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Your search keyword '"Meade, Kristin E."' showing total 10 results
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10 results on '"Meade, Kristin E."'

2. Contributors

Author

Agosti, Jan, primary, Alter, Miriam J., additional, Anaya, Daniel A., additional, Ansdell, Vernon, additional, Babineaux, Michael James, additional, Bartlett, John G., additional, Bash, Margaret C., additional, Beach, Michael J., additional, Becker, Natasha S., additional, Blue, Sky R., additional, Blumberg, Dean A., additional, Bower, John R., additional, Bryant, Amy E., additional, Campbell, Grant L., additional, Chow, Anthony W., additional, Coffman, Thomas J., additional, Cohen, Stephanie E., additional, Congeni, Blaise L., additional, Coyle, Christina M., additional, Dhanireddy, Shireesha, additional, Drekonja, Dimitri M., additional, Dunne, Eileen F., additional, Engelman, Joseph, additional, Fischer, Marc, additional, Froom, Paul, additional, Garcia, Hector H., additional, Geisler, William M., additional, Gershman, Mark D., additional, Haditsch, Martin, additional, Hull, Christopher M., additional, Huppert, Jill S., additional, Isturiz, Raul E., additional, Johnson, James R., additional, Johnson, Katherine J., additional, Kauffman, Carol A., additional, Kesson, Alison Margaret, additional, Klausner, Jeffrey D., additional, Kollef, Marin H., additional, Kriesel, John D., additional, Kunz, Anjali N., additional, Kurrus, Thomas A., additional, Machado, Fabiana Simão, additional, MacPherson, Douglas William, additional, Marano, Nina, additional, Marcy, S. Michael, additional, Meade, Bruce D., additional, Meade, Kristin E., additional, Morris, Arden M., additional, Morrow, Lee E., additional, Moser, Benjamin D., additional, Moss, Nicholas J., additional, Newman, Lori Marie, additional, Nguyen, Thao U., additional, Park, James O., additional, Partridge, Susan, additional, Pottinger, Paul S., additional, Pratt, R. Douglas, additional, Raugi, Gregory, additional, Robertson, Kis, additional, Sanford, Christopher, additional, Sawyer, Robert G., additional, Schneider, Eileen, additional, Sejvar, James J., additional, Sethi, Sanjay, additional, Shadomy, Sean V., additional, Shimoni, Zvi, additional, Smith, Theresa L., additional, Spitters, Christopher Edward, additional, Spitzer, Austin L., additional, Staples, J. Erin, additional, Steele, Russell W., additional, Tan, Michael J., additional, Tanowitz, Herbert B., additional, Täuber, Martin G., additional, Toney, John F., additional, Tsai, Theodore F., additional, Tulloch, Luis G., additional, Vasser, Heather M., additional, Visvesvara, Govinda S., additional, Wald, Anna, additional, Watson, Christopher M., additional, Wolf, Patrick S., additional, Wolfe, Martin S., additional, Woodward, Joseph F., additional, Workowski, Kimberly, additional, Wyatt, Casi M., additional, Yeh, Sylvia H., additional, and Yoder, Jonathan S., additional

Published
2012
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4. Prolonged High-Level Detection of Retrovirally Marked Hematopoietic Cells in Nonhuman Primates after Transduction of CD34+ Progenitors Using Clinically Feasible Methods.

Author

Wu, Tong, primary, Kim, Hyeoung Joon, primary, Sellers, Stephanie E., primary, Meade, Kristin E., primary, Agricola, Brian A., primary, Metzger, Mark E., primary, Kato, Ikunoshin, primary, Donahue, Robert E., primary, Dunbar, Cynthia E., primary, and Tisdale, John F., primary

Published
2006
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6. Prolonged High-Level Detection of Retrovirally Marked Hematopoietic Cells in Nonhuman Primates after Transduction of CD34+ Progenitors Using Clinically Feasible Methods

Author

Wu, Tong, primary, Joon Kim, Hyeoung, additional, Sellers, Stephanie E., additional, Meade, Kristin E., additional, Agricola, Brian A., additional, Metzger, Mark E., additional, Kato, Ikunoshin, additional, Donahue, Robert E., additional, Dunbar, Cynthia E., additional, and Tisdale, John F., additional

Published
2000
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7. Prolonged High-Level Detection of Retrovirally Marked Hematopoietic Cells in Nonhuman Primates after Transduction of CD34+Progenitors Using Clinically Feasible Methods

Author

Wu, Tong, Joon Kim, Hyeoung, Sellers, Stephanie E., Meade, Kristin E., Agricola, Brian A., Metzger, Mark E., Kato, Ikunoshin, Donahue, Robert E., Dunbar, Cynthia E., and Tisdale, John F.

Abstract

Low-level retroviral transduction and engraftment of hematopoietic long-term repopulating cells in large animals and humans remain primary obstacles to the successful application of hematopoietic stem cell (HSC) gene transfer in humans. Recent studies have reported improved efficiency by including stromal cells (STR), or the fibronectin fragment CH-296 (FN), and various cytokines such as flt3 ligand (FLT) during ex vivo culture and transduction in nonhuman primates. In this work, we extend our studies using the rhesus competitive repopulation model to further explore optimal and clinically feasible peripheral blood (PB) progenitor cell transduction methods. First, we compared transduction in the presence of either preformed autologous STR or immobilized FN. Long-term clinically relevant gene marking levels in multiple hematopoietic lineages from both conditions were demonstrated in vivo by semiquantitative PCR, colony PCR, and genomic Southern blotting, suggesting that FN could replace STR in ex vivo transduction protocols. Second, we compared transduction on FN in the presence of IL-3, IL-6, stem cell factor (SCF), and FLT (our best cytokine combination in prior studies) with a combination of megakaryocyte growth and development factor (MGDF), SCF, and FLT. Gene marking levels were equivalent in these animals, with no significant effect on retroviral gene transfer efficiency assessed in vivo by the replacement of IL-3 and IL-6 with MGDF. Our results indicate that SCF/G-CSF-mobilized PB CD34+cells are transduced with equivalent efficiency in the presence of either STR or FN, with stable long-term marking of multiple lineages at levels of 10–15% and transient marking as high as 54%. These results represent an advance in the field of HSC gene transfer using methods easily applied in the clinical setting.Molecular Therapy (2000) 1, 285–293; doi: 10.1006/mthe.2000.0034

Published
2000
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9. Contributors

Author

Agosti, Jan, Alter, Miriam J., Anaya, Daniel A., Ansdell, Vernon, Babineaux, Michael James, Bartlett, John G., Bash, Margaret C., Beach, Michael J., Becker, Natasha S., Blue, Sky R., Blumberg, Dean A., Bower, John R., Bryant, Amy E., Campbell, Grant L., Chow, Anthony W., Coffman, Thomas J., Cohen, Stephanie E., Congeni, Blaise L., Coyle, Christina M., Dhanireddy, Shireesha, Drekonja, Dimitri M., Dunne, Eileen F., Engelman, Joseph, Fischer, Marc, Froom, Paul, Garcia, Hector H., Geisler, William M., Gershman, Mark D., Haditsch, Martin, Hull, Christopher M., Huppert, Jill S., Isturiz, Raul E., Johnson, James R., Johnson, Katherine J., Kauffman, Carol A., Kesson, Alison Margaret, Klausner, Jeffrey D., Kollef, Marin H., Kriesel, John D., Kunz, Anjali N., Kurrus, Thomas A., Machado, Fabiana Simão, MacPherson, Douglas William, Marano, Nina, Marcy, S. Michael, Meade, Bruce D., Meade, Kristin E., Morris, Arden M., Morrow, Lee E., Moser, Benjamin D., Moss, Nicholas J., Newman, Lori Marie, Nguyen, Thao U., Park, James O., Partridge, Susan, Pottinger, Paul S., Pratt, R. Douglas, Raugi, Gregory, Robertson, Kis, Sanford, Christopher, Sawyer, Robert G., Schneider, Eileen, Sejvar, James J., Sethi, Sanjay, Shadomy, Sean V., Shimoni, Zvi, Smith, Theresa L., Spitters, Christopher Edward, Spitzer, Austin L., Staples, J. Erin, Steele, Russell W., Tan, Michael J., Tanowitz, Herbert B., Täuber, Martin G., Toney, John F., Tsai, Theodore F., Tulloch, Luis G., Vasser, Heather M., Visvesvara, Govinda S., Wald, Anna, Watson, Christopher M., Wolf, Patrick S., Wolfe, Martin S., Woodward, Joseph F., Workowski, Kimberly, Wyatt, Casi M., Yeh, Sylvia H., and Yoder, Jonathan S.

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10. Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene.

Author

Magnusson MK, Meade KE, Nakamura R, Barrett J, and Dunbar CE

Subjects
Adult, Benzamides, Hematopoietic Stem Cell Transplantation, Humans, Imatinib Mesylate, Leukemia, Myelomonocytic, Chronic genetics, Leukemia, Myelomonocytic, Chronic therapy, Male, Remission Induction, Treatment Outcome, Antineoplastic Agents administration & dosage, Leukemia, Myelomonocytic, Chronic drug therapy, Oncogene Proteins, Fusion genetics, Piperazines administration & dosage, Pyrimidines administration & dosage, Receptor, Platelet-Derived Growth Factor beta genetics
Abstract

Platelet-derived growth factor beta receptor (PDGFbetaR) fusion genes have been shown to be critical transforming oncogenes in a subset of patients with chronic myelomonocytic leukemia (CMML). The sensitivity of dysregulated tyrosine kinase oncogenes to the tyrosine kinase inhibitor STI571 (imatinib mesylate) makes it a potentially attractive treatment option in this subset of patients. We have recently cloned a novel member of the PDGFbetaR fusion oncogene family, rabaptin-5-PDGFbetaR. A patient with CMML carrying the rabaptin-5-PDGFbetaR fusion gene underwent allogeneic stem cell transplantation (SCT) and was monitored closely with a sensitive reverse transcriptase-polymerase chain assay to detect the novel fusion gene transcript. After achieving a molecular remission at 5 months after transplantation, 15 months after SCT the patient showed persistent and progressive evidence of molecular relapse. After demonstrating in vitro that cells transformed with this specific fusion oncogene are efficiently killed by STI571, the patient was started on STI571. The patient responded rapidly and entered molecular remission after 6 weeks of therapy, and he continues to be in remission 6 months later. These results suggest that STI571 may be an effective targeted therapy in patients with CMML related to PDGFbetaR fusion oncogenes.

Published
2002
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