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2,909 results on '"Mccluskey, P."'

1. Scaling toward Utopia or Dystopia: Challenges to Preserving Organizational Values through Growth

Author

Matthew S. McCluskey

Abstract

In their nascent stages, charter schools formed under competing ideologies. In academic circles, charter schools were envisioned as pedagogical laboratories that would allow for educator- and community-driven school improvement. In other circles, charter schools emerged as a free-market reform driven by accountability, choice, and growth. Amid the neoliberal accountability era, the latter ideology has emerged as a stronger driving force across the educational landscape, particularly amid the proliferation of Charter Management Organizations (CMOs). Based on real events, a charter school founder struggles to hold onto organizational values while scaling from a small charter school to a large CMO.

Published
2024
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2. Are Public School Libraries Accomplishing Their Mission? Public School Libraries Do Not Appear to Stock a Balance of Views. Policy Analysis No. 962

Author

Cato Institute and Neal McCluskey

Abstract

Over the past couple of years, school districts nationwide have seen a wave of challenges to books in libraries and on reading lists, as well as rising demands to know what titles are in schools. These challenges and demands have put public school libraries under significant scrutiny and raised fundamental questions about their purpose and operation. This policy analysis discusses the country's public school library situation, including who is supposed to control holdings and how acquisition works. Then it reports on a small experiment to address three questions: (1) Can the public see which books are in libraries; (2) do libraries contain potentially controversial books; and (3) can students access diverse views?

Published
2023

3. Leave Like a Champion: Teacher Embeddedness and Turnover at an Urban 'No-Excuses' Charter Management Organization

Author

Matthew S. McCluskey

Abstract

Teacher turnover remains considerably higher at Charter Management Organizations (CMOs), despite initially high perceptions of fit at the time of hire. Grounded in an emerging branch-off of job embeddedness theory - teacher embeddedness - this multi-site case study of one urban CMO used interviews of departed teachers and principals and focus groups of new and veteran teachers to determine the predominating factors of reduced feelings of embeddedness and, ultimately, turnover. Findings indicate that teacher embeddedness is threatened by methods the CMO has proliferated as "best practice" and factors researchers have empirically correlated with turnover.

Published
2024
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4. Investigating model influence on the analytical resolution of neutron reflectometry

Author

Shiaelis, Nicolas, Clifton, Luke A., and McCluskey, Andrew R.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Neutron reflectometry is a critical tool for investigating the structure of thin films and interfaces. However, the misapplication of the Born approximation to reflection geometry leads some to assume that the minimum thickness that may be probed by neutron reflectometry is limited by the Q-range of the measurement. In this study, we use model-dependent analysis, multiple isotopic contrasts, and magnetic spin states, to show that it is possible to resolve structures significantly smaller than this perceived limit. To quantify this "analytical resolution", we employ Bayesian model selection, offering a robust and quantifiable comparison between different analytical models. We believe that this work offers pivotal insights for the analysis of neutron reflectometry and hope that it will contribute to more accurate and information-rich analyses in the future., Comment: 21 pages, 7 figures

Published
2024

7. Spatially Resolved High Voltage Kelvin Probe Force Microcopy: A Novel Avenue for Examining Electrical Phenomena at Nanoscale

Author

McCluskey, Conor J., Sharma, Niyorjyoti, Maguire, Jesi R., Pauly, Serene, Rogers, Andrew, Lindsay, TJ, Holsgrove, Kristina M., Rodriguez, Brian J., Soin, Navneet, Gregg, John Marty, McQuaid, Raymond G. P., and Kumar, Amit

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Kelvin probe microscopy (KPFM) is a well-established scanning probe technique, used to measure surface potential accurately; it has found extensive use in the study of a range of materials phenomena. In its conventional form, KPFM frustratingly precludes imaging samples or scenarios where large surface potential exists or large surface potential gradients are created outside the typical +/-10V window. If the potential regime measurable via KPFM could be expanded, to enable precise and reliable metrology, through a high voltage KPFM (HV-KPFM) adaptation, it could open up pathways towards a range of novel experiments, where the detection limit of regular KPFM has so far prevented the use of the technique. In this work, HV-KPFM has been realised and shown to be capable of measuring large surface potential and potential gradients with accuracy and precision. The technique has been employed to study a range of materials (positive temperature coefficient of resistivity ceramics, charge storage fluoropolymers and pyroelectrics) where accurate spatially resolved mapping of surface potential within high voltage regime facilitates novel physical insight. The results demonstrate that HV-KPFM can be used as an effective tool to fill in existing gaps in surface potential measurements while also opening routes for novel studies in materials physics., Comment: Main Text: 16 pages, 5 figures Supplementary information:4 pages, 2 tables and 2 figures

Published
2024

8. Prevalence of Emergent Dolutegravir Resistance Mutations in People Living with HIV: A Rapid Scoping Review.

Author

Chu, Carolyn, Tao, Kaiming, Kouamou, Vinie, Avalos, Ava, Scott, Jake, Grant, Philip, Rhee, Soo-Yon, McCluskey, Suzanne, Jordan, Michael, Morgan, Rebecca, and Shafer, Robert

Subjects
HIV, epidemiology, systematic review, treatment, Humans, Cross-Sectional Studies, Prevalence, Lamivudine, HIV Infections, Heterocyclic Compounds, 3-Ring, Mutation, HIV Integrase Inhibitors, Anti-HIV Agents, Oxazines, Piperazines, Pyridones
Abstract

BACKGROUND: Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk of emergent integrase strand transfer inhibitor (INSTI) drug-resistance mutations (DRMs) in individuals receiving DTG-containing ART. METHODS: We performed a PubMed search using the term Dolutegravir, last updated 18 December 2023, to estimate the prevalence of VF with emergent INSTI DRMs in people living with HIV (PLWH) without previous VF on an INSTI who received DTG-containing ART. RESULTS: Of 2131 retrieved records, 43 clinical trials, 39 cohorts, and 6 cross-sectional studies provided data across 6 clinical scenarios based on ART history, virological status, and co-administered ARVs: (1) ART-naïve PLWH receiving DTG plus two NRTIs; (2) ART-naïve PLWH receiving DTG plus lamivudine; (3) ART-experienced PLWH with VF on a previous regimen receiving DTG plus two NRTIs; (4) ART-experienced PLWH with virological suppression receiving DTG plus two NRTIs; (5) ART-experienced PLWH with virological suppression receiving DTG and a second ARV; and (6) ART-experienced PLWH with virological suppression receiving DTG monotherapy. The median proportion of PLWH in clinical trials with emergent INSTI DRMs was 1.5% for scenario 3 and 3.4% for scenario 6. In the remaining four trial scenarios, VF prevalence with emergent INSTI DRMs was ≤0.1%. Data from cohort studies minimally influenced prevalence estimates from clinical trials, whereas cross-sectional studies yielded prevalence data lacking denominator details. CONCLUSIONS: In clinical trials, the prevalence of VF with emergent INSTI DRMs in PLWH receiving DTG-containing regimens has been low. Novel approaches are required to assess VF prevalence with emergent INSTI DRMs in PLWH receiving DTG in real-world settings.

Published
2024

9. Stat5 induces androgen receptor (AR) gene transcription in prostate cancer and offers a druggable pathway to target AR signaling.

Author

Maranto, Cristina, Sabharwal, Lavannya, Udhane, Vindhya, Pitzen, Samuel, McCluskey, Braedan, Qi, Songyan, OConnor, Christine, Devi, Savita, Johnson, Scott, Jacobsohn, Kenneth, Banerjee, Anjishnu, Iczkowski, Kenneth, Wang, Liang, Dehm, Scott, and Nevalainen, Marja

Subjects
Male, Humans, Receptors, Androgen, Prostatic Neoplasms, Castration-Resistant, Signal Transduction, Transcription, Genetic, Cell Line, Tumor, Gene Expression Regulation, Neoplastic
Abstract

Androgen receptor (AR) drives prostate cancer (PC) growth and progression, and targeting AR signaling is the mainstay of pharmacological therapies for PC. Resistance develops relatively fast as a result of refueled AR activity. A major gap in the field is the lack of understanding of targetable mechanisms that induce persistent AR expression in castrate-resistant PC (CRPC). This study uncovers an unexpected function of active Stat5 signaling, a known promoter of PC growth and clinical progression, as a potent inducer of AR gene transcription. Stat5 suppression inhibited AR gene transcription in preclinical PC models and reduced the levels of wild-type, mutated, and truncated AR proteins. Pharmacological Stat5 inhibition by a specific small-molecule Stat5 inhibitor down-regulated Stat5-inducible genes as well as AR and AR-regulated genes and suppressed PC growth. This work introduces the concept of Stat5 as an inducer of AR gene transcription in PC. Pharmacological Stat5 inhibitors may represent a new strategy for suppressing AR and CRPC growth.

Published
2024

12. Ultra-Wide Bandgap Gallium Oxide Films: UV-Luminescence and Phonon Dynamics at Extreme Temperatures

Author

Lukman, Isiaka, McCluskey, Matthew D., and Bergman, Leah

Subjects
Condensed Matter - Materials Science
Abstract

$\beta$-Ga$_2$O$_3$ is a semiconductor with bandgap in the deep-UV ~ 5 eV. Due to its strong phonon-hole coupling, holes are self-trapped inhibiting bandgap luminescence at the deep-UV. In contrast, the self-trapped holes (STH) can exhibit a strong luminescence at ~ 3.5 eV. This research addresses the thermal response of the STH photoluminescence (PL), and the role of phonon interactions at temperatures 77 K - 622 K in nanocrystalline films. It was found that the PL intensity strongly diminishes as a function of increasing temperature with activation energy ~ 72 meV. A study of the Raman modes revealed that the intensity of the high frequency modes of the Ga$_I$O$_4$ site decrease with temperature, implying a phonon annihilation process. These modes, which have comparable energy to the STH activation energy, thus can couple to the STH and transition them from a radiative to a non-radiative regime in accordance with the configurational coordinate model at the strong phonon coupling limit. The significantly broad Gaussian linewidth of the PL is also a manifestation of a strong STH-phonon coupling. Furthermore, the peak position of the STH exhibited a negligible temperature response, in contrast to the redshift of ~ 220 meV of the bandedge of the film. In contrast to the intensity behavior of the high frequency Raman modes, the low frequency ones were found to follow the thermal Bose-Einstein phonon population.

Published
2023

13. A novel model of autologous tooth transplantation for the study of nerve recruitment

Author

Teresa E. Fowler, Doan T. Bloomquist, Caroline Glessner, Poonam Patel, Jeffrey N. James, Kathryn Bollinger, Lynnette P. McCluskey, and Ryan F. Bloomquist

Subjects
Dental regeneration, Neuron biology, Innervation, Molar, Tibia, Bioengineering, Dentistry, RK1-715
Abstract

Abstract Background Limited treatment options exist for damaged nerves and despite impressive advances in tissue engineering, scientists and clinicians have yet to fully replicate nerve development and recruitment. Innervation is a critical feature for normal organ function. While most organs are innervated prior to birth, a rare example of postnatal nerve recruitment occurs in the natural development of secondary teeth during adolescence. Many animals undergo postnatal shedding of deciduous teeth with development and eruption of secondary teeth, a process requiring recruitment of nerve and vasculature to each tooth pulp for viability. Here, the investigators created a novel model for the study of postnatal innervation by exploiting the natural phenomenon of tooth-driven nerve recruitment. Methods The investigators theorized that developing teeth possess a special capacity to induce innervation which could be harnessed in a clinical setting for nerve regeneration, and hyptothesized that a transplant model could be created to capture this phenomenon. In this descriptive study, a rat model of autologous tooth transplantation and de novo nerve recruitment was developed by surgically transferring whole developing molars to the autologous tibia. Results Downstream histological analysis performed 6 to 14 weeks after surgery demonstrated integration of molar into tibia in 81% of postoperative rats, with progressive pulpal expression of nerve marker ß-tubulin III suggestive of neuronal recruitment. Conclusions These findings provide a novel model for the study of organ transplantation and support the theory that developing dental tissues may retain nerve-inductive properties postnatally.

Published
2024
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14. Transitioning to Emergency Remote Teaching in a Block Model Curriculum: A Case Study of Academics' Experiences in an Australian University

Author

Kaye Cleary, Gayani Samarawickrema, Trudy Ambler, Daniel Loton, Thomas Krcho, and Trish McCluskey

Abstract

This Australian university case study explores the transition to emergency, remote teaching (ERT) in an intensive Block Model curriculum during the COVID-19 pandemic. An online survey investigated academics' experiences of factors that helped or hindered their transition. A thematic analysis of the data revealed a symbiotic relationship between the Block Model curriculum, professional learning, and academics' sense of agency as they experienced their transition. We relate our findings to Whittle et al.'s 2020 framework and propose an extended framework based on how teaching was influenced by the changed environment. Drawing on the extended framework, we propose lessons for the future based on how academics were reflectively adapting to ERT. In the four-week Block Model, lessons were learned and applied in the subsequent Block. Critical lessons relevant to higher education institutions include increasing diversity of effective, un-invigilated assessment types, and fostering student wellbeing by facilitating learning spaces where students connect with peers and academics. Furthermore, academics need connections with peers and safe spaces in which to debrief on evolving situations and build confidence in using new learning technologies. Professional learning fostering an emergency-informed, safe learning environment effectively reduces isolation and better prepares institutions for future emergencies.

Published
2024
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16. The proto-galaxy of Milky Way-mass haloes in the FIRE simulations

Author

Horta, Danny, Cunningham, Emily C., Sanderson, Robyn, Johnston, Kathryn V., Deason, Alis, Wetzel, Andrew, McCluskey, Fiona, Garavito-Camargo, Nicolás, Necib, Lina, Faucher-Giguère, Claude-André, Arora, Arpit, and Gandhi, Pratik J.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Observational studies are finding stars believed to be relics of the earliest stages of hierarchical mass assembly of the Milky Way (i.e., proto-Galaxy). In this work, we contextualize these findings by studying the masses, ages, spatial distributions, morphology, kinematics, and chemical compositions of proto-galaxy populations from the 13 Milky Way (MW)-mass galaxies from the FIRE-2 cosmological zoom-in simulations. Our findings indicate that proto-Milky Way populations: i) can have a stellar mass range between $1\times10^{8}<\mathrm{M}_{\star}<2\times10^{10}[\mathrm{M}_{\odot}]$, a virial mass range between $3\times10^{10}<\mathrm{M}_{\star}<6\times10^{11}[\mathrm{M}_{\odot}]$, and be as young as $8 \lesssim \mathrm{Age} \lesssim 12.8$ [Gyr] ($1\lesssim z \lesssim 6$); ii) are predominantly centrally concentrated, with $\sim50\%$ of the stars contained within $5-10$ kpc; iii) on average show weak but systematic net rotation in the plane of the host's disc at $z=0$ (i.e., $0.25\lesssim\langle\kappa/\kappa_{\mathrm{disc}}\rangle\lesssim0.8$); iv) present [$\alpha$/Fe]-[Fe/H] compositions that overlap with the metal-poor tail of the host's old disc; v) tend to assemble slightly earlier in Local Group-like environments than in systems in isolation. Interestingly, we find that ~60% of the proto-Milky Way galaxies are comprised by 1 dominant system ($1/5\lesssim$M$_{\star}$/M$_{\star,\mathrm{proto-Milky Way}}$$\lesssim4/5$) and 4-5 lower mass systems (M$_{\star}$/M$_{\star,\mathrm{proto-Milky Way}}$$\lesssim1/10$); the other ~40% are comprised by 2 dominant systems and 3-4 lower mass systems. These massive/dominant proto-Milky Way fragments can be distinguished from the lower mass ones in chemical-kinematic samples, but appear (qualitatively) indistinguishable from one another. Our results could help observational studies disentangle if the Milky Way formed from one or two dominant systems., Comment: Accepted in MNRAS. 16 pages, 12 figures and 3 tables

Published
2023

17. R2D2 -- An equivalent-circuit model that quantitatively describes domain wall conductivity in ferroelectric LiNbO$_3$

Author

Zahn, Manuel, Beyreuther, Elke, Kiseleva, Iuliia, Lotfy, Ahmed Samir, McCluskey, Conor J., Maguire, Jesi R., Suna, Ahmet, Rüsing, Michael, Gregg, J. Marty, and Eng, Lukas M.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Applied Physics
Abstract

Ferroelectric domain wall (DW) conductivity (DWC) can be attributed to two separate mechanisms: (a) the injection/ejection of charge carriers across the Schottky barrier formed at the (metal-) electrode-DW junction and (b) the transport of those charge carriers along the DW. Current-voltage (IU) characteristics, recorded at variable temperatures from LiNbO$_3$ (LNO) DWs, are clearly able to differentiate between these two contributions. Practically, they allow us here to directly quantify the physical parameters relevant for the two mechanisms (a) and (b) mentioned above. These are, e.g., the resistance of the DW, the saturation current, the ideality factor, and the Schottky barrier height of the electrode/DW junction. Furthermore, the activation energies needed to initiate the thermally-activated electronic transport along the DWs, can be extracted. In addition, we show that electronic transport along LiNbO$_3$ DWs can be elegantly viewed and interpreted in an adapted semiconductor picture based on a double-diode/double-resistor equivalent circuit model, the R2D2 model. Finally, our R2D2 model was checked for its universality by fitting the DWC data not only to z-cut LNO bulk DWs, but equally to z-cut thin-film LNO DWs, and DWC from x-cut DWs as reported in literature., Comment: 10 pages, 7 figures; with included supporting information (6 pages, 4 figures)

Published
2023
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18. Accurate Estimation of Diffusion Coefficients and their Uncertainties from Computer Simulation

Author

McCluskey, Andrew R., Coles, Samuel W., and Morgan, Benjamin J.

Subjects
Condensed Matter - Statistical Mechanics, Condensed Matter - Materials Science
Abstract

Self-diffusion coefficients, $\D$, are routinely estimated from molecular dynamics simulations by fitting a linear model to the observed mean-squared displacements (MSDs) of mobile species. MSDs derived from simulation exhibit statistical noise that causes uncertainty in the resulting estimate of $\D$. An optimal scheme for estimating $\D$ minimises this uncertainty, i.e., it will have high statistical efficiency, and also gives an accurate estimate of the uncertainty itself. We present a scheme for estimating $\D$ from a single simulation trajectory with high statistical efficiency and accurately estimating the uncertainty in the predicted value. The statistical distribution of MSDs observable from a given simulation is modelled as a multivariate normal distribution using an analytical covariance matrix for an equivalent system of freely diffusing particles, which we parameterise from the available simulation data. We use Bayesian regression to sample the distribution of linear models that are compatible with this multivariate normal distribution, to obtain a statistically efficient estimate of $D^*$ and an accurate estimate of the associated statistical uncertainty.

Published
2023

20. Bioaerosols are the dominant source of warm-temperature immersion-mode INPs and drive uncertainties in INP predictability.

Author

Cornwell, Gavin, McCluskey, Christina, Hill, Thomas, Levin, Ezra, Rothfuss, Nicholas, Tai, Sheng-Lun, Burrows, Susannah, DeMott, Paul, Kreidenweis, Sonia, Prather, Kimberly, and Petters, Markus

Abstract

Ice-nucleating particles (INPs) are rare atmospheric aerosols that initiate primary ice formation, but accurately simulating their concentrations and variability in large-scale climate models remains a challenge. Doing so requires both simulating major particle sources and parameterizing their ice nucleation (IN) efficiency. Validating and improving model predictions of INP concentrations requires measuring their concentrations delineated by particle type. We present a method to speciate INP concentrations into contributions from dust, sea spray aerosol (SSA), and bioaerosol. Field campaign data from Bodega Bay, California, showed that bioaerosols were the primary source of INPs between -12° and -20°C, while dust was a minor source and SSA had little impact. We found that recent parameterizations for dust and SSA accurately predicted ambient INP concentrations. However, the model did not skillfully simulate bioaerosol INPs, suggesting a need for further research to identify major factors controlling their emissions and INP efficiency for improved representation in models.

Published
2023

23. Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor

Author

Högnäsbacka, Antonia A., Poot, Alex J., Plisson, Christophe, Bergare, Jonas, Bonsall, David R., McCluskey, Stuart P., Wells, Lisa A., Kooijman, Esther, Schuit, Robert C., Verlaan, Mariska, Beaino, Wissam, van Dongen, Guus A. M. S., Vugts, Danielle J., Elmore, Charles S., Passchier, Jan, and Windhorst, Albert D.

Published
2024
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24. Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

Author

Dawson, Amy, Zarou, Martha M., Prasad, Bodhayan, Bittencourt-Silvestre, Joana, Zerbst, Désirée, Himonas, Ekaterini, Hsieh, Ya-Ching, van Loon, Isabel, Blanco, Giovanny Rodriguez, Ianniciello, Angela, Kerekes, Zsombor, Krishnan, Vaidehi, Agarwal, Puneet, Almasoudi, Hassan, McCluskey, Laura, Hopcroft, Lisa E. M., Scott, Mary T., Baquero, Pablo, Dunn, Karen, Vetrie, David, Copland, Mhairi, Bhatia, Ravi, Coffelt, Seth B., Tiong, Ong Sin, Wheadon, Helen, Zanivan, Sara, Kirschner, Kristina, and Helgason, G. Vignir

Published
2024
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27. Impact of cross-section uncertainties on supernova neutrino spectral parameter fitting in the Deep Underground Neutrino Experiment

Author

DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Ahmad, Z., Ahmed, J., Aimard, B., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Amedo, P., Anderson, J., Andrade, D. A., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Campanelli, W. L. Anicézio, Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Arnold, L. O., Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Ayala-Torres, M., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barenboim, G., Alzás, P. Barham, Barker, G. J., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhambure, J., Bhardwaj, A., Bhatnagar, V., Bhattacharjee, M., Bhattacharya, M., Bhattarai, D., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blend, D., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Borkum, A., Bostan, N., Bour, P., Bracinik, J., Braga, D., Brailsford, D., Branca, A., Brandt, A., Bravo-Moreno, M., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., V., G. Caceres, Cagnoli, I., Cai, T., Caiulo, D., Calabrese, R., Calafiura, P., Calcutt, J., Calin, M., Calivers, L., Calvez, S., Calvo, E., Caminata, A., Benitez, A. Campos, Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Forero, J. F. Castaño, Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavallaro, G., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chalifour, M., Chappell, A., Chardonnet, E., Charitonidis, N., Chatterjee, A., Chattopadhyay, S., Chen, H., Chen, M., Chen, Y., Chen-Wishart, Z., Cheon, Y., Cherdack, D., Chi, C., Childress, S., Chirco, R., Chiriacescu, A., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christensen, A., Christian, D., Christodoulou, G., Chukanov, A., Chung, M., Church, E., Cicero, V., Clapa, D., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collot, J., Conley, E., Conrad, J. M., Convery, M., Cooke, P., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De, S., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, Deisting, A., De Jong, P., De la Torre, A., Delbart, A., De Leo, V., Delepine, D., Delgado, M., Dell'Acqua, A., Delmonte, N., De Lurgio, P., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., De Souza, G., Detje, J. P., Devi, R., Devine, J., Dharmapalan, R., Dias, M., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Emberger, L., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Ferraro, F., Ferry, G., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fischer, V., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Francis, K., Franco, D., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gabrielli, A., Gago, A., Gallagher, H., Gallas, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. 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P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhang, Y., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

A primary goal of the upcoming Deep Underground Neutrino Experiment (DUNE) is to measure the $\mathcal{O}(10)$ MeV neutrinos produced by a Galactic core-collapse supernova if one should occur during the lifetime of the experiment. The liquid-argon-based detectors planned for DUNE are expected to be uniquely sensitive to the $\nu_e$ component of the supernova flux, enabling a wide variety of physics and astrophysics measurements. A key requirement for a correct interpretation of these measurements is a good understanding of the energy-dependent total cross section $\sigma(E_\nu)$ for charged-current $\nu_e$ absorption on argon. In the context of a simulated extraction of supernova $\nu_e$ spectral parameters from a toy analysis, we investigate the impact of $\sigma(E_\nu)$ modeling uncertainties on DUNE's supernova neutrino physics sensitivity for the first time. We find that the currently large theoretical uncertainties on $\sigma(E_\nu)$ must be substantially reduced before the $\nu_e$ flux parameters can be extracted reliably: in the absence of external constraints, a measurement of the integrated neutrino luminosity with less than 10\% bias with DUNE requires $\sigma(E_\nu)$ to be known to about 5%. The neutrino spectral shape parameters can be known to better than 10% for a 20% uncertainty on the cross-section scale, although they will be sensitive to uncertainties on the shape of $\sigma(E_\nu)$. A direct measurement of low-energy $\nu_e$-argon scattering would be invaluable for improving the theoretical precision to the needed level., Comment: 25 pages, 21 figures

Published
2023
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28. Disk settling and dynamical heating: histories of Milky Way-mass stellar disks across cosmic time in the FIRE simulations

Author

McCluskey, Fiona, Wetzel, Andrew, Loebman, Sarah R., Moreno, Jorge, Faucher-Giguere, Claude-Andre, and Hopkins, Philip F.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We study the kinematics of stars both at their formation and today within 14 Milky Way (MW)-mass galaxies from the FIRE-2 cosmological zoom-in simulations. We quantify the relative importance of cosmological disk settling and post-formation dynamical heating. We identify three eras: a Pre-Disk Era (typically >8 Gyr ago), when stars formed on dispersion-dominated orbits; an Early-Disk Era (~ 8 - 4 Gyr ago), when stars started to form on rotation-dominated orbits but with high velocity dispersion, sigma_form; and a Late-Disk Era (< 4 Gyr ago), when stars formed with low sigma_form. sigma_form increased with time during the Pre-Disk Era, peaking ~ 8 Gyr ago, then decreased throughout the Early-Disk Era as the disk settled and remained low throughout the Late-Disk Era. By contrast, the velocity dispersion measured today, sigma_now, increases monotonically with age because of stronger post-formation heating for Pre-Disk stars. Importantly, most of sigma_now was in place at formation, not added post-formation, for stars younger than ~ 10 Gyr. We compare the evolution of the three velocity components: at all times, sigma_R,form > sigma_phi,form > sigma_Z,form. Post-formation heating primarily increased sigma_R at ages < 4 Gyr but acted nearly isotropically for older stars. The kinematics of young stars in FIRE-2 broadly agree with the range observed across the MW, M31, M33, and PHANGS-MUSE galaxies. The lookback time that the disk began to settle correlates with its dynamical state today: earlier-settling galaxies currently form colder disks. Including stellar cosmic-ray feedback does not significantly change disk rotational support at fixed stellar mass., Comment: 23 pages, accepted for publication in MNRAS

Published
2023
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29. Video Data Analysis and Police Body-Worn Camera Footage

Author

McCluskey, John D. and Uchida, Craig D.

Abstract

Video data analysis (VDA) represents an important methodological framework for contemporary research approaches to the myriad of footage available from cameras, devices, and phones. Footage from police body-worn cameras (BWCs) is anticipated to be a widely available platform for social science researchers to scrutinize the interactions between police and citizens. We examine issues of validity and reliability as related to BWCs in the context of VDA, based on an assessment of the quality of audio and video obtained from that platform. Second, we compare the coding of BWC footage obtained from a sample of police-citizen encounters to coding of the same events by on-scene coders using an instrument adapted from in-person systematic social observations (SSOs). Findings show that there are substantial and systematic audio and video gaps present in BWC footage as a source of data for social science investigation that likely impact the reliability of measures. Despite these problems, BWC data have substantial capacity for judging sequential developments, causal ordering, and the duration of events. Thus, the technology should open theoretical frames that are too cumbersome for in-person observation. Theoretical development with VDA in mind is suggested as an important pathway for future researchers in terms of framing data collection from BWCs and also suggesting areas where triangulation is essential.

Published
2023
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30. Point-of-care urine tenofovir testing to predict HIV drug resistance among individuals with virologic failure.

Author

McCluskey, Suzanne, Govender, Katya, Adamson, John, Gandhi, Monica, Moosa, Mahomed-Yunus, Muyindike, Winnie, Moodley, Pravi, Pillay, Melendhran, Masette, Godfrey, Sunpath, Henry, Pillay, Selvan, Chen, Geoffrey, Hedt-Gauthier, Bethany, Marconi, Vincent, Siedner, Mark, and Spinelli, Matthew

Subjects
Adult, Humans, Tenofovir, HIV Infections, Anti-HIV Agents, Point-of-Care Systems, Retrospective Studies, Anti-Retroviral Agents, HIV-1
Abstract

OBJECTIVE: We sought to evaluate the utility of a point-of-care (POC) urine tenofovir (TFV) assay, developed to objectively assess adherence, to predict HIV drug resistance (HIVDR) in people failing first-line antiretroviral therapy (ART). DESIGN: We retrospectively analyzed TFV levels as a biomarker of adherence in urine specimens collected during a clinical trial that enrolled adults with virologic failure on first-line ART in Uganda and South Africa. METHODS: Urine specimens were analyzed from participants on TFV-containing regimens who had a viral load >1000 copies/ml and paired genotypic resistance test (GRT) results. We assessed recent ART TFV adherence with a qualitative POC lateral flow urine assay with a cut-off value of 1500 ng/ml. We then calculated performance characteristics of the POC urine TFV assay to predict HIVDR, defined as intermediate or high-level resistance to any component of the current ART regimen. RESULTS: Urine specimens with paired plasma GRT results were available from 283 participants. The most common ART regimen during study conduct was emtricitabine, tenofovir disoproxil fumarate, and efavirenz. The overall prevalence of HIVDR was 86% ( n = 243/283). Of those with TFV detected on the POC assay, 91% ( n  = 204/224) had HIVDR, vs. only 66% ( n  = 39/59) among those with no TFV detected ( P- value < 0.001). Positive and negative predictive values of the assay to predict HIVDR were 91% and 34%, respectively. CONCLUSIONS: In populations with a high prevalence of HIVDR, the POC urine TFV assay can provide a low-cost, rapid method to guide requirements for confirmatory resistance testing and inform the need for regimen change.

Published
2023

31. Highly-parallelized simulation of a pixelated LArTPC on a GPU

Author

DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Ahmad, Z., Ahmed, J., Aimard, B., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alt, C., Alton, A., Alvarez, R., Amedo, P., Anderson, J., Andrade, D. A., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Campanelli, W. L. Anicézio, Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Antusch, S., Aranda-Fernandez, A., Arellano, L., Arnold, L. O., Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asquith, L., Aurisano, A., Aushev, V., Autiero, D., Ayala-Torres, M., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baller, B., Bambah, B., Barao, F., Barenboim, G., Alzás, P. Barham, Barker, G. J., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhambure, J., Bhardwaj, A., Bhatnagar, V., Bhattacharjee, M., Bhattacharya, M., Bhattarai, D., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bisignani, V., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blend, D., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Borkum, A., Bostan, N., Bour, P., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Branca, A., Brandt, A., Bravo-Moreno, M., Bremer, J., Brew, C., Brice, S. J., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., V., G. Caceres, Cagnoli, I., Cai, T., Caiulo, D., Calabrese, R., Calafiura, P., Calcutt, J., Calin, M., Calivers, L., Calvez, S., Calvo, E., Caminata, A., Caratelli, D., Carber, D., Carceller, J. C., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Forero, J. F. Castaño, Castillo, A., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavallaro, G., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chalifour, M., Chappell, A., Chardonnet, E., Charitonidis, N., Chatterjee, A., Chattopadhyay, S., Chen, H., Chen, M., Chen, Y., Chen, Z., Chen-Wishart, Z., Cheon, Y., Cherdack, D., Chi, C., Childress, S., Chirco, R., Chiriacescu, A., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christensen, A., Christian, D., Christodoulou, G., Chukanov, A., Chung, M., Church, E., Cicero, V., Clapa, D., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De, S., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, Deisting, A., De Jong, P., De la Torre, A., Delbart, A., De Leo, V., Delepine, D., Delgado, M., Dell'Acqua, A., Delmonte, N., De Lurgio, P., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., De Souza, G., Detje, J. P., Devi, R., Dharmapalan, R., Dias, M., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Eads, M., Earle, A., Edmunds, D., Eisch, J., Emberger, L., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Ferraro, F., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fischer, V., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Franco, D., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gabrielli, A., Gago, A., Gallagher, H., Gallas, A., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Ge, G., Geffroy, N., Gelli, B., Gendotti, A., Gent, S., Gerlach, L., Ghorbani-Moghaddam, Z., Giammaria, P., Giammaria, T., Giangiacomi, N., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Giovannella, S., Girerd, C., Giri, A. K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudeau, J., Goudzovski, E., Grace, C., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D., Green, P., Greenberg, S., Greenler, L., Greer, J., Grenard, J., Griffith, W. C., Groetschla, F. T., Groh, M., Grzelak, K., Gu, W., Guarino, V., Guarise, M., Guenette, R., Guerard, E., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Gupta, A., Gupta, V., Guthikonda, K. K., Guzowski, P., Guzzo, M. M., Gwon, S., Ha, C., Haaf, K., Habig, A., Hadavand, H., Hadef, A., Haenni, R., Hagaman, L., Hahn, A., Haiston, J., Hamacher-Baumann, P., Hamernik, T., Hamilton, P., Han, J., Hancock, J., Happacher, F., Harris, D. A., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C., Hatcher, R., Hatfield, K. W., Hatzikoutelis, A., Hayes, C., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Henry, S., Morquecho, M. A. Hernandez, Herner, K., Hewes, V., Hilgenberg, C., Hill, T., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Ho, J., Hoff, J., Holin, A., Holvey, T., Hoppe, E., Horton-Smith, G. A., Hostert, M., Houdy, T., Hourlier, A., Howard, B., Howell, R., Barrios, J. Hoyos, Hristova, I., Hronek, M. S., Huang, J., Huang, R. G., Hulcher, Z., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Oliveira, M. Ismerio, Itay, R., Jackson, C. M., Jain, V., James, E., Jang, W., Jargowsky, B., Jediny, F., Jena, D., Jeong, Y. S., Jesús-Valls, C., Ji, X., Jiang, J., Jiang, L., Jipa, A., Jo, J. H., Joaquim, F. R., Johnson, W., Jones, B., Jones, R., Jovancevic, N., Judah, M., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Koseyan, O. Kamer, Kamiya, F., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Katsioulas, I., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Kemularia, O., Kermaidic, Y., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Kleykamp, J., Klustova, A., Kobilarcik, T., Koehler, K., Koerner, L. W., Koh, D. H., Kohn, S., Koller, P. P., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Kotler, I., Kozhukalov, V., Kralik, R., Kreczko, L., Krennrich, F., Kreslo, I., Kropp, W., Kroupova, T., Kubu, M., Kudenko, Y., Kudryavtsev, V. A., Kuhlmann, S., Kulagin, S., Kumar, J., Kumar, P., Kunze, P., Kuravi, R., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kvasnicka, J., Kwak, D., Lambert, A., Land, B. J., Lane, C. E., Lang, K., Langford, T., Langstaff, M., Lanni, F., Lantwin, O., Larkin, J., Lasorak, P., Last, D., Laundrie, A., Laurenti, G., Lawrence, A., Laycock, P., Lazanu, I., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeBrun, P., LeCompte, T., Lee, C., Legin, V., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Lepin, L. M., Li, S. W., Li, Y., Liao, H., Lin, C. S., Lin, S., Lindebaum, D., Lineros, R. A., Ling, J., Lister, A., Littlejohn, B. R., Liu, J., Liu, Y., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Lord, T., LoSecco, J. M., Louis, W. C., Lu, X. -G., Luk, K. B., Lunday, B., Luo, X., Luppi, E., Lux, T., Luzio, V. P., Maalmi, J., MacFarlane, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., MacMahon, M., Maddalena, A., Madera, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Major, A., Majumdar, K., Maloney, J. A., Man, M., Mandrioli, G., Mandujano, R. C., Maneira, J., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Manyam, V. N., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Markiewicz, T., Marsden, D., Marshak, M., Marshall, C. M., Marshall, J., Marteau, J., Martín-Albo, J., Martinez, N., Caicedo, D. A. Martinez, López, F. Martínez, Miravé, P. Martínez, Martynenko, S., Mascagna, V., Mason, K., Mastbaum, A., Matichard, F., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., Mazzacane, A., McAskill, T., McCluskey, E., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Mefodiev, A., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Messier, M. D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Mikola, V., Milincic, R., Miller, G., Miller, W., Mills, J., Mineev, O., Minotti, A., Miranda, O. G., Miryala, S., Miscetti, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Moffat, K., Mogan, A., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montagna, E., Montanari, A., Montanari, C., Montanari, D., Montanino, D., Zetina, L. M. Montaño, Moon, S. H., Mooney, M., Moor, A. F., Moreno, D., Morescalchi, L., Moretti, D., Morris, C., Mossey, C., Mote, M., Motuk, E., Moura, C. A., Mousseau, J., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Muheim, F., Muir, A., Mulhearn, M., Munford, D., Munteanu, L. J., Muramatsu, H., Muraz, J., Murphy, M., Murphy, S., Musser, J., Nachtman, J., Nagai, Y., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Nath, A., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Negishi, K., Nelson, J. K., Nelson, M., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newton, H., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Nikolov, J., Niner, E., Nishimura, K., Norman, A., Norrick, A., Novella, P., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J. P., Olivier, A., Olshevskiy, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pan, S., Vazquez, W. Panduro, Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parozzi, E., Parsa, S., Parsa, Z., Parveen, S., Parvu, M., Pasciuto, D., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S. J., Patzak, T., Paudel, A., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J. M., Perez, A. Pena, Pennacchio, E., Penzo, A., Peres, O. L. G., Gonzalez, Y. F. Perez, Pérez-Molina, L., Pernas, C., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pia, V., Piastra, F., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Plows, K., Plunkett, R., Pollman, T., Pompa, F., Pons, X., Poonthottathil, N., Poppi, F., Pordes, S., Porter, J., Potekhin, M., Potenza, R., Potukuchi, B. V. K. S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Pratt, C., Prest, M., Psihas, F., Pugnere, D., Qian, X., Raaf, J. L., Radeka, V., Rademacker, J., Radev, R., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotonandrasana, A., Rakotondravohitra, L., Rameika, R., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Raut, S., Razafinime, H., Razakamiandra, R. F., Rea, E. M., Real, J. S., Rebel, B., Rechenmacher, R., Reggiani-Guzzo, M., Reichenbacher, J., Reitzner, S. D., Sfar, H. Rejeb, Renshaw, A., Rescia, S., Resnati, F., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Rice, L. C. J., Ricol, J. S., Rigamonti, A., Rigaut, Y., Rincón, E. V., Ritchie-Yates, A., Rivera, D., Rivera, R., Robert, A., Rocha, J. L. Rocabado, Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Romeo, E., Rosauro-Alcaraz, S., Rosier, P., Rossella, M., Rossi, M., Ross-Lonergan, M., Rout, J., Roy, P., Rubbia, A., Rubbia, C., Ferreira, G. Ruiz, Russell, B., Ruterbories, D., Rybnikov, A., Saa-Hernandez, A., Saakyan, R., Sacerdoti, S., Sahu, N., Sala, P., Samios, N., Samoylov, O., Sanchez, M. C., Sandberg, V., Sanders, D. A., Sankey, D., Santoro, D., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Sarra, I., Savage, G., Savinov, V., Scanavini, G., Scaramelli, A., Scarff, A., Scarpelli, A., Schefke, T., Schellman, H., Schifano, S., Schlabach, P., Schmitz, D., Schneider, A. W., Scholberg, K., Schukraft, A., Segreto, E., Selyunin, A., Senise, C. R., Sensenig, J., Sgalaberna, D., Shaevitz, M. H., Shafaq, S., Shaker, F., Shamma, M., Shanahan, P., Sharankova, R., Sharma, H. R., Sharma, R., Kumar, R., Shaw, K., Shaw, T., Shchablo, K., Shepherd-Themistocleous, C., Sheshukov, A., Shi, W., Shin, S., Shoemaker, I., Shooltz, D., Shrock, R., Silber, J., Simard, L., Sinclair, J., Sinev, G., Singh, Jaydip, Singh, J., Singh, L., Singh, P., Singh, V., Chauhan, S. Singh, Sipos, R., Sirri, G., Sitraka, A., Siyeon, K., Skarpaas, K., Smith, E., Smith, P., Smolik, J., Smy, M., Snider, E. L., Snopok, P., Snowden-Ifft, D., Nunes, M. Soares, Sobel, H., Soderberg, M., Sokolov, S., Salinas, C. J. Solano, Söldner-Rembold, S., Soleti, S. R., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Sotnikov, A., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Stalder, D., Stancari, M., Stanco, L., Steenis, J., Stein, R., Steiner, H. M., Lisbôa, A. F. Steklain, Stepanova, A., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Strigari, L., Stuart, A., Suarez, J. G., Subash, J., Surdo, A., Susic, V., Suter, L., Sutera, C. M., Sutton, K., Suvorov, Y., Svoboda, R., Swain, S. K., Szczerbinska, B., Szelc, A. M., Taffara, A., Talukdar, N., Tamara, J., Tanaka, H. A., Tang, S., Taniuchi, N., Oregui, B. Tapia, Tapper, A., Tariq, S., Tarpara, E., Tata, N., Tatar, E., Tayloe, R., Teklu, A. M., Tennessen, P., Tenti, M., Terao, K., Terranova, F., Testera, G., Thakore, T., Thea, A., Thompson, A., Thorn, C., Timm, S. C., Tishchenko, V., Todorović, N., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Travaglini, R., Trevor, J., Trilov, S., Trzaska, W. H., Tsai, Y., Tsai, Y. -T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tu, S. Z., Tufanli, S., Tull, C., Turner, J., Tuzi, M., Tyler, J., Tyley, E., Tzanov, M., Uboldi, L., Uchida, M. A., Urheim, J., Usher, T., Utaegbulam, H., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W. F., Vallecorsa, S., Van Berg, R., Van de Water, R. G., Forero, D. Vanegas, Vannerom, D., Varanini, F., Oliva, D. Vargas, Varner, G., Vasina, S., Vaughan, N., Vaziri, K., Vega, J., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., Vicenzi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vizcaya-Hernandez, A., Vrba, T., Vuong, Q., Wachala, T., Waldron, A. V., Wallbank, M., Walton, T., Wang, H., Wang, J., Wang, L., Wang, M. H. L. S., Wang, X., Wang, Y., Warburton, K., Warner, D., Wascko, M. O., Waters, D., Watson, A., Wawrowska, K., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., Whilhelmi, J., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, A., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wisniewski, W., Wolcott, J., Wolfs, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wospakrik, M., Wresilo, K., Wret, C., Wu, S., Wu, W., Wurm, M., Wyenberg, J., Xiao, Y., Xiotidis, I., Yaeggy, B., Yahlali, N., Yandel, E., Yang, G., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Yoon, Y. S., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhang, Y., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.

Subjects
Physics - Computational Physics, Physics - Instrumentation and Detectors
Abstract

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on $10^3$ pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype., Comment: 26 pages, 15 figures

Published
2022

32. Identification and reconstruction of low-energy electrons in the ProtoDUNE-SP detector

Author

DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Ahmad, Z., Ahmed, J., Aimard, B., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alt, C., Alton, A., Alvarez, R., Amedo, P., Anderson, J., Andrade, D. A., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Campanelli, W. L. Anicézio, Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Antusch, S., Aranda-Fernandez, A., Arellano, L., Arnold, L. O., Arroyave, M. A., Asaadi, J., Asquith, L., Aurisano, A., Aushev, V., Autiero, D., Ayala-Torres, M., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baller, B., Bambah, B., Barao, F., Barenboim, G., Barker, G. J., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhambure, J., Bhardwaj, A., Bhatnagar, V., Bhattacharjee, M., Bhattarai, D., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bisignani, V., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blend, D., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Borkum, A., Bostan, N., Bour, P., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., V., G. Caceres, Cagnoli, I., Cai, T., Caiulo, D., Calabrese, R., Calafiura, P., Calcutt, J., Calin, M., Calivers, L., Calvez, S., Calvo, E., Caminata, A., Caratelli, D., Carber, D., Carceller, J. C., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Forero, J. F. Castaño, Castillo, A., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavallaro, G., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chalifour, M., Chappell, A., Chardonnet, E., Charitonidis, N., Chatterjee, A., Chattopadhyay, S., Chen, H., Chen, M., Chen, Y., Chen, Z., Chen-Wishart, Z., Cheon, Y., Cherdack, D., Chi, C., Childress, S., Chirco, R., Chiriacescu, A., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christensen, A., Christian, D., Christodoulou, G., Chukanov, A., Chung, M., Church, E., Cicero, V., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cova, P., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Cussans, D., Dalager, O., Dallavalle, R., da Motta, H., Dar, Z. A., Peres, L. Da Silva, David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De, S., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, Deisting, A., De Jong, P., De la Torre, A., Delbart, A., De Leo, V., Delepine, D., Delgado, M., Dell'Acqua, A., Delmonte, N., De Lurgio, P., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Deptuch, G. W., De Roeck, A., De Romeri, V., De Souza, G., Detje, J. P., Devi, R., Dharmapalan, R., Dias, M., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Giulio, L., Ding, P., Di Noto, L., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Eads, M., Earle, A., Edmunds, D., Eisch, J., Emberger, L., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Ferraro, F., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fischer, V., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gabrielli, A., Gago, A., Gallagher, H., Gallas, A., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Ge, G., Geffroy, N., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Giammaria, P., Giammaria, T., Giangiacomi, N., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Girerd, C., Giri, A. K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D., Green, P., Greenberg, S., Greenler, L., Greer, J., Grenard, J., Griffith, W. C., Groetschla, F. T., Groh, M., Grzelak, K., Gu, W., Guardincerri, E., Guarino, V., Guarise, M., Guenette, R., Guerard, E., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Gupta, A., Gupta, V., Guthikonda, K. K., Guzowski, P., Guzzo, M. M., Gwon, S., Ha, C., Haaf, K., Habig, A., Hadavand, H., Haenni, R., Hagaman, L., Hahn, A., Haiston, J., Hamacher-Baumann, P., Hamernik, T., Hamilton, P., Han, J., Harris, D. A., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C., Hatcher, R., Hatfield, K. W., Hatzikoutelis, A., Hayes, C., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Henry, S., Morquecho, M. A. Hernandez, Herner, K., Hewes, V., Hilgenberg, C., Hill, T., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Hoff, J., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Barrios, J. Hoyos, Hristova, I., Hronek, M. S., Huang, J., Huang, R. G., Hulcher, Z., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Oliveira, M. Ismerio, Itay, R., Jackson, C. M., Jain, V., James, E., Jang, W., Jargowsky, B., Jediny, F., Jena, D., Jeong, Y. S., Jesús-Valls, C., Ji, X., Jiang, J., Jiang, L., Jipa, A., Jo, J. H., Joaquim, F. R., Johnson, W., Jones, B., Jones, R., Jovancevic, N., Judah, M., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Koseyan, O. Kamer, Kamiya, F., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Katsioulas, I., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Kemularia, O., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Kleykamp, J., Klustova, A., Kobilarcik, T., Koehler, K., Koerner, L. W., Koh, D. H., Kohn, S., Koller, P. P., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Kotler, I., Kozhukalov, V., Kralik, R., Kreczko, L., Krennrich, F., Kreslo, I., Kropp, W., Kroupova, T., Kudenko, Y., Kudryavtsev, V. A., Kuhlmann, S., Kulagin, S., Kumar, J., Kumar, P., Kunze, P., Kuravi, R., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kvasnicka, J., Kwak, D., Lambert, A., Land, B. J., Lane, C. E., Lang, K., Langford, T., Langstaff, M., Lanni, F., Lantwin, O., Larkin, J., Lasorak, P., Last, D., Laundrie, A., Laurenti, G., Lawrence, A., Laycock, P., Lazanu, I., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeBrun, P., LeCompte, T., Lee, C., Legin, V., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Lepin, L. M., Li, S. W., Li, Y., Liao, H., Lin, C. S., Lin, S., Lineros, R. A., Ling, J., Lister, A., Littlejohn, B. R., Liu, J., Liu, Y., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Lord, T., LoSecco, J. M., Louis, W. C., Lu, X. -G., Luk, K. B., Lunday, B., Luo, X., Luppi, E., Lux, T., Luzio, V. P., Maalmi, J., MacFarlane, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., Maddalena, A., Madera, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Major, A., Majumdar, K., Maloney, J. A., Mandrioli, G., Mandujano, R. C., Maneira, J., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Manyam, V. N., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Markiewicz, T., Marsden, D., Marshak, M., Marshall, C. M., Marshall, J., Marteau, J., Martín-Albo, J., Martinez, N., Caicedo, D. A. Martinez, López, F. Martínez, Miravé, P. Martínez, Martynenko, S., Mascagna, V., Mason, K., Mastbaum, A., Matichard, F., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., Mazzacane, A., McAskill, T., McCluskey, E., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Mefodiev, A., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Messier, M. D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Mikola, V., Milincic, R., Miller, G., Miller, W., Mills, J., Mineev, O., Minotti, A., Miranda, O. G., Miryala, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Moffat, K., Mogan, A., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montagna, E., Montanari, A., Montanari, C., Montanari, D., Montanino, D., Zetina, L. M. Montaño, Moon, S. H., Mooney, M., Moor, A. F., Moreno, D., Moretti, D., Morris, C., Mossey, C., Mote, M., Motuk, E., Moura, C. A., Mousseau, J., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Muheim, F., Muir, A., Mulhearn, M., Munford, D., Muramatsu, H., Murphy, M., Murphy, S., Musser, J., Nachtman, J., Nagai, Y., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Nath, A., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Negishi, K., Nelson, J. K., Nelson, M., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newton, H., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Nikolov, J., Niner, E., Nishimura, K., Norman, A., Norrick, A., Novella, P., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J. P., Olivier, A., Olshevskiy, A., Onel, Y., Onishchuk, Y., Ormachea, L. Otiniano, Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pan, S., Vazquez, W. Panduro, Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parozzi, E., Parsa, S., Parsa, Z., Parveen, S., Parvu, M., Pasciuto, D., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S. J., Patzak, T., Paudel, A., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J. M., Perez, A. Pena, Pennacchio, E., Penzo, A., Peres, O. L. G., Pernas, C., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pia, V., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Plows, K., Plunkett, R., Pompa, F., Pons, X., Poonthottathil, N., Poppi, F., Pordes, S., Porter, J., Porzio, S. D., Potekhin, M., Potenza, R., Potukuchi, B. V. K. S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Pratt, C., Prest, M., Psihas, F., Pugnere, D., Qian, X., Raaf, J. L., Radeka, V., Rademacker, J., Radev, R., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotonandrasana, A., Rakotondravohitra, L., Rameika, R., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Raut, S., Razafinime, H., Razakamiandra, R. F., Rea, E. M., Real, J. S., Rebel, B., Rechenmacher, R., Reggiani-Guzzo, M., Reichenbacher, J., Reitzner, S. D., Sfar, H. Rejeb, Renshaw, A., Rescia, S., Resnati, F., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Rice, L. C. J., Ricol, J. S., Rigamonti, A., Rigaut, Y., Rincón, E. V., Ritchie-Yates, A., Rivera, D., Rivera, R., Robert, A., Rocha, J. L. Rocabado, Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Romeo, E., Rosauro-Alcaraz, S., Rosier, P., Rossella, M., Rossi, M., Ross-Lonergan, M., Rout, J., Roy, P., Rubbia, A., Rubbia, C., Russell, B., Ruterbories, D., Rybnikov, A., Saa-Hernandez, A., Saakyan, R., Sacerdoti, S., Sahu, N., Sala, P., Samios, N., Samoylov, O., Sanchez, M. C., Sandberg, V., Sanders, D. A., Sankey, D., Santoro, D., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scanavini, G., Scaramelli, A., Scarff, A., Scarpelli, A., Schefke, T., Schellman, H., Schifano, S., Schlabach, P., Schmitz, D., Schneider, A. W., Scholberg, K., Schukraft, A., Segreto, E., Selyunin, A., Senise, C. R., Sensenig, J., Sgalaberna, D., Shaevitz, M. H., Shafaq, S., Shaker, F., Shamma, M., Shanahan, P., Sharankova, R., Sharma, H. R., Sharma, R., Kumar, R., Shaw, K., Shaw, T., Shchablo, K., Shepherd-Themistocleous, C., Sheshukov, A., Shi, W., Shin, S., Shoemaker, I., Shooltz, D., Shrock, R., Silber, J., Simard, L., Sinclair, J., Sinev, G., Singh, Jaydip, Singh, J., Singh, L., Singh, P., Singh, V., Chauhan, S. Singh, Sipos, R., Sirri, G., Sitraka, A., Siyeon, K., Skarpaas, K., Smith, E., Smith, P., Smolik, J., Smy, M., Snider, E. L., Snopok, P., Snowden-Ifft, D., Nunes, M. Soares, Sobel, H., Soderberg, M., Sokolov, S., Salinas, C. J. Solano, Söldner-Rembold, S., Soleti, S. R., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Sotnikov, A., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Stalder, D., Stancari, M., Stanco, L., Steenis, J., Stein, R., Steiner, H. M., Lisbôa, A. F. Steklain, Stepanova, A., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Strigari, L., Stuart, A., Suarez, J. G., Subash, J., Surdo, A., Susic, V., Suter, L., Sutera, C. M., Suvorov, Y., Svoboda, R., Szczerbinska, B., Szelc, A. M., Talukdar, N., Tamara, J., Tanaka, H. A., Tang, S., Oregui, B. Tapia, Tapper, A., Tariq, S., Tarpara, E., Tata, N., Tatar, E., Tayloe, R., Teklu, A. M., Tennessen, P., Tenti, M., Terao, K., Terranova, F., Testera, G., Thakore, T., Thea, A., Thompson, A., Thorn, C., Timm, S. C., Tishchenko, V., Todorović, N., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Travaglini, R., Trevor, J., Trilov, S., Trzaska, W. H., Tsai, Y., Tsai, Y. -T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tufanli, S., Tull, C., Turner, J., Tyler, J., Tyley, E., Tzanov, M., Uboldi, L., Uchida, M. A., Urheim, J., Usher, T., Utaegbulam, H., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. D. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W. F., Vallecorsa, S., Van Berg, R., Van de Water, R. G., Forero, D. Vanegas, Vannerom, D., Varanini, F., Oliva, D. Vargas, Varner, G., Vasina, S., Vaughan, N., Vaziri, K., Vega, J., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., Vicenzi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vrba, T., Vuong, Q., Wachala, T., Waldron, A. V., Wallbank, M., Walton, T., Wang, H., Wang, J., Wang, L., Wang, M. H. L. S., Wang, X., Wang, Y., Warburton, K., Warner, D., Wascko, M. O., Waters, D., Watson, A., Wawrowska, K., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., Whilhelmi, J., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, A., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wisniewski, W., Wolcott, J., Wolfs, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wospakrik, M., Wresilo, K., Wret, C., Wu, S., Wu, W., Xiao, Y., Xiotidis, I., Yaeggy, B., Yandel, E., Yang, G., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Yoon, Y. S., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhang, Y., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

Measurements of electrons from $\nu_e$ interactions are crucial for the Deep Underground Neutrino Experiment (DUNE) neutrino oscillation program, as well as searches for physics beyond the standard model, supernova neutrino detection, and solar neutrino measurements. This article describes the selection and reconstruction of low-energy (Michel) electrons in the ProtoDUNE-SP detector. ProtoDUNE-SP is one of the prototypes for the DUNE far detector, built and operated at CERN as a charged particle test beam experiment. A sample of low-energy electrons produced by the decay of cosmic muons is selected with a purity of 95%. This sample is used to calibrate the low-energy electron energy scale with two techniques. An electron energy calibration based on a cosmic ray muon sample uses calibration constants derived from measured and simulated cosmic ray muon events. Another calibration technique makes use of the theoretically well-understood Michel electron energy spectrum to convert reconstructed charge to electron energy. In addition, the effects of detector response to low-energy electron energy scale and its resolution including readout electronics threshold effects are quantified. Finally, the relation between the theoretical and reconstructed low-energy electron energy spectrum is derived and the energy resolution is characterized. The low-energy electron selection presented here accounts for about 75% of the total electron deposited energy. After the addition of lost energy using a Monte Carlo simulation, the energy resolution improves from about 40% to 25% at 50~MeV. These results are used to validate the expected capabilities of the DUNE far detector to reconstruct low-energy electrons., Comment: 19 pages, 10 figures

Published
2022

33. Postoperative intravenous iron to treat iron-deficiency anaemia in patients undergoing cardiac surgery: a protocol for a pilot, multicentre, placebo-controlled randomized trial (the POAM trial)

Author

Justyna Bartoszko, Sarah Miles, Saba Ansari, Deep Grewal, Michelle Li, Jeannie Callum, Stuart A. McCluskey, Yulia Lin, and Keyvan Karkouti

Subjects
anaemia, infusions, intravenous, iron deficiency, iron compounds, perioperative care, Anesthesiology, RD78.3-87.3
Abstract

Background: Iron-deficiency anaemia, occurring in 30–40% of patients undergoing cardiac surgery, is an independent risk factor for adverse outcomes. Our long-term goal is to assess if postoperative i.v. iron therapy improves clinical outcomes in patients with preoperative iron-deficiency anaemia undergoing cardiac surgery. Before conducting a definitive RCT, we first propose a multicentre pilot trial to establish the feasibility of the definitive trial. Methods: This internal pilot, double-blinded, RCT will include three centres. Sixty adults with preoperative iron-deficiency anaemia undergoing non-emergency cardiac surgery will be randomised on postoperative day 2 or 3 to receive either blinded i.v. iron (1000 mg ferric derisomaltose) or placebo. Six weeks after surgery, patients who remain iron deficient will receive a second blinded dose of i.v. iron according to their assigned treatment arm. Patients will be followed for 12 months. Clinical practice will not be otherwise modified. For the pilot study, feasibility will be assessed through rates of enrolment, protocol deviations, and loss to follow up. For the definitive study, the primary outcome will be the number of days alive and out of hospital at 90 days after surgery. Ethics and dissemination: The trial has been approved by the University Health Network Research Ethics Board (REB # 22-5685; approved by Clinical Trials Ontario funding on 22 December 2023) and will be conducted in accordance with the Declaration of Helsinki, Good Clinical Practices guidelines, and regulatory requirements. Clinical trial registration: NCT06287619.

Published
2024
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34. Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial

Author

Éric Dumont, Lusine Abrahamyan, Stuart Mccluskey, Angela Jerath, Humara Poonawala, Andrew Stevens, Jeannie Callum, Alan Tinmouth, Daniel Wong, Gianluigi Bisleri, Tarit Saha, David Mazer, Hilary Grocott, Jane Yang, Jeff Kinney, Yoan Lamarche, Damon Scales, George Tomlinson, Fuad Moussa, Andrew Shih, Michelle Zeller, Melanie Tokessy, Keyvan Karkouti, Vivek Rao, Summer Syed, Lilia Kaustov, Sophia Wong, Lani Lieberman, Kamrouz Ghadimi, Philippe Demers, Penny Johnson, Jerrold H Levy, Justyna Bartoszko, Miki Peer, Michael Law, Michelle Wong, Mackenzie Quantz, Antoine Rochon, Fraser Rubens, Shagun Jain, Yulia Lin, Katerina Pavenski, Deep Grewal, Deborah DuMerton, Darrin Payne, Saba Ansari, Robert Mayer, Rebecca Randall, Aftab Malik, Bethany Smethurst, Laura Molnar, Angela Sirosky-Yanyk, Mark Peterson, Christopher Harle, Etienne Couture, Diem Tran, Cristina Solomon, Sigurd Knaub, Kenichi A Tanaka, Blaine Achen, Sukhpal Brar, Matthew Coley, Dana Devine, Alana Flexman, Camila Machado de Souza, Maria Rosal Martins, Terri Sun, Rob Tanzola, Mathew Yan, Raffael Zamper, Jo Carrol, Nishanthi Liyanage, Simryn Selby, Reezanoor Kabir, Shelley Oliver, Alioska Escorcia, Susana Medic, Michelle Mozel, Ramanjot Kaur, Kelly Bizovie, Sarah Buchko, Raven Arly Gonzales, Korey Sutherland, Jenna Van Roekel, Alveena Babul, Ken Tanaka, Kofi Vandyck, Amir Butt, Hisako Okada, Robert Tanzola, Reegan Tod, Aiden Scholey, Wafaa Haider, Ester Cisneros-Aguilera, Alexandre Bergeron, Genevieve Belanger, Darren Mullane, Bevan Hughes, Sakara Hutspardol, Shirley Lim, Jian Mi, Debbie Kalar, Matthew Eang, Erick Lorenzana-Saldivar, Edward P Chen, Akash Gupta, Philip Lau, Pablo Perez D’Empaire, Chantal Armali, Amie Malkin, Connie Colavecchia, Harley Meirovich, Annie Bergeron, Francois Laforge, Kim Paradis, Nathalie Gagne, Marie Soleil Saillant, Marie-Claude Vézina, Olivier Royer, Marie-Ève Charest, Lee-Anne Fochesato, Yuxin Bai, Iqbal Jaffar, Nour Alhomsi, Janine Guevarra, Erin Jamula, Wan Chien (Betty) Hsu, Abbey Drew, Hakan Buyukdere, Drashtee Patel, Elizabeth Watt, Hadia Arabi Katbi, Kim Luciano, Amy Moorehead, Kamola Kasimova, Farzana Tasmin, Cielo Bingley, Victoria Barkley, Tob Reegan, Marianna Qu, Jessica Xiong, Sophie Robichaud, Christy Peterson, Manu Jairath, Mathew Tang, Jennita Aariaratnam, Leron DuMerton, Lucas Drew, Sahrish Masood, Toni Tidy, and Elizabeth Krok

Subjects
Medicine
Abstract

Introduction Reduced thrombin generation is an important component of post cardiopulmonary bypass (CPB) coagulopathy. To replenish coagulation factors and enhance thrombin generation in bleeding surgical patients, frozen plasma (FP) and four-factor prothrombin complex concentrate (4F-PCC) are used. However, the efficacy–safety balance of 4F-PCC relative to FP in cardiac surgery is unconfirmed.Methods and analysis LEX-211 (FARES-II) is an active-control, randomised, phase 3 study comparing two coagulation factor replacement therapies in bleeding adult cardiac surgical patients at 12 hospitals in Canada and the USA. The primary objective is to determine whether 4F-PCC (Octaplex/Balfaxar, Octapharma) is clinically non-inferior to FP for haemostatic effectiveness. Inclusion criteria are any index (elective or non-elective) cardiac surgery employing CPB and coagulation factor replacement with 4F-PCC or FP ordered in the operating room for bleeding management. Patients will be randomised to receive 1500 or 2000 international units of 4F-PCC or 3 or 4 units of FP, depending on body weight. The primary endpoint of haemostatic treatment response is ‘effective’ if no additional haemostatic intervention is required from 60 min to 24 hours after the first initiation of 4F-PCC or FP; or ‘ineffective’ if any other haemostatic intervention (including a second dose of study drug) is required. An estimated 410 evaluable patients will be required to demonstrate non-inferiority (one-sided α of 0.025, power ≥90%, non-inferiority margin 0.10). Secondary outcomes include transfusions, bleeding-related clinical endpoints, coagulation parameters and safety.Ethics and dissemination The trial has been approved by the institutional review boards of all participating centres. Trial completion is anticipated at the end of 2024, and results will be disseminated via publications in peer-reviewed journals and conference presentations in 2025. The results will advance our understanding of coagulation management in bleeding surgical patients, potentially reducing the need for allogeneic blood products and improving outcomes in surgical patients.Trial registration number NCT05523297.

Published
2024
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35. Ferroelectric Domain Wall Logic Gates

Author

Suna, Ahmet, McCluskey, Conor J., Maguire, Jesi R., Kumar, Amit, McQuaid, Raymond G. P., and Gregg, J. Marty

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science
Abstract

Fundamentally, lithium niobate is an extremely good electrical insulator. However, this can change dramatically when 180{\deg} domain walls are present, as they are often found to be strongly conducting. Absolute conductivities depend on the inclination angles of the walls with respect to the [001] polarisation axis and so, if these inclination angles can be altered, then electrical conductivities can be tuned, or even toggled on and off. In 500nm thick z-cut ion-sliced thin films, localised wall angle variations can be controlled by both the sense and magnitude of applied electrical bias. We show that this results in a diode-like charge transport response which is effective for half-wave rectification, albeit only at relatively low ac frequencies. Most importantly, however, we also demonstrate that such domain wall diodes can be used to construct "AND" and inclusive "OR" logic gates, where "0" and "1" output states are clearly distinguishable. Realistic device modelling allows an extrapolation of results for the operation of these domain wall diodes in more complex arrangements and, although non-ideal, output states can still be distinguished even in two-level cascade logic. Although conceptually simple, we believe that our experimental demonstration of operational domain wall-enabled logic gates represents a significant step towards the future broader realisation of "domain wall nanoelectronics".

Published
2022

36. The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 2—global current practice patterns for the management of Cytomegalovirus anterior uveitis

Author

Thng, Zheng Xian, Putera, Ikhwanuliman, Testi, Ilaria, Chan, Kevin, Westcott, Mark, Chee, Soon-Phaik, Dick, Andrew D., Kempen, John H., Bodaghi, Bahram, Thorne, Jennifer E., Barisani-Asenbauer, Talin, de Smet, Marc D., Smith, Justine R., McCluskey, Peter, La Distia Nora, Rina, Jabs, Douglas A., de Boer, Joke H., Sen, H. Nida, Goldstein, Debra A., Khairallah, Moncef, Davis, Janet L., Rosenbaum, James T., Jones, Nicholas P., Nguyen, Quan Dong, Pavesio, Carlos, Agrawal, Rupesh, and Gupta, Vishali

Published
2024
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37. The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 1—global current practice patterns for the management of Herpes Simplex Virus and Varicella Zoster Virus anterior uveitis

Author

Thng, Zheng Xian, Putera, Ikhwanuliman, Testi, Ilaria, Chan, Kevin, Westcott, Mark, Chee, Soon-Phaik, Dick, Andrew D., Kempen, John H., Bodaghi, Bahram, Thorne, Jennifer E., Barisani-Asenbauer, Talin, de Smet, Marc D., Smith, Justine R., McCluskey, Peter, La Distia Nora, Rina, Jabs, Douglas A., de Boer, Joke H., Sen, H. Nida, Goldstein, Debra A., Khairallah, Moncef, Davis, Janet L., Rosenbaum, James T., Jones, Nicholas P., Nguyen, Quan Dong, Pavesio, Carlos, Agrawal, Rupesh, and Gupta, Vishali

Published
2024
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38. The Role of Movement in Young Children's Spatial Experiences: A Review of Early Childhood Mathematics Education Research

Author

McCluskey, Catherine, Kilderry, Anna, Mulligan, Joanne, and Kinnear, Virginia

Abstract

Young children's spatial reasoning is critical to mathematics learning from an early age. Recent reviews have drawn attention to the importance of mathematical experiences in the early years; however, an explicit focus on research in spatial reasoning can contribute to a more coherent account of the field. This paper reports a scoping review of qualitative studies (n = 37) during the years 2009-2021. The studies analysed in this review provide insight into children's embodied spatial concepts and non-verbal expressions such as gesture and the relationship between spatial reasoning and mathematics learning in early childhood (birth to 8 years). Four main themes were found: (i) children's manipulation and transformation of objects, (ii) children's bodily engagement with and within spaces, (iii) children's representation and interpretation of spatial experiences, and (iv) contexts for spatial learning. While the review illuminates a deeper awareness and a more holistic and embodied view of children's spatial competencies, there remains few studies focussed on children under three years of age. Future directions for ongoing research are identified.

Published
2023
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41. Quercetin improves epithelial regeneration from airway basal cells of COPD patients

Author

Elizabeth S. McCluskey, Nathan Liu, Abhimaneu Pandey, Nathaniel Marchetti, Steven G. Kelsen, and Umadevi S. Sajjan

Subjects
HOXB2, ELF3, Goblet cell metaplasia, Chronic obstructive pulmonary disease, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Airway basal cells (BC) from patients with chronic obstructive pulmonary disease (COPD) regenerate abnormal airway epithelium and this was associated with reduced expression of several genes involved in epithelial repair. Quercetin reduces airway epithelial remodeling and inflammation in COPD models, therefore we examined whether quercetin promotes normal epithelial regeneration from COPD BC by altering gene expression. Methods COPD BC treated with DMSO or 1 µM quercetin for three days were cultured at air/liquid interface (ALI) for up to 4 weeks. BC from healthy donors cultured at ALI were used as controls. Polarization of cells was determined at 8 days of ALI. The cell types and IL-8 expression in differentiated cell cultures were quantified by flow cytometry and ELISA respectively. Microarray analysis was conducted on DMSO or 1 µM quercetin-treated COPD BC for 3 days to identify differentially regulated genes (DEG). Bronchial brushings obtained from COPD patients with similar age and disease status treated with either placebo (4 subjects) or 2000 mg/day quercetin (7 subjects) for 6 months were used to confirm the effects of quercetin on gene expression. Results Compared to placebo-, quercetin-treated COPD BC showed significantly increased transepithelial resistance, more ciliated cells, fewer goblet cells, and lower IL-8. Quercetin upregulated genes associated with tissue and epithelial development and differentiation in COPD BC. COPD patients treated with quercetin, but not placebo showed increased expression of two developmental genes HOXB2 and ELF3, which were also increased in quercetin-treated COPD BC with FDR

Published
2024
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42. Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

Author

Amy Dawson, Martha M. Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E. M. Hopcroft, Mary T. Scott, Pablo Baquero, Karen Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B. Coffelt, Ong Sin Tiong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, and G. Vignir Helgason

Subjects
Science
Abstract

Abstract Macrophages are fundamental cells of the innate immune system that support normal haematopoiesis and play roles in both anti-cancer immunity and tumour progression. Here we use a chimeric mouse model of chronic myeloid leukaemia (CML) and human bone marrow (BM) derived macrophages to study the impact of the dysregulated BM microenvironment on bystander macrophages. Utilising single-cell RNA sequencing (scRNA-seq) of Philadelphia chromosome (Ph) negative macrophages we reveal unique subpopulations of immature macrophages residing in the CML BM microenvironment. CML exposed macrophages separate from their normal counterparts by reduced expression of the surface marker CD36, which significantly reduces clearance of apoptotic cells. We uncover aberrant production of CML-secreted factors, including the immune modulatory protein lactotransferrin (LTF), that suppresses efferocytosis, phagocytosis, and CD36 surface expression in BM macrophages, indicating that the elevated secretion of LTF is, at least partially responsible for the supressed clearance function of Ph- macrophages.

Published
2024
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43. Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor

Author

Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, and Albert D. Windhorst

Subjects
EAI045, Epidermal growth factor receptor, EGFR, Tyrosine kinase inhibitor, TKI, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the receptor's function. However, subsequent treatment resistance mutations in the ATP binding site are common. The EGFR allosteric inhibitor, EAI045, is proposed to have an alternative mechanism of action, disrupting receptor signaling independent of the ATP-binding site. The antibody cetuximab is hypothesized to increase the number of accessible allosteric pockets for EAI045, thus increasing the potency of the inhibitor. This work aimed to gain further knowledge on pharmacokinetics, the EGFR mutation-targeting potential, and the influence of cetuximab on the uptake by radiolabeling EAI045 with carbon-11 and tritium. Results 2-(5-fluoro-2-hydroxyphenyl)-2-((2-iodobenzyl)amino)-N-(thiazol-2-yl)acetamide and 2-(5-fluoro-2-hydroxyphenyl)-N-(5-iodothiazol-2-yl)-2-(1-oxoisoindolin-2-yl)acetamide were synthesized as precursors for the carbon-11 and tritium labeling of EAI045, respectively. [11C]EAI045 was synthesized using [11C]CO in a palladium-catalyzed ring closure in a 10 ± 1% radiochemical yield (decay corrected to end of [11C]CO2 production), > 97% radiochemical purity and 26 ± 1 GBq/µmol molar activity (determined at end of synthesis) in 51 min. [3H]EAI045 was synthesized by a tritium-halogen exchange in a 0.2% radiochemical yield, 98% radiochemical purity, and 763 kBq/nmol molar activity. The ability of [11C]EAI045 to differentiate between L858R/T790M mutated EGFR expressing H1975 xenografts and wild-type EGFR expressing A549 xenografts was evaluated in female nu/nu mice. The uptake was statistically significantly higher in H1975 xenografts compared to A549 xenografts (0.45 ± 0.07%ID/g vs. 0.31 ± 0.10%ID/g, P = 0.0166). The synergy in inhibition between EAI045 and cetuximab was evaluated in vivo and in vitro. While there was some indication that cetuximab influenced the uptake of [3H]EAI045 in vitro, this could not be confirmed in vivo when tumor-bearing mice were administered cetuximab (0.5 mg), 24 h prior to injection of [11C]EAI045. Conclusions EAI045 was successfully labeled with tritium and carbon-11, and the in vivo results indicated [11C]EAI045 may be able to distinguish between mutated and non-mutated EGFR in non-small cell lung cancer mouse models. Cetuximab was hypothesized to increase EAI045 uptake; however, no significant effect was observed on the uptake of [11C]EAI045 in vivo or [3H]EAI045 in vitro in H1975 xenografts and cells.

Published
2024
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44. Advice on describing Bayesian analysis of neutron and X-ray reflectometry

Author

McCluskey, Andrew R., Caruana, Andrew J., Kinane, Christy J., Armstrong, Alexander J., Arnold, Tom, Cooper, Joshaniel F. K., Cortie, David L., Hughes, Arwel V., Moulin, Jean-François, Nelson, Andrew R. J., Potrzebowski, Wojciech, and Straostin, Vladimir

Subjects
Statistics - Applications, Condensed Matter - Materials Science, Condensed Matter - Soft Condensed Matter
Abstract

Driven by the availability of modern software and hardware, Bayesian analysis is becoming more popular in neutron and X-ray reflectometry analysis. The understandability and replicability of these analyses may be harmed by inconsistencies in how the probability distributions central to Bayesian methods are represented in the literature. Herein, we provide advice on how to report the results of Bayesian analysis as applied to neutron and X-ray reflectometry. This includes the clear reporting of initial starting conditions, the prior probabilities, and results of any analysis, and the posterior probabilities that are the Bayesian equivalent of the error bar, to enable replicability and improve understanding. We believe that this advice, grounded in our experience working in the field, will enable greater analytical reproducibility among the reflectometry community, as well as improve the quality and usability of results.

Published
2022
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45. Ultra-High Carrier Mobilities in Ferroelectric Domain Wall Corbino Cones at Room Temperature

Author

McCluskey, Conor J., Colbear, Matthew G., McConville, James P. V., McCartan, Shane J., Maguire, Jesi R., Conroy, Michele, Moore, Kalani, Harvey, Alan, Trier, Felix, Bangert, Ursel, Gruverman, Alexei, Bibes, Manuel, Kumar, Amit, McQuaid, Raymond G. P., and Gregg, J. Marty

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Recently, electrically conducting heterointerfaces between dissimilar band-insulators (such as lanthanum aluminate and strontium titanate) have attracted considerable research interest. Charge transport has been thoroughly explored and fundamental aspects of conduction firmly established. Perhaps surprisingly, similar insights into conceptually much simpler conducting homointerfaces, such as the domain walls that separate regions of different orientations of electrical polarisation within the same ferroelectric band-insulator, are not nearly so well-developed. Addressing this disparity, we herein report magnetoresistance in approximately conical 180o charged domain walls, which occur in partially switched ferroelectric thin film single crystal lithium niobate. This system is ideal for such measurements: firstly, the conductivity difference between domains and domain walls is extremely and unusually large (a factor of at least 1013) and hence currents driven through the thin film, between planar top and bottom electrodes, are overwhelmingly channelled along the walls; secondly, when electrical contact is made to the top and bottom of the domain walls and a magnetic field is applied along their cone axes (perpendicular to the thin film surface), then the test geometry mirrors that of a Corbino disc, which is a textbook arrangement for geometric magnetoresistance measurement. Our data imply carriers at the domain walls with extremely high room temperature Hall mobilities of up to ~ 3,700cm2V-1s-1. This is an unparalleled value for oxide interfaces (and for bulk oxides too) and is most comparable to mobilities in other systems typically seen at cryogenic, rather than at room, temperature., Comment: 22 pages main text, 24 pages supplementary information. Published in advanced materials, DOI:https://doi.org/10.1002/adma.202204298

Published
2022
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46. Reconstruction of interactions in the ProtoDUNE-SP detector with Pandora

Author

DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Ahmad, Z., Ahmed, J., Aimard, B., Akbar, F., Ali-Mohammadzadeh, B., Allison, K., Monsalve, S. Alonso, AlRashed, M., Alt, C., Alton, A., Alvarez, R., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Antusch, S., Aranda-Fernandez, A., Arellano, L., Arnold, L. O., Arroyave, M. A., Asaadi, J., Asquith, L., Aurisano, A., Aushev, V., Autiero, D., Lara, V. Ayala, Ayala-Torres, M., Azfar, F., Back, A., Back, H., Back, J. J., Backhouse, C., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baller, B., Bambah, B., Barao, F., Barenboim, G., Barker, G., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Battat, J., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Chagas, E. Belchior Batista das, Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhardwaj, A., Bhatnagar, V., Bhattacharjee, M., Bhattarai, D., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. d. M., Blazey, G. C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Borkum, A., Bostan, N., Bour, P., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Butorov, I., Cagnoli, I., Cai, T., Caiulo, D., Calabrese, R., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Caminata, A., Benitez, A. Campos, Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carroll, T., Forero, J. F. Castaño, Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavallaro, G., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chalifour, M., Chappell, A., Chardonnet, E., Charitonidis, N., Chatterjee, A., Chattopadhyay, S., Neyra, M. S. Chavarry, Chen, H., Chen, M., Chen, Y., Chen, Z., Chen-Wishart, Z., Cheon, Y., Cherdack, D., Chi, C., Childress, S., Chirco, R., Chiriacescu, A., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Christensen, A., Christian, D., Christodoulou, G., Chukanov, A., Chung, M., Church, E., Cicero, V., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J., Collot, J., Colton, N., Conley, E., Conley, R., Conrad, J., Convery, M., Copello, S., Cova, P., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Cussans, D., Dai, J., Dalager, O., Da Motta, H., Peres, L. Da Silva, David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De, S., Debbins, P., De Bonis, I., Decowski, M., De Gouvea, A., De Holanda, P. C., Astiz, I. L. De Icaza, Deisting, A., De Jong, P., Delbart, A., De Leo, V., Delepine, D., Delgado, M., Dell'Acqua, A., Delmonte, N., De Lurgio, P., Neto, J. R. De Mello, DeMuth, D. M., Dennis, S., Densham, C., Deptuch, G. W., De Roeck, A., De Romeri, V., De Souza, G., Devi, R., Dharmapalan, R., Dias, M., Diaz, J., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Giulio, L., Ding, P., Di Noto, L., Dirkx, G., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M., Domine, L., Donon, Y., Douglas, D., Dragone, A., Drake, G., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dunne, P., Dutta, B., Duyang, H., Dvornikov, O., Dwyer, D., Dyshkant, A., Eads, M., Earle, A., Edmunds, D., Eisch, J., Emberger, L., Emery, S., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C., Sanchez, L. Escudero, Eurin, G., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Falcone, A., Fani', M., Farnese, C., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Menendez, P. Fernandez, Ferraro, F., Fields, L., Filip, P., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fischer, V., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fogarty, S., Foreman, W., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gabrielli, A., Gago, A., Gallagher, H., Gallas, A., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Gauvreau, J., Gauzzi, P., Ge, G., Geffroy, N., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Giammaria, P., Giammaria, T., Giangiacomi, N., Gibin, D., Gil-Botella, I., Gilligan, S., Girerd, C., Giri, A., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Caamaño, D. González, Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D., Green, P., Green, S., Greenberg, S., Greenler, L., Greer, J., Grenard, J., Griffith, C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guardincerri, E., Guarino, V., Guarise, M., Guenette, R., Guerard, E., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Gupta, A., Gupta, V., Guthikonda, K., Guzowski, P., Guzzo, M. 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Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The Pandora Software Development Kit and algorithm libraries provide pattern-recognition logic essential to the reconstruction of particle interactions in liquid argon time projection chamber detectors. Pandora is the primary event reconstruction software used at ProtoDUNE-SP, a prototype for the Deep Underground Neutrino Experiment far detector. ProtoDUNE-SP, located at CERN, is exposed to a charged-particle test beam. This paper gives an overview of the Pandora reconstruction algorithms and how they have been tailored for use at ProtoDUNE-SP. In complex events with numerous cosmic-ray and beam background particles, the simulated reconstruction and identification efficiency for triggered test-beam particles is above 80% for the majority of particle type and beam momentum combinations. Specifically, simulated 1 GeV/$c$ charged pions and protons are correctly reconstructed and identified with efficiencies of 86.1$\pm0.6$% and 84.1$\pm0.6$%, respectively. The efficiencies measured for test-beam data are shown to be within 5% of those predicted by the simulation., Comment: 39 pages, 20 figures. Accepted version. Published version available in Eur. Phys. J. C 83, 618 (2023) https://doi.org/10.1140/epjc/s10052-023-11733-2

Published
2022
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47. ‘I’ve got no PPE to protect my mind’: understanding the needs and experiences of first responders exposed to trauma in the workplace

Author

Nicola Cogan, Ashleigh Craig, Lucy Milligan, Robyn McCluskey, Tara Burns, Wiktoria Ptak, Alison Kirk, Christoph Graf, Jolie Goodman, and Johannes De Kock

Subjects
First responder, occupational trauma, stigma of MH help-seeking, qualitative, mental health, Equipo de primera intervención, Psychiatry, RC435-571
Abstract

Background: First responders (FRs) are at high risk of being exposed to traumatic events in their occupational roles. Responding to critical incidents often involves exposure to life-threatening circumstances, dealing with fatalities and encountering highly stressful situations that may trigger traumatic responses. These experiences can lead to poor physical and mental health (MH) outcomes including post-traumatic stress disorder, co-morbid conditions such as depression, anxiety, substance abuse, insomnia, and suicidality. Little research has explored the perspectives and experiences of FRs in dealing with occupational trauma(s) and how best to meet their health needs.Objective: This study aimed to explore FRs’ experiences of exposure to occupational trauma and its impact on their mental wellbeing. The wider objective was to investigate how FRs can be supported to access appropriate and relevant help, addressing barriers like stigma.Method: A qualitative research design using in-depth semi-structured interviews with FRs (n = 54) was adopted. Interviews were audio-recorded, transcribed and analysed using an inductive thematic approach.Results: Themes developed were: (1) the pervasive, cumulative and salient impact of occupational trauma on MH (micro-traumas, nightmares, flashbacks and reliving experiences); (2) the demands of the job exacerbating the adverse effects of trauma (self and others); (3) insufficient support and unhelpful ways of coping following exposure to trauma (lack of psychological safety); (4) stigma and fear of judgement as barriers to MH help-seeking; and (5) need for specific, accessible and credible trauma-focused interventions and workplace support.Conclusions: The implications of these findings are discussed at the individual, service provider and organisational level, emphasising the importance of implementing a strengths-based, non-pathologising and de-stigmatising approach to trauma in the workplace as experienced by FRs. Emphasis is placed on the importance of overcoming barriers to accessing MH support and improving access to evidence-based, trauma-focused psychological interventions and workplace support.

Published
2024
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48. Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro

Author

Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, and Anthony Shock

Subjects
FcRn, neonatal Fc receptor, rozanolixizumab, Fcγ receptor, antibody bipolar bridging, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607
Abstract

ABSTRACTRozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format is frequently used for therapeutic mAbs due to its intrinsic lower affinity for Fc gamma receptors (FcγR) and lack of C1q engagement. However, with growing evidence suggesting that no Fc-containing agent is truly “silent” in this respect, we explored the engagement of FcγRs and potential functional consequences with rozanolixizumab. In the study presented here, rozanolixizumab was shown to bind to FcγRs in both protein-protein and cell-based assays, and the kinetic data were broadly as expected based on published data for an IgG4 mAb. Rozanolixizumab was also able to mediate antibody bipolar bridging (ABB), a phenomenon that led to a reduction of labeled FcγRI from the surface of human macrophages in an FcRn-dependent manner. However, the presence of exogenous human IgG, even at low concentrations, was able to prevent both binding and ABB events. Furthermore, data from in vitro experiments using relevant human cell types that express both FcRn and FcγRI indicated no evidence for functional sequelae in relation to cellular activation events (e.g., intracellular signaling, cytokine production) upon either FcRn or FcγR binding of rozanolixizumab. These data raise important questions about whether therapeutic antagonistic mAbs like rozanolixizumab would necessarily engage FcγRs at doses typically administered to patients in the clinic, and hence challenge the relevance and interpretation of in vitro assays performed in the absence of competing IgG.

Published
2024
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50. Association for the Promotion of Political Economy and the Law (APPEAL): Transforming Law and Economic Power

Author

McCluskey, Martha

Subjects
political economy and law, law and economics, legal theory, legal education, institutions, neoliberalism
Abstract

This article reflects on the Association for the Promotion of Political Economy and Law (APPEAL), formed in 2012 as the first contemporary scholarly group named for the emerging field of Law and Political Economy (LPE). APPEAL organizes academics and allies to address urgent social problems by exploring possibilities for reorienting the economy toward justice, equality, and democracy. To mobilize ideas for change, APPEAL emphasizes collaborative intellectual communities. I situate APPEAL in the context of a neoliberal political movement to capture law’s power by investing in the Law and Economics message that economic power inevitably limits democracy and social justice. Though vastly outmatched in funding, APPEAL brings together experts in economics, law, and other disciplines to clarify and change influential neoliberal ideas about both law and economics. I highlight APPEAL participants’ scholarship showing the interconnected social, political, and legal nature of economic power as the basis for transforming economic politics and policy.

Published
2023

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