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We assessed the efficacy and safety of 10-d monotherapy with the orally administered CCR5 antagonist maraviroc in 63 HIV-1-positive individuals prescreened for the absence of CXCR4-using virus. Maximum reduction in viral load occurred at a median of 10-15 d, with a mean reduction of >or=1.6 log(10) copies/ml at all twice daily doses >or=100 mg. These results provide proof of concept that CCR5 antagonism is a viable antiretroviral therapeutic approach.

In view of the role of hemoglobin in oxygen transport, the hemoglobin concentration in whole blood may indicate readiness for maximal physical performance. Hemoglobin concentrations were determined in members of the 1976 Canadian Olympic team and compared with those of the 1975 Canadian general population and with published data for the 1968 Australian and Dutch Olympic teams. The mean hemoglobin concentrations of the 123 male and 64 female Canadian Olympic athletes were 14.7 +/- 1.0 and 12.9 +/- 0.7 g/dL, respectively. Both male and female Canadian Olympic athletes had significantly lower (P less than 0.01) values than the other three groups. The suboptimal hemoglobin concentrations may be related to inadequate dietary intake of protein and iron.

Two experiments examined the effects of preliminary exercise on performance and learning of the Fitts' reciprocal tapping task. In the first experiment preliminary exercise was performed with either the preferred or nonpreferred arm. The tapping task was completed with the preferred by both groups. Low levels of preliminary exercise resulted in heightened performance for both groups, but higher levels resulted in a decrement for the group using the preferred arm. An arousal-plus-fatigue hypothesis can explain the results. A subsequent post-test without preliminary exercise showed no difference between the groups, indicating an effect on performance and not learning. In the second experiment preliminary exercise was provided by treadmill running to exhaustion. Again, a facilitatory effect of exercise was demonstrated on tapping performance even after exhaustive levels of running.