Search

Your search keyword '"Mckenna, Peter J."' showing total 486 results
Start Over Author "Mckenna, Peter J."
486 results on '"Mckenna, Peter J."'

3. Cortical volume abnormalities in schizophrenia: Correlations with symptoms and cognitive impairment

Author

García-León, María Ángeles, Fuentes-Claramonte, Paola, Soler-Vidal, Joan, Ramiro-Sousa, Nuria, Salgado-Pineda, Pilar, Salavert, Josep, Torres, Llanos, Guerrero-Pedraza, Amalia, Tristany, Josep, Karuk, Andriana, Barbosa, Lucila, Del Olmo-Encabo, Pablo, Canut-Altemir, Pedro, Munuera, Josep, Sarró, Salvador, Salvador, Raymond, McKenna, Peter J., and Pomarol-Clotet, Edith

Published
2024
Full Text
View/download PDF

5. Working memory deterioration as an early warning sign for relapse in remitted psychosis: A one-year naturalistic follow-up study

Author

Tao, Tiffany Junchen, Hui, Christy Lai Ming, Hui, Priscilla Wing Man, Ho, Elise Chun Ning, Lam, Bertha Sze Ting, Wong, Andreas Kar Hin, See, Sally Hiu Wah, Chan, Evie Wai Ting, Suen, Yi Nam, Lee, Edwin Ho Ming, Chan, Sherry Kit Wa, Chang, Wing Chung, Lo, William Tak Lam, Chong, Catherine Shiu Yin, Siu, Clara Man Wah, Choi, Yan Yin, Pomarol-Clotet, Edith, McKenna, Peter J, Honer, William G, and Chen, Eric Yu Hai

Published
2023
Full Text
View/download PDF

6. Striatal dopamine synthesis capacity and its association with negative symptoms upon resolution of positive symptoms in first-episode schizophrenia and delusional disorder

Author

Wong, Stephanie M. Y., Suen, Y. N., Wong, Charlotte W. C., Chan, Sherry K. W., Hui, Christy L. M., Chang, W. C., Lee, Edwin H. M., Cheng, Calvin P. W., Ho, Garrett C. L., Lo, Gladys Goh, Leung, Eric Y. L., Yeung, Paul K. M. Au, Chen, Sirong, Honer, William G., Mak, Henry K. F., Sham, P. C., McKenna, Peter J., Pomarol-Clotet, Edith, Veronese, Mattia, Howes, Oliver D., and Chen, Eric Y. H.

Published
2022
Full Text
View/download PDF

8. Psychometric properties of the Spanish version of the Health of Nation Outcome Scales for schizophrenia patients.

Author

Feria‐Raposo, Isabel, García‐León, María Ángeles, Rodríguez‐Cano, Elena, Blanco‐Blanco, Joan, Moreno‐Casbas, María Teresa, Gonzalez‐Castro, Ana Isabel, Gómez‐Lozano, María José, Guerrero‐Pedraza, Amalia, Sarri, Carmen, Portillo, Francisco, Sarró, Salvador, McKenna, Peter J., Salvador, Raymond, and Pomarol‐Clotet, Edith

Subjects
COGNITION disorders diagnosis, HEALTH status indicators, RESEARCH funding, CRONBACH'S alpha, DATA analysis, RESEARCH methodology evaluation, INTERVIEWING, RESEARCH evaluation, FUNCTIONAL assessment, KRUSKAL-Wallis Test, SCHIZOPHRENIA, SEVERITY of illness index, MANN Whitney U Test, PSYCHOMETRICS, STATISTICAL reliability, INTRACLASS correlation, STATISTICS, BARTHEL Index, INTER-observer reliability
Abstract

Accessible SummaryWhat is known on the subject?Functioning is one of the most affected areas in schizophrenia. Social, occupational and personal domains are affected, and these deficits are responsible for a major part of the disability associated with the disorder.There are several instruments to measure functioning, but the HoNOS provides a wide assessment of impairment in 12 areas of functioning.What does the paper add to existing knowledge?The Spanish version of the HoNOS shows good properties in terms of reliability and validity for use in schizophrenia patients.Although some authors divide the scale according to proposed underlying dimensions, in schizophrenia this division may not be appropriate.What are the implications for practice?A reliable and easy‐to‐use measure of impairment in different areas of functioning is useful for optimizing the treatment and rehabilitation of patients with schizophrenia. Introduction: The HoNOS scale was designed for the assessment of psychosocial impairment in various domains. While it is widely used in psychiatric settings, it has not been validated in Spanish for use in patients with schizophrenia. Aim: To examine the psychometric properties of the Spanish version of the HoNOS scale in a sample of schizophrenia patients. Method: A total of 194 individuals aged 18 to 65 with schizophrenia spectrum diagnoses were evaluated using the HoNOS. Illness severity and level of functioning were also assessed. Results: The HoNOS showed moderate internal consistency, good inter‐observer reliability and good test‐retest reliability. Factor analysis revealed an internal structure consisting of four factors, with item distribution differing from the theoretical dimensions proposed for the original scale. Discussion: The Spanish version of the HoNOS scale is a reliable and valid instrument for assessing psychosocial impairment in individuals diagnosed with schizophrenia spectrum disorders. However, further research is needed to determine its internal structure more accurately. Implications for Practice: The HoNOS scale provides researchers and clinicians with a valid measure of impairment in twelve different domains, which can facilitate and guide the treatment of schizophrenia patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect

Author

Fuentes-Claramonte, Paola, Ramiro, Núria, Torres, Llanos, Argila-Plaza, Isabel, Salgado-Pineda, Pilar, Soler-Vidal, Joan, García-León, María Ángeles, Albacete, Auria, Bosque, Clara, Panicalli, Francesco, Boix, Ester, Munuera, Josep, Tristany, Josep, Sarró, Salvador, Bernardo, Miquel, Salvador, Raymond, McKenna, Peter J., and Pomarol-Clotet, Edith

Published
2022
Full Text
View/download PDF

12. Interindividual variability of functional connectome in schizophrenia

Author

Santo-Angles, Aniol, Salvador, Raymond, Gomar, Jesús J., Guerrero-Pedraza, Amalia, Ramiro, Núria, Tristany, Josep, Teixidó, Cristina, Ortiz-Gil, Jordi, Aguirre, Candibel, Bosque, Clara, López-Araquistain, Laura, Maristany, Teresa, Salgado-Pineda, Pilar, Sarró, Salvador, McKenna, Peter J., Bernardo, Miquel, Pomarol-Clotet, Edith, and Schwarzbach, Jens

Published
2021
Full Text
View/download PDF

17. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

Author

Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, van Erp, Theo G.M., Walton, Esther, Hibar, Derrek P., Schmaal, Lianne, Jiang, Wenhao, Glahn, David C., Pearlson, Godfrey D., Yao, Nailin, Fukunaga, Masaki, Hashimoto, Ryota, Okada, Naohiro, Yamamori, Hidenaga, Bustillo, Juan R., Clark, Vincent P., Mueller, Bryon A., Cahn, Wiepke, de Zwarte, Sonja M.C., Hulshoff Pol, Hilleke E., Kahn, René S., Ophoff, Roel A., van Haren, Neeltje E.M., Andreassen, Ole A., Dale, Anders M., Doan, Nhat Trung, Gurholt, Tiril P., Hartberg, Cecilie B., Haukvik, Unn K., Jørgensen, Kjetil N., Lagerberg, Trine V., Melle, Ingrid, Westlye, Lars T., Gruber, Oliver, Kraemer, Bernd, Richter, Anja, Zilles, David, Calhoun, Vince D., Crespo-Facorro, Benedicto, Roiz-Santiañez, Roberto, Tordesillas-Gutiérrez, Diana, Loughland, Carmel, Carr, Vaughan J., Catts, Stanley, Cropley, Vanessa L., Fullerton, Janice M., Green, Melissa J., Henskens, Frans A., Jablensky, Assen, Lenroot, Rhoshel K., Mowry, Bryan J., Michie, Patricia T., Pantelis, Christos, Quidé, Yann, Schall, Ulrich, Scott, Rodney J., Cairns, Murray J., Seal, Marc, Tooney, Paul A., Rasser, Paul E., Cooper, Gavin, Shannon Weickert, Cynthia, Weickert, Thomas W., Morris, Derek W., Hong, Elliot, Kochunov, Peter, Beard, Lauren M., Gur, Raquel E., Gur, Ruben C., Satterthwaite, Theodore D., Wolf, Daniel H., Belger, Aysenil, Brown, Gregory G., Ford, Judith M., Macciardi, Fabio, Mathalon, Daniel H., O’Leary, Daniel S., Potkin, Steven G., Preda, Adrian, Voyvodic, James, Lim, Kelvin O., McEwen, Sarah, Yang, Fude, Tan, Yunlong, Tan, Shuping, Wang, Zhiren, Fan, Fengmei, Chen, Jingxu, Xiang, Hong, Tang, Shiyou, Guo, Hua, Wan, Ping, Wei, Dong, Bockholt, Henry J., Ehrlich, Stefan, Wolthusen, Rick P.F., King, Margaret D., Shoemaker, Jody M., Sponheim, Scott R., De Haan, Lieuwe, Koenders, Laura, Machielsen, Marise W., van Amelsvoort, Therese, Veltman, Dick J., Assogna, Francesca, Banaj, Nerisa, de Rossi, Pietro, Iorio, Mariangela, Piras, Fabrizio, Spalletta, Gianfranco, McKenna, Peter J., Pomarol-Clotet, Edith, Salvador, Raymond, Corvin, Aiden, Donohoe, Gary, Kelly, Sinead, Whelan, Christopher D., Dickie, Erin W., Rotenberg, David, Voineskos, Aristotle N., Ciufolini, Simone, Radua, Joaquim, Dazzan, Paola, Murray, Robin, Reis Marques, Tiago, Simmons, Andrew, Borgwardt, Stefan, Egloff, Laura, Harrisberger, Fabienne, Riecher-Rössler, Anita, Smieskova, Renata, Alpert, Kathryn I., Wang, Lei, Jönsson, Erik G., Koops, Sanne, Sommer, Iris E.C., Bertolino, Alessandro, Bonvino, Aurora, Di Giorgio, Annabella, Neilson, Emma, Mayer, Andrew R., Stephen, Julia M., Kwon, Jun Soo, Yun, Je-Yeon, Cannon, Dara M., McDonald, Colm, Lebedeva, Irina, Tomyshev, Alexander S., Akhadov, Tolibjohn, Kaleda, Vasily, Busatto, Geraldo F., Rosa, Pedro G.P., Serpa, Mauricio H., Zanetti, Marcus V., Hoschl, Cyril, Skoch, Antonin, Spaniel, Filip, Tomecek, David, Hagenaars, Saskia P., McIntosh, Andrew M., Whalley, Heather C., Lawrie, Stephen M., Knöchel, Christian, Oertel-Knöchel, Viola, Stäblein, Michael, Howells, Fleur M., Stein, Dan J., Temmingh, Henk S., Uhlmann, Anne, Lopez-Jaramillo, Carlos, Dima, Danai, McMahon, Agnes, Faskowitz, Joshua I., Gutman, Boris A., Jahanshad, Neda, Thompson, Paul M., and Turner, Jessica A.

Published
2018
Full Text
View/download PDF

20. Fingerprints as Predictors of Schizophrenia: A Deep Learning Study

Author

Salvador, Raymond, García-León, María Ángeles, Feria-Raposo, Isabel, Botillo-Martín, Carlota, Martín-Lorenzo, Carlos, Corte-Souto, Carmen, Aguilar-Valero, Tania, Gil-Sanz, David, Porta-Pelayo, David, Martín-Carrasco, Manuel, Del Olmo-Romero, Francisco, Santiago-Bautista, Jose Maria, Herrero-Muñecas, Pilar, Castillo-Oramas, Eglee, Larrubia-Romero, Jesús, Rios-Alvarado, Zoila, Larraz-Romeo, José Antonio, Guardiola-Ripoll, Maria, Almodóvar-Payá, Carmen, Fatjó-Vilas Mestre, Mar, Sarró, Salvador, McKenna, Peter J, HHFingerprints Group, Pomarol-Clotet, Edith, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Centro de Investigación Biomédica en Red - CIBERSAM (Salud Mental), and Government of Catalonia (España)

Subjects
Artificial intelligence, Psychiatry and Mental health, Diagnosis, Machine learning, Schizophrenia, Dermatoglyphics
Abstract

Background and hypothesis: The existing developmental bond between fingerprint generation and growth of the central nervous system points to a potential use of fingerprints as risk markers in schizophrenia. However, the high complexity of fingerprints geometrical patterns may require flexible algorithms capable of characterizing such complexity. Study design: Based on an initial sample of scanned fingerprints from 612 patients with a diagnosis of non-affective psychosis and 844 healthy subjects, we have built deep learning classification algorithms based on convolutional neural networks. Previously, the general architecture of the network was chosen from exploratory fittings carried out with an independent fingerprint dataset from the National Institute of Standards and Technology. The network architecture was then applied for building classification algorithms (patients vs controls) based on single fingers and multi-input models. Unbiased estimates of classification accuracy were obtained by applying a 5-fold cross-validation scheme. Study results: The highest level of accuracy from networks based on single fingers was achieved by the right thumb network (weighted validation accuracy = 68%), while the highest accuracy from the multi-input models was attained by the model that simultaneously used images from the left thumb, index and middle fingers (weighted validation accuracy = 70%). Conclusion: Although fitted models were based on data from patients with a well established diagnosis, since fingerprints remain lifelong stable after birth, our results imply that fingerprints may be applied as early predictors of psychosis. Specially, if they are used in high prevalence subpopulations such as those of individuals at high risk for psychosis. This work was supported by several grants funded by the Instituto de Salud Carlos III and the Spanish Ministry of Science and Innovation (co-funded by the European Regional Development Fund/European Social Fund “Investing in your future”): Miguel Servet Research Contract (CPII13/00018 to RS, CPII16/00018 to EP-C, CP20/00072 to MF-V), PFIS Contract (FI19/0352 to MG-R). Research Mobility programme (MV18/00054 to EP-C), Research Projects (PI18/00877 and PI21/00525 to RS). It has also been supported by the Centro de Investigación Biomédica en Red de Salud Mental and the Generalitat de Catalunya: 2014SGR1573 and 2017SGR1365 to EP-C and SLT008/18/00206 to IF-R from the Departament de Salut. The authors have declared that there are no conflicts of interest in relation to the subject of this study. Sí

Published
2022
Full Text
View/download PDF

23. Failure of deactivation in bipolar disorder during performance of an fMRI adapted version of the Stroop task

Author

Verdolini, Norma, primary, Moreno-Ortega, Marta, additional, Salgado-Pineda, Pilar, additional, Monté, Gemma, additional, de Aragón, Ana Martínez, additional, Dompablo, Mónica, additional, McKenna, Peter J., additional, Salvador, Raymond, additional, Palomo, Tomás, additional, Pomarol-Clotet, Edith, additional, and Rodriguez-Jimenez, Roberto, additional

Published
2023
Full Text
View/download PDF

27. Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task.

Author

Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Salgado-Pineda, Pilar, Ramiro, Núria, Soler-Vidal, Joan, Torres, Maria Llanos, Cano, Ramon, Argila-Plaza, Isabel, Panicali, Francesco, Sarri, Carmen, Jaurrieta, Núria, Sánchez, Manel, Boix-Quintana, Ester, Albacete, Auria, Maristany, Teresa, Sarró, Salvador, Raduà, Joaquim, McKenna, Peter J., Salvador, Raymond, and Pomarol-Clotet, Edith

Subjects
PREFRONTAL cortex, BRAIN, DIGITAL image processing, SCHIZOPHRENIA, PSYCHOSES, TASK performance, MAGNETIC resonance imaging, HEALTH outcome assessment, REGRESSION analysis, DOPAMINE, COMPARATIVE studies, REWARD (Psychology), DESCRIPTIVE statistics, RESEARCH funding, CLASSIFICATION of mental disorders, SOCIODEMOGRAPHIC factors
Abstract

Background: A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction error (RPE). Nevertheless, few functional imaging studies have examined if patients with negative symptoms show reduced RPE-associated activations. Methods: Matched groups of DSM-5 schizophrenia patients with high negative symptom scores (HNS, N = 27) or absent negative symptoms (ANS, N = 27) and healthy controls (HC, N = 30) underwent fMRI scanning while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Results: In the HC, whole-brain analysis revealed that RPE was positively associated with activation in the ventral striatum, the putamen, and areas of the lateral prefrontal cortex and orbitofrontal cortex, among other regions. Group comparison revealed no activation differences between the healthy controls and the ANS patients. However, compared to the ANS patients, the HNS patients showed regions of significantly reduced activation in the left ventrolateral and dorsolateral prefrontal cortex, and in the right lingual and fusiform gyrus. HNS and ANS patients showed no activation differences in ventral striatal or midbrain regions-of-interest (ROIs), but the HNS patients showed reduced activation in a left orbitofrontal cortex ROI. Conclusions: The findings do not suggest that a generalized reduction of RPE signalling underlies negative symptoms. Instead, they point to a more circumscribed dysfunction in the lateral frontal and possibly the orbitofrontal cortex. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

31. Neural correlates of referential/persecutory delusions in schizophrenia: examination using fMRI and a virtual reality underground travel paradigm.

Author

Fuentes-Claramonte, Paola, Salgado-Pineda, Pilar, Argila-Plaza, Isabel, García-León, María Ángeles, Ramiro, Núria, Soler-Vidal, Joan, Albacete, Auria, Delgado, Nicolas, Tavares, Paulo, Torres, María Llanos, Guerrero-Pedraza, Amalia, Portillo, Francisco, Boix, Ester, Munuera, Josep, Arévalo, Antonio, Sarró, Salvador, Salvador, Raymond, McKenna, Peter J., and Pomarol-Clotet, Edith

Subjects
RESEARCH, BRAIN, DELUSIONS, SCHIZOPHRENIA, VIRTUAL reality, MAGNETIC resonance imaging, RESEARCH funding, STATISTICAL correlation
Abstract

Background: The brain functional correlates of delusions have been relatively little studied. However, a virtual reality paradigm simulating travel on the London Underground has been found to evoke referential ideation in both healthy subjects and patients with schizophrenia, making brain activations in response to such experiences potentially identifiable. Method: Ninety patients with schizophrenia/schizoaffective disorder and 28 healthy controls underwent functional magnetic resonance imaging while they viewed virtual reality versions of full and empty Barcelona Metro carriages. Results: Compared to the empty condition, viewing the full carriage was associated with activations in the visual cortex, the cuneus and precuneus/posterior cingulate cortex, the inferior parietal cortex, the angular gyrus and parts of the middle and superior temporal cortex including the temporoparietal junction bilaterally. There were no significant differences in activation between groups. Nor were there activations associated with referentiality or presence of delusions generally in the patient group. However, patients with persecutory delusions showed a cluster of reduced activation compared to those without delusions in a region in the right temporal/occipital cortex. Conclusions: Performance of the metro task is associated with a widespread pattern of activations, which does not distinguish schizophrenic patients and controls, or show an association with referentiality or delusions in general. However, the finding of a cluster of reduced activation close to the right temporoparietal junction in patients with persecutory delusions specifically is of potential interest, as this region is believed to play a role in social cognition. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

33. Neural correlates of referential/persecutory delusions in schizophrenia: examination using fMRI and a virtual reality underground travel paradigm

Author

Fuentes-Claramonte, Paola, primary, Salgado-Pineda, Pilar, additional, Argila-Plaza, Isabel, additional, García-León, María Ángeles, additional, Ramiro, Núria, additional, Soler-Vidal, Joan, additional, Albacete, Auria, additional, Delgado, Nicolas, additional, Tavares, Paulo, additional, Torres, María Llanos, additional, Guerrero-Pedraza, Amalia, additional, Portillo, Francisco, additional, Boix, Ester, additional, Munuera, Josep, additional, Arévalo, Antonio, additional, Sarró, Salvador, additional, Salvador, Raymond, additional, McKenna, Peter J., additional, and Pomarol-Clotet, Edith, additional

Published
2022
Full Text
View/download PDF

35. New Information Technology in the Irish School System: A Summary

Author

McKenna, Peter J., Anderson, Ronald E., editor, Asper, Guillermo, editor, Becker, Henry J., editor, Collis, Betty, editor, Grinfelds, Andris, editor, Haider, Gunter, editor, Hawkridge, David, editor, Huh, Unna, editor, Hunter, Beverly, editor, Latchem, Colin, editor, Ragsdale, Ronald, editor, Salomon, Gavriel, editor, Walker, Decker, editor, Wantanabe, Ryo, editor, Plomp, Tjeerd, editor, and Kontogiannopoulou-Polydorides, Georgia, editor

Published
1996
Full Text
View/download PDF

39. A Multisite, Randomized Controlled Clinical Trial of Computerized Cognitive Remediation Therapy for Schizophrenia

Author

Gomar, Jesús J., Valls, Elia, Radua, Joaquim, Mareca, Celia, Tristany, Josep, del Olmo, Francisco, Rebolleda-Gil, Carlos, Jañez-Álvarez, María, de Álvaro, Francisco J., Ovejero, María R., Llorente, Ana, Teixidó, Cristina, Donaire, Ana M., García-Laredo, Eduardo, Lazcanoiturburu, Andrea, Granell, Luis, Mozo, Cristina de Pablo, Pérez-Hernández, Mónica, Moreno-Alcázar, Ana, Pomarol-Clotet, Edith, and McKenna, Peter J.

Published
2015
Full Text
View/download PDF

41. Brain imaging correlates of self- and other-reflection in schizophrenia

Author

Fuentes-Claramonte, Paola, Martin-Subero, Marta, Salgado-Pineda, Pilar, Santo-Angles, Aniol, Argila-Plaza, Isabel, Salavert, Josep, Arévalo, Antoni, Bosque, Clara, Sarri, Carmen, Guerrero-Pedraza, Amalia, Capdevila, Antoni, Sarró, Salvador, McKenna, Peter J., Pomarol-Clotet, Edith, Salvador, Raymond, and Universitat Autònoma de Barcelona

Subjects
Male, Social Cognition, Theory of Mind, Precuneus, lcsh:RC346-429, Temporo-parietal junction, 0302 clinical medicine, Semantic memory, Prefrontal cortex, fMRI, 05 social sciences, Brain, Regular Article, Cognition, Middle Aged, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, Schizophrenia, lcsh:R858-859.7, Female, Schizophrenic Psychology, Adult, Psychosis, Other-reflection, Cognitive Neuroscience, lcsh:Computer applications to medicine. Medical informatics, behavioral disciplines and activities, 050105 experimental psychology, Young Adult, 03 medical and health sciences, Neuroimaging, Social cognition, Fmri, mental disorders, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, lcsh:Neurology. Diseases of the nervous system, business.industry, Self-reflection, medicine.disease, Self Concept, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Highlights • Self- and other-reflection in schizophrenia were studied with fMRI. • Patients failed to activate the right temporo-parietal junction in other-reflection. • They also hyperactivated lateral prefrontal cortex for self and other-reflection. • These findings might be linked to altered self/other processing in schizophrenia., Background An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results. Methods Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing. Results Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity. Conclusions Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group.

Published
2021

42. Conciencia de déficit cognitivo en la esquizofrenia y su relación con la conciencia de enfermedad mental : correlatos con las características clínicas, la función cognitiva y los cambios cerebrales estructurales

Author

Pomarol-Clotet, Edith, McKenna, Peter J., Tobeña, Adolf, González Suárez, Beatriz, Pomarol-Clotet, Edith, McKenna, Peter J., Tobeña, Adolf, and González Suárez, Beatriz

Abstract

La manca de consciència de malaltia mental és una característica prevalent en l'esquizofrènia, i la seva relació amb altres variables clíniques, cognitives i / o neuroanatòmiques ha estat un tema freqüent de recerca, tot i que els resultats són inconsistents. Segons la concepció multidimensional que preval actualment, el insight està compost per tres facetes que poden aparèixer dissociades. En aquest context, ha augmentat l'interès per valorar una altra faceta potencial, el grau de consciència que els pacients amb esquizofrènia tenen dels seus dèficits cognitius. La consciència de dèficit cognitiu en l'esquizofrènia és un aspecte relativament poc investigat, i la seva relació amb la consciència de malaltia mental i amb els seus possibles variables etiològiques encara no s'ha aclarit. L'objectiu general d'aquesta tesi va ser estudiar la consciència de dèficit en l'esquizofrènia i la seva relació amb l'insight clínic. Es va examinar també la relació de les dues dimensions amb variables clíniques, cognitives i d'estructura cerebral amb la intenció d'identificar possibles patrons diferencials de relació amb les dues classes de falta de consciència. En el primer estudi es va examinar la consciència de dèficit cognitiu en una mostra de 42 pacients amb esquizofrènia crònica hospitalitzats i la seva relació amb la simptomatologia, la funció executiva, la memòria, l'insight clínic i l'estructura cerebral. La valoració de la consciència de dèficit es va dur a terme comparant l'autoinforme del pacient i l'avaluació cognitiva objectiva, i amb el càlcul de la puntuació de discrepància entre l'autoinforme del pacient i el de l'informant sobre el funcionament cognitiu de el primer. El insight clínic va ser valorat mitjançant l'escala SUMD (Scale to Assess Unawareness of Mental Disorder). Els resultats indicaven que la majoria dels pacients eren poc conscients dels dèficits cognitius presents, sense que aquesta manca de consciència estigués relacionada amb variables clíniques ni co, La falta de conciencia de enfermedad mental es una característica prevalente en la esquizofrenia, y su relación con otras variables clínicas, cognitivas y/o neuroanatómicas ha sido un tema frecuente de investigación, aunque los resultados son inconsistentes. Según la concepción multidimensional que prevalece actualmente, el insight está compuesto por tres facetas que pueden aparecer disociadas. En este contexto, ha aumentado el interés por valorar otra faceta potencial, el grado de conciencia que los pacientes con esquizofrenia tienen de sus déficits cognitivos. La conciencia de déficit cognitivo en la esquizofrenia es un aspecto relativamente poco investigado, y su relación con la conciencia de enfermedad mental y con sus posibles variables etiológicas aún no se ha clarificado. El objetivo general de esta tesis fue estudiar la conciencia de déficit en la esquizofrenia y su relación con el insight clínico. Se examinó también la relación de ambas dimensiones con variables clínicas, cognitivas y de estructura cerebral con la intención de identificar posibles patrones diferenciales de relación con las dos clases de falta de conciencia. En el primer estudio se examinó la conciencia de déficit cognitivo en una muestra de 42 pacientes con esquizofrenia crónica hospitalizados y su relación con la sintomatología, la función ejecutiva, la memoria, el insight clínico y la estructura cerebral. La valoración de la conciencia de déficit se llevó a cabo comparando el autoinforme del paciente y la evaluación cognitiva objetiva, y con el cálculo de la puntuación de discrepancia entre el autoinforme del paciente y el del informante sobre el funcionamiento cognitivo del primero. El insight clínico fue valorado mediante la escala SUMD (Scale to Assess Unawareness of Mental Disorder). Los resultados indicaban que la mayoría de los pacientes eran poco conscientes de los déficits cognitivos presentes, sin que dicha falta de conciencia estuviera relacionada con variables clínicas ni cogni, Lack of awareness of mental illness or poor insight is prevalent in schizophrenia, and its relationship with other clinical, cognitive and/or neuroanatomical variables has been the subject of significant investigation, although the results are inconsistent. According to a widely held current vies, insight is a multidimensional construct whose different aspects may be dissociated from one another, ie awareness of illness, awareness of the need for treatment and ability to label symptoms as pathological. In this context, there has recently been increased interest in another potential aspect of lack of insight in schizophrenia, the lack of awareness that patients have concerning their cognitive deficits. Nevertheless, awareness of cognitive deficit in schizophrenia remains relatively under-researched, and its relationship with awareness of mental illness and its possible etiological variables remains unclear. The general objective of this thesis was to examine lack of awareness of cognitive deficit in schizophrenia and its relationship with clinical insight. The relationship of both aspects of insight with clinical, cognitive, and neuroanatomical variables was also examined with the intention of identifying possible differential patterns between the two types of symptom. The first study examined cognitive deficit awareness in a sample of 42 hospitalized chronic schizophrenia patients, in relation to symptoms, memory and executive function, clinical insight and brain structure. Symptoms were evaluated using the Positive and Negative Symptom Scale (PANSS), obtaining scores for positive, negative, disorganized syndromes and depressive symptoms. Executive function and memory were assessed using two test batteries, the Behavioral Assessment of the Dysexecutive Syndrome (BADS) and the Rivermead Behavioral Memory Test (RBMT), respectively. Assessment of awareness of cognitive deficit was carried out by means of comparison between the patient's self-report and objective cognit, Universitat Autònoma de Barcelona. Programa de Doctorat en Psiquiatria

Published
2021

46. Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis

Author

Corlett, Philip R., Honey, Garry D., Aitken, Michael R.F., Dickinson, Anthony, Shanks, David R., Absalom, Anthony R., Lee, Michael, Pomarol-Clotet, Edith, Murray, Graham K., Mckenna, Peter J., Robbins, Trevor W., Bullmore, Edward T., and Fletcher, Paul C.

Subjects
Ketamine -- Physiological aspects, Frontal lobes -- Physiological aspects, Frontal lobes -- Research, Delusions -- Development and progression, Magnetic resonance imaging -- Usage, Health, Psychology and mental health
Published
2006

47. Clozapine alone versus clozapine and risperidone with refectory schizophrenia

Author

Honer, William G., Bergmann, Anderea, William, Richard, Thornton, Allen E., Falkai, Peter, Chen, Eric Y.H., MacEwan, William G., Pomoral-Clotet, Edith, Wasan, Kishor, Chan, Raymond C.K., McKenna, Peter J., Procyshyn, Ric, Wong, Jessica O.Y., and Stip, Emmanuel

Subjects
Clozapine -- Dosage and administration, Clozapine -- Comparative analysis, Risperidone -- Dosage and administration, Risperidone -- Comparative analysis, Drug therapy, Combination -- Comparative analysis, Schizophrenia -- Drug therapy
Abstract

A random study on patients with schizophrenia and a poor response to the treatment with clozapine was conducted. The treatment of schizophrenia with multiple antipsychotic drugs is common but the addition of risperidone to clozapine did not improve the symptoms in patients with severe schizophrenia.

Published
2006

48. Battery for the Assessment of the Theory of Mind

Author

Serra-Mayoral, Anna, primary, Mareca, Cèlia, additional, Cano, Ramon, additional, Romaguera, Anna, additional, Alsina, Montserrat, additional, Gutiérrez, Lina, additional, Valls, Èlia, additional, Sarró, Salvador, additional, McKenna, Peter J., additional, Pomarol-Clotet, Edith, additional, and Calderón, Caterina, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results