira, Fernandes Charpiot, Ida Maria Maximina, Ferreira, Teresa Cristina Alves, Vicari, Alessandra Rosa, Pereira, Tomás, Coelho, Maria Eduarda Heinzen de Almeida, Mazzali, Marilda, Ferreira, Gustavo Fernandes, Campos, Juliana Bastos, Rocha, Nicole Gomes Campos, Saldanha, Anita Leme da Rocha, Martinez, Tania Leme da Rocha, Romão, João Egídio, Teixeira Araújo, Maria Regina, Braga, Sibele Lessa, Deboni, Luciane Mônica, Krüger, Franco Silveira da Mota, Neto, Miguel Moysés, Claudino, Auro Buffani, Cláudio de Oliveira, Lívia, Matuck, Tereza Azevedo, Bignelli, Alexandre Tortoza, Hokazono, Silvia Regina, Suassuna, José Hermógenes Rocco, Rioja, Suzimar da Silveira, Madeira, Rafael Lage, Vilaça, Sandra Simone, Calazans, Carlos Alberto Chalabi, Calazans, Daniel Costa Chalabi, Malafronte, Patrícia, Miorin, Antonio, de Aguiar, Filipe Carrilho, Andrade, Larissa Guedes da Fonte, de Carvalho, Fabiana Loss, Martins, Karoline Sesiuk, Pinheiro, Hélady Sanders, Sertório, Emiliana Spadarotto, Pereira, André Barreto, Machado, David José Barros, Pozzi, Carolina Maria, Kroth, Leonardo Viliano, Filho, Lauro Monteiro Vasconcellos, Maciel, Rafael Fabio, Silva, Amanda Maíra Damasceno, Baptista, Ana Paula Maia, de Souza, Pedro Augusto Macedo, Lasmar, Marcus Faria, Saber, Luciana Tanajura Santamaria, Palma, Lilian Monteiro Pereira, de Barros Almeida, Ricardo Augusto Monteiro, Universidade Estadual Paulista (UNESP), Federal University of Ceará, Hospital Universitário Walter Cantídio, Hospital Geral de Fortaleza, Universidade de São Paulo (USP), Fundação Oswaldo Ramos, Hospital Israelita Albert Einstein, Santa Casa de Misericórdia de Porto Alegre, Medical School FAMERP, Federal University of Maranhão, Federal Univertisy of Rio Grande do Sul, Onofre Lopes University Hospital, Hospital Santa Isabel, Universidade Estadual de Campinas (UNICAMP), Hospital de Base de Brasília, Hospital Beneficência Portuguesa de São Paulo (BP), Hospital Santa Marcelina, University of Brasília - UnB, and Hospital São Francisco na Providência de Deus

Subjects
medicine.medical_specialty, infectious disease, MEDLINE, Anosmia, kidney transplantation/nephrology, Azathioprine, Disease, clinical research/practice, COVID-19 Testing, Text mining, infection and infectious agents ‐ viral, Risk Factors, Internal medicine, Health care, Case fatality rate, medicine, Humans, Immunology and Allergy, Pharmacology (medical), Retrospective Studies, Internet, Transplantation, SARS-CoV-2, business.industry, COVID-19, Original Articles, health services and outcomes research, Kidney Transplantation, complication: infectious, Transplant Recipients, ROC Curve, Original Article, medicine.symptom, business, Body mass index, medicine.drug
Abstract

Made available in DSpace on 2022-04-28T19:44:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01 This analysis, using data from the Brazilian kidney transplant (KT) COVID-19 study, seeks to develop a prediction score to assist in COVID-19 risk stratification in KT recipients. In this study, 1379 patients (35 sites) were enrolled, and a machine learning approach was used to fit models in a derivation cohort. A reduced Elastic Net model was selected, and the accuracy to predict the 28-day fatality after the COVID-19 diagnosis, assessed by the area under the ROC curve (AUC-ROC), was confirmed in a validation cohort. The better calibration values were used to build the applicable ImAgeS score. The 28-day fatality rate was 17% (n = 235), which was associated with increasing age, hypertension and cardiovascular disease, higher body mass index, dyspnea, and use of mycophenolate acid or azathioprine. Higher kidney graft function, longer time of symptoms until COVID-19 diagnosis, presence of anosmia or coryza, and use of mTOR inhibitor were associated with reduced risk of death. The coefficients of the best model were used to build the predictive score, which achieved an AUC-ROC of 0.767 (95% CI 0.698–0.834) in the validation cohort. In conclusion, the easily applicable predictive model could assist health care practitioners in identifying non-hospitalized kidney transplant patients that may require more intensive monitoring. Trial registration: ClinicalTrials.gov NCT04494776. Department of Internal Medicine Universidade Estadual Paulista-UNESP Department of Clinical Medicine Federal University of Ceará Hospital Universitário Walter Cantídio Hospital Geral de Fortaleza Department of Medicine Nephrology Division Federal University of São Paulo Department of Transplantation Hospital do Rim Fundação Oswaldo Ramos Renal Transplant Unit Hospital Israelita Albert Einstein Santa Casa de Misericórdia de Porto Alegre Hospital de Base Medical School FAMERP Federal University of Maranhão Hospital de Clínicas de Porto Alegre Federal Univertisy of Rio Grande do Sul Division of Nephrology and Kidney Transplantation Onofre Lopes University Hospital Hospital Santa Isabel Division of Nephrology School of Medical Sciences Renal Transplant Unit Renal Transplant Research Laboratoy University of Campinas – UNICAMP Hospital de Base de Brasília Hospital Beneficência Portuguesa de São Paulo (BP) Division of Nephrology School of Medicine of Ribeirão Preto University of Sao Paulo Hospital Santa Marcelina Hospital Universitário de Brasília University of Brasília - UnB, DF Hospital São Francisco na Providência de Deus Department of Internal Medicine Universidade Estadual Paulista-UNESP

Published
2022

33. Biopsia percutanea do rim transplantado

Author

Mazzali, Marilda, 1963, Alves Filho, Gentil, 1951-2015, Universidade Estadual de Campinas. Faculdade de Ciências Médicas, Programa de Pós-Graduação em Medicina, and UNIVERSIDADE ESTADUAL DE CAMPINAS

Subjects
Biópsia, Cirurgia - Técnica
Abstract

Orientador : Gentil Alves Filho Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas Resumo: Não informado Abstract: Not informed Mestrado Medicina Interna Doutor em Medicina

Published
2021
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34. Evaluation of Trypanosoma cruzi parasitic load by real-time PCR and blood culture in long-term kidney transplant recipients

Author

Jesus Guimarães Ferreira, Juliana, primary, Antonio de Almeida, Eros, additional, Barbosa Marcon, Gláucia Elisete, additional, Gonçalves Lima, Rodrigo, additional, Barroso Pereira, Mariane, additional, Ramos Gadelha, Fernanda, additional, Mazzali, Marilda, additional, Martins, Luiz Cláudio, additional, Silva Wanderley, Jamiro, additional, and Botelho Costa, Sandra Cecília, additional

Published
2021
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36. Recurrence of IgA Nephropathy after Kidney Transplantation in Adults

Author

Uffing, Audrey, primary, Pérez-Saéz, Maria José, additional, Jouve, Thomas, additional, Bugnazet, Mathilde, additional, Malvezzi, Paolo, additional, Muhsin, Saif A., additional, Lafargue, Marie-Camille, additional, Reindl-Schwaighofer, Roman, additional, Morlock, Alina, additional, Oberbauer, Rainer, additional, Buxeda, Anna, additional, Burballa, Carla, additional, Pascual, Julio, additional, von Moos, Seraina, additional, Seeger, Harald, additional, La Manna, Gaetano, additional, Comai, Giorgia, additional, Bini, Claudia, additional, Russo, Luis Sanchez, additional, Farouk, Samira, additional, Nissaisorakarn, Pitchaphon, additional, Patel, Het, additional, Agrawal, Nikhil, additional, Mastroianni-Kirsztajn, Gianna, additional, Mansur, Juliana, additional, Tedesco-Silva, Hélio, additional, Ventura, Carlucci Gualberto, additional, Agena, Fabiana, additional, David-Neto, Elias, additional, Akalin, Enver, additional, Alani, Omar, additional, Mazzali, Marilda, additional, Manfro, Roberto Ceratti, additional, Bauer, Andrea Carla, additional, Wang, Aileen X., additional, Cheng, Xingxing S., additional, Schold, Jesse D., additional, Berger, Stefan P., additional, Cravedi, Paolo, additional, and Riella, Leonardo V., additional

Published
2021
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42. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism

Author

Mazzali, Marilda, Kanellis, John, Han, Lin, Feng, Lili, Xia, Yi-Yang, Chen, Qiang, Kang, Duk-Hee, Gordon, Katherine L., Watanabe, Susumu, Nakagawa, Takahiko, Lan, Hui Y., and Johnson, Richard J.

Subjects
Uric acid -- Physiological aspects, Hypertension -- Physiological aspects, Hyperuricemia -- Physiological aspects, Cell proliferation -- Physiological aspects, Biological sciences
Abstract

Hyperuricemia is associated with hypertension and vascular disease, but whether this represents a causal relationship or an epiphenomenon remains unknown. We recently reported a model of mild hyperuricemia in rats that results in increased blood pressure and mild renal fibrosis. In this study, we examined the effect of hyperuricemia on the renal vasculature. Rats fed 2% oxonic acid and a low-salt diet for 7 wk developed mild hyperuricemia (1.8 vs. 1.4 mg/dl, P < 0.05), hypertension [147 vs. 127 mmHg systolic blood pressure (SBP), P < 0.05], and afferent arteriolar thickening, with a 35% increase in medial area (P < 0.05). Allopurinol or benziodarone prevented the hyperuricemia, hypertension, and arteriolopathy. Hydrochlorothiazide treatment did not prevent the hyperuricemia or arteriolopathy despite controlling blood pressure. In contrast, the arteriolopathy and hypertension were prevented by both enalapril and losartan. Uric acid also directly stimulated vascular smooth muscle cell proliferation in vitro, and this was partially inhibited by losartan. Thus hyperuricemia induces a renal arteriolopathy in rats that is blood pressure independent and involves the renin-angiotensin system. uric acid; hypertension; angiotensin II

Published
2002

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