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1. Defining a longevity biotechnology company

Author

Boekstein, Nicola, Barzilai, Nir, Bertram, André, Betts-LaCroix, Joe, Fortney, Kristen, Helliwell, Stephen B., Hufford, Michael, Mannick, Joan, McLaughlin, Jerry, Mellon, Jim, Morgen, Eric, Regge, Nils, Robinton, Daisy A., Sinclair, David A., Young, Sergey, Starr, Risa, Zhavoronkov, Alex, and Peyer, James

Published
2023
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2. Longevity biotechnology:bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Author

Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, Bakula, Daniela, Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, and Bakula, Daniela

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Published
2024

4. Counselor Identity: Conformity or Distinction?

Author

McLaughlin, Jerry E. and Boettcher, Kathryn

Abstract

The authors explore 3 debates in other disciplines similar to counseling's identity debate in order to learn about common themes and outcomes. Conformity, distinction, and cohesion emerged as common themes. They conclude that counselors should retain their distinctive, humanistic approach rather than conforming to the dominant, medical approach.

Published
2009

5. The Pros and Cons of Viewing Formal Diagnosis from a Social Constructionist Perspective

Author

McLaughlin, Jerry E.

Abstract

Over the last few years, counselor training has focused more on formal diagnosis, but this increased focus has been questioned. In the end, the question seems less about whether formal diagnosis will be taught and more about how it will be taught. The author argues that diagnosis should be taught from a social constructionist rather than an objectivist perspective because of the former perspective's humanistic focus.

Published
2006

7. Reducing Diagnostic Bias.

Author

McLaughlin, Jerry E.

Abstract

Skill using the American Psychiatric Association's 2000 "Diagnostic and Statistical Manual of Mental Disorders, Text Revision" is essential for increased professional credibility, career marketability, and third-party reimbursement of professional counselors. This article focuses on how to improve counselors' skill with the manual, by providing definitions, empirical demonstrations, and strategies for reducing three forms of bias that can lead to misdiagnosis. (Contains 74 references.) (Author)

Published
2002

11. Resveratrol is rapidly metabolized in athymic (Nu/Nu) mice and does not inhibit human melanoma xenograft tumor growth

Author

Niles, Richard M., Cook, Carla P., Meadows, Gary G., Fu, Ya-Min, McLaughlin, Jerry L., and Rankin, Gary O.

Subjects
Melanoma -- Prevention, Transforming growth factors -- Analysis, Cancer -- Research, Oncology, Experimental, Food/cooking/nutrition
Abstract

Resveratrol has been shown to have anticarcinogenic activity. We previously found that resveratrol inhibited growth and induced apoptosis in 2 human melanoma cell lines. In this study we determined whether resveratrol would inhibit human melanoma xenograft growth. Athymic mice received control diets or diets containing 110 [micro]mol/L or 263 [micro]mol/L resveratrol, 2 wk prior to subcutaneous injection of the tumor cells. Tumor growth was measured during a 3-wk period. Metabolism of resveratrol was assayed by bolus gavage of 75 mg/kg resveratrol in tumor-bearing and nontumor-bearing mice. Pellets containing 10-100 mg resveratrol were implanted into the mice, next to newly palpated tumors, and tumor growth determined. We also determined the effect of a major resveratrol metabolite, piceatannol, on experimental lung metastasis. Resveratrol, at any concentration tested, did not have a statistically significant effect on tumor growth. The higher levels of resveratrol tested (0.006% in food or 100mg in slow-release pellets) tended to stimulate tumor growth (P = 0.08-0.09). Resveratrol and its major metabolites, resveratrol glucuronide and piceatannol, were found in serum, liver, skin, and tumor tissue. Piceatannol did not affect the in vitro growth of a murine melanoma cell line, but significantly stimulated the number of lung metastases when these melanoma cells were directly injected into the tail vein of the mouse. These results suggest that resveratrol is not likely to be useful in the treatment of melanoma and that the effects of phytochemicals on cell cultures may not translate to the whole animal system.

Published
2006

13. Contributors

Author

Ackerman, Veda L., primary, Adelson, P. David, additional, Agbeko, Rachel S., additional, Almodovar, Melvin C., additional, Alonso, Estella M., additional, Aneja, Raj K., additional, Angus, Derek C., additional, Argent, Andrew C., additional, Aspesberro, Francois P., additional, Bakar, Adnan M., additional, Bambach, Barbara, additional, Bass, Lee M., additional, Bayir, Hülya, additional, Beaulieu, Pierre, additional, Bell, Michael J., additional, Bender, M.A., additional, Benson, Jeffrey C., additional, Benton, Wade W., additional, Berg, Robert A., additional, Berkowitz, Darryl H., additional, Bhutta, Omar J., additional, Biagas, Katherine C., additional, Blatt, Julie, additional, Blowey, Douglas L., additional, Blumer, Jeffrey L., additional, Bradley, John S, additional, Brandom, Barbara W., additional, Brodsky, Linda, additional, Brogan, Thomas V., additional, Brothers, Adam W., additional, Bunchman, Timothy E., additional, Burd, Randall S., additional, Burns, Jeffrey, additional, Bush, Sean P., additional, Bystrak, Louis L., additional, Campbell, Angela J.P., additional, Cannavino, Christopher R., additional, Carcillo, Joseph A., additional, Carrillo-Lopez, Hector, additional, Cassara, Antonio, additional, Caty, Michael G., additional, Charpie, John R., additional, Chavez, Adrian, additional, Christenson, John C., additional, Clark, Jonna D., additional, Clark, Robert S.B., additional, Clement, Katherine C., additional, Coalson, Jacqueline J., additional, Coopersmith, Craig M., additional, Coppola, Christopher P., additional, Corey, Seth J., additional, Cox, Peter N., additional, Cummings, James J., additional, Curley, Martha A.Q., additional, Czosnyka, Marek, additional, D’Angelis, Christopher A., additional, Dahmer, Mary K., additional, Dalton, Heidi J., additional, Davis, Peter J., additional, Morena, M. Theresa de la, additional, Oliveira, Cláudio Flauzino de, additional, Dhanani, Sonny, additional, Dobyns, Emily L., additional, Donner, Elizabeth J., additional, Doughty, Lesley, additional, Dreyfuss, Didier, additional, Duncan, Christine, additional, Durand, Philippe, additional, Duthie, Susan, additional, Eigen, Howard, additional, Maamoun El-Dawy, Waleed M., additional, Elliott, Steven, additional, Emery, Helen M., additional, Escobar, Mauricio A., additional, Evans, Jacqueline M., additional, Felmet, Kate, additional, Fineman, Jeffrey R., additional, Fink, Ericka L., additional, Fiser, Richard T., additional, Fish, Frank A., additional, Fletcher, James E., additional, Forbes, Michael J., additional, Fort, Amber E., additional, Fost, Norman, additional, Frader, Joel E., additional, Franzon, Deborah E., additional, Fricker, F. Jay, additional, Friess, Stuart, additional, Fuhrman, Bradley P., additional, Garcia-Casal, Xiomara, additional, Gauvin, France, additional, Gaynor, J. William, additional, Gilad, Eli, additional, Gilbert, James C., additional, Glaser, Nicole S., additional, Goldstein, Stuart L., additional, Goodman, Denise M., additional, Graciano, Ana Lía, additional, Gunnarsson, Björn, additional, Hahn, Cecil D., additional, Hall, Mark, additional, Hamilton, Melinda Fiedor, additional, Han, Yong Y., additional, Hanson, Cherissa, additional, Harding, Cary O., additional, Hartman, Mary E., additional, Hazelzet, Jan A., additional, Heard, Christopher M.B., additional, Heine, Ann Marie, additional, Hernan, Lynn J., additional, Hertzig, Jeremy S., additional, Heulitt, Mark J., additional, Hoffman, Julien I.E., additional, Huhta, James C., additional, Ichord, Rebecca, additional, Inglis, Andrew, additional, Linggi Irby, Gretchen A., additional, Jacobs, Brian, additional, Jardine, David, additional, Jarillo-Quijada, Alberto, additional, Javouey, Etienne, additional, Jefferis Kirk, Christa C., additional, Johns, James A., additional, Joshi, Prashant, additional, Kagan, Richard J., additional, Kannankeril, Prince J., additional, Kanter, Robert K., additional, Karam, Oliver, additional, Kasten, Kevin R., additional, Kelly, Michael, additional, Khanna, Paritosh C., additional, Kochanek, Patrick M., additional, Kocis, Keith C., additional, Kocoshis, Samuel A., additional, Koves, Ildiko H., additional, Kulik, Thomas J., additional, Kumar, Vasanth H., additional, Lacroix, Jacques, additional, Lakshminrusimha, Satyan, additional, Langley, Joanne M., additional, Laussen, Peter C., additional, Levin, Daniel L., additional, Lewis-Newby, Mithya, additional, Lieh-Lai, Mary W., additional, Lindsey, Daphne, additional, Litalien, Catherine, additional, Lynch, Robert E., additional, Makley, Amy T., additional, Marcin, James P., additional, Mariscalco, Mary Michele, additional, Markovitz, Barry, additional, Martin, Lynn D., additional, Maxvold, Norma J., additional, Mazur, Paula M., additional, McArthur, Jennifer A., additional, McLaughlin, Jerry, additional, McLaughlin, Gwenn E., additional, Redwine, Karen McNiece, additional, Mehta, Nilesh M., additional, Mehta, Renuka, additional, Melvin, Ann J., additional, Menon, Sharad, additional, Mian, Ayesa N., additional, Michelson, Kelly, additional, Michienzi, Kelly A., additional, Moloney-Harmon, Patricia A., additional, Monagle, Paul, additional, Moss, Michele M., additional, Mou, Steven S., additional, Muenzer, Jared T., additional, Nadkarni, Vinay, additional, Nakagawa, Thomas A., additional, Naran, Navyn, additional, Nguyen, Trung, additional, Nicholson, Carol E., additional, Nielsen, Katie R., additional, Northway, Tracie, additional, Norwood, Victoria F., additional, Notterman, Daniel A., additional, Nowak, Jeffrey E., additional, Oishi, Peter, additional, Orr, Richard A., additional, Ouellette, Yves, additional, Parakininkas, Daiva, additional, Parker, Margaret M., additional, Pearson-Shaver, Tony, additional, Pérez Fontán, J. Julio, additional, Peters, Mark, additional, Pihoker, Catherine, additional, Pinsk, Maury N., additional, Pollack, Murray M., additional, Pon, Steven, additional, Quasney, Michael, additional, Rajasekaran, Surender, additional, Rampersad, Sally E., additional, Ranjit, Suchitra, additional, Reade, Erin P., additional, Reese Jr., James J., additional, Relvas, Monica, additional, Remy, Kenneth E., additional, Ricard, Jean-Damien, additional, Rice, Tom B., additional, Ridling, Debra Ann, additional, Roberts, Joan S., additional, Ross, Ashley S., additional, Roth, Kimberly R., additional, Rotta, Alexandre T., additional, Rowin, Mark E., additional, Roy, John, additional, Rubino, Christopher M., additional, Ruppel, Randall A., additional, Rushton, Cynda H., additional, Ryan, Rita M., additional, Salonia, Rosanne, additional, Salvin, Joshua, additional, Sanders Jr., Ronald C., additional, Sarnaik, Ajit A., additional, Sarnaik, Ashok P., additional, Saumon, Georges, additional, Sawin, Robert, additional, Scanlon, Matthew C., additional, Schenkman, Kenneth A., additional, Schexnayder, Stephen M., additional, Schleien, Charles L., additional, Schwartz, George J., additional, Schwartz, Steven M., additional, Shann, Frank, additional, Shaw, Dennis W.W., additional, Shemie, Sam D., additional, Shoykhet, Mish, additional, Sivarajan, V. Ben, additional, Skippen, Peter W., additional, Slonim, Anthony D., additional, Smith, Laurie, additional, Smith, Lincoln S., additional, Standage, Stephen W., additional, Steinberg, Joel B., additional, Steinhorn, David M., additional, Stojanovski, Sasko D., additional, Storm, Elizabeth A., additional, Stroud, Michael H., additional, Sturgill, Marc G., additional, Sutton, Robert M., additional, Symons, Jordan M., additional, Tailounie, Muayyad, additional, Talano, Julie-An, additional, Tamburro Jr., Robert, additional, Tasker, Robert C., additional, Thompson, Ann E., additional, Tilton, Ann H., additional, Tinmouth, Alan, additional, Tobias, Joseph D., additional, Tobin, Nicole H., additional, Todres, I. David, additional, Tucci, Marisa, additional, Ulate, Kalia P., additional, Valentine, Kevin M., additional, Vaughan, David J., additional, Venkataraman, Shekhar T., additional, Visoiu, Mihaela, additional, von Saint André–von Arnim, Amélie, additional, Wainwright, Mark S., additional, Wakeham, Martin K., additional, Watson, R. Scott, additional, Webb, Ashley N., additional, Weigle, Carl, additional, Weimer, Maria B., additional, Wessel, David L., additional, Wetzel, Randall C., additional, Wong, Hector R., additional, Wood, Ellen G., additional, Woolf, Alan D., additional, Woytash, James J., additional, Yanay, Ofer, additional, Zaritsky, Arno, additional, Zerr, Danielle M., additional, and Zimmerman, Jerry J., additional

Published
2011
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14. Cellular Respiration

Author

Zimmerman, Jerry J., primary, von Saint André-von Arnim, Amélie, additional, and McLaughlin, Jerry, additional

Published
2011
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16. Identification of cytotoxic agent in kombucha herbal medicine

Author

DiGeorgio, Susan and McLaughlin, Jerry L.

Subjects
Antineoplastic agents -- Physiological aspects, Medicine, Herbal -- Adverse and side effects, Medicine, Botanic -- Adverse and side effects, Botany, Medical -- Research, Fungi -- Physiological aspects, Health
Published
2000

19. New bioactive steroids from Melia volkensii

Author

Rogers, Lingling L., Zeng, Lu, and McLaughlin, Jerry L.

Subjects
Steroids (Drugs) -- Research, Biological sciences, Chemistry
Abstract

Several bioactive steroidal compounds isolated from the 'Melia volkensii' family are presented. The compounds (E)-volkendousin, 2,19-oxymeliavosin and (Z)-volkendousin were isolated as white needles. On the other hand, meliavosin was isolated as white prisms. Test showed the activeness and cytotoxicity of (E)-volkendousin and the relatively weak activities of the remaining compounds.

Published
1998

20. Membrane conformations and their relation to cytotoxicity of asimicin and its analogues

Author

Shimada, Hiroko, Grutzner, John B., Kozlowski, John F., and McLaughlin, Jerry L.

Subjects
Cell-mediated cytotoxicity -- Research, Proteins -- Structure, Conformational analysis -- Research, Biological sciences, Chemistry
Abstract

A study was conducted on membrane conformations in relation to cytotoxicity of asimicin and its analogues. The results indicate that the tetrahydrofuran (THF) rings of acetogenins are located near the polar interfacial head group region of the DMPC. The findings also suggest that an asimicin-type acetogenin can either exhibit sickle-shaped or U-shaped conformations, depending on the length of the alkyl chain between the lactone ring and the THF rings.

Published
1998

21. Thwarting Resistance

Author

Oberlies, Nicholas, primary, Alali, Feras, additional, McLaughlin, Jerry, additional, and Johnson, Holly, additional

Published
1999
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22. Determining absolute configurations of stereocenters in annonaceous acetogenins through formaldehyde acetal derivatives and Mosher ester methodology

Author

Gu, Zhe-ming, Zeng, Lu, Fang, Xin-ping, Colman-Saizarbitoria, Trina, Huo, Mei, and McLaughlin, Jerry L.

Subjects
Lactones -- Research, Stereochemistry -- Analysis, Biological sciences, Chemistry
Abstract

NMR studies of formaldehyde acetal derivatives of annonaceous acetogenins that have diols in their aliphatic chains help determine relative stereochemistries of two stereogenic centers that evolve from the diols. Synthesis of per-Mosher ester derivatives of the acetals helps determine the absolute configurations of chiral positions that have other hydroxyl groups.

Published
1994

23. Gonionenin: a new cytotoxic annonaceous acetogenin from Goniothalamus giganteus and the conversion of mono-THF acetogenins to bis-THF acetogenins

Author

Gu, Zhe-ming, Fang, Xin-ping, Zeng, Lu, Song, Rong, Ng, Jocelyn H., Wood, Karl V., Smith, David L., and McLaughlin, Jerry L.

Subjects
Antineoplastic agents -- Research, Ring formation (Chemistry) -- Analysis, Biological sciences, Chemistry
Abstract

A new mono-THF acetogenin, gonionenin, which has a double bond in the aliphatic chain, is isolated from the bark of Goniothalamus giganteus. Mono-THF acetogenins are converted into bis-THF Annonaceous acetogenins with epoxidation and cyclization. The bis-THF compounds exhibit more bioactivities than the parent compounds. The facile reactions give high yields.

Published
1994

24. Reducing diagnostic bias. (Practice)

Author

McLaughlin, Jerry E.

Subjects
Practice, Prevention, Diagnostic errors -- Prevention, Mental health counseling -- Practice, Psychiatric counseling -- Practice
Abstract

Skill using the American Psychiatric Association's (2000) Diagnostic and Statistical Manual of Mental Disorders, Text Revision is essential for the increased professional credibility, career marketability, and third-party reimbursement of professional [...]

Published
2002

25. Determination of absolute configuration of stereogenic carbinol centers in annonaceous acetogenins by 1H- and 19F-NMR analysis of Mosher ester derivatives

Author

Rieser, Matthew J., Hui, Yu-hua, Rupprecht, J. Kent, Kozlowski, John F., Wood, Karl V., McLaughlin, Jerry L., Hanson, Paul R., and Zhiping Zhuang

Subjects
Methanol -- Analysis, Nuclear magnetic resonance spectroscopy -- Usage, Chemistry
Abstract

The absolute configuration of stereogenic carbinol centers in several annonaceous acetogenins was determined by 1H- and 19F-nuclear magnetic resonance analysis of Mosher ester derivatives. These acetogenins include five adjacent bis-tetrahydrofuran acetogenins (uvaricin, bullatacin, bullatacinone, asimicin and rolliniastatin 1) and four mono-tetrahydrofuran acetogenins (reticulatacin, isoannonacin-10-one, annonacin-10-one and annonacin). The configuration at the C(4) carbinol center in the acetogenins examined is R.

Published
1992

26. Annonaceous Acetogenins

Author

Gu, Zhe-Ming, primary, Zhao, Geng-Xian, additional, Oberlies, Nicholas H., additional, Zeng, Lu, additional, and McLaughlin, Jerry L., additional

Published
1995
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34. Healthy mind, healthy body: promote the healthy employee and organization

Author

McLaughlin, Jerry

Subjects
Employers, Wellness programs, Employee incentives, Business, Human resources and labor relations
Abstract

The investment in employee health is essential to long-term growth, lower costs, and improved productivity. According to MetLife's 8th annual 'Study of Employee Benefits Trends,' released in April, 37 percent [...]

Published
2010

36. City of Regeneration.

Author

McLaughlin, Jerry

Subjects
AIR forces, BOMBERS (Airplanes)
Published
2018

37. Muconin and mucoxin: additional nonclassical bioactive acetogenins from Rollinia mucosa

Author

Shi, Guoen, Kozlowski, John F., Schwedler, Jon T., Wood, Karl V., MacDougal, John M., and McLaughlin, Jerry L.

Subjects
Cancer -- Cytopathology, Biological sciences, Chemistry
Abstract

An acetogenin closely related to mucocin, the first tetrahydropyran (THP) ring-bearing acetogenin, that has an unsubstituted THP ring and an adjacent tetrahydrofuran ring (THF) has been isolated from Rollinia mucosa. Called muconin, it provides further proof of the existence of a new acetogenin type with THP ring(s) as the most significant structural characteristic. Mucoxin, the first acetogenin with a hydroxylated THF ring, is also reported. Muconin showed potent and selective in vitro cytotoxicities against pancreatic cancer and breast cancer (MCF-7) in a group of six human solid tumor cell lines. Mucoxin showed selective inhibition against MCF-7 in the same test run.

Published
1996

38. Mucocin: a new annonaceous acetogenin bearing a tetrahydropyran ring

Author

Shi, Guoen, Alfonso, Dorothee, Fatope, Majekodunmi O., Zeng, Lu, Gu, Zhe-ming, Zhao, Geng-xian, He, Kan, MacDougal, John M., and McLaughlin, Jerry L.

Subjects
Biomolecules -- Research, Conformational analysis -- Evaluation, Nuclear magnetic resonance -- Usage, Chemistry
Abstract

The research of the structure and bioactivity of mucocin indicates the first annonaceous acetogenin to bear a hydroxylated tetrahydropyran (THP) ring and a tetrahydrofuran (THF) ring. The NMR data reveal the trans configuration of the THF ring, and the presence of methylated alpha, beta-unsaturated gamma-lactone with a 4-OH. DEPT experiments reveals the existence of two methyl, ten methine and two quaternary carbons in acetogenin. The absolute stereochemistry of mucocin analyzed by the advanced Mosher ester methodology indicates absolute configurations are R, R and S at C-23, C-4 and C-36.

Published
1995

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