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2. Enterovirus D68-Associated Acute Respiratory Illness — New Vaccine Surveillance Network, United States, July–November 2018–2020

Author

Shah, Melisa M., Perez, Ariana, Lively, Joana Y., Avadhanula, Vasanthi, Boom, Julie A., Chappell, James, Englund, Janet A., Fregoe, Wende, Halasa, Natasha B., Harrison, Christopher J., Hickey, Robert W., Klein, Eileen J., McNeal, Monica M., Michaels, Marian G., Moffatt, Mary E., Otten, Catherine, Sahni, Leila C., Schlaudecker, Elizabeth, Schuster, Jennifer E., Selvarangan, Rangaraj, Staat, Mary A., Stewart, Laura S., Weinberg, Geoffrey A., Williams, John V., Ng, Terry Fan Fei, Routh, Janell A., Gerber, Susan I., McMorrow, Meredith L., Rha, Brian, and Midgley, Claire M.

Published
2021

3. Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants

Author

Church, James A, Rukobo, Sandra, Govha, Margaret, Gough, Ethan K, Chasekwa, Bernard, Lee, Benjamin, Carmolli, Marya P, Panic, Gordana, Giallourou, Natasa, Ntozini, Robert, Mutasa, Kuda, McNeal, Monica M, Majo, Florence D., Tavengwa, Naume V., Swann, Jonathan R., Moulton, Lawrence H, Kirkpatrick, Beth D, Humphrey, Jean H, and Prendergast, Andrew J

Published
2021
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4. Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Author

Bowen, Michael D, Mijatovic-Rustempasic, Slavica, Esona, Mathew D, Teel, Elizabeth N, Gautam, Rashi, Sturgeon, Michele, Azimi, Parvin H, Baker, Carol J, Bernstein, David I, Boom, Julie A, Chappell, James, Donauer, Stephanie, Edwards, Kathryn M, Englund, Janet A, Halasa, Natasha B, Harrison, Christopher J, Johnston, Samantha H, Klein, Eileen J, McNeal, Monica M, Moffatt, Mary E, Rench, Marcia A, Sahni, Leila C, Selvarangan, Rangaraj, Staat, Mary A, Szilagyi, Peter G, Weinberg, Geoffrey A, Wikswo, Mary E, Parashar, Umesh D, and Payne, Daniel C

Subjects
Prevention, Vaccine Related, Clinical Research, Pediatric, Immunization, Infectious Diseases, Good Health and Well Being, Child, Child, Preschool, Epidemiological Monitoring, Female, Genotype, Humans, Infant, Male, Rotavirus, Rotavirus Infections, Rotavirus Vaccines, United States, rotavirus, genotype, prevalence, surveillance, vaccine, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundGroup A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006.MethodsOver 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping.ResultsIn the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype.ConclusionsContinued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.

Published
2016

6. Understanding Variation in Rotavirus Vaccine Effectiveness Estimates in the United States: The Role of Rotavirus Activity and Diagnostic Misclassification

Author

Amin, Avnika B., Lash, Timothy L., Tate, Jacqueline E., Waller, Lance A., Wikswo, Mary E., Parashar, Umesh D., Stewart, Laura S., Chappell, James D., Halasa, Natasha B., Williams, John V., Michaels, Marian G., Hickey, Robert W., Klein, Eileen J., Englund, Janet A., Weinberg, Geoffrey A., Szilagyi, Peter G., Staat, Mary Allen, McNeal, Monica M., Boom, Julie A., Sahni, Leila C., Selvarangan, Rangaraj, Harrison, Christopher J., Moffatt, Mary E., Schuster, Jennifer E., Pahud, Barbara A., Weddle, Gina M., Azimi, Parvin H., Johnston, Samantha H., Payne, Daniel C., Bowen, Michael D., and Lopman, Benjamin A.

Published
2022
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7. Endemic Coronavirus Infections are Associated with Strong Homotypic Immunity in a US Cohort of Children from Birth to 4 Years

Author

Morrow, Ardythe L, primary, Payne, Daniel C, additional, Conrey, Shannon C, additional, McMorrow, Meredith, additional, McNeal, Monica M, additional, Niu, Liang, additional, Burrell, Allison R, additional, Schlaudecker, Elizabeth P, additional, Mattison, Claire, additional, Burke, Rachel M, additional, DeFranco, Emily, additional, Teoh, Zheyi, additional, Wrammert, Jens, additional, Atherton, Lydia J, additional, Thornburg, Natalie J, additional, and Staat, Mary A, additional

Published
2024
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8. mRNA-Based Vaccines Are Highly Immunogenic and Confer Protection in the Gnotobiotic Pig Model of Human Rotavirus Diarrhea

Author

Hensley, Casey, primary, Roier, Sandro, additional, Zhou, Peng, additional, Schnur, Sofia, additional, Nyblade, Charlotte, additional, Parreno, Viviana, additional, Frazier, Annie, additional, Frazier, Maggie, additional, Kiley, Kelsey, additional, O’Brien, Samantha, additional, Liang, Yu, additional, Mayer, Bryan T., additional, Wu, Ruizhe, additional, Mahoney, Celia, additional, McNeal, Monica M., additional, Petsch, Benjamin, additional, Rauch, Susanne, additional, and Yuan, Lijuan, additional

Published
2024
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12. Rotavirus-Specific Immunoglobulin A Responses Are Impaired and Serve as a Suboptimal Correlate of Protection Among Infants in Bangladesh

Author

Lee, Benjamin, Carmolli, Marya, Dickson, Dorothy M., Colgate, E. Ross, Diehl, Sean A., Uddin, Muhammad Ikhtear, Islam, Shahidul, Hossain, Motaher, Rafique, Tanzeem Ahmed, Bhuiyan, Taufiqur Rahman, Alam, Masud, Nayak, Uma, Mychaleckyj, Josyf C., McNeal, Monica M., Petri, William A., Qadri, Firdausi, Haque, Rashidul, and Kirkpatrick, Beth D.

Published
2018

13. Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis in US Mothers and Children Aged 0-2: PREVAIL Cohort Study

Author

Morrow, Ardythe L, Staat, Mary A, DeFranco, Emily A, McNeal, Monica M, Cline, Allison R, Conrey, Shannon C, Schlaudecker, Elizabeth P, Piasecki, Alexandra M, Burke, Rachel M, Niu, Liang, Hall, Aron J, Bowen, Michael D, Gerber, Susan I, Langley, Gayle E, Thornburg, Natalie J, Campbell, Angela P, Vinjé, Jan, Parashar, Umesh D, and Payne, Daniel C

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundAcute gastroenteritis (AGE) and acute respiratory infections (ARIs) cause significant pediatric morbidity and mortality. Developing childhood vaccines against major enteric and respiratory pathogens should be guided by the natural history of infection and acquired immunity. The United States currently lacks contemporary birth cohort data to guide vaccine development. ObjectiveThe PREVAIL (Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis Longitudinal) Cohort study was undertaken to define the natural history of infection and immune response to major pathogens causing AGE and ARI in US children. MethodsMothers in Cincinnati, Ohio, were enrolled in their third trimester of pregnancy, with intensive child follow-up to 2 years. Blood samples were obtained from children at birth (cord), 6 weeks, and 6, 12, 18, and 24 months. Whole stool specimens and midturbinate nasal swabs were collected weekly and tested by multipathogen molecular assays. Saliva, meconium, maternal blood, and milk samples were also collected. AGE (≥3 loose or watery stools or ≥1 vomiting episode within 24 hours) and ARI (cough or fever) cases were documented by weekly cell phone surveys to mothers via automated SMS text messaging and review of medical records. Immunization records were obtained from registries and providers. follow-up ended in October 2020. Pathogen-specific infections are defined by a PCR-positive sample or rise in serum antibody. ResultsOf the 245 enrolled mother–child pairs, 51.8% (n=127) were White, 43.3% (n=106) Black, 55.9% (n=137) publicly insured, and 86.5% (n=212) initiated breastfeeding. Blood collection was 100.0% for mothers (n=245) and 85.7% for umbilical cord (n=210). A total of 194/245 (79.2%) mother–child pairs were compliant based on participation in at least 70% (≥71/102 study weeks) of child-weeks and providing 70% or more of weekly samples during that time, or blood samples at 18 or 24 months. Compliant participants (n=194) had 71.0% median nasal swab collection (IQR 30.0%-90.5%), with 98.5% (191/194) providing either an 18- or 24-month blood sample; median response to weekly SMS text message surveys was 95.1% (IQR 76.5%-100%). Compliant mothers reported 2.0 AGE and 4.5 ARI cases per child-year, of which 25.5% (160/627) and 38.06% (486/1277) of cases, respectively, were medically attended; 0.5% of AGE (3/627) and 0.55% of ARI (7/1277) cases were hospitalized. ConclusionsThe PREVAIL Cohort demonstrates intensive follow-up to document the natural history of enteric and respiratory infections and immunity in children 0-2 years of age in the United States and will contribute unique data to guide vaccine recommendations. Testing for pathogens and antibodies is ongoing. International Registered Report Identifier (IRRID)RR1-10.2196/22222

Published
2021
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14. Respiratory Virus Surveillance Among Children with Acute Respiratory Illnesses--New Vaccine Surveillance Network, United States, 2016-2021

Author

Perez, Ariana, Lively, Joana Y., Curns, Aaron, Weinberg, Geoffrey A., Halasa, Natasha B., Staat, Mary Allen, Szilagyi, Peter G., Stewart, Laura S., McNeal, Monica M., Clopper, Benjamin, Zhou, Yingtao, Whitaker, Brett L., LeMasters, Elizabeth, Harker, Elizabeth, Englund, Janet A., Klein, Eileen J., Selvarangan, Rangaraj, Harrison, Christopher J., Boom, Julie A., Sahni, Leila C., Michaels, Marian G., Williams, John V., Langley, Gayle E., Gerber, Susan I., Campbell, Angela, Hall, Aron J., Rha, Brian, MD, and McMorrow, Meredith

Subjects
University of Rochester. School of Medicine and Dentistry, Baylor College of Medicine, Diseases, Influenza vaccines, Medical centers, Medical research, Influenza, Vaccination, COVID-19, Medicine, Experimental
Abstract

The New Vaccine Surveillance Network (NVSN) is a prospective, active, population-based surveillance platform that enrolls children with acute respiratory illnesses (ARIs) at seven pediatric medical centers. ARIs are caused by [...]

Published
2022

18. Enteropathogens and Rotavirus Vaccine Immunogenicity in a Cluster Randomized Trial of Improved Water, Sanitation and Hygiene in Rural Zimbabwe

Author

Church, James A., Rogawski McQuade, Elizabeth T., Mutasa, Kuda, Taniuchi, Mami, Rukobo, Sandra, Govha, Margaret, Lee, Benjamin, Carmolli, Marya P., Chasekwa, Bernard, Ntozini, Robert, McNeal, Monica M., Moulton, Lawrence H., Kirkpatrick, Beth D., Liu, Jie, Houpt, Eric R., Humphrey, Jean H., Platts-Mills, James A., and Prendergast, Andrew J.

Published
2019
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19. Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation

Author

Iqbal, Najeeha T., Syed, Sana, Sadiq, Kamran, Khan, Marium N., Iqbal, Junaid, Ma, Jennie Z., Umrani, Fayaz, Ahmed, Sheraz, Maier, Elizabeth A., Denson, Lee A., Haberman, Yael, McNeal, Monica M., Setchell, Kenneth D. R., Zhao, Xueheng, Qureshi, Shahida, Shen, Lanlan, Moskaluk, Christopher A., Liu, Ta-Chiang, Yilmaz, Omer, Brown, Donald E., Barratt, Michael J., Kung, Vanderlene L., Gordon, Jeffrey I., Moore, Sean R., and Ali, S. Asad

Published
2019
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24. Sustained Within-season Vaccine Effectiveness Against Influenza-associated Hospitalization in Children: Evidence From the New Vaccine Surveillance Network, 2015–2016 Through 2019–2020

Author

Sahni, Leila C, primary, Naioti, Eric A, additional, Olson, Samantha M, additional, Campbell, Angela P, additional, Michaels, Marian G, additional, Williams, John V, additional, Staat, Mary Allen, additional, Schlaudecker, Elizabeth P, additional, McNeal, Monica M, additional, Halasa, Natasha B, additional, Stewart, Laura S, additional, Chappell, James D, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Szilagyi, Peter G, additional, Weinberg, Geoffrey A, additional, Harrison, Christopher J, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Azimi, Parvin H, additional, Singer, Monica N, additional, Avadhanula, Vasanthi, additional, Piedra, Pedro A, additional, Munoz, Flor M, additional, Patel, Manish M, additional, and Boom, Julie A, additional

Published
2022
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31. Sustained Within-season Vaccine Effectiveness Against Influenza-associated Hospitalization in Children: Evidence From the New Vaccine Surveillance Network, 2015–2016 Through 2019–2020.

Author

Sahni, Leila C, Naioti, Eric A, Olson, Samantha M, Campbell, Angela P, Michaels, Marian G, Williams, John V, Staat, Mary Allen, Schlaudecker, Elizabeth P, McNeal, Monica M, Halasa, Natasha B, Stewart, Laura S, Chappell, James D, Englund, Janet A, Klein, Eileen J, Szilagyi, Peter G, Weinberg, Geoffrey A, Harrison, Christopher J, Selvarangan, Rangaraj, Schuster, Jennifer E, and Azimi, Parvin H

Subjects
INFLUENZA prevention, INFLUENZA vaccines, RESPIRATORY diseases, CONFIDENCE intervals, CHILDREN'S hospitals, MULTIPLE regression analysis, ACQUISITION of data, VACCINE effectiveness, AGE factors in disease, MEDICAL records, DESCRIPTIVE statistics, RESEARCH funding, ODDS ratio, HOSPITAL care of children, LONGITUDINAL method, EVALUATION, CHILDREN
Abstract

Background Adult studies have demonstrated within-season declines in influenza vaccine effectiveness (VE); data in children are limited. Methods We conducted a prospective, test-negative study of children 6 months through 17 years hospitalized with acute respiratory illness at 7 pediatric medical centers during the 2015–2016 through 2019–2020 influenza seasons. Case-patients were children with an influenza-positive molecular test matched by illness onset to influenza-negative control-patients. We estimated VE [100% × (1 – odds ratio)] by comparing the odds of receipt of ≥1 dose of influenza vaccine ≥14 days before illness onset among influenza-positive children to influenza-negative children. Changes in VE over time between vaccination date and illness onset date were estimated using multivariable logistic regression. Results Of 8430 children, 4653 (55%) received ≥1 dose of influenza vaccine. On average, 48% were vaccinated through October and 85% through December each season. Influenza vaccine receipt was lower in case-patients than control-patients (39% vs 57%, P <.001); overall VE against hospitalization was 53% (95% confidence interval [CI]: 46, 60%). Pooling data across 5 seasons, the odds of influenza-associated hospitalization increased 4.2% (−3.2%, 12.2%) per month since vaccination, with an average VE decrease of 1.9% per month (n = 4000, P =.275). Odds of hospitalization increased 2.9% (95% CI: −5.4%, 11.8%) and 9.6% (95% CI: −7.0%, 29.1%) per month in children ≤8 years (n = 3084) and 9–17 years (n = 916), respectively. These findings were not statistically significant. Conclusions We observed minimal, not statistically significant within-season declines in VE. Vaccination following current Advisory Committee on Immunization Practices (ACIP) guidelines for timing of vaccine receipt remains the best strategy for preventing influenza-associated hospitalizations in children. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Enterovirus D68-Associated Acute Respiratory Illness ─ New Vaccine Surveillance Network, United States, July–November 2018–2020

Author

Shah, Melisa M., primary, Perez, Ariana, additional, Lively, Joana Y., additional, Avadhanula, Vasanthi, additional, Boom, Julie A., additional, Chappell, James, additional, Englund, Janet A., additional, Fregoe, Wende, additional, Halasa, Natasha B., additional, Harrison, Christopher J., additional, Hickey, Robert W., additional, Klein, Eileen J., additional, McNeal, Monica M., additional, Michaels, Marian G., additional, Moffatt, Mary E., additional, Otten, Catherine, additional, Sahni, Leila C., additional, Schlaudecker, Elizabeth, additional, Schuster, Jennifer E., additional, Selvarangan, Rangaraj, additional, Staat, Mary A., additional, Stewart, Laura S., additional, Weinberg, Geoffrey A., additional, Williams, John V., additional, Ng, Terry Fan Fei, additional, Routh, Janell A., additional, Gerber, Susan I., additional, McMorrow, Meredith L., additional, Rha, Brian, additional, and Midgley, Claire M., additional

Published
2021
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33. Clinical Influenza Testing Practices in Hospitalized Children at United States Medical Centers, 2015-2018

Author

Tenforde, Mark W, primary, Campbell, Angela P, additional, Michaels, Marian G, additional, Harrison, Christopher J, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Selvarangan, Rangaraj, additional, Halasa, Natasha B, additional, Stewart, Laura S, additional, Weinberg, Geoffrey A, additional, Williams, John V, additional, Szilagyi, Peter G, additional, Staat, Mary A, additional, Boom, Julie A, additional, Sahni, Leila C, additional, Singer, Monica N, additional, Azimi, Parvin H, additional, Zimmerman, Richard K, additional, McNeal, Monica M, additional, Talbot, H Keipp, additional, Monto, Arnold S, additional, Martin, Emily T, additional, Gaglani, Manjusha, additional, Silveira, Fernanda P, additional, Middleton, Donald B, additional, Ferdinands, Jill M, additional, and Rolfes, Melissa A, additional

Published
2021
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34. Additional file 3 of Performance of BioFire array or QuickVue influenza A + B test versus a validation qPCR assay for detection of influenza A during a volunteer A/California/2009/H1N1 challenge study

Author

McIlwain, David R., Chen, Han, Apkarian, Maria, Affrime, Melton, Bock, Bonnie, Kim, Kenneth, Nilanjan Mukherjee, Nolan, Garry P., and McNeal, Monica M.

Abstract

Additional file 3: Figure S1. Confirmatory PCR product from positive virus control. An expected single band of ~177bp amplified by PCR demonstrates the specificity of the primers to amplify the targeted region of the HA gene.

Published
2021
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38. Rotavirus Genotype Trends and Gastrointestinal Pathogen Detection in the United States, 2014–2016: Results From the New Vaccine Surveillance Network

Author

Esona, Mathew D, primary, Ward, M Leanne, additional, Wikswo, Mary E, additional, Rustempasic, Slavica M, additional, Gautam, Rashi, additional, Perkins, Charity, additional, Selvarangan, Rangaraj, additional, Harrison, Christopher J, additional, Boom, Julie A, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Staat, Mary Allen, additional, McNeal, Monica M, additional, Halasa, Natasha, additional, Chappell, James, additional, Weinberg, Geoffrey A, additional, Payne, Daniel C, additional, Parashar, Umesh D, additional, and Bowen, Michael D, additional

Published
2021
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40. Comparative genomic analysis of genogroup 1 and genogroup 2 rotaviruses circulating in seven US cities, 2014–2016

Author

Esona, Mathew D, primary, Gautam, Rashi, additional, Katz, Eric, additional, Jaime, Jose, additional, Ward, M Leanne, additional, Wikswo, Mary E, additional, Betrapally, Naga S, additional, Rustempasic, Slavica M, additional, Selvarangan, Rangaraj, additional, Harrison, Christopher J, additional, Boom, Julie A, additional, Englund, Jan, additional, Klein, Eileen J, additional, Staat, Mary Allen, additional, McNeal, Monica M, additional, Halasa, Natasha, additional, Chappell, James, additional, Weinberg, Geoffrey A, additional, Payne, Daniel C, additional, Parashar, Umesh D, additional, and Bowen, Michael D, additional

Published
2021
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41. Pediatric Respiratory and Enteric Virus Acquisition and Immunogenesis in US Mothers and Children Aged 0-2: PREVAIL Cohort Study (Preprint)

Author

Morrow, Ardythe L, primary, Staat, Mary A, additional, DeFranco, Emily A, additional, McNeal, Monica M, additional, Cline, Allison R, additional, Conrey, Shannon C, additional, Schlaudecker, Elizabeth P, additional, Piasecki, Alexandra M, additional, Burke, Rachel M, additional, Niu, Liang, additional, Hall, Aron J, additional, Bowen, Michael D, additional, Gerber, Susan I, additional, Langley, Gayle E, additional, Thornburg, Natalie J, additional, Campbell, Angela P, additional, Vinjé, Jan, additional, Parashar, Umesh D, additional, and Payne, Daniel C, additional

Published
2020
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42. Respiratory Syncytial Virus–Associated Hospitalizations Among Young Children: 2015–2016

Author

Rha, Brian, primary, Curns, Aaron T., additional, Lively, Joana Y., additional, Campbell, Angela P., additional, Englund, Janet A., additional, Boom, Julie A., additional, Azimi, Parvin H., additional, Weinberg, Geoffrey A., additional, Staat, Mary A., additional, Selvarangan, Rangaraj, additional, Halasa, Natasha B., additional, McNeal, Monica M., additional, Klein, Eileen J., additional, Harrison, Christopher J., additional, Williams, John V., additional, Szilagyi, Peter G., additional, Singer, Monica N., additional, Sahni, Leila C., additional, Figueroa-Downing, Daniella, additional, McDaniel, Darius, additional, Prill, Mila M., additional, Whitaker, Brett L., additional, Stewart, Laura S., additional, Schuster, Jennifer E., additional, Pahud, Barbara A., additional, Weddle, Gina, additional, Avadhanula, Vasanthi, additional, Munoz, Flor M., additional, Piedra, Pedro A., additional, Payne, Daniel C., additional, Langley, Gayle, additional, and Gerber, Susan I., additional

Published
2020
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43. Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Children: Multicenter Surveillance, United States, January–March 2020

Author

Rha, Brian, primary, Lively, Joana Y, additional, Englund, Janet A, additional, Staat, Mary A, additional, Weinberg, Geoffrey A, additional, Selvarangan, Rangaraj, additional, Halasa, Natasha B, additional, Williams, John V, additional, Boom, Julie A, additional, Sahni, Leila C, additional, Michaels, Marian G, additional, Stewart, Laura S, additional, Harrison, Christopher J, additional, Szilagyi, Peter G, additional, McNeal, Monica M, additional, Klein, Eileen J, additional, Strelitz, Bonnie, additional, Lacombe, Kirsten, additional, Schlaudecker, Elizabeth, additional, Moffatt, Mary E, additional, Schuster, Jennifer E, additional, Pahud, Barbara A, additional, Weddle, Gina, additional, Hickey, Robert W, additional, Avadhanula, Vasanthi, additional, Wikswo, Mary E, additional, Hall, Aron J, additional, Curns, Aaron T, additional, Gerber, Susan I, additional, and Langley, Gayle, additional

Published
2020
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50. Clinical Influenza Testing Practices in Hospitalized Children at United States Medical Centers, 2015-2018.

Author

Tenforde, Mark W, Campbell, Angela P, Michaels, Marian G, Harrison, Christopher J, Klein, Eileen J, Englund, Janet A, Selvarangan, Rangaraj, Halasa, Natasha B, Stewart, Laura S, Weinberg, Geoffrey A, Williams, John V, Szilagyi, Peter G, Staat, Mary A, Boom, Julie A, Sahni, Leila C, Singer, Monica N, Azimi, Parvin H, Zimmerman, Richard K, McNeal, Monica M, and Talbot, H Keipp

Subjects
INFLUENZA diagnosis, REVERSE transcriptase polymerase chain reaction, RESPIRATORY disease diagnosis, RESPIRATORY infections, POLYMERASE chain reaction, HOSPITAL care of children
Abstract

At nine US hospitals that enrolled children hospitalized with acute respiratory illness (ARI) during 2015-2016 through 2017-2018 influenza seasons, 50% of children with ARI received clinician-initiated testing for influenza and 35% of cases went undiagnosed due to lack of clinician-initiated testing. Marked heterogeneity in testing practice was observed across sites. [ABSTRACT FROM AUTHOR]

Published
2022
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