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OBJECTIVE: The purpose of this study was to determine the in vitro effects of a single exposure of bupivacaine on the mechanical properties of bovine cartilage explants at 3 weeks. DESIGN: Femoral condyle articular cartilage explants were aseptically harvested from juvenile bovine stifle joints before being exposed to chondrogenic medium containing 0.50% (wt/vol) bupivacaine, 0.25% (wt/vol) bupivacaine, or no medication (control) for 1 hour. Explants were then washed and maintained in culture in vitro for 3 weeks before testing. Cell viability, tensile and compressive mechanical properties, histological properties, and biochemical properties were then assessed. RESULTS: Explants exhibited a dose-dependent decrease in mean tensile Youngs modulus with increasing bupivacaine concentration (9.86 MPa in the controls, 6.48 MPa in the 0.25% bupivacaine group [P = 0.048], and 4.72 MPa in the 0.50% bupivacaine group [P = 0.005]). Consistent with these results, collagen content and collagen crosslinking decreased with bupivacaine exposure as measured by mass spectrometry. Compressive properties of the explants were unaffected by bupivacaine exposure. Explants also exhibited a trend toward dose-dependent decreases in viability (51.2% for the controls, 47.3% for the 0.25% bupivacaine-exposed group, and 37.0% for the 0.50% bupivacaine-exposed group [P = 0.072]). CONCLUSIONS: Three weeks after 1-hour bupivacaine exposure, the tensile properties of bovine cartilage explants were significantly decreased, while the compressive properties remained unaffected. These decreases in tensile properties corresponded with reductions in collagen content and crosslinking of collagen fibers. Physicians should be judicious regarding the intra-articular administration of bupivacaine in native joints.

The question of whether Everettian quantum mechanics (EQM) justifies the existence of metaphysical indeterminacy has recently come to the fore. Metaphysical indeterminacy has been argued to emerge from three sources: coherent superpositions, the indefinite number of branches in the quantum multiverse and the nature of these branches. This paper reviews the evidence and concludes that those arguments don't rely on EQM alone and rest on metaphysical auxiliary assumptions that transcend the physics of EQM. We show how EQM can be ontologically interpreted without positing metaphysical indeterminacy by adopting a deflationary attitude towards branches. Two ways of developing the deflationary view are then proposed: one where branches are eliminated, and another where they are reduced to the universal quantum state.

BACKGROUND: Chlorhexidine gluconate (CHG) solution is commonly used as an antiseptic irrigation for bacterial decontamination during orthopaedic surgery. Although the chondrotoxicity of CHG on articular cartilage has been reported, the full extent of CHG-related chondrotoxicity and its effects on the extracellular matrix and mechanical properties are unknown. PURPOSE: To investigate the in vitro effects of a single 1-minute CHG exposure on the viability, biochemical content, and mechanics of native articular cartilage explants. STUDY DESIGN: Controlled laboratory study. METHODS: Articular cartilage explants (6 per group) were harvested from femoral condyles of the porcine stifle and sectioned at tidemark. Explants were bathed in CHG solution (0.05% CHG in sterile water) at varying concentrations (0% control, 0.01% CHG, and 0.05% CHG) for 1 minute, followed by complete phosphate-buffered saline wash and culture in chondrogenic medium. At 7 days after CHG exposure, cell viability, matrix content (collagen and glycosaminoglycan [GAG]), and compressive mechanical properties (creep indentation testing) were assessed. RESULTS: One-minute CHG exposure was chondrotoxic to explants, with both 0.05% CHG (2.6% ± 4.1%) and 0.01% CHG (76.3% ± 8.6%) causing a decrease in chondrocyte viability compared with controls (97.5% ± 0.6%; P < .001 for both). CHG exposure at either concentration had no significant effect on collagen content, while 0.05% CHG exposure led to a significant decrease in mean GAG per wet weight compared with the control group (2.6% ± 1.7% vs 5.2% ± 1.9%; P = .029). There was a corresponding weakening of mechanical properties in explants treated with 0.05% CHG compared with controls, with decreases in mean aggregate modulus (177.8 ± 90.1 kPa vs 280.8 ± 19.8 kPa; P < .029) and shear modulus (102.6 ± 56.5 kPa vs 167.9 ± 16.2 kPa; P < .020). CONCLUSION: One-minute exposure to CHG for articular cartilage explants led to dose-dependent decreases in chondrocyte viability, GAG content, and compressive mechanical properties. This raises concern for the risk of mechanical failure of the cartilage tissue after CHG exposure. CLINICAL RELEVANCE: Clinicians should be judicious regarding the use of CHG irrigation at these concentrations in the presence of native articular cartilage.

The glabrous skin of the rhinarium (naked nose) of many mammalian species exhibits a polygonal pattern of grooves that retain physiological fluid, thereby keeping their nose wet and, among other effects, facilitating the collection of chemosensory molecules. Here, we perform volumetric imaging of whole-mount rhinaria from sequences of embryonic and juvenile cows, dogs, and ferrets. We demonstrate that rhinarial polygonal domains are not placode-derived skin appendages but arise through a self-organized mechanical process consisting of the constrained growth and buckling of the epidermal basal layer, followed by the formation of sharp epidermal creases exactly facing an underlying network of stiff blood vessels. Our numerical simulations show that the mechanical stress generated by excessive epidermal growth concentrates at the positions of vessels that form rigid base points, causing the epidermal layers to move outward and shape domes—akin to arches rising against stiff pillars. Remarkably, this gives rise to a larger length scale (the distance between the vessels) in the surface folding pattern than would otherwise occur in the absence of vessels. These results hint at a concept of "mechanical positional information" by which material properties of anatomical elements can impose local constraints on an otherwise globally self-organized mechanical pattern. In addition, our analyses of the rhinarial patterns in cow clones highlight a substantial level of stochasticity in the pre-pattern of vessels, while our numerical simulations also recapitulate the disruption of the folding pattern in cows affected by a hereditary disorder that causes hyperextensibility of the skin. [Display omitted] • Rhinarial polygonal domains are not placode-derived but mechanically self-organized • The rhinarial skin pattern is mechanically coupled with underlying blood vessels • Epidermal domes rise against stiffer blood vessels—like arches against pillars • Rhinarial folds are as variable among cow clones as among unrelated individuals Dagenais et al. demonstrate that the characteristic polygonal folding patterns on the noses of many mammalian species, such as dogs, ferrets, and cows, emerge via a peculiar self-organizational process involving mechanical positional information encoded by the spatial distribution of stiffness in adjacent tissues. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: Amorphous nanomaterials are metastable nanomaterials which only have short‐range order within a few neighboring atoms, based on the local chemical bondings. Different from crystalline materials, the amorphous nanomaterials lack of long‐range order exhibit many intriguing and unique structu ral features, such as abundant active sites, structural flexibility, intrinsic isotropy and fast ionic transport. However, due to the unco nventional structural complexity, the systematic study and understanding of amorphous nanomaterials are still in the early stage. In this review, we will describe our journey to the synthesis, characterization and applications of amorphous nanomaterials, including catalysis, energy storage, optics and mechanics. What is the most favorite and original chemistry developed in your research group? Our group developed a variety of universal methods, such as "coordination etching" method, "self‐hydrolytic etch‐precipitation" method, photoetching method, co‐precipitation method, etc., to achieve the controllable preparation of amorphous nanomaterials with different morphology, size and dimension, and the catalytic, mechanical and optical properties of the materials and their potential applications were also studied. Moreover, the relevant mechanisms were proposed, the structure‐activity relationship was established, and the development and application of amorphous micro‐nanomaterials were promoted. How do you get into this specific field? Could you please share some experiences with our readers? My journey into the field of amorphous nanomaterials began 20 years ago when I developed a fascination for materials science and nanotechnology. During my early research experiences, I encountered the intriguing world of amorphous nanomaterials. These materials, lacking a long‐range crystalline order, presented both challenges and opportunities in terms of their synthesis and understanding their properties. It's a field where creativity and precision intersect, driving me to continually seek innovative solutions and deepen my understanding of nanoscale phenomena. How do you supervise your students? As a professor, I supervise students by setting clear expectations, holding regular meetings for feedback and guidance, and encouraging independent thinking. I support their career development by identifying opportunities and creating a collaborative environment. Adapting to individual needs, I foster a fair and consistent approach to help students grow professionally and academically. What is the most important personality for scientific research? One of the most important traits for scientific research is curiosity. It drives researchers to ask questions, explore new ideas, and seek innovative solutions. Curiosity fuels the desire to understand the unknown, propelling scientific discovery and breakthroughs. Additionally, persistence is crucial as research often involves challenges and setbacks that require perseverance to overcome. Clear communication skills are also vital for sharing findings and collaborating effectively within the scientific community. Who influences you mostly in your life? As a researcher, my greatest influences come from my mentors, Prof. Hesun Zhu, Qianshu Li and Shihe Yang who guide my academic journey and collaborators who inspire new ideas and perspectives. My mentors, who provide guidance and expertise play a crucial role in shaping my approach to research and career development. Their insights and support empower me to navigate challenges and continuously strive for excellence in my scientific endeavors. What are your hobbies? My hobbies are a blend of activities that complement and enrich my professional life. I enjoy participating in discussions and workshops within my academic community, where I can exchange ideas and learn from peers outside of formal research settings. Key Scientists: [ABSTRACT FROM AUTHOR]

Sub-plate mantle flow traction (MFT) has been considered as a major driving force for plate motion; however, the force acting on the overlying plate is difficult to constrain. One of the reasons lies in the variable rheological flow laws of mantle rocks, for example, linear versus power-law rheology, applied in previous studies. Here, systematic numerical models are conducted to evaluate MFT under variable rheological, geometrical and kinematic conditions. The results indicate that MFT with power-law rheology is much lower than that with linear rheology under the same mantle/plate velocity contrast. In addition, existence of a lithospheric root in the overlying plate could enhance MFT, where integrated normal force acting on the walls of lithospheric root is much lower than the shear force in a large-scale domain. In the acting domain of several thousand kilometres, MFT with power-law rheology is comparable to the ridge push of about 3×1012 N m−1, whereas that with linear rheology is comparable to the slab pull of about 3×1013 N m−1. The roles of MFT in driving plate motion are further analysed for the Tethyan evolution. It indicates that MFT with power-law rheology could partially support the Wilson cycles experienced in the Tethyan system, whereas that with linear rheology could easily dominate any kinds of plate tectonic evolutions. The quantitative evaluation of MFT in this study clarifies the roles of rheological flow laws on MFT and could help us to better understand the contrasting results in previous numerical studies. [ABSTRACT FROM AUTHOR]

To what extent mechanical anisotropy is required to explain the dynamics of the lithosphere is an important yet unresolved question. If anisotropy affects stress and deformation, and hence processes such as fault loading, how can we quantify its role from observations? Here, we derive analytical solutions and build a theoretical framework to explore how a shear zone with linear anisotropic viscosity can lead to deviatoric stress heterogeneity, strain-rate enhancement, as well as non-coaxial principal stress and strain rate. We develop an open-source finite-element software based on FEniCS for more complicated scenarios in both 2-D and 3-D. Mechanics of shear zones with transversely isotropic and orthorhombic anisotropy subjected to misoriented shortening and simple shearing are explored. A simple regional example for potential non-coaxiality for the Leech River Schist above the Cascadia subduction zone is presented. Our findings and these tools may help to better understand, detect and evaluate mechanical anisotropy in natural settings, with potential implications including the transfer of lithospheric stress and deformation through fault loading. [ABSTRACT FROM AUTHOR]

The mechanics of granular materials at the macroscopic scale inherently depends on the particle interactions occurring at the microscopic scale. In recent decades, growing investigations have explored the mechanics of granular materials subjected to thermal cycles, as they involve complex responses that bear significance for science, engineering, and technology. However, the fundamental understanding of the mechanics of granular materials subjected to thermal cycles remains hindered by the absence of empirical evidence into the microscopic particle interactions that govern the macroscopic response of such materials. For the first time, this study presents direct experimental evidence obtained via synchrotron X-ray microtomography to reveal the behavior of the particles that constitute granular materials during thermal cycling. This work experimentally confirms the existing theory by which thermally induced particle interactions drive a macroscopic volumetric expansion and contraction of granular materials upon heating and cooling, respectively, and the development of irreversible volumetric deformations upon the completion of thermal cycles. The results uncover the evolution of particle non-uniform translations, rotations, and contact variations during thermal cycling, which all inherently depend on particle shape. [ABSTRACT FROM AUTHOR]

Plants are fascinating living systems, possessing starkly different morphology to mammals, yet they have still evolved ways to defend themselves, consume prey, communicate, and in the case of plants like Mimosa pudica even move in response to a variety of stimuli. The complex physiological pathways driving this are of great interest, though many questions remain. In this work, a known responsive plant, M. pudica is mechanically stimulated, in terms of wounding via removal of pinnae, nonwounding mechanical poking, and nonwounding pulses of air through a designed small nozzle approach. Removal of clusters called pinnae resulted in rapid, asymmetric response in the adjacent pinnae, while mechanical poking and air pulse responses are slower and more localized. Additionally, while the response from poking propagated across the plant, wind stimuli consistently resulted in the actuation of only the leaflets directly stimulated, suggesting unique sensing mechanisms. Mechanical damage may imply a potential predator, while mechanical stimulation from airflow may be processed as wind, which is of little danger. These findings demonstrate an intricate, stimulant‐dependent mechanical sensing process, which is important in plant physiology, mechanobiology, and future biohybrid soft robotic designs. [ABSTRACT FROM AUTHOR]

Salt diapirs dominate the structure in many sedimentary basins and control the preservation and migration of hydrocarbon. The formation of salt diapirs generally falls into two endmember models: active (up-building) and passive (down-building) diapirism. In the active model, salt diapirs rise from salt buoyancy to pierce through the sedimentary overburden, whereas in the passive model, salt diapirs result from differential loading of sediments during deposition. These endmember models are mostly conceptual or kinematic, the mechanics of active and passive diapirism and their relative roles and interactions in the formation of salt diapirs remain uncertain. Here, we use two-dimensional high-resolution numerical models to investigate the primary factors and critical conditions for active and passive diapirism. Our results indicate that it is improper to use driving mechanisms to classify salt diapirs, because the buoyancy-driven active salt diapirism involves differential loading, while the passive diapirism requires salt buoyancy. The rise of salt diapirs is more sensitive to the effective viscosity of the overburden than to the salt viscosity. Stiff overburdens could prevent the rise of salt diapirs, but they could be pierced by salt diapirs if plastic yield of the overburden is allowed. During deposition, the coupled salt-sediment deformation, driven by both salt buoyancy and differential loading of sediments, can lead to various diapiric salt structures and minibasins. Regional tectonic stress generally promotes salt diapirism by enhancing strain weakening of salts and overburdens. We suggest that the classification of active and passive salt diapirism is an oversimplification in most cases. We propose a general model of the formation of salt diapirs that usually begins with dome initiation driven by salt buoyancy, followed by syndepositional down-building controlled by sedimentation and differential loading and ends with canopy formation when sedimentation stops. [ABSTRACT FROM AUTHOR]

Earth's plate tectonic behaviour arises from lithospheric ductile weakening and shear-localization. The ubiquity of mylonites at lithospheric shear zones is evidence that localization is caused by mineral grain size reduction. Most lithospheric mylonites are polymineralic, suggesting that the interaction between mineral phases by Zener pinning promotes grain size reduction and weakening. Yet this interaction only occurs where mineral phases mix at the grain scale. Phase mixing and its effect on microstructure and strength have been shown in deformation experiments and natural field samples. Our theory for the interaction between phase mixing (treated as a stress driven diffusion) with two-phase grain damage has been compared to lab experiments. But using processes at the tiny grain-scale embedded within the small hand-sample and lab scales to model large-scale lithospheric processes, requires an upscaling scheme that captures the physics from micro- to macrostructures. For example, weakening from grain-damage in zones of mixing can lead to banded viscosity structure at the small scale that manifests as viscous anisotropy at the large scale. Here we provide a new framework for self-consistently upscaling from microscopic (grain) scales, to mesoscopic (petrological heterogeneity) scales to macroscopic (tectonic) scales. The first upscaling step models phase mixing and grain size evolution in a small 'mesoscopic' lab-scale volume or 'patch', which is equivalent to a point in the macroscopic space. Within this mesoscale patch, stress driven diffusive mixing is described by an analytical solution for mineral phase fraction, provided a minimalist Fourier representation of phase fraction, and a transformation to the patch frame of reference as well as to the principal stress directions at that point. The orientation and volume fraction of mixed-phase regions can then be extracted from the analytical solution for phase fraction. The grain size and viscosity in the mixed bands are determined by two-phase grain-damage theory; the unmixed zone properties follow from mono-phase grain damage theory. The mesoscale banded viscosity field leads to a macroscale anisotropic viscosity at that point in space. But, the evolution of properties at each macroscale point involves tracking only a few quantities (phase fraction, grain sizes) rather than modelling each patch of mesoscale space as its own 2-D or 3-D system. For the final upscaling, the anisotropic viscosity field is used in a macroscale lithosphere flow model. We show an example of this scheme for a lithospheric Rayleigh–Taylor drip driven by ridge-push compressive stress, which can cause anisotropic weakening via grain mixing and damage that may help initiate subduction and passive margin collapse. [ABSTRACT FROM AUTHOR]

Background: The anterior cruciate ligament (ACL) is loaded under tension when the tibia translates anteriorly relative to the femur. The shape of the articular surfaces of the tibiofemoral joint may influence the amount of anterior tibial translation under compressive loading. Thus, a steep lateral tibial plateau and a shallow medial plateau are thought to be risk factors for ACL injury. Purpose/Hypothesis: The purpose of this study was to evaluate whether tibial plateau slope and depth influence peak ACL strain during a single-leg jump. We hypothesized that there would be a significant correlation between tibial plateau slope and depth with ACL strain. Study Design: Descriptive laboratory study. Methods: A total of 17 healthy participants (8 male, 9 female) were assessed using magnetic resonance imaging (MRI) and high-speed biplanar radiography to obtain peak ACL strain during a single-leg jump. Two orthopaedic surgeons used the sagittal plane MRI scans to measure the medial and lateral tibial plateau slopes and the medial tibial plateau depth. The intraclass correlation coefficient was used to assess measurement reliability, and the Spearman rank correlation was used to evaluate the relationship between measurements of tibial morphology and peak ACL strain during the single-leg jump. Results: The overall range of intraclass correlation coefficients for intra- and interrater reliability of the medial and lateral tibial plateau slopes and medial plateau depth was 0.59 to 0.97. No significant correlations were found between peak ACL strain and any of the slope or depth measurements. Conclusion: In this cohort of healthy participants, correlations between any of the tibial plateau measurements with peak ACL strain during a single-leg jump were not detected. These findings are consistent with prior work, suggesting that tibial plateau slope and depth may not be linked to risk for ACL rupture. However, it is possible that tibial plateau morphology may interact with other factors to increase ACL injury risk or that individuals with extreme slope angles may produce differing results. Clinical Relevance: This study enhances the knowledge of the loading mechanisms for the ACL and thus improves the understanding of risk factors for ACL injury. [ABSTRACT FROM AUTHOR]

In contrast to single‐phase materials the manufacturing process of composites creates multiscale interfaces among constituent materials and between laminar multilayers. Targeting the interfaces in these composite structures, this paper presents a perspective study on the impact safety of potential future composite rail vehicles. The aim is to conceptually explore the key role of interfacial discontinuities of composite material structures as they are a critical issue affecting the impact performance of future composite rail vehicles. Following a theoretical description, the issues are addressed in two parts. First, composite materials are characteristically analyzed from the perspective of their interfacial discontinuities within the materials and between the laminate multilayers to identify their influence. Second, the structural conditions required for crashworthiness are determined in relation to the dual requirements of global stability and local deformability for efficient energy absorption. The key findings are: (1) The interfacial discontinuities of the material phases and the designed structural assemblies need to be tailored for crashworthiness performance and (2) Global stability and locally deformability are the key dual requirements for the energy absorbing progressive deformations that are essential for application of composite for crashworthiness of rail vehicles. The research conceptually explores a key issue of the impact mechanics of composite structures from the perspective of impact safety of composite rail vehicles. [ABSTRACT FROM AUTHOR]

This study compared lower extremity, trunk, and upper extremity kinematics between tee and front toss hitting in youth baseball athletes. Twenty youth baseball athletes (14.3±2.9 yrs) performed three maximal effort swings off front toss and tee. Kinematic data were collected during the preparatory and acceleration phases. Lower extremity, trunk, and upper extremity kinematics were compared between tee and front toss hitting using 1-dimensional statistical parametric mapping (SPM). There was a significant difference in trunk kinematics between tee and front toss during the preparatory phase (p=.001); the trunk rotated more toward the back side when hitting off a tee compared to front toss (p<0.001). There was also a significant difference in trunk kinematics between tee and front toss for 67% of the acceleration phase; the trunk rotated more towards the back side from 0 to 67% when hitting off the tee (p<0.001). Significant differences were found in trunk kinematics between tee and front toss hitting in youth baseball players, where the trunk is less rotated toward the pitcher in the tee than in the front toss. Coaches utilize various training modalities to enhance hitting performance; however, differences in trunk kinematics should be considered between modalities when developing fundamental hitting techiques in youth baseball athletes. [ABSTRACT FROM AUTHOR]

Biological structures optimized through natural selection provide valuable insights for engineering load-bearing components. This paper reviews six key strategies evolved in nature for efficient mechanical load handling: hierarchically structured composites, cellular structures, functional gradients, hard shell–soft core architectures, form follows function, and robust geometric shapes. The paper also discusses recent research that applies these strategies to engineering design, demonstrating their effectiveness in advancing technical solutions. The challenges of translating nature's designs into engineering applications are addressed, with a focus on how advancements in computational methods, particularly artificial intelligence, are accelerating this process. The need for further development in innovative material characterization techniques, efficient modeling approaches for heterogeneous media, multi-criteria structural optimization methods, and advanced manufacturing techniques capable of achieving enhanced control across multiple scales is underscored. By highlighting nature's holistic approach to designing functional components, this paper advocates for adopting a similarly comprehensive methodology in engineering practices to shape the next generation of load-bearing technical components. [ABSTRACT FROM AUTHOR]

This paper describes the orthodontic treatment of two cases that were successful in winning the William Houston Gold Medal at the Membership in Orthodontics Examinations of the Royal College of Surgeons of Edinburgh in 2022. Both cases discuss the management of palatally impacted maxillary canines and treatment was initiated during the emerging COVID-19 crisis and completed over a 27-month period. The first case describes the management of a 15-year-old female with a Class II division 1 incisor relationship complicated by a palatally impacted upper left canine, moderate upper and lower arch crowding, and a lower centreline discrepancy with an associated right lateral displacement on closure. Treatment involved open surgical exposure of the impacted canine, a quad helix appliance, premolar extractions, and upper and lower fixed appliances. The second case describes the management of a 14-year-old female with a Class III incisor relationship complicated by bilaterally impacted maxillary canines, impeded eruption of the lower right second molar, moderate lower and severe upper arch crowding, and an upper centreline discrepancy. These case reports aim to demonstrate the high standards of care achieved by Orthodontic Specialty Trainee Registrars in the UK and provide aspirational standards for future trainees. [ABSTRACT FROM AUTHOR]

Older adults have difficulty maintaining balance when faced with postural disturbances, a task that is influenced by the stiffness of the triceps surae and Achilles tendon. Age-related changes in Achilles tendon stiffness have been reported at matched levels of effort, but measures typically have not been made at matched loads, which is important due to age-dependent changes in strength. Moreover, there has been limited investigation into age-dependent changes in muscle stiffness. Here, we investigate how age alters muscle and tendon stiffness and their influence on ankle stiffness. We hypothesized that age-related changes in muscle and tendon contribute to reduced ankle stiffness in older adults and evaluated this hypothesis when either load or effort were matched. We used B-mode ultrasound with joint-level perturbations to quantify ankle, muscle, and tendon stiffness across a range of loads and efforts in seventeen healthy younger and older adults. At matched loads relevant to standing and the stance phase of walking, there was no significant difference in ankle, muscle, or tendon stiffness between groups (all p > 0.13). However, at matched effort, older adults exhibited a significant decrease in ankle (27%; p = 0.008), muscle (37%; p = 0.02), and tendon stiffness (22%; p = 0.03) at 30% of maximum effort. This is consistent with our finding that older adults were 36% weaker than younger adults in plantarflexion (p = 0.004). Together, these results indicate that, at the loads tested in this study, there are no age-dependent changes in the mechanical properties of muscle or tendon, only differences in strength that result in altered ankle, muscle, and tendon stiffness at matched levels of effort. [ABSTRACT FROM AUTHOR]

Background: Facet fractures are frequently associated with clinically observed cervical facet dislocations (CFDs); however, to date there has only been one experimental study, using functional spinal units (FSUs), which has systematically produced CFD with concomitant facet fracture. The role of axial compression and distraction on the mechanical response of the cervical facets under intervertebral motions associated with CFD in FSUs has previously been shown. The same has not been demonstrated in multi‐segment lower cervical spine specimens under flexion loading (postulated to be the local injury vector associated with CFD). Methods: This study investigated the mechanical response of the bilateral inferior C6 facets of thirteen C5‐C7 specimens (67±13 yr, 6 male) during non‐destructive constrained flexion, superimposed with each of five axial conditions: (1) 50 N compression (simulating weight of the head); (2‐4) 300, 500, and 1000 N compression (simulating the spectrum of intervertebral compression resulting from neck muscle bracing prior to head‐first impact and/or externally applied compressive forces); and, (5) 2 mm of C6/C7 distraction (simulating the intervertebral distraction present during inertial loading of the cervical spine by the weight of the head). Linear mixed‐effects models (α = 0.05) assessed the effect of axial condition. Results: Increasing amounts of intervertebral compression superimposed on flexion rotations, resulted in increased facet surface strains (range of estimated mean difference relative to Neutral: maximum principal = 77 to 110 με, minimum principal = 126 to 293 με, maximum shear = 203 to 375 με) and angular deflection of the bilateral inferior C6 facets relative to the C6 vertebral body (range of estimated mean difference relative to Neutral = 0.59° to 1.47°). Conclusions: These findings suggest increased facet engagement and higher load transfer through the facet joint, and potentially a higher likelihood of facet fracture under the compressed axial conditions. [ABSTRACT FROM AUTHOR]

Purpose Mastering the skill of smashing in a game can be quite challenging. Unfortunately, it’s not always easy to control the distance of the smash. The present study investigated the impact of different smashing distances on muscle activation patterns and kinematics of the upper limbs. Material and methods Ten collegiate athletes from a top-ranked team in Korea participated in the present study with a mean age, weight, and height of 21 ± 1 years, 71.9 ± 9.1 kg, and 1.78 ± 2.24 m, respectively. Three valid data points for each subject at three different distances were analyzed using a one-way analysis of variance (ANOVA). Results The results demonstrated that with increasing smashing distance, the internal rotation angle of the elbow and wrist joints decreased, while the angular velocity of flexion and internal rotation of the shoulder, elbow, and wrist joints increased. Muscle activation increased for all muscles except the biceps brachii (BICLO) with increasing distance. The greatest changes in activation levels were observed in the anterior deltoid (DELTA), extensor carpi radialis (ECR), and flexor carpi ulnaris (FCU). Conclusions During tasks with different smashing distances, muscle activation in the upper limbs (except the biceps) increased with increasing distances. Additionally, the internal rotation angle of the upper limbs decreased with increased distances, while the angular velocity of flexion and internal rotation of the shoulder, elbow, and wrist joints increased.

Cristae are high-curvature structures in the inner mitochondrial membrane (IMM) that are crucial for ATP production. While cristae-shaping proteins have been defined, analogous lipid-based mechanisms have yet to be elucidated. Here, we combine experimental lipidome dissection with multi-scale modeling to investigate how lipid interactions dictate IMM morphology and ATP generation. When modulating phospholipid (PL) saturation in engineered yeast strains, we observed a surprisingly abrupt breakpoint in IMM topology driven by a continuous loss of ATP synthase organization at cristae ridges. We found that cardiolipin (CL) specifically buffers the inner mitochondrial membrane against curvature loss, an effect that is independent of ATP synthase dimerization. To explain this interaction, we developed a continuum model for cristae tubule formation that integrates both lipid and protein-mediated curvatures. This model highlighted a snapthrough instability, which drives IMM collapse upon small changes in membrane properties. We also showed that cardiolipin is essential in low-oxygen conditions that promote PL saturation. These results demonstrate that the mechanical function of cardiolipin is dependent on the surrounding lipid and protein components of the IMM.

[Display omitted] Folded protein hydrogels are emerging as promising new materials for medicine and healthcare applications. Folded globular proteins can be modelled as colloids which exhibit site specific cross-linking for controlled network formation. However, folded proteins have inherent mechanical stability and unfolded in response to an applied force. It is not yet understood how colloidal network theory maps onto folded protein hydrogels and whether it models the impact of protein unfolding on network properties. To address this, we study a hybrid system which contains folded proteins (patchy colloids) and unfolded proteins (biopolymers). We use a model protein, bovine serum albumin (BSA), to explore network architecture and mechanics in folded protein hydrogels. We alter both the photo-chemical cross-linking reaction rate and the mechanical properties of the protein building block, via illumination intensity and redox removal of robust intra-protein covalent bonds, respectively. This dual approach, in conjunction with rheological and structural techniques, allows us to show that while reaction rate can 'fine-tune' the mechanical and structural properties of protein hydrogels, it is the force-lability of the protein which has the greatest impact on network architecture and rigidity. To understand these results, we consider a colloidal model which successfully describes the behaviour of the folded protein hydrogels but cannot account for the behaviour observed in force-labile hydrogels containing unfolded protein. Alternative models are needed which combine the properties of colloids (folded proteins) and biopolymers (unfolded proteins) in cross-linked networks. This work provides important insights into the accessible design space of folded protein hydrogels without the need for complex and costly protein engineering, aiding the development of protein-based biomaterials. [ABSTRACT FROM AUTHOR]

Writing is a multifaceted skill, challenging both to impart and acquire, intertwined with other essential abilities like reading and listening. Yet, mastering writing fluency holds immense value for students, jobseekers, graduates, and professionals alike. This study delved into the writing aptitude of 152 Junior High School students, scrutinizing their portfolio submissions. Employing a descriptive research approach, data analysis centered on evaluating students' writing capabilities. The rubrics used in evaluating students' output covers grammar, mechanics, and structure as the main aspects to be checked. The results uncovered a prevalent occurrence of grammatical errors, notably in verb forms and tenses, contrasted with fewer mechanical mistakes. Notably, age and grade level significantly influenced writing proficiency, while gender primarily impacted mechanics mastery. Moreover, the nature of writing errors varied across age, gender, and grade levels. These findings accentuate the necessity for customized instructional strategies to target specific grammatical weaknesses, alongside tailored support based on demographic characteristics to elevate overall writing competency among Junior High School students. By addressing these nuances, educators can effectively nurture proficient writers equipped for the challenges of academia and beyond. [ABSTRACT FROM AUTHOR]

Fault geometry is a key factor in controlling the mechanics of faulting. However, there is currently limited theoretical knowledge regarding the effect of non-planar fault geometry on earthquake mechanics. Here, we address this gap by introducing an expansion of the relation between fault traction and slip, up to second order, relative to the deviation from a planar fault geometry. This expansion enables the separation of the effects of non-planarities from those of planar faults. This expansion is realized in the boundary integral equation, assuming a small fault slope. It provides an interpretation for the effect of complex fault geometry on fault traction, for any fault geometry and any slip distribution. Hence, the results are also independent of the friction that applies on the fault. The findings confirm that fault geometry has a strong influence on in-plane faulting (mode II) by altering the normal traction on the fault and making it more resistant to slipping for any fault geometry. On the contrary, for out-of-plane faulting (mode III), fault geometry has a much smaller influence. Additionally, we analyse some singularities that arise for specific fault geometries often used in earthquake simulations and provide guidelines for their elimination. To conclude this study, we discuss the limits of the infinitesimal strain theory when non-planar faults are considered. [ABSTRACT FROM AUTHOR]

Significant compositional differences may exist in the lithospheric mantle and above the core–mantle boundary (CMB) relative to the ambient mantle. The intrinsic density differences may affect the development of thermal boundary layer (TBL) instabilities associated with lithospheric delamination and formation of thermochemical plumes. In this study, we explored the instability of two-layer thermochemical fluid using two different techniques: marginal stability analysis with a propagator-matrix method and finite element modelling. We investigated both the instabilities in lithospheric mantle (i.e. lithospheric instability) and the mantle above the CMB (i.e. plume-forming instability) using a background temperature T bg(z) with the TBL. For lithospheric instability, we found that two-layer fluid with free-slip boundary conditions mainly undergoes the same three different convective modes (i.e. two oscillatory convection modes and one layered convection regime) as that with no-slip boundary conditions reported in Jaupart et al. However, with free-slip boundary conditions, the transitions between these convection modes occur at larger values of buoyancy number B. Free-slip boundary conditions lead to smaller critical Rayleigh number Rac , but larger convective wavelength and oscillation frequency ωc , compared with those with no-slip boundary conditions. Our numerical modelling results demonstrate that Rac and ωc predicted from the classical marginal stability analyses using T bg(z) with TBL temperature may have significant errors when the oscillatory period is comparable with or larger than the timescale of lithospheric thermal diffusion that causes T bg(z) to vary with time significantly. In this case, using a more gently sloped background temperature profile ignoring the TBL temperature, the stability analysis predicts more accurate stability conditions, thus presenting an effective remedy to the stability analysis. For plume-forming instability, because of the reduced viscosity in the hot and compositionally dense bottom layer, the transition to the layered convection occurs at significantly smaller B values, and in the oscillatory convection regime, Rac is larger but ωc is smaller, compared with those for lithospheric instability. Finally, our study provides a successful benchmark of numerical models of thermochemical convection by comparing Rac and ωc from numerical models with those from the marginal stability analysis. [ABSTRACT FROM AUTHOR]

The existence of pores, cracks and cleavage in rocks results in significant non-linear elastic phenomena. One important non-linear elastic characteristic is the deviation of the stress–strain curve from the linear path predicted by Hooke's law. To provide a more accurate description of the non-linear elastic characteristics of rocks and to characterize the propagation of non-linear elastic waves, we introduce the Preisach–Mayergoyz space model. This model effectively captures the non-linear mesoscopic elasticity of rocks, allowing us to observe the stress–strain and modulus–stress relationships under different stress protocols. Additionally, we analyse the discrete memory characteristics of rocks subjected to cyclic loading. Based on the Preisach–Mayergoyz space model, we develop a new non-linear elastic constitutive relationship in the form of an exponential function. The new constitutive relationship is validated through copropagating acousto-elastic testing, and the experimental result is highly consistent with the data predicted by the theoretical non-linear elastic constitutive relationship. By combining the new non-linear elastic constitutive relationship with the strain–displacement formula and the differential equation of motion, we derive the non-linear elastic wave equation. We numerically solve the non-linear elastic wave equation with the finite difference method and observe two important deformations during the propagation of non-linear elastic waves: amplitude attenuation and dispersion. We also observe wave front discontinuities and uneven energy distribution in the 2D wavefield snapshot, which are different from those of linear elastic waves. We qualitatively explain these special manifestations of non-linear elastic wave propagation. [ABSTRACT FROM AUTHOR]

The objectives of this network meta-analysis were: (a) to estimate and compare the pooled effects of some injury prevention programs (IPPs) whose exercise-based components were categorized using a movement pattern-specific taxonomy on reducing overall and some specific body regions (lower extremity, thigh, knee, and ankle) injury incidences in youth team sport athletes and (b) to explore the individual effects of these components on the injury incidence rates (IIRs) previously mentioned. Searches were performed in PubMed, Web of Science, SPORTDiscus, and Cochrane Library. Eligible criteria were: exercise-based interventions comprised of exercises involving athletic motor skill competencies and evaluated against a control group, overall IIRs were reported, and youth (≤19 years old) team sport players. For the current analysis, a taxonomy based on movement patterns was employed for exercise component identification (upper body pushing and pulling; lower body concentric and eccentric; core; mechanics; acceleration; and lower body stability). Pooled effects were calculated by frequentist random effects pairwise and network meta-analyses. Nineteen studies were included. Most of the IPPs exhibit risk reduction when compared to their control groups on overall, lower extremity, and ankle injuries. Interventions comprised of lower body concentric and eccentric, core, mechanics, and lower body stability exercises were the most effective measures for reducing these injuries. None of the IPPs demonstrated to be effective for reducing thigh injuries, and contradictory results were found for knee injuries. Individual analysis at component level revealed that the lower body (bilateral and unilateral, concentric, and eccentric) component was the only one associated with a significant reduction on overall injuries. Indirect evidence suggests that interventions incorporating lower body concentric and eccentric, core, mechanics, and lower body stability exercises might be the most effective for reducing overall, lower extremity, and ankle injuries in youth team sports. [ABSTRACT FROM AUTHOR]

This article is concerned with the minimization of peak stresses occurring in linear elasticity. We propose to minimize the maximal von Mises stress of the elastic body. This leads to a non-smooth shape functional. We derive the shape derivative and associate it with the Clarke sub-differential. Using a steepest descent algorithm, we present numerical simulations. We compare our results to the usual p -norm regularization and show that our algorithm performs better in the presented tests. This article is part of the theme issue 'Non-smooth variational problems with applications in mechanics'. [ABSTRACT FROM AUTHOR]

Bio-based polymers are a promising material with which to tackle the use of disposable and non-degradable plastics in agriculture, such as mulching films. However, their poor mechanical properties and the high cost of biomaterials have hindered their widespread application. Hence, in this study, we improved polysaccharide-based films and enriched them with plant nutrients to make them suitable for mulching and fertilizing. Films were produced combining sodium carboxymethyl cellulose (CMC), chitosan (CS), and sodium alginate (SA) at different weight ratios with glycerol and CaCl2 as a plasticizer and crosslinker, respectively, and enriched with ammonium phosphate monobasic (NH4H2PO4). A polysaccharide weight ratio of 1:1 generated a film with a more crosslinked structure and a lower expanded network than that featuring the 17:3 ratio, whereas CaCl2 increased the films' water resistance, thermal stability, and strength characteristics, slowing the release rates of NH4+ and PO43−. Thus, composition and crosslinking proved crucial to obtaining promising films for soil mulching. [ABSTRACT FROM AUTHOR]

Chiton articulatus is a species of mollusk living in the tropical Pacific intertidal rocky shores of Mexico. This species feeds on solid waste organic sources, including hard crustose algae that grow on rocky substrates, by grazing on them with its radula, a flexible chitinous membrane lined with mineralized major lateral teeth. In this study, the composition, morphology, and resulting mechanics of the mature teeth of this species, which have yet to be examined, are revealed. The results show the presence of multiphasic mature teeth, each consisting of aligned hard magnetite nanoparticles on the leading edge of the tooth underneath which are magnetite lamellae, followed by goethite, lepidocrocite, and eventually hydroxyapatite near the trailing edge. This multiregional structure demonstrates a gradation in hardness as well as different microstructural features integrated with tough interfaces. The combination of these microstructural and phase arrangements results in an abrasion‐resistant tough structure with a self‐sharpening ability. The results of this work will help contribute to developing new bioinspired designs while also helping to understand the evolution and feeding habits of these intriguing invertebrates. [ABSTRACT FROM AUTHOR]

Deep-sea mining, as a critical direction for the future development of mineral resources, places significant importance on the mechanical characteristics of its transportation pipelines for the safety and efficiency of the entire mining system. This paper establishes a simulation model of the deep-sea mining system based on oceanic environmental loads and the mechanical theory of deep-sea mining transportation pipelines. Through a static analysis, the effective tension along the pipeline length, the maximum values of bending moment, and the minimum values of bending radius are determined as critical points for the dynamic analysis of pipeline mechanical characteristic monitoring. A dynamic simulation analysis of the pipeline's mechanical characteristics was conducted, and simulation sensor data were obtained as inputs for the prediction model construction. A prediction model of pipeline mechanical characteristics based on the BP neural network was constructed, with the model's prediction correlation coefficients all exceeding 0.95, enabling an accurate prediction of pipeline state parameters. [ABSTRACT FROM AUTHOR]

Cardiac amyloidosis is an infiltrative disease primarily caused by extracellular tissue deposition of amyloid fibrils in the myocardial interstitium. The aim of the present review was to summarize findings regarding changes in myocardial mechanics, valvular abnormalities, and vascular remodeling detected in patients with cardiac amyloidosis. [ABSTRACT FROM AUTHOR]

We have developed a finite element model to simulate the penetration of nanoneedles into the cellular nucleus. It is found that the nuclear lamina, the primary supporting structure of the nuclear membrane, plays a crucial role in maintaining the integrity of the nuclear envelope and enhancing stress concentration in the nuclear membrane. Notably, nuclear lamina A exhibits a more pronounced effect compared to nuclear lamina B. Subsequently, we further conducted experiments by controlling the time of osteopontin (OPN) treatment to modify the nuclear lamina density, and the results showed that an increase in nuclear lamina density enhances the probability of nanoneedle penetration into the nuclear membrane. Through employing both simulation and experimental techniques, we have gathered compelling evidence indicating that an augmented density of nuclear lamina A can enhance the penetration of nanoneedles into the nuclear membrane. [ABSTRACT FROM AUTHOR]

Measuring mechanical forces of cell-cell interactions is important for studying morphogenesis in multicellular organisms. We previously reported an imagebased statistical method for inferring effective mechanical potentials of pairwise cell-cell interactions by fitting cell tracking data with a theoretical model. However, whether this method is applicable to tissues with non-cellular components such as cavities remains elusive. Here we evaluated the applicability of the method to cavity-harboring tissues. Using synthetic data generated by simulations, we found that the effect of expanding cavities was added to the pregiven potentials used in the simulations, resulting in the inferred effective potentials having an additional repulsive component derived from the expanding cavities. Interestingly, simulations by using the effective potentials reproduced the cavity-harboring structures. Then, we applied our method to the mouse blastocysts, and found that the inferred effective potentials can reproduce the cavity-harboring structures. Pairwise potentials with additional repulsive components were also detected in two-dimensional cell sheets, by which curved sheets including tubes and cups were simulated. We conclude that our inference method is applicable to tissues harboring cavities and cell sheets, and the resultant effective potentials are useful to simulate the morphologies. [ABSTRACT FROM AUTHOR]

Thrombus computed tomography (CT) imaging characteristics may correspond with thrombus mechanical properties and thus predict thrombectomy success. The impact of red blood cell (RBC) content on these properties (imaging and mechanics) has been widely studied. However, the additional effect of platelets has not been considered. The objective of the current study was to examine the individual and combined effects of blood clot RBC and platelet content on resultant CT imaging and mechanical characteristics. Human blood clot analogues were prepared from a combination of preselected RBC volumes and platelet concentrations to decouple their contributions. The resulting clot RBC content (%) and platelet content (%) were determined using Martius Scarlet Blue and CD42b staining, respectively. Non-contrast and contrast-enhanced CT (NCCT and CECT) scans were performed to measure the clot densities. CECT density increase was taken as a proxy for clinical perviousness. Unconfined compressive mechanics were analysed by performing 10 cycles of 80% strain. RBC content is the major determinant of clot NCCT density. However, additional consideration of the platelet content improves the association. CECT density increase is influenced by clot platelet and not RBC content. Platelet content is the dominant component driving clot stiffness, especially at high strains. Both RBC and platelet content contribute to the clot's viscoelastic and plastic compressive properties. The current in vitro results suggest that CT density is reflective of RBC content and subsequent clot viscoelasticity and plasticity, and that perviousness reflects the clot's platelet content and subsequent stiffness. However, these indications should be confirmed in a clinical stroke cohort. [ABSTRACT FROM AUTHOR]

Background: When the lead leg of a pitcher contacts the ground, the knee braces and then rapidly extends, initiating energy transfer to begin pelvis and trunk rotation. Purpose: To investigate the relationship of lead knee extension during the pitching delivery with peak lead knee extension velocity, ball velocity, and elbow varus torque in high school and professional pitchers. Study Design: Descriptive laboratory study. Methods: Data from 50 professional (PRO) and 50 high school (HS) pitcher groups were retrospectively analyzed. Pitchers threw 8 to 12 fastballs under 3-dimensional motion analysis (480 Hz). The groups were divided according to high or low lead knee extension: PRO-high (n = 18), PRO-low (n = 16), HS-high (n = 16), and HS-low (n = 17). Lead knee flexion, lead knee extension velocity, ball velocity, and elbow varus torque were analyzed between groups. Regression analyses were performed to quantify associations between lead knee extension and ball velocity and elbow varus torque for all pitchers. Results: At foot contact, all pitchers landed with similar knee flexion. PRO-high and HS-high pitchers had significantly greater lead knee extension through remaining pitching time points compared with the PRO-low and HS-low pitchers. PRO-high pitchers had faster ball velocity than PRO-low pitchers (39.8 ± 1.1 vs 39.3 ± 1.3 m/s, respectively), and HS-high pitchers had faster ball velocity than HS-low pitchers (34.1 ± 2.6 vs 31.2 ± 1.8 m/s, respectively) (P <.05). PRO-high pitchers had decreased elbow varus torque compared with PRO-low pitchers (85.3 ± 10.7 vs 95.4 ± 13.3 N·m, respectively); conversely, HS-high pitchers had greater elbow varus torque than HS-low pitchers (64.2 ± 14.7 vs 56.3 ± 12.2 N·m, respectively). For every 1° increase in lead knee extension, ball velocity increased by 0.47 m/s (P <.001) and elbow varus torque increased by 0.27 N·m (P =.025). Conclusion: Proper lead knee extension allowed efficient energy transfer through the kinetic chain to produce optimal ball velocity and minimize elbow varus torque in professional pitchers. Conversely, while proper lead knee extension improved ball velocity among high school pitchers, this did not minimize elbow varus torque. Clinical Relevance: Professional pitchers can extend their lead knee with minimal impact at the elbow. In high school pitchers, cognizance of proper full-body pitching mechanics remains a priority over increased velocity. [ABSTRACT FROM AUTHOR]

Graphene‐skinned fiber fabric is prepared by chemical vapor deposition (CVD) of continuous graphene on fabric, which enables conformal graphene coverage on fibers and inherits high electrical and thermal conductivity of graphene. However, in the fabric‐shaped configuration, high electrical and thermal contact resistances between fibers, and the lack of conductive and thermal pathways along radial direction of fibers limit the improvement of electrical and thermal conductivity. Herein, carbon nanotubes (CNTs), due to the 1D structure with excellent electrical and thermal conductivity, are introduced to build rich “bridges” to connect the isolated fibers to build new electron and phonon transport channels. Thus, the conceptual design of CNT/graphene‐skinned glass fiber fabric (CNT/GGFF) is creatively proposed and realized by a carefully designed CVD. Constructing the 3D electrically and thermally conductive network in CNT/GGFF leads to >90% decrease of sheet resistance, 4.5 times increase of tensile strength, and >70% decrease of thermal resistance compared with GGFF, making it promising for applications in composite materials, heat dissipation, and de‐icing. Moreover, the thermal resistance of CNT/GGFF exhibits temperature‐independent, extending applications to aviation and space because changes in thermal conductivity of traditional materials with environmental temperatures can adversely affect the thermal stability, reliability, and lifetime of aircrafts. [ABSTRACT FROM AUTHOR]

This work is devoted to the interaction of nucleotides. The goal of this study is to learn or try to learn how the interaction between nucleotides with exposure to a liquid takes place. Will the interacting forces of the nucleotides be sufficient to approach the incision? A numerical imitation of the interaction is conducted using the discrete element method and a Gears predictor–corrector as part of the integrated scheme. In this work, the results reflect the dynamics of nucleotides: velocity, displacement, and force graphs are presented with and without the effect of the liquid. During changes caused by the influence of a liquid, the nucleotide interaction transforms and passes three stages: a full stop, one similar to viscous damping, and one similar to non-dissipative behaviors. The main contribution of this work is a better understanding of the behavior of infinitely small objects that would be difficult to observe in vivo. The changing influence of a liquid can transform into certain effects. As a result, a model is provided, which can be based on the results of well-known physical experiments (DNA unzipping) for modeling nucleotide interactions. [ABSTRACT FROM AUTHOR]

Tissue buckling is an increasingly appreciated mode of morphogenesis in the embryo, but it is often unclear how geometric and material parameters are molecularly determined in native developmental contexts to generate diverse functional patterns. Here, we study the link between differential mechanical properties and the morphogenesis of distinct anteroposterior compartments in the intestinal tract--the esophagus, small intestine, and large intestine. These regions originate from a simple, common tube but adopt unique forms. Using measured data from the developing chick gut coupled with a minimal theory and simulations of differential growth, we investigate divergent lumen morphologies along the entire early gut and demonstrate that spatiotemporal geometries, moduli, and growth rates control the segment-specific patterns of mucosal buckling. Primary buckling into wrinkles, folds, and creases along the gut, as well as secondary buckling phenomena, including period-doubling in the foregut and multiscale creasing-wrinkling in the hindgut, are captured and well explained by mechanical models. This study advances our existing knowledge of how identity leads to form in these regions, laying the foundation for future work uncovering the relationship between molecules and mechanics in gut morphological regionalization. [ABSTRACT FROM AUTHOR]

The Lagrange method is applied to two dynamic models of a Slinky, one based on point masses and linear springs and a second where the Slinky is represented as a sequence of half hoops connected by torsion springs. For the first time, the use of Lagrange's method applied to a Slinky has produced a multi-body dynamic model that can potentially with minor modification reproduce all the interesting behaviour Slinkies are well known for; descending stairs, pseudo levitation, transmission of longitudinal and transverse waves. In this paper, the models are derived and a limited exploration of the two dynamic models' behaviour is considered. For unforced oscillation, the point mass model and torsion spring model produce a similar amplitude and frequency. When considering forced oscillations, the point mass model has a very different spectrum of natural frequencies than the torsion spring model. The torsion spring model is considered for different forcing conditions. [ABSTRACT FROM AUTHOR]

Tetralogy of Fallot is the most common heart defect associated with cyanosis characterized by the co-occurrence of pulmonary stenosis, right ventricular hypertrophy, and ventricular septal defect with over-riding of the aorta. The present review purposed to summarize myocardial, valvular and vascular abnormalities, which were described in a series of patients following repair of tetralogy of Fallot. It was also aimed to describe potential differences in these parameter using different surgical strategies. [ABSTRACT FROM AUTHOR]

Bedrock temperature contains effective information about changes in the crustal stress. A new method of detecting crustal stress change by bedrock temperature (DSCT) has been proposed. Understanding the stress-induced temperature response characteristics of loaded rocks is fundamental for applying DSCT. In this study, temperature observation experiments of different rocks and water-saturated sandstones subjected to tiered cyclic loading were conducted to investigate the temperature–stress relationship throughout the whole rock deformation and failure process. Through experiments, some valuable results are obtained: (i) temperature changes synchronously with stress and has a very strong linear correlation with it; (ii) the magnitude of temperature response to stress (TRS) is approximately 1 mK MPa−1, ranging from strong to weak are sandstone, marble, diorite and basalt, respectively. The differences in TRS of various rocks are determined by their major rock-forming minerals, textures and structures; (iii) the evolution of TRS experiences three stages: the TRS rises rapidly in the compression stage, slowly in the acoustic emission quiet period and a significant increase in TRS before rock failure is observed on marble, sandstone and basalt, consistent with the abnormal bedrock temperature rise preceding earthquakes; (iv) the TRS of water-saturated sandstones is higher compared to the dry ones, and the abnormal sharp increase in TRS before rock failure is also more significant in the former. These findings mentioned above promote the understanding of thermal anomalies preceding earthquakes. [ABSTRACT FROM AUTHOR]

In this work we present a novel, experimentally efficient set-up for performing non-contacting laser vibrometry on geologic materials and their analogues. We show it is possible to acoustically monitor a granular material experiment in real time compared to the typical timescale of analogue modelling experiments. We acquire non-contacting waveform data with consistently high signal-to-noise ratio. Compared to previously used standard contacting transducers, the novel joint use of sources and receivers that are both laser-based resulted in measured signals with improved waveforms and temporal bandwidths. These data acquisition improvements, in our case where surface waves are prominent in the data, enable enhanced multichannel surface wave processing, for example, in terms of reliable dispersion curve estimates. We find, given the high waveform fidelity of our acquisition system, that the observed surface waves are highly sensitive to relatively small changes in the medium's elastic properties, making them a demonstrably reliable to monitor any processes that affect elasticity in these models in near real time. As a demonstration, we continuously monitor a scaled analogue model containing granular glass beads. By continuously monitoring—that is, performing repeatable active-source acousto-seismic surveys at short time-lapse intervals—over a period of 10 hr, we find that an increase of relative humidity of 10 per cent can lead to as much as a factor of two increase in surface wave group velocities. Finally, we discuss future applications of the developed method by considering surface wave inversion for fault and stress monitoring during the deformation of a model. [ABSTRACT FROM AUTHOR]

Increasing recycled plastic content in cars to 25% by 2030 is one of the key measures for decarbonizing the automotive industry defined by the European Commission. This should include the recovery of plastics from end-of-life vehicles (ELVs), but such materials are hardly used in compounds today. To close the knowledge gap, two ELV recyclate grades largely based on bumper recycling were analyzed in comparison to a packaging-based post-consumer recyclate (PCR). The composition data were used to design polypropylene (PP) compounds for automotive applications with virgin base material and mineral reinforcement, which were characterized in relation to a commercial virgin-based compound. A compound with a 40 wt.-% ELV-based bumper recyclate can exceed one with just a 25 wt.-% packaging-based recyclate in terms of stiffness/impact balance. While the virgin reference can nearly be matched regarding mechanics, the flowability is not reached by any of the PCR compounds, making further development work necessary. [ABSTRACT FROM AUTHOR]

This research manuscript describes the process of degradation of an Armox 600 armour plate during the impact of a 5.56x45 mm SS109 projectile. The creation process of the numerical FEM model of the projectile is presented. The projectile impact angle is set between 15° and 90°, and this phenomenon is investigated via numerical and experimental approaches. The experiment is conducted under the same conditions as the numerical approach to validate the FEM model. The experiments are conducted using a high-speed camera. This research manuscript presents the influence of the projectile impact angle on the degradation of the armour plate and its protection capability for different angles. The results demonstrate the dependence of the transferred energy on the armour plate, speed of the particles after impact, and trace dimensions on the armour plate for different impact angles. [ABSTRACT FROM AUTHOR]

The article focuses on the historical evolution of Australia's motor mechanic trade from 1900 to 1970, exploring its impact on Australian society, economy, and the emergence of a new workforce segment. Topics include the transformation of landscapes due to the introduction of motor cars, the socio-economic role of mechanics within Australia's working class, and a critical examination of their evolving professional identity amid societal changes and technological advancements.

Background: Although immobilizing the upper limb is known to aid rehabilitation and improve symptoms for specific conditions, there is evidence suggesting that casting or splinting the upper limb can substantially alter walking biomechanics, including kinetics, kinematics, and spatiotemporal aspects. Objectives: This study aimed to explore how unilateral casting of either the dominant or non-dominant upper limb affects the maximum three-dimensional mechanical power of the ankle joint during walking. Methods: In this quasi-experimental study, 30 healthy women (average age ± standard deviation: 29.5 ± 3.45 years) participated. They walked under three conditions: Without immobilization, with immobilization of the dominant upper limb, and with immobilization of the non-dominant upper limb, along a path equipped with force plates and cameras. The instantaneous muscle power at the ankle joint in each plane was measured. A repeated measures analysis of variance (ANOVA) was conducted to identify significant differences among the three conditions. Results: Significant changes were observed in all parameters of maximum power generation and absorption at the ankle joint across all planes when walking with the dominant and non-dominant upper limbs splinted (P ≤ 0.05). Conclusions: Considering that muscle power is a crucial biomechanical parameter during walking, the observed alterations in this parameter due to upper limb splinting highlight the need for awareness to prevent potential walking difficulties when using upper limb braces. [ABSTRACT FROM AUTHOR]

Stem cell homeostasis in the shoot apical meristem involves a core regulatory feedback loop between the signalling peptide CLAVATA3 (CLV3), produced in stem cells, and the transcription factor WUSCHEL, expressed in the underlying organising centre. clv3 mutant meristems display massive overgrowth, which is thought to be caused by stem cell over proliferation, although it is unknown how uncontrolled stem cell divisions lead to this altered morphology. Here, we reveal local buckling defects in mutant meristems, and use analytical models to show how mechanical properties and growth rates may contribute to the phenotype. Indeed, clv3 mutant meristems are mechanically more heterogeneous than the wild type, and also display regional growth heterogeneities. Furthermore, stereotypical wild-type meristem organisation, in which cells simultaneously express distinct fate markers, is lost in mutants. Finally, cells in mutant meristems are auxin responsive, suggesting that they are functionally distinguishable from wild-type stem cells. Thus, all benchmarks show that clv3 mutant meristem cells are different from wild-type stem cells, suggesting that overgrowth is caused by the disruption of a more complex regulatory framework that maintains distinct genetic and functional domains in the meristem. [ABSTRACT FROM AUTHOR]

In this paper, we propose a mechanical model for a game of tug of war (rope pulling). We focus on a game opposing two players, modelling each player's body as a structure composed of straight rods that can be actuated in three different ways to generate a pulling force. We first examine the static problem of two opponents being in a deadlock configuration of mechanical equilibrium; here we show that this situation is essentially governed by the ratio of masses of the players, with the heavier player having a strong advantage. We then turn to the dynamic problem and model the response of the system to an abrupt change in activation by one of the players. In this case, the system exhibits a nontrivial response; in particular, we compare a sudden pulling and a sudden "letting up," and demonstrate the existence of regimes in which the lighter player can momentarily take the advantage. [ABSTRACT FROM AUTHOR]