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4. Comparison of Immersed Boundary Simulations of Heart Valve Hemodynamics against In Vitro 4D Flow MRI Data

Author

Kaiser, Alexander D., Schiavone, Nicole K., Elkins, Christopher J., McElhinney, Doff B., Eaton, John K., and Marsden, Alison L.

Subjects
Quantitative Biology - Tissues and Organs, Physics - Fluid Dynamics, 76Z05 (Primary), 92C55, 92C10 (Secondary), J.3.1
Abstract

The immersed boundary (IB) method is a mathematical framework for fluid-structure interaction problems (FSI) that was originally developed to simulate flows around heart valves. Direct comparison of FSI simulations around heart valves against experimental data is challenging, however, due to the difficulty of performing robust and effective simulations, the complications of modeling a specific physical experiment, and the need to acquire experimental data that is directly comparable to simulation data. Such comparators are a necessary precursor for further formal validation studies of FSI simulations involving heart valves. In this work, we performed physical experiments of flow through a pulmonary valve in an in vitro pulse duplicator, and measured the corresponding velocity field using 4D flow MRI (4-dimensional flow magnetic resonance imaging). We constructed a computer model of this pulmonary artery setup, including modeling valve geometry and material properties via a technique called design-based elasticity, and simulated flow through it with the IB method. The simulated flow fields showed excellent qualitative agreement with experiments, excellent agreement on integral metrics, and reasonable relative error in the entire flow domain and on slices of interest. These results illustrate how to construct a computational model of a physical experiment for use as a comparator., Comment: Ann Biomed Eng (2023)

Published
2021
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7. Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications

Author

Chen, Linfeng, Tang, Qiming, Zhang, Keying, Huang, Qianyang, Ding, Yun, Jin, Bo, Liu, Szumam, Hwa, KuoYuan, Chou, C. James, Zhang, Yani, Thyparambil, Sheeno, Liao, Weili, Han, Zhi, Mortensen, Richard, Schilling, James, Li, Zhen, Heaton, Robert, Tian, Lu, Cohen, Harvey J., Sylvester, Karl G., Arent, Rebecca C., Zhao, Xinyang, McElhinney, Doff B., Wu, Yumei, Bai, Wenpei, and Ling, Xuefeng B.

Published
2023
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13. Hemodynamics in Patients with Aortic Coarctation: A Comparison of in vivo 4D-Flow MRI and FSI Simulation

Author

Nair, Priya J., Pfaller, Martin R., Dual, Seraina A., Loecher, Michael, McElhinney, Doff B., Ennis, Daniel B., Marsden, Alison L., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bernard, Olivier, editor, Clarysse, Patrick, editor, Duchateau, Nicolas, editor, Ohayon, Jacques, editor, and Viallon, Magalie, editor

Published
2023
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14. Right Ventricular Function and T1‐Mapping in Boys With Duchenne Muscular Dystrophy

Author

Dual, Seraina A, Maforo, Nyasha G, McElhinney, Doff B, Prosper, Ashley, Wu, Holden H, Maskatia, Shiraz, Renella, Pierangelo, Halnon, Nancy, and Ennis, Daniel B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease, Cardiovascular, Brain Disorders, Clinical Research, Muscular Dystrophy, Intellectual and Developmental Disabilities (IDD), Pediatric, Duchenne/ Becker Muscular Dystrophy, Rare Diseases, Contrast Media, Gadolinium, Humans, Magnetic Resonance Imaging, Magnetic Resonance Imaging, Cine, Male, Muscular Dystrophy, Duchenne, Myocardium, Prospective Studies, Reproducibility of Results, Stroke Volume, Ventricular Function, Right, Duchenne muscular dystrophy, cardiomyopathy, cardiovascular magnetic resonance, late gadolinium enhancement, myocardial remodeling, T1&#8208, mapping, T1-mapping, Physical Sciences, Engineering, Medical and Health Sciences, Nuclear Medicine & Medical Imaging, Clinical sciences
Abstract

BackgroundClinical management of boys with Duchenne muscular dystrophy (DMD) relies on in-depth understanding of cardiac involvement, but right ventricular (RV) structural and functional remodeling remains understudied.PurposeTo evaluate several analysis methods and identify the most reliable one to measure RV pre- and postcontrast T1 (RV-T1) and to characterize myocardial remodeling in the RV of boys with DMD.Study typeProspective.PopulationBoys with DMD (N = 27) and age-/sex-matched healthy controls (N = 17) from two sites.Field strength/sequence3.0 T using balanced steady state free precession, motion-corrected phase sensitive inversion recovery and modified Look-Locker inversion recovery sequences.AssessmentBiventricular mass (Mi), end-diastolic volume (EDVi) and ejection fraction (EF) assessment, tricuspid annular excursion (TAE), late gadolinium enhancement (LGE), pre- and postcontrast myocardial T1 maps. The RV-T1 reliability was assessed by three observers in four different RV regions of interest (ROI) using intraclass correlation (ICC).Statistical testsThe Wilcoxon rank sum test was used to compare RV-T1 differences between DMD boys with negative LGE(-) or positive LGE(+) and healthy controls. Additionally, correlation of precontrast RV-T1 with functional measures was performed. A P-value  0.91) for assessing RV-T1. Precontrast RV-T1 was significantly higher in boys with DMD compared to controls. Both LGE(-) and LGE(+) boys had significantly elevated precontrast RV-T1 compared to controls (1543 [1489-1597] msec and 1550 [1402-1699] msec vs. 1436 [1399-1473] msec, respectively). Compared to healthy controls, boys with DMD had preserved RVEF (51.8 [9.9]% vs. 54.2 [7.2]%, P = 0.31) and significantly reduced RVMi (29.8 [9.7] g vs. 48.0 [15.7] g), RVEDVi (69.8 [29.7] mL/m2 vs. 89.1 [21.9] mL/m2 ), and TAE (22.0 [3.2] cm vs. 26.0 [4.7] cm). Significant correlations were found between precontrast RV-T1 and RVEF (β = -0.48%/msec) and between LV-T1 and LVEF (β = -0.51%/msec).Data conclusionPrecontrast RV-T1 is elevated in boys with DMD compared to healthy controls and is negatively correlated with RVEF.Level of evidence1 TECHNICAL EFFICACY: Stage 2.

Published
2021

16. Recommendations for centers performing pediatric heart surgery in the United States

Author

Backer, Carl L., Overman, David M., Dearani, Joseph A., Romano, Jennifer C., Tweddell, James S., Kumar, S. Ram, Marino, Bradley S., Bacha, Emile A., Jaquiss, Robert D.B., Zaidi, Ali N., Gurvitz, Michelle, Costello, John M., Pierick, Trudy A., Ravekes, William J., Reagor, James A., St. Louis, James D., Spaeth, James, Mahle, William T., Shin, Andrew Y., Lopez, Keila N., Karamlou, Tara, Welke, Karl F., Bryant, Roosevelt, Husain, S. Adil, Chen, Jonathan M., Kaza, Aditya, Wells, Winfield J., Glatz, Andrew C., Cohen, Mitchell I., McElhinney, Doff B., Parra, David A., and Pasquali, Sara K.

Published
2023
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18. Risk Factors for Mortality and Circulatory Outcome Among Neonates Prenatally Diagnosed With Ebstein Anomaly or Tricuspid Valve Dysplasia: A Multicenter Study

Author

Freud, Lindsay R, McElhinney, Doff B, Kalish, Brian T, Escobar‐Diaz, Maria C, Komarlu, Rukmini, Puchalski, Michael D, Jaeggi, Edgar T, Szwast, Anita L, Freire, Grace, Levasseur, Stéphanie M, Kavanaugh‐McHugh, Ann, Michelfelder, Erik C, Moon‐Grady, Anita J, Donofrio, Mary T, Howley, Lisa W, Tierney, Elif Seda Selamet, Cuneo, Bettina F, Morris, Shaine A, Pruetz, Jay D, van der Velde, Mary E, Kovalchin, John P, Ikemba, Catherine M, Vernon, Margaret M, Samai, Cyrus, Satou, Gary M, Gotteiner, Nina L, Phoon, Colin K, Silverman, Norman H, and Tworetzky, Wayne

Subjects
Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Lung, Cardiovascular, Heart Disease, Infant Mortality, Clinical Research, Good Health and Well Being, Blood Flow Velocity, Ebstein Anomaly, Echocardiography, Female, Heart Valve Diseases, Hospital Mortality, Humans, Infant, Newborn, Logistic Models, Male, Perinatal Mortality, Prenatal Diagnosis, Retrospective Studies, Risk Factors, Tricuspid Valve, congenital heart disease, Ebstein anomaly, mortality, neonate, outcome, palliation, right ventricle, tricuspid regurgitation, Cardiorespiratory Medicine and Haematology
Abstract

Background In a recent multicenter study of perinatal outcome in fetuses with Ebstein anomaly or tricuspid valve dysplasia, we found that one third of live-born patients died before hospital discharge. We sought to further describe postnatal management strategies and to define risk factors for neonatal mortality and circulatory outcome at discharge. Methods and Results This 23-center, retrospective study from 2005 to 2011 included 243 fetuses with Ebstein anomaly or tricuspid valve dysplasia. Among live-born patients, clinical and echocardiographic factors were evaluated for association with neonatal mortality and palliated versus biventricular circulation at discharge. Of 176 live-born patients, 7 received comfort care, 11 died

Published
2020

20. Outcomes After Development of Ventricular Arrhythmias in Single Ventricular Heart Disease Patients With Fontan Palliation

Author

Giacone, Heather M., Chubb, Henry, Dubin, Anne M., Motonaga, Kara S., Ceresnak, Scott R., Goodyer, William R., Hanisch, Debra, Trela, Anthony V., Boramanand, Nicole, Lencioni, Erin, Boothroyd, Derek, Graber-Naidich, Anna, Wright, Gail, Haeffele, Christiane, Hollander, Seth A., McElhinney, Doff B., Ma, Michael, Hanley, Frank L., and Chen, Sharon

Published
2023
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21. Impact and Modifiers of Ventricular Pacing in Patients With Single Ventricle Circulation

Author

Chubb, Henry, Bulic, Anica, Mah, Douglas, Moore, Jeremy P., Janousek, Jan, Fumanelli, Jennifer, Asaki, S. Yukiko, Pflaumer, Andreas, Hill, Allison C., Escudero, Carolina, Kwok, Sit Yee, Mangat, Jasveer, Ochoa Nunez, Luis A., Balaji, Seshadri, Rosenthal, Eric, Regan, William, Horndasch, Michaela, Asakai, Hiroko, Tanel, Ronn, Czosek, Richard J., Young, Ming-Lon, Bradley, David J., Paul, Thomas, Fischbach, Peter, Malloy-Walton, Lindsey, McElhinney, Doff B., and Dubin, Anne M.

Published
2022
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25. Reintervention and Survival After Transcatheter Pulmonary Valve Replacement

Author

McElhinney, Doff B., Zhang, Yulin, Levi, Daniel S., Georgiev, Stanimir, Biernacka, Elżbieta Katarzyna, Goldstein, Bryan H., Shahanavaz, Shabana, Qureshi, Athar M., Cabalka, Allison K., Bauser-Heaton, Holly, Torres, Alejandro J., Morray, Brian H., Armstrong, Aimee K., Millan-Iturbe, Oscar, Peng, Lynn F., Aboulhosn, Jamil A., Rużyłło, Witold, Berger, Felix, Sondergaard, Lars, Schranz, Dietmar, Cheatham, John P., Jones, Thomas K., Ewert, Peter, and Schubert, Stephan

Published
2022
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30. Multicenter Study of Endocarditis After Transcatheter Pulmonary Valve Replacement

Author

McElhinney, Doff B., Zhang, Yulin, Aboulhosn, Jamil A., Morray, Brian H., Biernacka, Elżbieta Katarzyna, Qureshi, Athar M., Torres, Alejandro J., Shahanavaz, Shabana, Goldstein, Bryan H., Cabalka, Allison K., Bauser-Heaton, Holly, Georgiev, Stanimir, Berger, Felix, Millan-Iturbe, Oscar, Peng, Lynn F., Armstrong, Aimee K., Levi, Daniel S., Fronczak-Jakubczyk, Aneta, Sondergaard, Lars, Anderson, Jason H., Schranz, Dietmar, Jones, Thomas K., Cheatham, John P., Schubert, Stephan, and Ewert, Peter

Published
2021
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32. Durability of Aortic Homografts in Pulmonary Atresia and Major Aortopulmonary Collateral Arteries

Author

Ragheb, Daniel K., Martin, Elisabeth, Zhang, Yulin, Jaggi, Ayush, Asija, Ritu, Peng, Lynn F., Ma, Michael, Hanley, Frank L., and McElhinney, Doff B.

Abstract

Objectives:It is well-known that right ventricle-to-pulmonary artery homograft conduit durability is worse for smaller conduits and smaller/younger patients. However, there is limited literature on age and conduit-size specific outcomes, or on the role of conduit oversizing. Methods:Patients diagnosed with tetralogy of Fallot and major aortopulmonary collateral arteries undergoing right ventricular outflow tract (RVOT) reconstruction with a valved aortic homograft conduit from November 2001 through March 2023, at our institution were included. Conduits were grouped and evaluated by diameter, diameter Z-score, and patient age at implant. The primary time-related outcome was freedom from RVOT reintervention. Factors associated with freedom from time-related outcomes were assessed with univariable Cox regression analysis. Results:A total of 863 RVOT conduits were implanted in 722 patients. On multivariable analysis, younger age, male sex, Alagille syndrome, smaller diameter of the conduit, and smaller Z-score were associated with shorter freedom from reintervention. Among patients with smaller diameter conduits, larger Z-scores were associated with longer freedom from conduit reintervention (P< .001). Transcatheter interventions were commonly used to extend conduit lifespan across ages and conduit sizes. Conclusions:Larger conduit diameter, older age, and higher conduit Z-score were associated with longer freedom from reintervention in patients undergoing RVOT reconstruction in this cohort. Oversizing of conduits, even beyond a Z-score of 4, is generally appropriate.

Published
2024
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36. High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers

Author

Huang, Qianyang, Hao, Shiying, Yao, Xiaoming, You, Jin, Li, Xiao, Lai, Donghai, Han, Chunle, Schilling, James, Hwa, Kuo Yuan, Thyparambil, Sheeno, Whitin, John, Cohen, Harvey J., Chubb, Henry, Ceresnak, Scott R., McElhinney, Doff B., Wong, Ronald J., Shaw, Gary M., Stevenson, David K., Sylvester, Karl G., and Ling, Xuefeng B.

Published
2021
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38. Transcatheter Pulmonary Valve Replacement With the Sapien Prosthesis

Author

Shahanavaz, Shabana, Zahn, Evan M., Levi, Daniel S., Aboulhousn, Jamil A., Hascoet, Sebastien, Qureshi, Athar M., Porras, Diego, Morgan, Gareth J., Bauser Heaton, Holly, Martin, Mary Hunt, Keeshan, Britton, Asnes, Jeremy D., Kenny, Damien, Ringewald, Jeremy M., Zablah, Jenny E., Ivy, Margaret, Morray, Brian H., Torres, Alejandro J., Berman, Darren P., Gillespie, Matthew J., Chaszczewski, Kasey, Zampi, Jeffrey D., Walsh, Kevin P., Julien, Plessis, Goldstein, Bryan H., Sathanandam, Shyam K., Karsenty, Clement, Balzer, David T., and McElhinney, Doff B.

Published
2020
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41. Targeted multiplex validation of CSF proteomic biomarkers: implications for differentiation of PCNSL from tumor-free controls and other brain tumors.

Author

Jingjing Ma, Zhiguang Lin, Yaqi Zhang, Yun Ding, Qiming Tang, Yufeng Qian, Bo Jin, Luo, Ruben Y., Wei-Li Liao, Thyparambil, Sheeno, Zhi Han, Chou, C. James, Schilling, James, Qing Li, Mengxue Zhang, Yunan Lin, Yan Ma, Sylvester, Karl G., Nagpal, Seema, and McElhinney, Doff B.

Subjects
DIFFUSE large B-cell lymphomas, NON-Hodgkin's lymphoma, CENTRAL nervous system, BRAIN damage, SPINAL cord, BRAIN tumors
Abstract

Introduction: Primary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin's lymphoma that affects brain parenchyma, eyes, cerebrospinal fluid, and spinal cord. Diagnosing PCNSL can be challenging because imaging studies often show similar patterns as other brain tumors, and stereotactic brain lesion biopsy conformation is invasive and not always possible. This study aimed to validate a previous proteomic profiling (PMID: 32610669) of cerebrospinal fluid (CSF) and develop a CSF-based proteomic panel for accurate PCNSL diagnosis and differentiation. Methods: CSF samples were collected from patients of 30 PCNSL, 30 other brain tumors, and 31 tumor-free/benign controls. Liquid chromatography tandemmass spectrometry targeted proteomics analysis was used to establish CSF-based proteomic panels. Results: Final proteomic panels were selected and optimized to diagnose PCNSL from tumor-free controls or other brain tumor lesions with an area under the curve (AUC) of 0.873 (95%CI: 0.723-0.948) and 0.937 (95%CI: 0.807- 0.985), respectively. Pathways analysis showed diagnosis panel features were significantly enriched in pathways related to extracellular matrices-receptor interaction, focal adhesion, and PI3K-Akt signaling, while prion disease, mineral absorption and HIF-1 signaling were significantly enriched with differentiation panel features. Discussion: This study suggests an accurate clinical test panel for PCNSL diagnosis and differentiation with CSF-based proteomic signatures, which may help overcome the challenges of current diagnostic methods and improve patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Global metabolomics revealed deviations from the metabolic aging clock in colorectal cancer patients

Author

Zhang, Long, primary, Mo, Shaobo, additional, Zhu, Xiurui, additional, Chou, C. James, additional, Jin, Bo, additional, Han, Zhi, additional, Schilling, James, additional, Liao, Weili, additional, Thyparambil, Sheeno, additional, Luo, Ruben Y., additional, Whitin, John C., additional, Tian, Lu, additional, Nagpal, Seema, additional, Ceresnak, Scott R., additional, Cohen, Harvey J., additional, McElhinney, Doff B., additional, Sylvester, Karl G., additional, Gong, Yangming, additional, Fu, Chen, additional, Ling, Xuefeng B., additional, and Peng, Junjie, additional

Published
2024
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46. Unique Molecular Patterns Uncovered in Kawasaki Disease Patients with Elevated Serum Gamma Glutamyl Transferase Levels: Implications for Intravenous Immunoglobulin Responsiveness.

Author

Wang, Yue, Li, Zhen, Hu, Guang, Hao, Shiying, Deng, Xiaohong, Huang, Min, Ren, Miao, Jiang, Xiyuan, Kanegaye, John T, Ha, Kee-Soo, Lee, JungHwa, Li, Xiaofeng, Jiang, Xuejun, Yu, Yunxian, Tremoulet, Adriana H, Burns, Jane C, Whitin, John C, Shin, Andrew Y, Sylvester, Karl G, McElhinney, Doff B, Cohen, Harvey J, Ling, Xuefeng B, and Pediatric Emergency Medicine Kawasaki Disease Research Group

Subjects
Pediatric Emergency Medicine Kawasaki Disease Research Group, Neutrophils, Humans, Mucocutaneous Lymph Node Syndrome, Acute Disease, Reactive Oxygen Species, gamma-Glutamyltransferase, Sialyltransferases, Alanine Transaminase, C-Reactive Protein, Immunoglobulins, Intravenous, Odds Ratio, Risk Factors, Cohort Studies, Apoptosis, Gene Expression, Drug Resistance, Child, Preschool, Infant, Female, Male, Clinical Research, Genetics, 2.1 Biological and endogenous factors, Aetiology, General Science & Technology
Abstract

BackgroundResistance to intravenous immunoglobulin (IVIG) occurs in 10-20% of patients with Kawasaki disease (KD). The risk of resistance is about two-fold higher in patients with elevated gamma glutamyl transferase (GGT) levels. We sought to understand the biological mechanisms underlying IVIG resistance in patients with elevated GGT levels.MethodWe explored the association between elevated GGT levels and IVIG-resistance with a cohort of 686 KD patients (Cohort I). Gene expression data from 130 children with acute KD (Cohort II) were analyzed using the R square statistic and false discovery analysis to identify genes that were differentially represented in patients with elevated GGT levels with regard to IVIG responsiveness. Two additional KD cohorts (Cohort III and IV) were used to test the hypothesis that sialylation and GGT may be involved in IVIG resistance through neutrophil apoptosis.ResultsThirty-six genes were identified that significantly explained the variations of both GGT levels and IVIG responsiveness in KD patients. After Bonferroni correction, significant associations with IVIG resistance persisted for 12 out of 36 genes among patients with elevated GGT levels and none among patients with normal GGT levels. With the discovery of ST6GALNAC3, a sialyltransferase, as the most differentially expressed gene, we hypothesized that sialylation and GGT are involved in IVIG resistance through neutrophil apoptosis. We then confirmed that in Cohort III and IV there was significantly less reduction in neutrophil count in IVIG non-responders.ConclusionsGene expression analyses combining molecular and clinical datasets support the hypotheses that: (1) neutrophil apoptosis induced by IVIG may be a mechanism of action of IVIG in KD; (2) changes in sialylation and GGT level in KD patients may contribute synergistically to IVIG resistance through blocking IVIG-induced neutrophil apoptosis. These findings have implications for understanding the mechanism of action in IVIG resistance, and possibly for development of novel therapeutics.

Published
2016

47. Outcomes and Predictors of Perinatal Mortality in Fetuses With Ebstein Anomaly or Tricuspid Valve Dysplasia in the Current Era

Author

Freud, Lindsay R, Escobar-Diaz, Maria C, Kalish, Brian T, Komarlu, Rukmini, Puchalski, Michael D, Jaeggi, Edgar T, Szwast, Anita L, Freire, Grace, Levasseur, Stéphanie M, Kavanaugh-McHugh, Ann, Michelfelder, Erik C, Moon-Grady, Anita J, Donofrio, Mary T, Howley, Lisa W, Tierney, Elif Seda Selamet, Cuneo, Bettina F, Morris, Shaine A, Pruetz, Jay D, van der Velde, Mary E, Kovalchin, John P, Ikemba, Catherine M, Vernon, Margaret M, Samai, Cyrus, Satou, Gary M, Gotteiner, Nina L, Phoon, Colin K, Silverman, Norman H, McElhinney, Doff B, and Tworetzky, Wayne

Subjects
Paediatrics, Reproductive Medicine, Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Infant Mortality, Lung, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Congenital Structural Anomalies, Reproductive health and childbirth, Good Health and Well Being, Abortion, Eugenic, Adult, Birth Weight, Cardiac Catheterization, Cardiac Surgical Procedures, Down Syndrome, Ebstein Anomaly, Female, Gestational Age, Heart Defects, Congenital, Hospital Mortality, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Palliative Care, Pericardial Effusion, Pregnancy, Pregnancy Outcome, Retrospective Studies, Risk Factors, Treatment Outcome, Tricuspid Valve, Tricuspid Valve Insufficiency, Ultrasonography, Prenatal, Young Adult, Ebstein anomaly, echocardiography, heart defects, congenital, mortality, tricuspid valve insufficiency, heart defects, congenital, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Abstract

BackgroundEbstein anomaly and tricuspid valve dysplasia are rare congenital tricuspid valve malformations associated with high perinatal mortality. The literature consists of small, single-center case series spanning several decades. We performed a multicenter study to assess the outcomes and factors associated with mortality after fetal diagnosis in the current era.Methods and resultsFetuses diagnosed with Ebstein anomaly and tricuspid valve dysplasia from 2005 to 2011 were included from 23 centers. The primary outcome was perinatal mortality, defined as fetal demise or death before neonatal discharge. Of 243 fetuses diagnosed at a mean gestational age of 27±6 weeks, there were 11 lost to follow-up (5%), 15 terminations (6%), and 41 demises (17%). In the live-born cohort of 176 live-born patients, 56 (32%) died before discharge, yielding an overall perinatal mortality of 45%. Independent predictors of mortality at the time of diagnosis were gestational age

Published
2015

50. Mid-Term Valve-Related Outcomes After Transcatheter Tricuspid Valve-in-Valve or Valve-in-Ring Replacement

Author

Boudjemline, Younes, Milani, Guiti, Bocks, Martin L., Asnes, Jeremy D., Mahadevan, Vaikom, Himbert, Dominique, Goldstein, Bryan H., Fagan, Thomas E., Cheatham, John P., Momenah, Tarek S., Kim, Dennis W., Colombo, Antonio, Ancona, Marco, Butera, Gianfranco, Forbes, Thomas J., Horlick, Eric, Pedra, Carlos, Alfonsi, Jacopo, Jones, Thomas K., Foerster, Susan, Shahanavaz, Shabana, Crittendon, Ivory, Schranz, Dietmar, Qureshi, Athar, Thomas, Martyn, Kenny, Damien P., Hoyer, Mark, Bleiziffer, Sabine, Kefer, Joelle, Testa, Luca, Gillespie, Matthew, Khan, Danyal, Pass, Robert H., Abdel-Wahab, Mohamed, Wijeysundera, Harindra, Casselman, Filip, Moe, Tabitha, Hayes, Nicholas, Alli, Oluseun, Nayak, Keshav R., Patel, Priti, Piazza, Nicolo, Seaman, Cameron, Windecker, Stephan, Kuo, James, Ing, Frank F., Makkar, Raj R., Greif, Martin, Cerillio, Alfredo G., Champagnac, Didier, Nietlispach, Fabian, Maisano, Francesco, Treede, Hendrik, Seiffert, Moritz, Teles, Rui Campante, Feuchtner, Gudrun, Bonaros, Nikolaos, Bruschi, Giuseppe, Pesarini, Gabriele, McElhinney, Doff B., Aboulhosn, Jamil A., Dvir, Danny, Whisenant, Brian, Zhang, Yulin, Eicken, Andreas, Ribichini, Flavio, Tzifa, Aphrodite, Hainstock, Michael R., Martin, Mary H., Kornowski, Ran, Schubert, Stephan, Latib, Azeem, Thomson, John D.R., Torres, Alejandro J., Meadows, Jeffery, Delaney, Jeffrey W., Guerrero, Mayra E., Salizzoni, Stefano, El-Said, Howaida, Finkelstein, Ariel, George, Isaac, Gewillig, Marc, Alvarez-Fuente, Maria, Lamers, Luke, Cheema, Asim N., Kreutzer, Jacqueline N., Rudolph, Tanja, Hildick-Smith, David, and Cabalka, Allison K.

Published
2019
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