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1. Metabolically Healthy, but Obese Individuals and Associations with Echocardiographic Parameters and Inflammatory Biomarkers: Results from the CARLA Study

Author

Efremov L, Lacruz ME, Tiller D, Medenwald D, Greiser KH, Kluttig A, Wienke A, Nuding S, and Mikolajczyk R

Subjects
obesity phenotypes, visceral adipose tissue, cardiac remodeling, inflammatory biomarkers, Specialties of internal medicine, RC581-951
Abstract

Ljupcho Efremov,1 Maria Elena Lacruz,2 Daniel Tiller,3 Daniel Medenwald,1 Karin Halina Greiser,4 Alexander Kluttig,1 Andreas Wienke,1 Sebastian Nuding,5 Rafael Mikolajczyk1 1Institute of Medical Epidemiology, Biostatistics, and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; 2Clinical Cancer Register, Saxony-Anhalt, Halle (Saale), Germany; 3IT Department, Data Integration Center, University Hospital Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; 4Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany; 5Department of Internal Medicine III, University Hospital Martin-Luther-University Halle-Wittenberg, Halle (Saale), GermanyCorrespondence: Rafael MikolajczykInstitute of Medical Epidemiology, Biostatistics, and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin-Luther-University Halle-Wittenberg, Magdeburger Str. 8, Halle (Saale) 06112, GermanyEmail rafael.mikolajczyk@uk-halle.deIntroduction: The research on heterogeneity among obese individuals has identified the metabolically healthy, but obese (MHO) phenotype as a distinct group that does not experience the typical cardiovascular-related diseases (CVD). It is unclear if this group differs with regard to preconditions for CVDs. Our aim was to assess differences in echocardiographic parameters and inflammatory biomarkers between MHO and metabolically healthy, normal weight individuals (MHNW).Methods: The analyses used data from 1412 elderly participants from a German population-based cohort study (CARLA), which collected detailed information on demographic, biochemical, and echocardiographic variables. Participants were subdivided into four groups (MHNW, MHO, MUNW (metabolically unhealthy, normal weight) and MUO (metabolically unhealthy, obese)) based on BMI≥ 30 kg/m2 (obese or normal weight) and presence of components of the metabolic syndrome. The clinical characteristics of the 4 groups were compared with ANOVA or Chi-Square test, in addition to two linear regression models for 16 echocardiographic parameters. The difference in inflammatory biomarkers (hsCRP, IL-6 and sTNF-RI) between the groups was examined with a multinomial logistic regression model.Results: The MHO individuals were on average 64.2± 8.4 years old, with a higher proportion of women (71.6%), low percentage of smokers, larger waist circumference (109.3± 10.5 cm vs 89.1± 10.8 cm, p< 0.0001) and higher odds ratios for hsCRP, IL-6 and sTNF-RI compared to MHNW individuals. Linear regression models revealed greater left atrial (LA) diameter (2.73 (95% CI: 1.35– 4.11) mm), LA volume (7.86 (95% CI: 2.88– 12.83) mL), and left ventricular mass index (LVMI) (11.82 (95% CI: 4.43– 19.22) g/m1.7) in the MHO group compared to the MHNW group.Conclusion: The MHO phenotype is associated with echocardiographic markers of cardiac remodeling (LA diameter, volume and LVMI) and higher odds ratios for inflammatory biomarkers.Keywords: obesity phenotypes, visceral adipose tissue, cardiac remodeling, inflammatory biomarkers

Published
2020

2. Number of radiotherapy treatment machines in the population and cancer mortality: an ecological study

Author

Medenwald D, Vordermark D, and Dietzel CT

Subjects
cancer mortality, radiotherapy machines, population, demand, Infectious and parasitic diseases, RC109-216
Abstract

Daniel Medenwald,1,2 Dirk Vordermark,1 Christian T Dietzel1 1Department of Radiation Oncology, University Hospital Halle (Saale), Halle (Saale), Germany; 2Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany Objectives: The aim of this study was to assess the association between the number of radiotherapy treatment machines (RTMs) in the population and incidence-adjusted cancer mortality. Methods: Data on cancer incidence and mortality were obtained from the GLOBOCAN project (only high-quality data, C3, or higher according to GLOBOCAN quality label), information on the number of RTMs from the Directory of Radiotherapy Centers database, and remaining data from the World Bank and World Health Organization database. We used linear regression models to assess the associations between RTM per 10,000,000 inhabitants (logarithmized) and the log-transformed mortality/incidence ratio. Models were adjusted for public health variables. To assess the bias due to unobserved confounders, mortality from leukemia was considered as a negative control. Here radiotherapy treatment is less frequently applied, but a common set of confounders is shared with cancer types where radiotherapy plays a stronger role, enabling us to estimate the bias due to confounding of unmeasured parameters. To assess an exposure–effect size relationship, estimated cancer type-specific estimates were related to the proportion of subjects receiving radiotherapy. Results: We found an inverse linear relationship between RTM in the population and the cancer mortality to incidence ratio for prostate cancer (14.1% per doubling of RTM; 95% CI: 0.1%–26.1%), female breast cancer (12.3%; 95% CI: 2.7%–20.9%), and lung cancer in women (11.2%; 95% CI: 4.3%–17.6%). There was no evidence for bias due to unobserved confounders after covariate adjustment. For women, an exposure-effect size relationship was found (P=0.02). Conclusion: In this ecological study, we found evidence that the population density of RTM is related to cancer mortality independently of other public health parameters. Keywords: radiotherapy machines, population, cancer mortality, negative controls

Published
2018

4. Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations: An overview and recommendations of the consortium academic radiation oncology of the German Society for Radiation Oncology (DEGRO)

Author

Dapper, H., Belka, C., Bock, F., Budach, V., Budach, W., Christiansen, H., Debus, J., Distel, L., Dunst, J., Eckert, F., Eich, H., Eicheler, W., Engenhart-Cabillic, R., Fietkau, R., Fleischmann, D. F., Frerker, B., Giordano, F. A., Grosu, A. L., Herfarth, K., Hildebrandt, G., Kaul, D., Kölbl, O., Krause, M., Krug, D., Martin, D., Matuschek, C., Medenwald, D., Nicolay, N. H., Niewald, M., Oertel, M., Petersen, C., Pohl, F., Raabe, A., Rödel, C., Rübe, C., Schmalz, C., Schmeel, L. C., Steinmann, D., Stüben, G., Thamm, R., Vordermark, D., Vorwerk, H., Wiegel, T., Zips, D., and Combs, S. E.

Published
2022
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5. Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer—results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group

Author

Ostheimer, C., Mäurer, M., Ebert, N., Schmitt, D., Krug, D., Baumann, R., Henkenberens, C., Giordano, F. A., Sautter, L., López, Guerra, Fleischmann, D. F., Niyazi, M., Käsmann, L., Kaul, D., Thieme, A. H., Billiet, C., Dobiasch, S., Arnold, C. R., Oertel, M., Haussmann, J., Gauer, T., Goy, Y., Suess, C., Ziegler, S., Panje, C. M., Baues, C., Trommer, M., Skripcak, T., and Medenwald, D.

Published
2021
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6. MRI, FDG-PET/CT and Image-Guidance for Re-Irradiation of Locoregionally Recurrent or Second Primary Head-and-Neck Squamous Cell Carcinoma Patients – Results of a Multicenter Cohort Study

Author

Ruhle, A., primary, Roesch, J., additional, Oertel, M., additional, Fabian, A., additional, Wegen, S., additional, Trommer, M., additional, Hering, D., additional, Maeurer, M., additional, Dobiasch, S., additional, von der Grün, J., additional, Medenwald, D., additional, Süß, C., additional, Hoeck, M., additional, Fleischmann, D.F., additional, Löser, A., additional, Heß, S., additional, Tamaskovic, B., additional, Vinsensia, M., additional, Hecht, M., additional, and Nicolay, N.H., additional

Published
2023
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7. Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer—results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group

Author

Ostheimer, C., Mäurer, M., Ebert, N., Schmitt, D., Krug, D., Baumann, R., Henkenberens, C., Giordano, F. A., Sautter, L., López, Guerra, Fleischmann, D. F., Niyazi, M., Käsmann, L., Kaul, D., Thieme, A. H., Billiet, C., Dobiasch, S., Arnold, C. R., Oertel, M., Haussmann, J., Gauer, T., Goy, Y., Suess, C., Ziegler, S., Panje, C. M., Baues, C., Trommer, M., Skripcak, T., and Medenwald, D.

Published
2021
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10. Neoadjuvant Chemoradiation (CROSS) vs. Perioperative Chemotherapy (FLOT) in Esophageal Adenocarcinoma (EAC): ESOPEC – a Randomised Controlled Prospective Multicentre Phase III Trial

Author

Brunner, T.B., Lordick, F., Schmoor, C., Schmidberger, H., Kirste, S., Rieken, S., Petersen, C., Nicolay, N.H., Fokas, E., Dunst, J., Rades, D., Eble, M.J., Krause, M., Roedel, C., Medenwald, D., Niehoff, P., Wittig-Sauerwein, A., Baues, C., Grosu, A., and Hoeppner, J.

Published
2024
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13. Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations

Author

Dapper, H., Belka, C., Bock, F., Budach, V., Budach, W., Christiansen, H., Debus, J., Distel, L., Dunst, J., Eckert, F., Eich, H., Eicheler, W., Engenhart-Cabillic, R., Fietkau, R., Fleischmann, D. F., Frerker, B., Giordano, F. A., Grosu, A. L., Herfarth, K., Hildebrandt, G., Kaul, D., Kölbl, O., (0000-0003-1776-9556) Krause, M., Krug, D., Martin, D., Matuschek, C., Medenwald, D., Nicolay, N. H., Niewald, M., Oertel, M., Petersen, C., Pohl, F., Raabe, A., Rödel, C., Rübe, C., Schmalz, C., Schmeel, L. C., Steinmann, D., Stüben, G., Thamm, R., Vordermark, D., Vorwerk, H., Wiegel, T., Zips, D., Combs, S. E., Dapper, H., Belka, C., Bock, F., Budach, V., Budach, W., Christiansen, H., Debus, J., Distel, L., Dunst, J., Eckert, F., Eich, H., Eicheler, W., Engenhart-Cabillic, R., Fietkau, R., Fleischmann, D. F., Frerker, B., Giordano, F. A., Grosu, A. L., Herfarth, K., Hildebrandt, G., Kaul, D., Kölbl, O., (0000-0003-1776-9556) Krause, M., Krug, D., Martin, D., Matuschek, C., Medenwald, D., Nicolay, N. H., Niewald, M., Oertel, M., Petersen, C., Pohl, F., Raabe, A., Rödel, C., Rübe, C., Schmalz, C., Schmeel, L. C., Steinmann, D., Stüben, G., Thamm, R., Vordermark, D., Vorwerk, H., Wiegel, T., Zips, D., and Combs, S. E.

Abstract

The new Medical Licensing Regulations 2025 (Ärztliche Approbationsordnung, ÄApprO) will soon be passed by the Federal Council (Bundesrat) and will be implemented step by step by the individual faculties in the coming months. The further development of medical studies essentially involves an orientation from fact-based to competence-based learning and focuses on practical, longitudinal and interdisciplinary training. Radiation oncology and radiation therapy are important components of therapeutic oncology and are of great importance for public health, both clinically and epidemiologically, and therefore should be given appropriate attention in medical education. This report is based on a recent survey on the current state of radiation therapy teaching at university hospitals in Germany as well as the contents of the National Competence Based Learning Objectives Catalogue for Medicine 2.0 (Nationaler Kompetenzbasierter Lernzielkatalog Medizin 2.0, NKLM) and the closely related Subject Catalogue (Gegenstandskatalog, GK) of the Institute for Medical and Pharmaceutical Examination Questions (Institut für Medizinische und Pharmazeutische Prüfungsfragen, IMPP). The current recommendations of the German Society for Radiation Oncology (Deutsche Gesellschaft für Radioonkologie, DEGRO) regarding topics, scope and rationale for the establishment of radiation oncology teaching at the respective faculties are also included.

Published
2022

14. Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations

Author

Dapper, H., primary, Belka, C., additional, Bock, F., additional, Budach, V., additional, Budach, W., additional, Christiansen, H., additional, Debus, J., additional, Distel, L., additional, Dunst, J., additional, Eckert, F., additional, Eich, H., additional, Eicheler, W., additional, Engenhart-Cabillic, R., additional, Fietkau, R., additional, Fleischmann, D. F., additional, Frerker, B., additional, Giordano, F. A., additional, Grosu, A. L., additional, Herfarth, K., additional, Hildebrandt, G., additional, Kaul, D., additional, Kölbl, O., additional, Krause, M., additional, Krug, D., additional, Martin, D., additional, Matuschek, C., additional, Medenwald, D., additional, Nicolay, N. H., additional, Niewald, M., additional, Oertel, M., additional, Petersen, C., additional, Pohl, F., additional, Raabe, A., additional, Rödel, C., additional, Rübe, C., additional, Schmalz, C., additional, Schmeel, L. C., additional, Steinmann, D., additional, Stüben, G., additional, Thamm, R., additional, Vordermark, D., additional, Vorwerk, H., additional, Wiegel, T., additional, Zips, D., additional, and Combs, S. E., additional

Published
2021
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15. Exosomal Hsp70 in Liquid Biopsies - A Biomarker for Prediction and Response Monitoring in Cancer

Author

Wang F, Multhoff G, Salvermoser L, Xanthopoulos A, Skerra A, Werner C, Schlapschy M, Schwab M, Bache M, Shevstov M, Medenwald D, Windberg M, and Stangl S

Subjects
business.industry, allergology, medicine, Cancer research, Biomarker (medicine), Cancer, Liquid biopsy, medicine.disease, business, Microvesicles, Glioblastoma
Abstract

In contrast to normal cells, tumor cells of multiple entities overexpress the Heat Shock Protein 70 (Hsp70) not only in the cytosol, but also present it on their plasma membrane in a tumor-specific manner. Furthermore, membrane-Hsp70 positive tumor cells actively release Hsp70 into lipid microvesicles termed exosomes into the blood. Due to conformational changes of Hsp70 in the lipid environment, most commercially available antibodies fail to detect membrane-bound and exosomal Hsp70. To fill this gap and to assess the role of exosomal Hsp70 in the circulation as a potential tumor biomarker, we established the novel complete Hsp70 (compHsp70) sandwich ELISA using two monoclonal antibodies (mAbs) that are able to recognize both, free and lipid-associated Hsp70 on the cell surface of viable tumor cells and exosomes. The epitopes of the mAbs cmHsp70.1 (aa 451-461) and cmHsp70.2 (aa 614-623) that are conserved among different species reside in the substrate-binding domain of Hsp70, with measured affinities of 0.42 nM and 0.44 nM, respectively. Validation of the compHsp70 ELISA revealed a high intra- and inter-assay precision, linearity in a concentration range of 1.56 to 25 ng/ml, high recovery rates of ‘spiked’ liposomal Hsp70 (>84%), comparable values between human serum and plasma samples, and no interference by food intake or age of the donors. Hsp70 concentrations in the circulation of patients with glioblastoma, squamous cell or adeno non-small cell lung carcinoma (NSCLC) at diagnosis were significantly higher than those of healthy volunteers. Hsp70 concentrations dropped concomitantly with the decrease in viable tumor mass on irradiation of patients with approximately 20 Gy (range 18 – 22.5 Gy) or after completion of radiotherapy (60 - 70 Gy). In summary, the compHsp70 ELISA presented herein provides a highly sensitive and reliable tool for measuring free and exosomal Hsp70 in liquid biopsies of tumor patients, levels of which can be used as a predictive tumor-specific biomarker, risk assessment and for monitoring therapeutic outcome.

Published
2021

20. PH-0054 Re-Irradiation in head & neck cancer - a pooled analysis of 253 individual cases

Author

Roesch, J., primary, Oertel, M., additional, Fabian, A., additional, Höck, M., additional, von der Grün, J., additional, Löser, A., additional, Süss, C., additional, Vinsensia, M., additional, Tamaskovics, B., additional, Heß, S., additional, Waltenberger, M., additional, Wegen, S., additional, Trommer, M., additional, Mäurer, M., additional, Medenwald, D., additional, Rühle, A., additional, Käsmann, L., additional, Fleischmann, D., additional, Dobiasch, S., additional, and Hecht, M., additional

Published
2021
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21. Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer-results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group (Jan, 10.1007/s00066-020-01727-4, 2021)

Author

Ostheimer, C., Maeurer, M., Ebert, N., Schmitt, D., Krug, D., Baumann, R., Henkenberens, C., Giordano, F. A., Sautter, L., Lopez, Guerra, Fleischmann, D. F., Niyazi, M., Kaesmann, L., Kaul, D., Thieme, A. H., Billiet, C., Dobiasch, S., Arnold, C. R., Oertel, M., Haussmann, J., Gauer, T., Goy, Y., Suess, C., Ziegler, S., Panje, C. M., Baues, C., Trommer, M., Skripcak, T., Medenwald, D., Ostheimer, C., Maeurer, M., Ebert, N., Schmitt, D., Krug, D., Baumann, R., Henkenberens, C., Giordano, F. A., Sautter, L., Lopez, Guerra, Fleischmann, D. F., Niyazi, M., Kaesmann, L., Kaul, D., Thieme, A. H., Billiet, C., Dobiasch, S., Arnold, C. R., Oertel, M., Haussmann, J., Gauer, T., Goy, Y., Suess, C., Ziegler, S., Panje, C. M., Baues, C., Trommer, M., Skripcak, T., and Medenwald, D.

Published
2021

22. Multidisziplinäre Prähabilitation zur Verbesserung postoperativer Outcomes gebrechlicher onkologischer Patienten, welche sich einer neoadjuvanten Therapie unterziehen: randomisiert-kontrollierte Pilotstudie

Author

Friedrichs, J, Kleeff, J, Michl, P, Klose, J, Vordermark, D, Schmidt, H, Röder, C, Regenspurger, K, Jahn, P, Medenwald, D, Ronellenfitsch, U, Friedrichs, J, Kleeff, J, Michl, P, Klose, J, Vordermark, D, Schmidt, H, Röder, C, Regenspurger, K, Jahn, P, Medenwald, D, and Ronellenfitsch, U

Published
2021

25. Short to mid-term mortality of prostatectomy vs. radiotherapy as a primary treatment for prostate cancer

Author

Medenwald, D, Vordermark, D, and Dietzel, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: To assess the extent of short to mid-term mortality and its temporal course after prostatectomy and radiotherapy in the general population. Methods: Data from SEER-database and German epidemiologic cancer registries were used for the years 2005-2013. Metastasized cases and deaths from [for full text, please go to the a.m. URL], 17. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2018
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32. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Author

Teumer, A. (Alexander), Chaker, L. (Layal), Groeneweg, S. (Stefan), Li, Y. (Yong), Di Munno, C. (Celia), Barbieri, C. (Caterina), Schultheiss, U.T. (Ulla T.), Traglia, M. (Michela), Ahluwalia, T.S. (Tarunveer Singh), Akiyama, M. (Masato), Appel, E.V.R. (Emil Vincent R.), Arking, D.E. (Dan), Arnold, A.M. (Alice), Astrup, A. (Arne), Beekman, M. (Marian), Beilby, J.P. (John), Bekaert, S. (Sofie), Boerwinkle, E. (Eric), Brown, S.J. (Stephen), Buyzere, M. (Marc) de, Campbell, P.J. (Purdey J.), Ceresini, G. (Graziano), Cerqueira, C. (Charlotte), Cucca, F. (Francesco), Deary, I.J. (Ian), Deelen, J. (Joris), Eckardt, K.-U. (Kai-Uwe), Ekici, A.B. (Arif B.), Hagen, K. (Knut), Ferrrucci, L. (Luigi), Fiers, T. (Tom), Fiorillo, E. (Edoardo), Ford, I. (Ian), Fox, C.S. (Caroline), Fuchsberger, C. (Christian), Galesloot, T.E. (Tessel), Gieger, C. (Christian), Gögele, M. (Martin), Grandi, A. (Alessandro) de, Grarup, N. (Niels), Greiser, K.H. (Karin Halina), Haljas, K. (Kadri), Hansen, T. (Torben), Harris, S.E. (Sarah), Heemst, D. (Diana) van, Heijer, M. (Martin) den, Hicks, A.A. (Andrew A.), Hollander, W. (Wouter) den, Homuth, G. (Georg), Hui, J. (Jennie), Ikram, M.A. (Arfan), Ittermann, T. (Till), Jensen, R.A. (Richard A.), Jing, J. (Jiaojiao), Jukema, J.W. (Jan Wouter), Kajantie, E. (Eero), Kamatani, Y. (Yoichiro), Kasbohm, E. (Elisa), Kaufman, J.-M. (Jean-Marc), Kiemeney, L.A. (Lambertus A.), Kloppenburg, M. (Margreet), Kronenberg, F. (Florian), Kubo, M. (Michiaki), Lahti, J. (Jari), Lapauw, B. (Bruno), Li, S. (Shuo), Liewald, D.C.M. (David C. M.), Alizadeh, B.Z. (Behrooz), Boezen, H.M. (Marike), Franke, L. (Lude), van der Harst, P. (Pim), Navis, G. (Gerjan), Rots, M.G. (M.), Snieder, H. (Harold), Swertz, M.A. (Morris A.), Wijmenga, C. (Cisca), Lim, E.M. (Ee Mun), Linneberg, A. (Allan), Marina, M. (Michela), Mascalzoni, D. (Deborah), Matsuda, K. (Koichi), Medenwald, D. (Daniel), Meisinger, C. (Christa), Meulenbelt, I. (Ingrid), Meyer, T. (Thorsten), Meyer zu Schwabedissen, H.E. (Henriette E.), Mikolajczyk, R. (Rafael), Moed, H. (Heleen), Netea-Maier, R.T. (Romana), Nolte, I.M. (Ilja), Okada, Y. (Yukinori), Pala, M. (Mauro), Penninx, B.W.J.H., Pedersen, O. (Oluf), Petersmann, A. (Astrid), Porcu, E. (Eleonora), Postmus, D. (Douwe), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Ramos, Y.F.M. (Yolande F. M.), Rawal, R. (Rajesh), Redmond, P. (Paul), Richards, J.B. (Brent), Rietzschel, E.R. (Ernst), Rivadeneira Ramirez, F. (Fernando), Roef, G.L. (Greet), Rotter, J.I. (Jerome I.), Sala, C. (Cinzia), Schlessinger, D. (David), Selvin, E. (Elizabeth), Slagboom, P.E. (Eline), Soranzo, N. (Nicole), Sørensen, T.I.A. (Thorkild), Spector, T.D. (Timothy), Starr, J.M. (John), Stott, D.J. (David. J.), Taes, Y.E. (Youri), Taliun, D. (Daniel), Tanaka, T. (Toshiko), Thuesen, L. (Leif), Tiller, D. (Daniel), Toniolo, D. (Daniela), Uitterlinden, A.G. (Andre G.), Visser, W.E. (Edward), Walsh, J.P. (John P.), Wilson, S.G. (Scott), Wolffenbuttel, B.H.R. (Bruce), Yang, Q. (Qiong Fang), Zheng, H.-F. (Hou-Feng), Cappola, A.R. (Anne), Peeters, R.P. (Robin), Naitza, S. (Silvia), Völzke, H. (Henry), Sanna, S. (Serena), Köttgen, A. (Anna), Visser, T.J. (Theo), Medici, M. (Marco), Teumer, A. (Alexander), Chaker, L. (Layal), Groeneweg, S. (Stefan), Li, Y. (Yong), Di Munno, C. (Celia), Barbieri, C. (Caterina), Schultheiss, U.T. (Ulla T.), Traglia, M. (Michela), Ahluwalia, T.S. (Tarunveer Singh), Akiyama, M. (Masato), Appel, E.V.R. (Emil Vincent R.), Arking, D.E. (Dan), Arnold, A.M. (Alice), Astrup, A. (Arne), Beekman, M. (Marian), Beilby, J.P. (John), Bekaert, S. (Sofie), Boerwinkle, E. (Eric), Brown, S.J. (Stephen), Buyzere, M. (Marc) de, Campbell, P.J. (Purdey J.), Ceresini, G. (Graziano), Cerqueira, C. (Charlotte), Cucca, F. (Francesco), Deary, I.J. (Ian), Deelen, J. (Joris), Eckardt, K.-U. (Kai-Uwe), Ekici, A.B. (Arif B.), Hagen, K. (Knut), Ferrrucci, L. (Luigi), Fiers, T. (Tom), Fiorillo, E. (Edoardo), Ford, I. (Ian), Fox, C.S. (Caroline), Fuchsberger, C. (Christian), Galesloot, T.E. (Tessel), Gieger, C. (Christian), Gögele, M. (Martin), Grandi, A. (Alessandro) de, Grarup, N. (Niels), Greiser, K.H. (Karin Halina), Haljas, K. (Kadri), Hansen, T. (Torben), Harris, S.E. (Sarah), Heemst, D. (Diana) van, Heijer, M. (Martin) den, Hicks, A.A. (Andrew A.), Hollander, W. (Wouter) den, Homuth, G. (Georg), Hui, J. (Jennie), Ikram, M.A. (Arfan), Ittermann, T. (Till), Jensen, R.A. (Richard A.), Jing, J. (Jiaojiao), Jukema, J.W. (Jan Wouter), Kajantie, E. (Eero), Kamatani, Y. (Yoichiro), Kasbohm, E. (Elisa), Kaufman, J.-M. (Jean-Marc), Kiemeney, L.A. (Lambertus A.), Kloppenburg, M. (Margreet), Kronenberg, F. (Florian), Kubo, M. (Michiaki), Lahti, J. (Jari), Lapauw, B. (Bruno), Li, S. (Shuo), Liewald, D.C.M. (David C. M.), Alizadeh, B.Z. (Behrooz), Boezen, H.M. (Marike), Franke, L. (Lude), van der Harst, P. (Pim), Navis, G. (Gerjan), Rots, M.G. (M.), Snieder, H. (Harold), Swertz, M.A. (Morris A.), Wijmenga, C. (Cisca), Lim, E.M. (Ee Mun), Linneberg, A. (Allan), Marina, M. (Michela), Mascalzoni, D. (Deborah), Matsuda, K. (Koichi), Medenwald, D. (Daniel), Meisinger, C. (Christa), Meulenbelt, I. (Ingrid), Meyer, T. (Thorsten), Meyer zu Schwabedissen, H.E. (Henriette E.), Mikolajczyk, R. (Rafael), Moed, H. (Heleen), Netea-Maier, R.T. (Romana), Nolte, I.M. (Ilja), Okada, Y. (Yukinori), Pala, M. (Mauro), Penninx, B.W.J.H., Pedersen, O. (Oluf), Petersmann, A. (Astrid), Porcu, E. (Eleonora), Postmus, D. (Douwe), Pramstaller, P.P. (Peter Paul), Psaty, B.M. (Bruce), Ramos, Y.F.M. (Yolande F. M.), Rawal, R. (Rajesh), Redmond, P. (Paul), Richards, J.B. (Brent), Rietzschel, E.R. (Ernst), Rivadeneira Ramirez, F. (Fernando), Roef, G.L. (Greet), Rotter, J.I. (Jerome I.), Sala, C. (Cinzia), Schlessinger, D. (David), Selvin, E. (Elizabeth), Slagboom, P.E. (Eline), Soranzo, N. (Nicole), Sørensen, T.I.A. (Thorkild), Spector, T.D. (Timothy), Starr, J.M. (John), Stott, D.J. (David. J.), Taes, Y.E. (Youri), Taliun, D. (Daniel), Tanaka, T. (Toshiko), Thuesen, L. (Leif), Tiller, D. (Daniel), Toniolo, D. (Daniela), Uitterlinden, A.G. (Andre G.), Visser, W.E. (Edward), Walsh, J.P. (John P.), Wilson, S.G. (Scott), Wolffenbuttel, B.H.R. (Bruce), Yang, Q. (Qiong Fang), Zheng, H.-F. (Hou-Feng), Cappola, A.R. (Anne), Peeters, R.P. (Robin), Naitza, S. (Silvia), Völzke, H. (Henry), Sanna, S. (Serena), Köttgen, A. (Anna), Visser, T.J. (Theo), and Medici, M. (Marco)

Abstract

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves’ disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets.

Published
2018
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33. Predictive value of GTV in radiotherapy of NSCLC - early results of the NCT03055715 trial

Author

Ostheimer, C., Baues, C., Baumann, R., Billiet, C., Dobiasch, S., Ebert, N., Fleischmann, D., Gauer, T., Goy, Y., Haussmann, J., Henkenberens, C., Kaessmann, L., Lopez Guerra, J., Kaul, D., Krug, D., Maeurer, M., Niyazi, M., Oertel, M., Panje, C., Sautter, L., Schmitt, D., Suess, C., Trommer-Nestler, M., Ziegler, S., Medenwald, D., Ostheimer, C., Baues, C., Baumann, R., Billiet, C., Dobiasch, S., Ebert, N., Fleischmann, D., Gauer, T., Goy, Y., Haussmann, J., Henkenberens, C., Kaessmann, L., Lopez Guerra, J., Kaul, D., Krug, D., Maeurer, M., Niyazi, M., Oertel, M., Panje, C., Sautter, L., Schmitt, D., Suess, C., Trommer-Nestler, M., Ziegler, S., and Medenwald, D.

Published
2018

34. Acute toxicity in the radical radiotherapy of advanced NSCLC-results of the NCT03055715 trial of the yDEGRO Trial Group

Author

Ostheimer, C., Baues, C., Baumann, R., Billiet, C., Dobiasch, S., Ebert, N., Fleischmann, D. F., Gauer, T., Giordano, F., Goy, Y., Hausmann, J., Henkenberens, C., Kaesmann, L., Guerra, Lopez J. L., Kaul, D., Krug, D., M, Maeurer, Niyazi, M., Oertel, M., Panje, C. M., Pyschny, F., Schmitt, D., Sautter, L., Suess, C., Thieme, A. H., Trommer-Nestler, M., Ziegler, S., Medenwald, D., Ostheimer, C., Baues, C., Baumann, R., Billiet, C., Dobiasch, S., Ebert, N., Fleischmann, D. F., Gauer, T., Giordano, F., Goy, Y., Hausmann, J., Henkenberens, C., Kaesmann, L., Guerra, Lopez J. L., Kaul, D., Krug, D., M, Maeurer, Niyazi, M., Oertel, M., Panje, C. M., Pyschny, F., Schmitt, D., Sautter, L., Suess, C., Thieme, A. H., Trommer-Nestler, M., Ziegler, S., and Medenwald, D.

Published
2018

35. Prognostic and predictive value of GTV in the radical radiotherapy of advanced NSCLC-early results of the NCT03055715 trial of the yDEGRO Trial Group

Author

Ostheimer, C., Baues, C., Baumann, R., Billiet, C., Dobiasch, S., Ebert, N., Fleischmann, D. F., Gauer, T., Giordano, F., Goy, Y., Hausmann, J., Henkenberens, C., Kaesmann, L., Guerra, Lopez J. L., Kaul, D., Krug, D., Maeurer, M., Niyazi, M., Oertel, M., Panje, C. M., Pyschny, F., Schmitt, D., Sautter, L., Suess, C., Thieme, A. H., Trommer-Nestler, M., Ziegler, S., Medenwald, D., Ostheimer, C., Baues, C., Baumann, R., Billiet, C., Dobiasch, S., Ebert, N., Fleischmann, D. F., Gauer, T., Giordano, F., Goy, Y., Hausmann, J., Henkenberens, C., Kaesmann, L., Guerra, Lopez J. L., Kaul, D., Krug, D., Maeurer, M., Niyazi, M., Oertel, M., Panje, C. M., Pyschny, F., Schmitt, D., Sautter, L., Suess, C., Thieme, A. H., Trommer-Nestler, M., Ziegler, S., and Medenwald, D.

Published
2018

36. Prognostic relevance of tumor volume and its changes in the radical radiotherapy of advanced NSCLC - a multicenter retrospective evaluation of the working group young DEGRO of the German Society of Radiation Oncology (DEGRO)

Author

Ostheimer, C., Baues, C., Baumann, R., Dobiasch, S., Eze, C., Fleischmann, D., Gauer, T., Giordano, F. A., Goy, Y., Hausmann, J., Henkenberens, C., Kaul, D. P., Kloock, L., Krug, D., Kaesmann, L., Niyazi, K-M., Maeurer, M., Oertel, M., Panje, C., Rosenbrock, J., Sautter, L., Schmitt, D., Suess, C., Thieme, A. H., Trommer-Nestler, M., Ziegler, S., Ebert, N., Medenwald, D., Ostheimer, C., Baues, C., Baumann, R., Dobiasch, S., Eze, C., Fleischmann, D., Gauer, T., Giordano, F. A., Goy, Y., Hausmann, J., Henkenberens, C., Kaul, D. P., Kloock, L., Krug, D., Kaesmann, L., Niyazi, K-M., Maeurer, M., Oertel, M., Panje, C., Rosenbrock, J., Sautter, L., Schmitt, D., Suess, C., Thieme, A. H., Trommer-Nestler, M., Ziegler, S., Ebert, N., and Medenwald, D.

Published
2018

37. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Author

Teumer, A, Chaker, Layal, Groeneweg, Stefan, Li, Yi, Di Munno, Celia, Barbieri, C, Schultheiss, UT, Traglia, M, Ahluwalia, TS, Akiyama, M, Appel, EVR, Arking, DE, Arnold, A, Astrup, A, Beekman, M, Beilby, JP, Bekaert, S, Boerwinkle, E, Brown, SJ, de Buyzere, M, Campbell, PJ, Ceresini, G, Cerqueira, C, Cucca, F, Deary, IJ, Deelen, J, Eckardt, KU, Ekici, AB, Eriksson, JG, Ferrrucci, L, Fiers, T, Fiorillo, E, Ford, I, Fox, CS, Fuchsberger, C, Galesloot, TE, Gieger, C, Gogele, M, De Grandi, A, Grarup, N, Greiser, KH, Haljas, K, Hansen, T, Harris, SE, van Heemst, D, Heijer, M, Hicks, AA, den Hollander, W, Homuth, G, Hui, JN, Ikram, Arfan, Ittermann, T, Jensen, RA, Jing, J, Jukema, JW, Kajalltie, E, Kamatani, Y, Kasbohm, E, Kaufman, JM, Kiemeney, LA, Kloppenburg, M, Kronenberg, F, Kubo, M, Lahti, J, Lapauw, B, Li, S, Liewald, DCM, Lim, EM, Linneberg, A, Marina, M, Mascalzoni, D, Matsuda, K, Medenwald, D, Meisinger, C, Meulenbelt, I, Meyer, T, zu Schwabedissen, HEM, Mikolajczyk, R, Moed, M, Netea-Maier, RT, Nolte, IM, Okadah, Y, Pala, M, Pattaro, C, Pedersen, O, Petersmann, A, Porcu, E, Postmus, I, Pramstaller, PP, Psaty, BM, Ramos, YFM, Rawal, R, Redmond, P, Richards, JB, Rietzschel, ER, Rivadeneira, Fernando, Roef, G, Rotter, JI, Sala, CF, Schlessinger, D, Selvin, E, Slagboom, PE (Eline), Soranzo, N, Sorensen, TIA, Spector, TD, Starr, JM, Stott, DJ, Taes, Y, Taliun, D, Tanaka, T, Thuesen, B, Tiller, D, Toniolo, D, Uitterlinden, André, Visser, Edward, Walsh, JP, Wilson, SG, Wolffenbuttel, BHR, Yang, Q, Zheng, HF, Cappola, A, Peeters, Robin, Naitza, S, Volzke, H, Sanna, S, Kottgen, A, Visser, Theo, Medici, Marco, Teumer, A, Chaker, Layal, Groeneweg, Stefan, Li, Yi, Di Munno, Celia, Barbieri, C, Schultheiss, UT, Traglia, M, Ahluwalia, TS, Akiyama, M, Appel, EVR, Arking, DE, Arnold, A, Astrup, A, Beekman, M, Beilby, JP, Bekaert, S, Boerwinkle, E, Brown, SJ, de Buyzere, M, Campbell, PJ, Ceresini, G, Cerqueira, C, Cucca, F, Deary, IJ, Deelen, J, Eckardt, KU, Ekici, AB, Eriksson, JG, Ferrrucci, L, Fiers, T, Fiorillo, E, Ford, I, Fox, CS, Fuchsberger, C, Galesloot, TE, Gieger, C, Gogele, M, De Grandi, A, Grarup, N, Greiser, KH, Haljas, K, Hansen, T, Harris, SE, van Heemst, D, Heijer, M, Hicks, AA, den Hollander, W, Homuth, G, Hui, JN, Ikram, Arfan, Ittermann, T, Jensen, RA, Jing, J, Jukema, JW, Kajalltie, E, Kamatani, Y, Kasbohm, E, Kaufman, JM, Kiemeney, LA, Kloppenburg, M, Kronenberg, F, Kubo, M, Lahti, J, Lapauw, B, Li, S, Liewald, DCM, Lim, EM, Linneberg, A, Marina, M, Mascalzoni, D, Matsuda, K, Medenwald, D, Meisinger, C, Meulenbelt, I, Meyer, T, zu Schwabedissen, HEM, Mikolajczyk, R, Moed, M, Netea-Maier, RT, Nolte, IM, Okadah, Y, Pala, M, Pattaro, C, Pedersen, O, Petersmann, A, Porcu, E, Postmus, I, Pramstaller, PP, Psaty, BM, Ramos, YFM, Rawal, R, Redmond, P, Richards, JB, Rietzschel, ER, Rivadeneira, Fernando, Roef, G, Rotter, JI, Sala, CF, Schlessinger, D, Selvin, E, Slagboom, PE (Eline), Soranzo, N, Sorensen, TIA, Spector, TD, Starr, JM, Stott, DJ, Taes, Y, Taliun, D, Tanaka, T, Thuesen, B, Tiller, D, Toniolo, D, Uitterlinden, André, Visser, Edward, Walsh, JP, Wilson, SG, Wolffenbuttel, BHR, Yang, Q, Zheng, HF, Cappola, A, Peeters, Robin, Naitza, S, Volzke, H, Sanna, S, Kottgen, A, Visser, Theo, and Medici, Marco

Published
2018

38. Number of radiotherapy centres in the population and cancer mortality: A global perspective

Author

Medenwald, D and Dietzel, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objectives: To assess the association between the number of radiotherapy centres (RTC) in the population and incidence adjusted cancer mortality on a global scale. Methods: Data on cancer incidence and mortality were obtained from the GLOBOCAN projects, while we extracted country-specific information[for full text, please go to the a.m. URL], 16. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2017
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39. OC-0329: Predictive value of GTV in radiotherapy of NSCLC - early results of the NCT03055715 trial

Author

Ostheimer, C., primary, Baues, C., additional, Baumann, R., additional, Billiet, C., additional, Dobiasch, S., additional, Ebert, N., additional, Fleischmann, D., additional, Gauer, T., additional, Goy, Y., additional, Haussmann, J., additional, Henkenberens, C., additional, Kaessmann, L., additional, López guerra, J., additional, Kaul, D., additional, Krug, D., additional, Maeurer, M., additional, Niyazi, M., additional, Oertel, M., additional, Panje, C., additional, Sautter, L., additional, Schmitt, D., additional, Suess, C., additional, Trommer-Nestler, M., additional, Ziegler, S., additional, and Medenwald, D., additional

Published
2018
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40. Prognostic relevance of the interaction between short-term, metronome-paced heart rate variability, and inflammation: Results from the population-based CARLA cohort study

Author

Medenwald, D. (Daniel), Swenne, C.A. (Cees), Loppnow, H. (Harald), Kors, J.A. (Jan), Pietzner, D. (Diana), Tiller, D. (Daniel), Thiery, J.P. (Joachim), Nuding, S. (Sebastian), Greiser, K.H. (Karin Halina), Haerting, J. (Johannes), Werdan, K. (Karl), Kluttig, A. (Alexander), Medenwald, D. (Daniel), Swenne, C.A. (Cees), Loppnow, H. (Harald), Kors, J.A. (Jan), Pietzner, D. (Diana), Tiller, D. (Daniel), Thiery, J.P. (Joachim), Nuding, S. (Sebastian), Greiser, K.H. (Karin Halina), Haerting, J. (Johannes), Werdan, K. (Karl), and Kluttig, A. (Alexander)

Abstract

Aims To determine the interaction between HRV and inflammation and their association with cardiovascular/all-cause mortality in the general population. Methods and results Subjects of the CARLA study (n = 1671; 778 women, 893 men, 45-83 years of age) were observed for an average follow-up period of 8.8 years (226 deaths, 70 cardiovascular deaths). Heart rate variability parameters were calculated from 5-min segments of 20-min resting electrocardiograms. High-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and soluble tumour necrosis factor-alpha receptor type 1 (sTNF-R1) were measured as inflammation parameters. The HRV parameters determined included the standard deviation of normal-to-normal intervals (SDNN), the root-mean-square of successive normal-interval differences (RMSSD), the low- and high-frequency (HF) power, the ratio of both, and non-linear pa

Published
2017
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44. Performance of Sokolow-Lyon index in detection of echocardiographically diagnosed left ventricular hypertrophy in a normal Eastern German population - results of the CARLA study

Author

Schröder, J. (Jochen), Nuding, S. (Sebastian), Müller-Werdan, U. (Ursula), Werdan, K. (Karl), Kluttig, A. (Alexander), Russ, M. (Martin), Greiser, K.H. (Karin Halina), Kors, J.A. (Jan), Haerting, J. (Johannes), Medenwald, D. (Daniel), Schröder, J. (Jochen), Nuding, S. (Sebastian), Müller-Werdan, U. (Ursula), Werdan, K. (Karl), Kluttig, A. (Alexander), Russ, M. (Martin), Greiser, K.H. (Karin Halina), Kors, J.A. (Jan), Haerting, J. (Johannes), and Medenwald, D. (Daniel)

Abstract

Background: Arterial hypertension is a common disease with high prevalence in the general population. Left ventricular hypertrophy (LVH) is an independent risk factor in arterial hypertension. Electrocardiographic indices like the Sokolow-Lyon index (SLI) are recommended as diagnostic screening methods for LVH. We assessed the diagnostic performance of the SLI in a cohort of a large general population. Methods: We used electrocardiographic and echocardiographic data from the prospective, population-based cohort study CARdio-vascular Disease, Living and Ageing in Halle (CARLA). Linear and logistic regression models were used to assess the association of SLI with LVH. To assess the impact of the body-mass-index (BMI), we performed interaction analyses. Results: AUC of SLI to predict LVH was 55.3 %, sensitivity of the SLI was 5 %, specificity 97 %. We found a significant association of SLI after covariate-adjustment with echocardiographically detected LVH (increase of left-ventricular mass index, LVMI 7.0 g/m2 per 1 mV increase of SLI, p < 0.0001). However, this association was mainly caused by an association of SLI with the left-ventricular internal diameter (LVIDd, increase of 0.06 cm/m2 per 1 mV increase of SLI, p < 0.0001). In obese (BMI > 30 kg/m2) we found the strongest association with an increase of 9.2 g/m2 per 1 mV. Conclusions: Although statistically significant, relations of SLI and echocardiographic parameters of LVH were weak and mainly driven by the increase in LVIDd, implicating a more eccentric type of LVH in the collective. The relations were strongest when obese subjects were taken into account. Our data do not favour the SLI as a diagnostic screening test to identify patients at risk for LVH, especially in non-obese subjects without eccentric LVH.

Published
2015
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45. Performance of Sokolow-Lyon index in detection of echocardiographically diagnosed left ventricular hypertrophy in a normal Eastern German population - results of the CARLA study

Author

Schroder, J, Nuding, S, Muller-Werdan, U, Werdan, K, Kluttig, A, Russ, M, Greiser, KH, Kors, Jan, Haerting, J, Medenwald, D, Schroder, J, Nuding, S, Muller-Werdan, U, Werdan, K, Kluttig, A, Russ, M, Greiser, KH, Kors, Jan, Haerting, J, and Medenwald, D

Abstract

Background: Arterial hypertension is a common disease with high prevalence in the general population. Left ventricular hypertrophy (LVH) is an independent risk factor in arterial hypertension. Electrocardiographic indices like the Sokolow-Lyon index (SLI) are recommended as diagnostic screening methods for LVH. We assessed the diagnostic performance of the SLI in a cohort of a large general population. Methods: We used electrocardiographic and echocardiographic data from the prospective, population-based cohort study CARdio-vascular Disease, Living and Ageing in Halle (CARLA). Linear and logistic regression models were used to assess the association of SLI with LVH. To assess the impact of the body-mass-index (BMI), we performed interaction analyses. Results: AUC of SLI to predict LVH was 55.3 %, sensitivity of the SLI was 5 %, specificity 97 %. We found a significant association of SLI after covariate-adjustment with echocardiographically detected LVH (increase of left-ventricular mass index, LVMI 7.0 g/m(2) per 1 mV increase of SLI, p < 0.0001). However, this association was mainly caused by an association of SLI with the left-ventricular internal diameter (LVIDd, increase of 0.06 cm/m(2) per 1 mV increase of SLI, p < 0.0001). In obese (BMI > 30 kg/m(2)) we found the strongest association with an increase of 9.2 g/m(2) per 1 mV. Conclusions: Although statistically significant, relations of SLI and echocardiographic parameters of LVH were weak and mainly driven by the increase in LVIDd, implicating a more eccentric type of LVH in the collective. The relations were strongest when obese subjects were taken into account. Our data do not favour the SLI as a diagnostic screening test to identify patients at risk for LVH, especially in non-obese subjects without eccentric LVH.

Published
2015

47. Inflammation and prolonged QT time: Results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) study

Author

Medenwald, D. (Daniel), Kors, J.A. (Jan), Loppnow, H. (Harald), Thiery, J.P. (Joachim), Kluttig, A. (Alexander), Nuding, S. (Sebastian), Tiller, D. (Daniel), Greiser, K.H. (Karin Halina), Werdan, K. (Karl), Haerting, J. (Johannes), Medenwald, D. (Daniel), Kors, J.A. (Jan), Loppnow, H. (Harald), Thiery, J.P. (Joachim), Kluttig, A. (Alexander), Nuding, S. (Sebastian), Tiller, D. (Daniel), Greiser, K.H. (Karin Halina), Werdan, K. (Karl), and Haerting, J. (Johannes)

Abstract

Background: Previous research found an association of CRP with QT time in population based samples. Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive. Objective: To determine the association between inflammation with an abnormally prolonged QT-time (APQT) in men and women of the elderly general population. Methods: Data descend from the baseline examination of the prospective, population-based Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study. After exclusion of subjects with atrial fibrillation and missing ECG recording the final study cohort consisted of 919 men and 797 women. Blood parameters of inflammation were the soluble TNF-Receptor 1 (sTNF-R1), the high-sensitive C-reactive protein (hsCRP), and Interleukin 6 (IL-6). In accordance with major cardiologic societies we defined an APQT above a QT time of 460 ms in women and 450 ms in men. Effect sizes and the corresponding 95% confidence intervals (CI) were estimated by performing multiple linear and logistic regression analyses including the analysis of sex differences by interaction terms. Results: After covariate adjustment we found an odds ratio (OR) of 1.89 (95% CI: 1.13, 3.17) per 1000 pg/mL increase of sTNF-R1 in women, and 0.74 (95% CI: 0.48, 1.15) in men. In the covariate adjusted linear regression sTNF-R1 was again positively associated with QT time in women (5.75 ms per 1000 pg/mL, 95% CI: 1.32, 10.18), but not in men. Taking possible confounders into account IL-6 and hsCRP were not significantly related to APQT in both sexes. Conclusion: Our findings from cross-sectional analyses give evidence for an involvement of TNF-alpha in the pathology of APQT in women.

Published
2014
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48. Inflammation and Prolonged QT Time: Results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study

Author

Medenwald, D, Kors, Jan, Loppnow, H, Thiery, J, Kluttig, A, Nuding, S, Tiller, D, Greiser, KH, Werdan, K, Haerting, J, Medenwald, D, Kors, Jan, Loppnow, H, Thiery, J, Kluttig, A, Nuding, S, Tiller, D, Greiser, KH, Werdan, K, and Haerting, J

Abstract

Background: Previous research found an association of CRP with QT time in population based samples. Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive. Objective: To determine the association between inflammation with an abnormally prolonged QT-time (APQT) in men and women of the elderly general population. Methods: Data descend from the baseline examination of the prospective, population-based Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study. After exclusion of subjects with atrial fibrillation and missing ECG recording the final study cohort consisted of 919 men and 797 women. Blood parameters of inflammation were the soluble TNF-Receptor 1 (sTNF-R1), the high-sensitive C-reactive protein (hsCRP), and Interleukin 6 (IL-6). In accordance with major cardiologic societies we defined an APQT above a QT time of 460 ms in women and 450 ms in men. Effect sizes and the corresponding 95% confidence intervals (CI) were estimated by performing multiple linear and logistic regression analyses including the analysis of sex differences by interaction terms. Results: After covariate adjustment we found an odds ratio (OR) of 1.89 (95% CI: 1.13, 3.17) per 1000 pg/mL increase of sTNF-R1 in women, and 0.74 (95% CI: 0.48, 1.15) in men. In the covariate adjusted linear regression sTNF-R1 was again positively associated with QT time in women (5.75 ms per 1000 pg/mL, 95% CI: 1.32, 10.18), but not in men. Taking possible confounders into account IL-6 and hsCRP were not significantly related to APQT in both sexes. Conclusion: Our findings from cross-sectional analyses give evidence for an involvement of TNF-alpha in the pathology of APQT in women.

Published
2014

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