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25 results on '"McCaffrey, Joanne"'

1. Asset management: The Coast Guard way

Author

McCaffrey, Joanne, CAPT

Subjects
RESOURCE MANAGEMENT, BUILDING AND CONSTRUCTION - Maintenance and Repair, COAST GUARD - United States - Costs, EFFICIENCY
Published
2008

3. Electroporation of a nanoparticle-associated DNA vaccine induces higher inflammation and immunity compared to its delivery with microneedle patches in pigs

Author

Bernelin-Cottet, Cindy, Urien, Céline, McCaffrey, Joanne, Collins, Damien, Donadei, Agnese, McDaid, Dennis, Jakob, Virginie, Barnier-Quer, Christophe, Collin, Nicolas, Bouguyon, Edwige, Bordet, Elise, Barc, Céline, Boulesteix, Olivier, Leplat, Jean-Jacques, Blanc, Fany, Contreras, Vanessa, Bertho, Nicolas, Moore, Anne C., and Schwartz-Cornil, Isabelle

Published
2019
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11. Asset Management

Author

Lawrence, Wade, Hubbard, Eugene E., and McCaffrey, Joanne

Published
2008

12. Early immune responses in skin and lymph node after skin delivery of Toll-like receptor agonists in neonatal and adult pigs

Author

Vreman, Sandra, Rebel, Johanna M.J., McCaffrey, Joanne, Ledl, Kristina, Arkhipova, Ksenia, Collins, Damien, McDaid, Dennis, Savelkoul, Huub F.J., Skovgaard, Kerstin, Moore, Anne C., Stockhofe-Zurwieden, Norbert, Vreman, Sandra, Rebel, Johanna M.J., McCaffrey, Joanne, Ledl, Kristina, Arkhipova, Ksenia, Collins, Damien, McDaid, Dennis, Savelkoul, Huub F.J., Skovgaard, Kerstin, Moore, Anne C., and Stockhofe-Zurwieden, Norbert

Abstract

The skin is potentially an important vaccine delivery route facilitated by a high number of resident antigen presenting cells (APCs), which are known to be stimulated by different Toll-like receptor agonists (TLRa). In this study, neonatal and adult pigs were vaccinated in the skin using dissolving microneedle patches to investigate the immuno-stimulatory potential of different TLRa and possible age-dependent differences early after vaccination. These patches contained TLR1/2a (Pam3Cys), TLR7/8a (R848) or TLR9a (CpG ODN) combined with inactivated porcine reproductive and respiratory syndrome virus (PRRSV) or with an oil-in-water stable emulsion. Vaccinated skin and draining lymph nodes were analysed for immune response genes using microfluidic high-throughput qPCR to evaluate the early immune response and activation of APCs. Skin pathology and immunohistochemistry were used to evaluate the local immune responses and APCs in the vaccinated skin, respectively. In both neonatal and adult pigs, skin vaccination with TLR7/8a induced the most prominent early inflammatory and immune cell responses, particularly in the skin. Skin histopathology and immunohistochemistry of APCs showed comparable results for neonatal and adult pigs after vaccination with the different TLRa vaccines. However, in vaccinated neonatal pigs in the skin and draining lymph node more immune response related genes were upregulated compared to adult pigs. We showed that both neonatal and adult skin could be stimulated to develop an immune response, particularly after TLR7/8a vaccination, with age-dependent differences in regulation of immune genes. Therefore, age-dependent differences in local early immune responses should be considered when developing skin vaccines.

Published
2021

13. Early immune responses in skin and lymph node after skin delivery of Toll-like receptor agonists in neonatal and adult pigs

Author

Vreman, Sandra, primary, Rebel, Johanna M.J., additional, McCaffrey, Joanne, additional, Ledl, Kristina, additional, Arkhipova, Ksenia, additional, Collins, Damien, additional, McDaid, Dennis, additional, Savelkoul, Huub F.J., additional, Skovgaard, Kerstin, additional, Moore, Anne C., additional, and Stockhofe-Zurwieden, Norbert, additional

Published
2021
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14. DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

Author

Cole, Grace, primary, Ali, Ahlam A., additional, McErlean, Emma, additional, Mulholland, Eoghan J., additional, Short, Amy, additional, McCrudden, Cian M., additional, McCaffrey, Joanne, additional, Robson, Tracy, additional, Kett, Vicky L., additional, Coulter, Jonathan A., additional, Dunne, Nicholas J., additional, Donnelly, Ryan F., additional, and McCarthy, Helen O., additional

Published
2019
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15. Systemic RALA/iNOS nanoparticles; a potent gene therapy for metastatic breast cancer coupled as a biomarker of treatment

Author

McCrudden, Cian M., McBride, John W., McCaffrey, Joanne, Ali, Ahlam A., Dunne, Nicholas J., Kett, Vicky L., Coulter, Jonathan A., Robson, Tracy, and McCarthy, Helen O.

Subjects
Prostate cancer, Radiation, Nitric oxide synthase, nanoparticle, Carcinoma, lcsh:RM1-950, Promoter, Tumor cells, breast cancer, lcsh:Therapeutics. Pharmacology, SDG 3 - Good Health and Well-being, Mesenchymal transition, nitric oxide, nonviral gene therapy, metastasis, Original Article, Amphipathic peptide, Human osteocalcin, Delivery
Abstract

This study aimed to determine the therapeutic benefit of a nanoparticular formulation for the delivery of inducible nitric oxide synthase (iNOS) gene therapy in a model of breast cancer metastasis. Nanoparticles comprising a cationic peptide vector, RALA, and plasmid DNA were formulated and characterized using a range of physiochemical analyses. Nanoparticles complexed using iNOS plasmids and RALA approximated 60 nm in diameter with a charge of 25 mV. A vector neutralization assay, performed to determine the immunogenicity of nanoparticles in immunocompetent C57BL/6 mice, revealed that no vector neutralization was evident. Nanoparticles harboring iNOS plasmids (constitutively active cytomegalovirus [CMV]-driven or transcriptionally regulated human osteocalcin [hOC]-driven) evoked iNOS protein expression and nitrite accumulation and impaired clonogenicity in the highly aggressive MDA-MB-231 human breast cancer model. Micrometastases of MDA-MB-231-luc-D3H1 cells were established in female BALB/c SCID mice by intracardiac delivery. Nanoparticulate RALA/CMV-iNOS or RALA/hOC-iNOS increased median survival in mice bearing micrometastases by 27% compared with controls and also provoked elevated blood nitrite levels. Additionally, iNOS gene therapy sensitized MDA-MB-231-luc-D3H1 tumors to docetaxel treatment. Studies demonstrated that systemically delivered RALA-iNOS nanoparticles have therapeutic potential for the treatment of metastatic breast cancer. Furthermore, detection of nitrite levels in the blood serves as a reliable biomarker of treatment. Keywords: nonviral gene therapy, nitric oxide, nanoparticle, breast cancer, metastasis

Published
2017
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16. Socialization and Career Orientation Among Black and White College Women

Author

Turner, Barbara F. and McCaffrey, Joanne Hammar

Abstract

In a study of career orientation among black and white college women, support was found for hypotheses derived from Rotter's Social Learning Theory. As hypothesized, variables expressive of external control predicted level of career expectation among blacks, whereas variables expressive of internal control predicted high career expectations among whites. (Author)

Published
1974

18. Arginine‐Rich Peptide‐Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

Author

Udhayakumar, Vimal K., primary, De Beuckelaer, Ans, additional, McCaffrey, Joanne, additional, McCrudden, Cian M., additional, Kirschman, Jonathan L., additional, Vanover, Daryll, additional, Van Hoecke, Lien, additional, Roose, Kenny, additional, Deswarte, Kim, additional, De Geest, Bruno G., additional, Lienenklaus, Stefan, additional, Santangelo, Philip J., additional, Grooten, Johan, additional, McCarthy, Helen O., additional, and De Koker, Stefaan, additional

Published
2017
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21. Potentiating the Anticancer Properties of Bisphosphonates by Nanocomplexation with the Cationic Amphipathic Peptide, RALA

Author

Massey, Ashley S., primary, Pentlavalli, Sreekanth, additional, Cunningham, Richard, additional, McCrudden, Cian M., additional, McErlean, Emma M., additional, Redpath, Philip, additional, Ali, Ahlam A., additional, Annett, Stephanie, additional, McBride, John W., additional, McCaffrey, Joanne, additional, Robson, Tracy, additional, Migaud, Marie E., additional, and McCarthy, Helen O., additional

Published
2016
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22. DNA vaccination for prostate cancer: key concepts and considerations.

Author

Cole, Grace, McCaffrey, Joanne, Ali, Ahlam A., and McCarthy, Helen O.

Subjects
*PROSTATE cancer treatment, *DNA vaccines, *IMMUNOTHERAPY, *CLINICAL trials, *CONDOMS
Abstract

While locally confined prostate cancer is associated with a low five year mortality rate, advanced or metastatic disease remains a major challenge for healthcare professionals to treat and is usually terminal. As such, there is a need for the development of new, efficacious therapies for prostate cancer. Immunotherapy represents a promising approach where the host's immune system is harnessed to mount an anti-tumour effect, and the licensing of the first prostate cancer specific immunotherapy in 2010 has opened the door for other immunotherapies to gain regulatory approval. Among these strategies DNA vaccines are an attractive option in terms of their ability to elicit a highly specific, potent and wide-sweeping immune response. Several DNA vaccines have been tested for prostate cancer and while they have demonstrated a good safety profile they have faced problems with low efficacy and immunogenicity compared to other immunotherapeutic approaches. This review focuses on the positive aspects of DNA vaccines for prostate cancer that have been assessed in preclinical and clinical trials thus far and examines the key considerations that must be employed to improve the efficacy and immunogenicity of these vaccines. [ABSTRACT FROM AUTHOR]

Published
2017
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25. What we did: Our process of implementation.

Author

Patel, Krishna, Mccaffrey, Joanne, and Freeman, Jenny

Subjects
INTERNET, PATIENT-professional relations, PATIENT education, RADIOLOGIC technologists, TUMORS, SOCIAL support
Abstract

The article discusses the local information leaflet produced by North Middlesex University Hospital's (NMUH) NHS Trust which holds information for the patient treatment pathway. The information prescription facilitator (IPF) and Macmillan information lead developed the stepwise-process to obtain accurate local information. The revised leaflet is uploaded onto the information prescription system (IPS) providing a personalized platform to patients relevant to them.

Published
2012

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