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271 results on '"Meda, Shashwath A."'

1. Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis

Author

Lizano, Paulo, Kiely, Chelsea, Mijalkov, Mite, Meda, Shashwath A, Keedy, Sarah K., Hoang, Dung, Zeng, Victor, Lutz, Olivia, Pereira, Joana B., Ivleva, Elena I., Volpe, Giovanni, Xu, Yanxun, Lee, Adam M., Rubin, Leah H., Kristian Hill, S, Clementz, Brett A., Tamminga, Carol A., Pearlson, Godfrey D., Sweeney, John A., Gershon, Elliot S., Keshavan, Matcheri S., and Bishop, Jeffrey R.

Published
2023
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2. Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study

Author

Chye, Yann, Mackey, Scott, Gutman, Boris A, Ching, Christopher RK, Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth C, Cousijn, Janna, Dagher, Alain, Foxe, John J, Goudriaan, Anna E, Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne M, Korucuoglu, Ozlem, Li, Chiang‐Shan R, London, Edythe D, Lorenzetti, Valentina, Luijten, Maartje, Martin‐Santos, Rocio, Meda, Shashwath A, Momenan, Reza, Morales, Angelica, Orr, Catherine, Paulus, Martin P, Pearlson, Godfrey, Reneman, Liesbeth, Schmaal, Lianne, Sinha, Rajita, Solowij, Nadia, Stein, Dan J, Stein, Elliot A, Tang, Deborah, Uhlmann, Anne, Holst, Ruth, Veltman, Dick J, Verdejo‐Garcia, Antonio, Wiers, Reinout W, Yücel, Murat, Thompson, Paul M, Conrod, Patricia, and Garavan, Hugh

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Alcoholism, Alcohol Use and Health, Neurosciences, Drug Abuse (NIDA only), Brain Disorders, Substance Misuse, Mental health, Good Health and Well Being, Adolescent, Adult, Brain, Cannabis, Cocaine, Ethanol, Female, Humans, Magnetic Resonance Imaging, Male, Methamphetamine, Neuroimaging, Nicotine, Substance-Related Disorders, Young Adult, addiction, structural MRI, substance dependence, Medical and Health Sciences, Psychology and Cognitive Sciences, Substance Abuse, Biomedical and clinical sciences, Health sciences
Abstract

While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.

Published
2020

3. 398. The Basic Neurocognitive Continuum (BANCC): The Affiliation of Neurobiological and Cognitive Measures in a Data-Based Approach

Author

Warren, Hailey, primary, Tamminga, Carol A., additional, Pearlson, Godfrey, additional, Keshavan, Macheri, additional, Gershon, Elliot S., additional, Ivleva, Elena I., additional, McDowell, Jennifer E., additional, Meda, Shashwath A., additional, Keedy, Sarah, additional, Gibbons, Robert, additional, and Clementz, Brett A., additional

Published
2024
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10. 197. Inflammatory Differences in Multilayer Functional Network Topology Impacts Cognition in Psychosis

Author

Kiely, Chelsea, primary, Mijalkov, Mite, additional, Meda, Shashwath, additional, Hoang, Jolie, additional, Pereira, Joana, additional, Ivleva, Elena I., additional, Volpe, Giovanni, additional, Xu, Yanxun, additional, Lee, Adam, additional, Clementz, Brett A., additional, Tamminga, Carol, additional, Pearlson, Godfrey, additional, Keedy, Sarah, additional, Sweeney, John A., additional, Keshavan, Matcheri, additional, Bishop, Jeffrey, additional, and Lizano, Paulo, additional

Published
2023
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12. NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis

Author

Alliey-Rodriguez, Ney, Grey, Tamar A., Shafee, Rebecca, Asif, Huma, Lutz, Olivia, Bolo, Nicolas R., Padmanabhan, Jaya, Tandon, Neeraj, Klinger, Madeline, Reis, Katherine, Spring, Jonathan, Coppes, Lucas, Zeng, Victor, Hegde, Rachal R., Hoang, Dung T., Bannai, Deepthi, Nawaz, Uzma, Henson, Philip, Liu, Siyuan, Gage, Diane, McCarroll, Steven, Bishop, Jeffrey R., Hill, Scot, Reilly, James L., Lencer, Rebekka, Clementz, Brett A., Buckley, Peter, Glahn, David C., Meda, Shashwath A., Narayanan, Balaji, Pearlson, Godfrey, Keshavan, Matcheri S., Ivleva, Elena I., Tamminga, Carol, Sweeney, John A., Curtis, David, Badner, Judith A., Keedy, Sarah, Rapoport, Judith, Liu, Chunyu, and Gershon, Elliot S.

Published
2019
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13. S100A10 identified in a genome-wide gene x cannabis dependence interaction analysis of risky sexual behaviours

Author

Polimanti, Renato, Meda, Shashwath A., Pearlson, Godfrey D., Zhao, Hongyu, Sherva, Richard, Farrer, Lindsay A., Kranzler, Henry R., and Gelernter, Joel

Subjects
Risk taking -- Genetic aspects -- Health aspects, Marijuana -- Health aspects -- Psychological aspects, Sexual behavior -- Genetic aspects -- Health aspects, Health, Psychology and mental health
Abstract

Background: We conducted a genome-wide gene x environment interaction analysis to identify genetic variants that interact with cannabis dependence (CaD) in influencing risky sexual behaviours (RSB). Methods: Our sample included cannabis-exposed and sexually experienced African-American and European-American participants. A DSM-IV CaD diagnosis and RSB were evaluated using the SemiStructured Assessment for Drug Dependence and Alcoholism. We analyzed RSBs as a score that takes into account experiences of unprotected sex and multiple sexual partners. Results: A total of 3350 people participated in our study; 43% had a CaD diagnosis, 56% were African-American and 33% were women. We identified a genome-wide significant locus in African-American participants (S100A10 rs72993629, p = 2.73 x [10.sup.-8]) and a potential transpopulation signal in women (CLTC rs12944716, p = 5.27 x [10.sup.-8]). A resting-state fMRI follow-up analysis of S100A10 rs72993629 conducted in an independent cohort showed 2 significant associations: reduced power of the left paracentral lobule in amplitude of low frequency fluctuations (ALFF) analysis (p = 7.8 x [10.sup.-3]) and reduced power of the right pallidum in fractional ALFF analysis (p = 4.6 x [10.sup.-3]). The activity of these brain regions is known to be involved in sexual functions and behaviours. The S100A10 result functionally recapitulated our S100B finding observed in our previous genome-wide association study of CaD. The probability of identifying 2 S100 genes in 2 independent genome-wide investigations by chance is approximately 1 in 1.1 million. Limitations: We were not able to identify any African-American cohort with appropriate sample size, and phenotypic assessment is available to replicate our findings. Conclusion: The S100A10 and S100B genes, which are located on different chromosomes, encode specialized calcium-binding proteins. These data support a role for calcium homeostasis in individuals with CaD and its induced behaviours., Introduction Cannabis is the most widely used illicit drug worldwide, and in developed countries the number of cannabis users is rapidly increasing as a consequence of decriminalization/ legalization and decreased [...]

Published
2017
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29. Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by 'resting state' functional magnetic resonance imaging

Author

Lui, Su, Li, Tao, Deng, Wei, Jiang, Lijun, Wu, Qizhu, Tang, Hehan, Yue, Qiang, Huang, Xiaoqi, Chan, Raymond C., Collier, David A., Meda, Shashwath A., Pearlson, Godfrey, Mechelli, Andrea, Sweeney, John A., and Gong, Qiyong

Subjects
Schizophrenia -- Drug therapy, Schizophrenia -- Patient outcomes, Schizophrenia -- Research, Cerebrum -- Physiological aspects, Cerebrum -- Research, Neuroimaging -- Usage, Neuroimaging -- Research, Antipsychotic drugs -- Dosage and administration, Antipsychotic drugs -- Research, Health, Psychology and mental health
Published
2010

30. Anterior Default Mode Network Mediates the Relationship Between Systemic Inflammation and Cognition in Idiopathic Psychosis

Author

Lizano, Paulo, primary, Keedy, Sarah, additional, Meda, Shashwath, additional, Hill, Kristian, additional, Lee, Adam, additional, Lutz, Olivia, additional, Rubin, Leah, additional, Tamminga, Carol, additional, Clementz, Brett, additional, Pearlson, Godfrey, additional, Gershon, Elliot, additional, Sweeney, John A., additional, Keshavan, Matcheri, additional, and Bishop, Jeffrey, additional

Published
2021
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32. Effects of weather and season on human brain volume

Author

Book, Gregory A., primary, Meda, Shashwath A., additional, Janssen, Ronald, additional, Dager, Alecia D., additional, Poppe, Andrew, additional, Stevens, Michael C., additional, Assaf, Michal, additional, Glahn, David, additional, and Pearlson, Godfrey D., additional

Published
2021
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33. Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study.

Author

Lorenzetti, Valentina, Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, Meda, Shashwath, Momenan, Reza, Morales, Angelica, Orr, Catherine, Paulus, Martin, Pearlson, Godfrey, Reneman, Liesbeth, Schmaal, Lianne, Sinha, Rajita, Solowij, Nadia, Stein, Dan, Stein, Elliot, Tang, Deborah, Uhlmann, Anne, van Holst, Ruth, Veltman, Dick, Verdejo-Garcia, Antonio, Wiers, Reinout, Yücel, Murat, Thompson, Paul, Conrod, Patricia, Garavan, Hugh, Chye, Yann, Mackey, Scott, Gutman, Boris, Ching, Christopher, Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth, Cousijn, Janna, Dagher, Alain, Foxe, John, Goudriaan, Anna, Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne, Korucuoglu, Ozlem, Li, Chiang-Shan, London, Edythe, Lorenzetti, Valentina, Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, Meda, Shashwath, Momenan, Reza, Morales, Angelica, Orr, Catherine, Paulus, Martin, Pearlson, Godfrey, Reneman, Liesbeth, Schmaal, Lianne, Sinha, Rajita, Solowij, Nadia, Stein, Dan, Stein, Elliot, Tang, Deborah, Uhlmann, Anne, van Holst, Ruth, Veltman, Dick, Verdejo-Garcia, Antonio, Wiers, Reinout, Yücel, Murat, Thompson, Paul, Conrod, Patricia, Garavan, Hugh, Chye, Yann, Mackey, Scott, Gutman, Boris, Ching, Christopher, Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth, Cousijn, Janna, Dagher, Alain, Foxe, John, Goudriaan, Anna, Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne, Korucuoglu, Ozlem, Li, Chiang-Shan, and London, Edythe

Abstract

While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.

Published
2020

34. Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study

Author

Diagnostiek & Vroege Psychose Medisch, Onderzoek, Chye, Yann, Mackey, Scott, Gutman, Boris A., Ching, Christopher R.K., Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth C., Cousijn, Janna, Dagher, Alain, Foxe, John J., Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne M., Korucuoglu, Ozlem, Li, Chiang Shan R., London, Edythe D., Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, Meda, Shashwath A., Momenan, Reza, Morales, Angelica, Orr, Catherine, Paulus, Martin P., Pearlson, Godfrey, Reneman, Liesbeth, Schmaal, Lianne, Sinha, Rajita, Solowij, Nadia, Stein, Dan J., Stein, Elliot A., Tang, Deborah, Uhlmann, Anne, van Holst, Ruth, Veltman, Dick J., Verdejo-Garcia, Antonio, Wiers, Reinout W., Yücel, Murat, Thompson, Paul M., Conrod, Patricia, Garavan, Hugh, Diagnostiek & Vroege Psychose Medisch, Onderzoek, Chye, Yann, Mackey, Scott, Gutman, Boris A., Ching, Christopher R.K., Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth C., Cousijn, Janna, Dagher, Alain, Foxe, John J., Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne M., Korucuoglu, Ozlem, Li, Chiang Shan R., London, Edythe D., Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, Meda, Shashwath A., Momenan, Reza, Morales, Angelica, Orr, Catherine, Paulus, Martin P., Pearlson, Godfrey, Reneman, Liesbeth, Schmaal, Lianne, Sinha, Rajita, Solowij, Nadia, Stein, Dan J., Stein, Elliot A., Tang, Deborah, Uhlmann, Anne, van Holst, Ruth, Veltman, Dick J., Verdejo-Garcia, Antonio, Wiers, Reinout W., Yücel, Murat, Thompson, Paul M., Conrod, Patricia, and Garavan, Hugh

Published
2020

37. Biotyping in psychosis: using multiple computational approaches with one data set

Author

Tamminga, Carol A., primary, Clementz, Brett A., additional, Pearlson, Godfrey, additional, Keshavan, Macheri, additional, Gershon, Elliot S., additional, Ivleva, Elena I., additional, McDowell, Jennifer, additional, Meda, Shashwath A., additional, Keedy, Sarah, additional, Calhoun, Vince D., additional, Lizano, Paulo, additional, Bishop, Jeffrey R., additional, Hudgens-Haney, Matthew, additional, Alliey-Rodriguez, Ney, additional, Asif, Huma, additional, and Gibbons, Robert, additional

Published
2020
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38. Effects of Weather and Season on Human Brain Volume

Author

Book, Gregory A., primary, Meda, Shashwath A., additional, Janssen, Ronald, additional, Dager, Alecia D., additional, Poppe, Andrew, additional, Stevens, Michael C., additional, Assaf, Michal, additional, Glahn, David, additional, and Pearlson, Godfrey D., additional

Published
2020
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39. Resting state auditory-language cortex connectivity is associated with hallucinations in clinical and biological subtypes of psychotic disorders

Author

Okuneye, Victoria T., primary, Meda, Shashwath, additional, Pearlson, Godfrey D., additional, Clementz, Brett A., additional, Keshavan, Matcheri S., additional, Tamminga, Carol A., additional, Ivleva, Elena, additional, Sweeney, John A., additional, Gershon, Elliot S., additional, and Keedy, Sarah K., additional

Published
2020
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48. Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study

Author

Chye, Yann, Mackey, Scott, Gutman, Boris, Ching, Christopher, Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth, Cousijn, Janna, Dagher, Alain, Foxe, John, Goudriaan, Anna, Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne, Korucuoglu, Ozlem, Li, Chiang-Shan R, London, Edythe D, Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, Meda, Shashwath, Momenan, Reza, Morales, Angelica M, Orr, Catherine, Paulus, Martin P, Pearlson, Godfrey, Reneman, Liesbeth, Schmaal, Lianne, Sinha, Rajita, Solowij, Nadia, Stein, Dan J, Stein, Elliot A, Tang, Deborah, Uhlmann, Anne, Van Holst, Ruth, Veltman, Dick, Verdejo-Garcia, Antonio, Wiers, Reinout, Yucel, Murat, Thompson, Paul M, Conrod, Patricia, Garavan, Hugh, Chye, Yann, Mackey, Scott, Gutman, Boris, Ching, Christopher, Batalla, Albert, Blaine, Sara, Brooks, Samantha, Caparelli, Elisabeth, Cousijn, Janna, Dagher, Alain, Foxe, John, Goudriaan, Anna, Hester, Robert, Hutchison, Kent, Jahanshad, Neda, Kaag, Anne, Korucuoglu, Ozlem, Li, Chiang-Shan R, London, Edythe D, Lorenzetti, Valentina, Luijten, Maartje, Martin-Santos, Rocio, Meda, Shashwath, Momenan, Reza, Morales, Angelica M, Orr, Catherine, Paulus, Martin P, Pearlson, Godfrey, Reneman, Liesbeth, Schmaal, Lianne, Sinha, Rajita, Solowij, Nadia, Stein, Dan J, Stein, Elliot A, Tang, Deborah, Uhlmann, Anne, Van Holst, Ruth, Veltman, Dick, Verdejo-Garcia, Antonio, Wiers, Reinout, Yucel, Murat, Thompson, Paul M, Conrod, Patricia, and Garavan, Hugh

Abstract

2019 Society for the Study of Addiction While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.

Published
2019

49. Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study

Author

Chye, Yann, primary, Mackey, Scott, additional, Gutman, Boris A., additional, Ching, Christopher R.K., additional, Batalla, Albert, additional, Blaine, Sara, additional, Brooks, Samantha, additional, Caparelli, Elisabeth C., additional, Cousijn, Janna, additional, Dagher, Alain, additional, Foxe, John J., additional, Goudriaan, Anna E., additional, Hester, Robert, additional, Hutchison, Kent, additional, Jahanshad, Neda, additional, Kaag, Anne M., additional, Korucuoglu, Ozlem, additional, Li, Chiang‐Shan R., additional, London, Edythe D., additional, Lorenzetti, Valentina, additional, Luijten, Maartje, additional, Martin‐Santos, Rocio, additional, Meda, Shashwath A., additional, Momenan, Reza, additional, Morales, Angelica, additional, Orr, Catherine, additional, Paulus, Martin P., additional, Pearlson, Godfrey, additional, Reneman, Liesbeth, additional, Schmaal, Lianne, additional, Sinha, Rajita, additional, Solowij, Nadia, additional, Stein, Dan J., additional, Stein, Elliot A., additional, Tang, Deborah, additional, Uhlmann, Anne, additional, Holst, Ruth, additional, Veltman, Dick J., additional, Verdejo‐Garcia, Antonio, additional, Wiers, Reinout W., additional, Yücel, Murat, additional, Thompson, Paul M., additional, Conrod, Patricia, additional, and Garavan, Hugh, additional

Published
2019
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50. Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol‐Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort

Author

Meda, Shashwath A., primary, Narayanan, Balaji, additional, Chorlian, David, additional, Meyers, Jacquelyn L., additional, Gelernter, Joel, additional, Hesselbrock, Victor, additional, Bauer, Lance, additional, Calhoun, Vince D., additional, Porjesz, Bernice, additional, and Pearlson, Godfrey D., additional

Published
2019
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