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337 results on '"McDevitt, Michael R."'

2. Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy

Author

Bicak, Mesude, Lückerath, Katharina, Kalidindi, Teja, Phelps, Michael E, Strand, Sven-Erik, Morris, Michael J, Radu, Caius G, Damoiseaux, Robert, Peltola, Mari T, Peekhaus, Norbert, Ho, Austin, Veach, Darren, Malmborg Hager, Ann-Christin, Larson, Steven M, Lilja, Hans, McDevitt, Michael R, Klein, Robert J, and Ulmert, David

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Genetics, Urologic Diseases, Prostate Cancer, Biotechnology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Actinium, Alpha Particles, Animals, Biomarkers, Tumor, Humans, Immunoconjugates, Male, Mice, Mice, Nude, Neoplasms, Experimental, Prostate-Specific Antigen, Prostatic Neoplasms, Tissue Kallikreins, hu11B6, 225Ac, radiommunotherapy, prostate cancer, hK2
Abstract

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First, we evaluated the possibility of exploiting IgG3, the IgG subclass with superior activation of complement and ability to mediate FC-γ-receptor binding, for immunotherapeutically enhanced hK2 targeted α-radioimmunotherapy. Second, we compared the therapeutic efficacy of a single high activity vs. fractionated activity. Finally, we used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after targeted α-therapy. [225Ac]hu11B6-IgG3 was a functionally enhanced alternative to [225Ac]hu11B6-IgG1 but offered no improvement of therapeutic efficacy. Progression-free survival was slightly increased with a single high activity compared to fractionated activity. Tumor-free animals succumbing after treatment revealed no evidence of treatment-associated toxicity. In addition to up-regulation of canonical aggressive prostate cancer genes, such as MMP7, ETV1, NTS, and SCHLAP1, we also noted a significant decrease in both KLK3 (prostate-specific antigen ) and FOLH1 (prostate-specific membrane antigen) but not in AR and KLK2, demonstrating efficacy of sequential [225Ac]hu11B6 in a mouse model.

Published
2020

3. Harnessing Androgen Receptor Pathway Activation for Targeted Alpha Particle Radioimmunotherapy of Breast Cancer

Author

Thorek, Daniel LJ, Ku, Anson T, Mitsiades, Nicholas, Veach, Darren, Watson, Philip A, Metha, Dipti, Strand, Sven-Erik, Sharma, Sai Kiran, Lewis, Jason S, Abou, Diane S, Lilja, Hans G, Larson, Steven M, McDevitt, Michael R, and Ulmert, David

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Biotechnology, Breast Cancer, Estrogen, 2.1 Biological and endogenous factors, Aetiology, Alpha Particles, Animals, Biomarkers, Tumor, Breast Neoplasms, Cell Line, Tumor, Disease Models, Animal, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Female, Hexokinase, Humans, Immunoconjugates, Mice, Molecular Targeted Therapy, Radioimmunotherapy, Radiometry, Receptors, Androgen, Signal Transduction, Tissue Distribution, Xenograft Model Antitumor Assays, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeThe impact of androgen receptor (AR) activity in breast cancer biology is unclear. We characterized and tested a novel therapy to an AR-governed target in breast cancer.Experimental Design: We evaluated the expression of prototypical AR gene products human kallikrein 2 (hK2) and PSA in breast cancer models. We screened 13 well-characterized breast cancer cell lines for hK2 and PSA production upon in vitro hormone stimulation by testosterone [dihydrotestosterone (DHT)]. AR-positive lines were further evaluated by exposure to estrogen (17β-Estradiol) and the synthetic progestin D-Norgestrel. We then evaluated an anti-hK2-targeted radiotherapy platform (hu11B6), labeled with alpha (α)-particle emitting Actinium-225, to specifically treat AR-expressing breast cancer xenografts under hormone stimulation.ResultsD-Norgestrel and DHT activated the AR pathway, while 17β-Estradiol did not. Competitive binding for AR protein showed similar affinity between DHT and D-Norgestrel, indicating direct AR-ligand interaction. In vivo production of hK2 was sufficient to achieve site-specific delivery of therapeutic radionuclide to tumor tissue at >20-fold over background muscle uptake; effecting long-term local tumor control.Conclusions[225Ac]hu11B6 targeted radiotherapy was potentiated by DHT and by D-Norgestrel in murine xenograft models of breast cancer. AR activity in breast cancer correlates with kallikrein-related peptidase-2 and can be activated by D-Norgestrel, a common contraceptive, and AR induction can be harnessed for hK2-targeted breast cancer α-emitter radiotherapy.

Published
2019

5. Alpha-Emitting Radionuclides: Current Status and Future Perspectives

Author

Miederer, Matthias, primary, Benešová-Schäfer, Martina, additional, Mamat, Constantin, additional, Kästner, David, additional, Pretze, Marc, additional, Michler, Enrico, additional, Brogsitter, Claudia, additional, Kotzerke, Jörg, additional, Kopka, Klaus, additional, Scheinberg, David A., additional, and McDevitt, Michael R., additional

Published
2024
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8. Deconvoluting hepatic processing of carbon nanotubes.

Author

Alidori, Simone, Bowman, Robert L, Yarilin, Dmitry, Romin, Yevgeniy, Barlas, Afsar, Mulvey, J Justin, Fujisawa, Sho, Xu, Ke, Ruggiero, Alessandro, Riabov, Vladimir, Thorek, Daniel LJ, Ulmert, Hans David S, Brea, Elliott J, Behling, Katja, Kzhyshkowska, Julia, Manova-Todorova, Katia, Scheinberg, David A, and McDevitt, Michael R

Subjects
Liver, Animals, Mice, Inbred BALB C, Macaca fascicularis, Mice, Nanotubes, Carbon, Materials Testing, Endocytosis, Pharmacokinetics, Female, Male, Inbred BALB C, Nanotubes, Carbon
Abstract

Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulates a range of metabolic functions and coincidently accumulates most particulate drugs. Here we provide the unexpected details of hepatic processing of covalently functionalized nanotubes including receptor-mediated endocytosis, cellular trafficking and biliary elimination. Ammonium-functionalized fibrillar nanocarbon is found to preferentially localize in the fenestrated sinusoidal endothelium of the liver but not resident macrophages. Stabilin receptors mediate the endocytic clearance of nanotubes. Biocompatibility is evidenced by the absence of cell death and no immune cell infiltration. Towards clinical application of this platform, nanotubes were evaluated for the first time in non-human primates. The pharmacologic profile in cynomolgus monkeys is equivalent to what was reported in mice and suggests that nanotubes should behave similarly in humans.

Published
2016

12. Supplementary Figures 1 and 2 from Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response

Author

Storey, Claire M., primary, Altai, Mohamed, primary, Bicak, Mesude, primary, Veach, Darren R., primary, Lückerath, Katharina, primary, Adrian, Gabriel, primary, McDevitt, Michael R., primary, Kalidindi, Teja, primary, Park, Julie E., primary, Herrmann, Ken, primary, Abou, Diane, primary, Zedan, Wahed, primary, Peekhaus, Norbert, primary, Klein, Robert J., primary, Damoiseaux, Robert, primary, Larson, Steven M., primary, Lilja, Hans, primary, Thorek, Daniel, primary, and Ulmert, David, primary

Published
2023
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13. Data from Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response

Author

Storey, Claire M., primary, Altai, Mohamed, primary, Bicak, Mesude, primary, Veach, Darren R., primary, Lückerath, Katharina, primary, Adrian, Gabriel, primary, McDevitt, Michael R., primary, Kalidindi, Teja, primary, Park, Julie E., primary, Herrmann, Ken, primary, Abou, Diane, primary, Zedan, Wahed, primary, Peekhaus, Norbert, primary, Klein, Robert J., primary, Damoiseaux, Robert, primary, Larson, Steven M., primary, Lilja, Hans, primary, Thorek, Daniel, primary, and Ulmert, David, primary

Published
2023
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14. Tumor Therapy with Targeted Atomic Nanogenerators

Author

McDevitt, Michael R., Ma, Dangshe, Lai, Lawrence T., Simon, Jim, Borchardt, Paul, Frank, R. Keith, Wu, Karen, Pellegrini, Virginia, Curcio, Michael J., Miederer, Matthias, Bander, Neil H., and Scheinberg, David A.

Published
2001

15. Supplementary Figure S1 from PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

Author

Veach, Darren R., primary, Storey, Claire M., primary, Lückerath, Katharina, primary, Braun, Katharina, primary, von Bodman, Christian, primary, Lamminmäki, Urpo, primary, Kalidindi, Teja, primary, Strand, Sven-Erik, primary, Strand, Joanna, primary, Altai, Mohamed, primary, Damoiseaux, Robert, primary, Zanzonico, Pat, primary, Benabdallah, Nadia, primary, Pankov, Dmitry, primary, Scher, Howard I., primary, Scardino, Peter, primary, Larson, Steven M., primary, Lilja, Hans, primary, McDevitt, Michael R., primary, Thorek, Daniel L.J., primary, and Ulmert, David, primary

Published
2023
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16. Figure S1 from A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy

Author

Santich, Brian H., primary, Cheal, Sarah M., primary, Ahmed, Mahiuddin, primary, McDevitt, Michael R., primary, Ouerfelli, Ouathek, primary, Yang, Guangbin, primary, Veach, Darren R., primary, Fung, Edward K., primary, Patel, Mitesh, primary, Burnes Vargas, Daniela, primary, Malik, Aiza A., primary, Guo, Hong-Fen, primary, Zanzonico, Pat B., primary, Monette, Sebastien, primary, Michel, Adam O., primary, Rudin, Charles M., primary, Larson, Steven M., primary, and Cheung, Nai K., primary

Published
2023
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17. Supplementary Data from Harnessing Androgen Receptor Pathway Activation for Targeted Alpha Particle Radioimmunotherapy of Breast Cancer

Author

Thorek, Daniel L.J., primary, Ku, Anson T., primary, Mitsiades, Nicholas, primary, Veach, Darren, primary, Watson, Philip A., primary, Metha, Dipti, primary, Strand, Sven-Erik, primary, Sharma, Sai Kiran, primary, Lewis, Jason S., primary, Abou, Diane S., primary, Lilja, Hans G., primary, Larson, Steven M., primary, McDevitt, Michael R., primary, and Ulmert, David, primary

Published
2023
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18. Supplementary Methods from PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

Author

Veach, Darren R., primary, Storey, Claire M., primary, Lückerath, Katharina, primary, Braun, Katharina, primary, von Bodman, Christian, primary, Lamminmäki, Urpo, primary, Kalidindi, Teja, primary, Strand, Sven-Erik, primary, Strand, Joanna, primary, Altai, Mohamed, primary, Damoiseaux, Robert, primary, Zanzonico, Pat, primary, Benabdallah, Nadia, primary, Pankov, Dmitry, primary, Scher, Howard I., primary, Scardino, Peter, primary, Larson, Steven M., primary, Lilja, Hans, primary, McDevitt, Michael R., primary, Thorek, Daniel L.J., primary, and Ulmert, David, primary

Published
2023
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19. Supplementary Table S1 from PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

Author

Veach, Darren R., primary, Storey, Claire M., primary, Lückerath, Katharina, primary, Braun, Katharina, primary, von Bodman, Christian, primary, Lamminmäki, Urpo, primary, Kalidindi, Teja, primary, Strand, Sven-Erik, primary, Strand, Joanna, primary, Altai, Mohamed, primary, Damoiseaux, Robert, primary, Zanzonico, Pat, primary, Benabdallah, Nadia, primary, Pankov, Dmitry, primary, Scher, Howard I., primary, Scardino, Peter, primary, Larson, Steven M., primary, Lilja, Hans, primary, McDevitt, Michael R., primary, Thorek, Daniel L.J., primary, and Ulmert, David, primary

Published
2023
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22. Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response

Author

Storey, Claire M., primary, Altai, Mohamed, additional, Bicak, Mesude, additional, Veach, Darren R., additional, Lückerath, Katharina, additional, Adrian, Gabriel, additional, McDevitt, Michael R., additional, Kalidindi, Teja, additional, Park, Julie E., additional, Herrmann, Ken, additional, Abou, Diane, additional, Zedan, Wahed, additional, Peekhaus, Norbert, additional, Klein, Robert J., additional, Damoiseaux, Robert, additional, Larson, Steven M., additional, Lilja, Hans, additional, Thorek, Daniel, additional, and Ulmert, David, additional

Published
2023
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23. Engineering CAR-T cells for radiohapten capture in imaging and radioimmunotherapy applications

Author

Kurtz, Keifer, primary, Eibler, Laura, additional, Dacek, Megan M., additional, Carter, Lukas M., additional, Veach, Darren R., additional, Lovibond, Samantha, additional, Reynaud, Emma, additional, Qureshy, Sarah, additional, McDevitt, Michael R., additional, Bourne, Christopher, additional, Monette, Sebastien, additional, Punzalan, Blesida, additional, Khayat, Shireen, additional, Verma, Svena, additional, Kesner, Adam L., additional, Cheung, Nai-Kong V., additional, Schöder, Heiko, additional, Gajecki, Leah, additional, Cheal, Sarah M., additional, Larson, Steven M., additional, Scheinberg, David A., additional, and Krebs, Simone, additional

Published
2023
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24. Efficacy of HER2-Targeted Intraperitoneal 225Ac α-Pretargeted Radioimmunotherapy for Small-Volume Ovarian Peritoneal Carcinomatosis.

Author

Chung, Sebastian K., Vargas, Daniela Burnes, Chandler, Christopher S., Katugampola, Sumudu, Veach, Darren R., McDevitt, Michael R., Seo, Shin H., Vaughn, Brett A., Rinne, Sara S., Punzalan, Blesida, Patel, Mitesh, Hong Xu, Hong-Fen Guo, Zanzonico, Pat B., Monette, Sébastien, Guangbin Yang, Ouerfelli, Ouathek, Nash, Garrett M., Cercek, Andrea, and Fung, Edward K.

Published
2023
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28. Assessing Functional Androgen Receptor Pathway Activity in Response to Radiotherapy Using hK2-targeted PET Imaging

Author

Storey, Claire M., primary, Altai, Mohamed, additional, Bicak, Mesude, additional, Veach, Darren R., additional, Lueckerath, Katharina, additional, Adrian, Gabriel, additional, McDevitt, Michael R., additional, Kalidindi, Teja, additional, Park, Julie E., additional, Herrmann, Ken, additional, Abou, Diane, additional, Zedan, Wahed, additional, Peekhaus, Norbert, additional, Klein, Robert J., additional, Damoiseaux, Robert, additional, Larson, Steven M., additional, Lilija, Hans, additional, Thorek, Daniel, additional, Thorek, Daniel LJ, additional, and Ulmert, David, additional

Published
2022
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29. [18F]-Labeled PARP-1 PET Imaging of PSMA Targeted Alpha Particle Radiotherapy Response

Author

Zhang, Hanwen, primary, Abou, Diane, additional, Villmer, Alexandria, additional, Benabdallah, Nadia, additional, Jiang, Wen, additional, Ulmert, David, additional, Carlin, Sean, additional, Rogers, Buck E., additional, Turtle, Norman F., additional, McDevitt, Michael R., additional, Baumann, Brian, additional, Simons, Brian W., additional, Zhou, Dong, additional, and Thorek, Daniel L. J., additional

Published
2022
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30. Treatment of Patients with Acute Myeloid Leukemia with the Targeted Alpha-Particle Nanogenerator Actinium-225-Lintuzumab

Author

Rosenblat, Todd L., primary, McDevitt, Michael R., additional, Carrasquillo, Jorge A., additional, Pandit-Taskar, Neeta, additional, Frattini, Mark G., additional, Maslak, Peter G., additional, Park, Jae H., additional, Douer, Dan, additional, Cicic, Dragan, additional, Larson, Steven M., additional, Scheinberg, David A., additional, and Jurcic, Joseph G., additional

Published
2022
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31. Preface

Author

Renugopalakrishnan, V., Koester, Steven J., McDevitt, Michael R., Ajayan, Pulickel M., Liepmann, Dorian, Demirci, Utkan, Paulmurugan, Ramasamy, and Viswanathan, Sowmya

Published
2014
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33. Paradoxical glomerular filtration of carbon nanotubes

Author

Ruggiero, Alessandro, Villa, Carlos H., Bander, Evan, Rey, Diego A., Berqkvist, Magnus, Batt, Carl A., Manova-Todorova, Katia, Deen, William M., Scheinberg, David A., McDevitt, Michael R., and Weinbaum, Sheldon

Published
2010

34. Abstract P168: Pretargeted radioimmunotherapy using 225Ac for intraperitoneal Her2-expressing epithelial ovarian carcinoma xenografts

Author

Chung, Sebastian K., primary, Chandler, Christopher S., additional, Vargas, Daniela Burnes, additional, Seo, Shin H., additional, McDevitt, Michael R., additional, Veach, Darren, additional, Punzalan, Blesida, additional, Hong, Xu, additional, Guo, Hong-fen, additional, Nash, Garrett M., additional, Cercek, Andrea, additional, Cheung, Nai-Kong V., additional, Larson, Steven M., additional, and Cheal, Sarah M., additional

Published
2021
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38. [18F]-Labeled PARP-1 PET imaging of PSMA targeted alpha particle radiotherapy response.

Author

Zhang, Hanwen, Abou, Diane, Lu, Peng, Hasson, Abbie Meghan, Villmer, Alexandria, Benabdallah, Nadia, Jiang, Wen, Ulmert, David, Carlin, Sean, Rogers, Buck E., Turtle, Norman F., McDevitt, Michael R., Baumann, Brian, Simons, Brian W., Dehdashti, Farrokh, Zhou, Dong, and Thorek, Daniel L. J.

Subjects
ALPHA rays, POLY ADP ribose, POSITRON emission tomography, RADIOACTIVE tracers, POLY(ADP-ribose) polymerase, DNA ligases, AUTORADIOGRAPHY
Abstract

The growing interest and clinical translation of alpha particle (α) therapies brings with it new challenges to assess target cell engagement and to monitor therapeutic effect. Noninvasive imaging has great potential to guide α-treatment and to harness the potential of these agents in the complex environment of disseminated disease. Poly(ADP) ribose polymerase 1 (PARP-1) is among the most abundantly expressed DNA repair enzymes with key roles in multiple repair pathways—such as those induced by irradiation. Here, we used a third-generation PARP1-specific radiotracer, [18F]-PARPZ, to delineate castrate resistant prostate cancer xenografts. Following treatment with the clinically applied [225Ac]-PSMA-617, positron emission tomography was performed and correlative autoradiography and histology acquired. [18F]-PARPZ was able to distinguish treated from control (saline) xenografts by increased uptake. Kinetic analysis of tracer accumulation also suggests that the localization of the agent to sites of increased PARP-1 expression is a consequence of DNA damage response. Together, these data support expanded investigation of [18F]-PARPZ to facilitate clinical translation in the ⍺-therapy space. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Engineered Cells as a Test Platform for Radiohaptens in Pretargeted Imaging and Radioimmunotherapy Applications

Author

Dacek, Megan M., primary, Veach, Darren R., additional, Cheal, Sarah M., additional, Carter, Lukas M., additional, McDevitt, Michael R., additional, Punzalan, Blesida, additional, Burnes Vargas, Daniela, additional, Kubik, Thomas Z., additional, Monette, Sebastien, additional, Santich, Brian H., additional, Yang, Guangbin, additional, Ouerfelli, Ouathek, additional, Kesner, Adam L., additional, Cheung, Nai-Kong V., additional, Scheinberg, David A., additional, Larson, Steven M., additional, and Krebs, Simone, additional

Published
2021
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41. A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy

Author

Santich, Brian H., primary, Cheal, Sarah M., additional, Ahmed, Mahiuddin, additional, McDevitt, Michael R., additional, Ouerfelli, Ouathek, additional, Yang, Guangbin, additional, Veach, Darren R., additional, Fung, Edward K., additional, Patel, Mitesh, additional, Burnes Vargas, Daniela, additional, Malik, Aiza A., additional, Guo, Hong-Fen, additional, Zanzonico, Pat B., additional, Monette, Sebastien, additional, Michel, Adam O., additional, Rudin, Charles M., additional, Larson, Steven M., additional, and Cheung, Nai K., additional

Published
2021
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42. PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates

Author

Veach, Darren R., primary, Storey, Claire M., additional, Lückerath, Katharina, additional, Braun, Katharina, additional, von Bodman, Christian, additional, Lamminmäki, Urpo, additional, Kalidindi, Teja, additional, Strand, Sven-Erik, additional, Strand, Joanna, additional, Altai, Mohamed, additional, Damoiseaux, Robert, additional, Zanzonico, Pat, additional, Benabdallah, Nadia, additional, Pankov, Dmitry, additional, Scher, Howard I., additional, Scardino, Peter, additional, Larson, Steven M., additional, Lilja, Hans, additional, McDevitt, Michael R., additional, Thorek, Daniel L.J., additional, and Ulmert, David, additional

Published
2021
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43. Carbon Nanotubes

Author

Scheinberg, David A., primary, Villa, Carlos H., additional, Escorcia, Freddy, additional, and McDevitt, Michael R., additional

Published
2011
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46. PSA-targeted Alpha-, Beta- and Positron Emitting Immuno-Theranostics in Murine Prostate Cancer Models and Non-Human Primates

Author

Veach, Darren R., primary, Storey, Claire M., additional, Lückerath, Katharina, additional, Braun, Katharina, additional, von Bodman, Christian, additional, Lamminmäki, Urpo, additional, Kalidindi, Teja, additional, Strand, Sven-Erik, additional, Strand, Joanna, additional, Altai, Mohamed, additional, Damoiseaux, Robert, additional, Zanzonico, Pat, additional, Benabdallah, Nadia, additional, Pankov, Dmitry, additional, Scher, Howard I., additional, Scardino, Peter, additional, Larson, Steven M., additional, Lilja, Hans, additional, McDevitt, Michael R., additional, Thorek, Daniel L. J., additional, and Ulmert, David, additional

Published
2020
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47. A Genomic Profile of Local Immunity in the Melanoma Microenvironment Following Treatment with α Particle-Emitting Ultrasmall Silica Nanoparticles

Author

Urbanska, Aleksandra M., primary, Khanin, Raya, additional, Alidori, Simone, additional, Wong, Sam, additional, Mello, Barbara P., additional, Almeida, Bryan Aristega, additional, Chen, Feng, additional, Ma, Kai, additional, Turker, Melik Z., additional, Korontsvit, Tatyana, additional, Scheinberg, David A., additional, Zanzonico, Pat B., additional, Wiesner, Ulrich, additional, Bradbury, Michelle S., additional, Quinn, Thomas P., additional, and McDevitt, Michael R., additional

Published
2020
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48. Alpha radioimmunotherapy using 225Ac-proteus-DOTA for solid tumors - safety at curative doses

Author

Cheal, Sarah M., primary, McDevitt, Michael R., additional, Santich, Brian H., additional, Patel, Mitesh, additional, Yang, Guangbin, additional, Fung, Edward K., additional, Veach, Darren R., additional, Bell, Meghan, additional, Ahad, Afruja, additional, Vargas, Daniela Burnes, additional, Punzalan, Blesida, additional, Pillarsetty, Naga Vara Kishore, additional, Xu, Hong, additional, Guo, Hong-fen, additional, Monette, Sébastien, additional, Michel, Adam O., additional, Piersigilli, Alessandra, additional, Scheinberg, David A., additional, Ouerfelli, Ouathek, additional, Cheung, Nai-Kong V., additional, and Larson, Steven M., additional

Published
2020
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