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7. Brief Report: Comparability of DSM-IV and DSM-5 ASD Research Samples

Author

Mazefsky, C. A., McPartland, J. C., Gastgeb, H. Z., and Minshew, N. J.

Abstract

Diagnostic and Statistical Manual (DSM-5) criteria for ASD have been criticized for being too restrictive, especially for more cognitively-able individuals. It is unclear, however, if high-functioning individuals deemed eligible for research via standardized diagnostic assessments would meet DSM-5 criteria. This study investigated the impact of DSM-5 on the diagnostic status of 498 high-functioning participants with ASD research diagnoses. The percent of participants satisfying all DSM-5-requirements varied significantly with reliance on data from the "Autism Diagnostic Observation Schedule" (ADOS; 33 %) versus "Autism Diagnostic Interview-Revised" (ADI-R; 83 %), highlighting the impact of diagnostic methodology on ability to document DSM-5 symptoms. Utilizing combined ADOS/ADI-R data, 93 % of participants met DSM-5 criteria, which suggests likely continuity between DSM-IV and DSM-5 research samples characterized with these instruments in combination.

Published
2013
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8. Re: Stillbirth collection by Man et al

Author

Cox, P., Marton, T., Hargitai, B., Coetzee, A., Bowen, C., Penman, D., Evans, M., Gannon, C., French, P., Cohen, M., Holden, S., Allotey, J., Evans, C., Murphy, A., Turner, K., Cullinane, C., Stahlschmidt, J., Kokai, G., Al Adnani, M., Marnerides, A., Vadgama, B., and McPartland, J.

Published
2017
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25. A subtle, painful lesion on the lower limb.

Author

O'Brennan, E. A., McPartland, J., and Parslew, R.A. G.

Subjects
*LEG, *HAMARTOMA, *SMOOTH muscle, *ADIPOSE tissue diseases
Abstract

Histological examination reveals pronounced proliferation of smooth muscle bundles of the arrector pili muscle. CPD questions Learning objective To demonstrate knowledge of the clinical presentation and histological features of congenital smooth muscle hamartoma. Question 1 Which is the most common clinical finding that differentiates congenital smooth muscle hamartoma from other lesions?. [Extracted from the article]

Published
2020
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28. Dialogues Clin Neurosci

Author

Lerner, M. D., White, S. W., McPartland, J. C., and Psychology

Subjects
cognitive-behavioral therapy, alliance, social skills training, mechanism, autism spectrum disorder, social knowledge, moderator, Cognitive Therapy, Child Development Disorders, Pervasive, Child, Preschool, biomarker, Humans, mediator, Child, Social Behavior, intervention
Abstract

Research into psychosocial interventions (particularly cognitive-behavior therapies and social skills training) for social-communication deficits among individuals with autism spectrum disorder (ASD) has proliferated over the past decade. While this research has provided some empirical support for the efficacy of these interventions, little work has begun to elucidate therapeutic mechanisms-the when, why, how, for whom, and under what conditions an intervention may produce change, identification of mechanisms underlying these effects should help advance ASD intervention research. This article describes methods for assessing such mechanisms (ie, mediators and moderators) and presents promising candidates for common mechanisms impacting treatment response: behavior modification, therapeutic relationship, social knowledge, social motivation, social information processing, executive functioning, and internalizing comorbidities. Finally, future directions are discussed as a program of psychosocial intervention research designed to identify predictors of individual differences in treatment response (including biomarkers), isolate active therapeutic ingredients, and promote dissemination of optimized interventions. Published version

Published
2012

32. Mechanisms of change in psychosocial interventions for autism spectrum disorders.

Author

Lerner, M. D., White, S. W., McPartland, J. C., Lerner, M. D., White, S. W., and McPartland, J. C.

Abstract

Research into psychosocial interventions (particularly cognitive-behavior therapies and social skills training) for social-communication deficits among individuals with autism spectrum disorder (ASD) has proliferated over the past decade. While this research has provided some empirical support for the efficacy of these interventions, little work has begun to elucidate therapeutic mechanisms-the when, why, how, for whom, and under what conditions an intervention may produce change, identification of mechanisms underlying these effects should help advance ASD intervention research. This article describes methods for assessing such mechanisms (ie, mediators and moderators) and presents promising candidates for common mechanisms impacting treatment response: behavior modification, therapeutic relationship, social knowledge, social motivation, social information processing, executive functioning, and internalizing comorbidities. Finally, future directions are discussed as a program of psychosocial intervention research designed to identify predictors of individual differences in treatment response (including biomarkers), isolate active therapeutic ingredients, and promote dissemination of optimized interventions.

Published
2012

33. Mechanisms of change in psychosocial interventions for autism spectrum disorders.

Author

Psychology, Lerner, M. D., White, S. W., McPartland, J. C., Psychology, Lerner, M. D., White, S. W., and McPartland, J. C.

Abstract

Research into psychosocial interventions (particularly cognitive-behavior therapies and social skills training) for social-communication deficits among individuals with autism spectrum disorder (ASD) has proliferated over the past decade. While this research has provided some empirical support for the efficacy of these interventions, little work has begun to elucidate therapeutic mechanisms-the when, why, how, for whom, and under what conditions an intervention may produce change, identification of mechanisms underlying these effects should help advance ASD intervention research. This article describes methods for assessing such mechanisms (ie, mediators and moderators) and presents promising candidates for common mechanisms impacting treatment response: behavior modification, therapeutic relationship, social knowledge, social motivation, social information processing, executive functioning, and internalizing comorbidities. Finally, future directions are discussed as a program of psychosocial intervention research designed to identify predictors of individual differences in treatment response (including biomarkers), isolate active therapeutic ingredients, and promote dissemination of optimized interventions.

Published
2012

41. Process flowsheet development for the Pullalli project.

Author

Boster B., Practical aspects of international management and processing. 11-Mar-9613-Mar-96, McPartland J., Pickarts J., Boster B., Practical aspects of international management and processing. 11-Mar-9613-Mar-96, McPartland J., and Pickarts J.

Abstract

A project feasibility study for Pullalli, on the western flank of the Andes, 140 km NW of Santiago, Chile, is being undertaken by Pegasus Minera de Chile. Phases I and II of metallurgical evaluation included laboratory-scale heap leaching and milling/cyanidation testwork on multiple drill core composites and bulk ore samples. Phase III included pilot-scale milling/cyanidation test work on the high grade ore and additional laboratory-scale heap leaching of low grade ore. Results gave overall gold recovery of greater than 90% from the high grade ore. The proposed flowsheet includes selective mining and separate processing of low grade (crushing and heap leaching) and high grade ores. The latter are leached for 12 hours in an agitated cyanidation circuit followed by sands and slimes separation: sands are added to the low grade ore heap leaching operation and slimes thickened and processed in a CIP circuit., A project feasibility study for Pullalli, on the western flank of the Andes, 140 km NW of Santiago, Chile, is being undertaken by Pegasus Minera de Chile. Phases I and II of metallurgical evaluation included laboratory-scale heap leaching and milling/cyanidation testwork on multiple drill core composites and bulk ore samples. Phase III included pilot-scale milling/cyanidation test work on the high grade ore and additional laboratory-scale heap leaching of low grade ore. Results gave overall gold recovery of greater than 90% from the high grade ore. The proposed flowsheet includes selective mining and separate processing of low grade (crushing and heap leaching) and high grade ores. The latter are leached for 12 hours in an agitated cyanidation circuit followed by sands and slimes separation: sands are added to the low grade ore heap leaching operation and slimes thickened and processed in a CIP circuit.

Published
1996

48. PARTY FOR THE KIDS.

Author

Mcpartland, J. O. H. N.

Subjects
CHILD psychology
Published
1955

50. Preserved reward outcome processing in ASD as revealed by event-related potentials

Author

McPartland James C, Crowley Michael J, Perszyk Danielle R, Mukerji Cora E, Naples Adam J, Wu Jia, and Mayes Linda C

Subjects
Autism spectrum disorder, Reward processing, Event-related potentials, Electroencephalography, ERP, EEG, Feedback-related negativity, Medial-frontal negativity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background Problems with reward system function have been posited as a primary difficulty in autism spectrum disorders. The current study examined an electrophysiological marker of feedback monitoring, the feedback-related negativity (FRN), during a monetary reward task. The study advanced prior understanding by focusing exclusively on a developmental sample, applying rigorous diagnostic characterization and introducing an experimental paradigm providing more subtly different feedback valence (reward versus non-reward instead of reward versus loss). Methods Twenty-six children with autism spectrum disorder and 28 typically developing peers matched on age and full-scale IQ played a guessing game resulting in monetary gain (“win”) or neutral outcome (“draw”). ERP components marking early visual processing (N1, P2) and feedback appraisal (FRN) were contrasted between groups in each condition, and their relationships to behavioral measures of social function and dysfunction, social anxiety, and autism symptomatology were explored. Results FRN was observed on draw trials relative to win trials. Consistent with prior research, children with ASD exhibited a FRN to suboptimal outcomes that was comparable to typical peers. ERP parameters were unrelated to behavioral measures. Conclusions Results of the current study indicate typical patterns of feedback monitoring in the context of monetary reward in ASD. The study extends prior findings of normative feedback monitoring to a sample composed exclusively of children and demonstrates that, as in typical development, individuals with autism exhibit a FRN to suboptimal outcomes, irrespective of neutral or negative valence. Results do not support a pervasive problem with reward system function in ASD, instead suggesting any dysfunction lies in more specific domains, such as social perception, or in response to particular feedback-monitoring contexts, such as self-evaluation of one’s errors.

Published
2012
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