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612 results on '"Medico, Enzo"'

1. Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells

Author

Rio-Vilariño, Anxo, Cenigaonandia-Campillo, Aiora, García-Bautista, Ana, Mateos-Gómez, Pedro A., Schlaepfer, Marina I., del Puerto-Nevado, Laura, Aguilera, Oscar, García-García, Laura, Galeano, Carlos, de Miguel, Irene, Serrano-López, Juana, Baños, Natalia, Fernández-Aceñero, María Jesús, Lacal, Juan Carlos, Medico, Enzo, García-Foncillas, Jesús, and Cebrián, Arancha

Published
2024
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2. Comprehensive genomic profiling on metastatic Melanoma: results from a network screening from 7 Italian Cancer Centres

Author

Pallocca, Matteo, Molineris, Ivan, Berrino, Enrico, Marcozzi, Benedetta, Betti, Martina, Levati, Lauretta, D’Atri, Stefania, Menin, Chiara, Madonna, Gabriele, Ghiorzo, Paola, Bulgarelli, Jenny, Ferraresi, Virgina, Venesio, Tiziana, Rodolfo, Monica, Rivoltini, Licia, Lanfrancone, Luisa, Ascierto, Paolo Antonio, Mazzarella, Luca, Pelicci, Pier Giuseppe, De Maria, Ruggero, Ciliberto, Gennaro, Medico, Enzo, and Russo, Giandomenico

Published
2024
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3. Correction: Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells

Author

Rio-Vilariño, Anxo, Cenigaonandia-Campillo, Aiora, García-Bautista, Ana, Mateos-Gómez, Pedro A., Schlaepfer, Marina I., del Puerto-Nevado, Laura, Aguilera, Oscar, García-García, Laura, Galeano, Carlos, de Miguel, Irene, Serrano-López, Juana, Baños, Natalia, Fernández-Aceñero, María Jesús, Lacal, Juan Carlos, Medico, Enzo, García-Foncillas, Jesús, and Cebrián, Arancha

Published
2024
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6. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts.

Author

Woo, Xing, Giordano, Jessica, Srivastava, Anuj, Zhao, Zi-Ming, Lloyd, Michael, de Bruijn, Roebi, Suh, Yun-Suhk, Patidar, Rajesh, Chen, Li, Scherer, Sandra, Bailey, Matthew, Yang, Chieh-Hsiang, Cortes-Sanchez, Emilio, Xi, Yuanxin, Wang, Jing, Wickramasinghe, Jayamanna, Kossenkov, Andrew, Rebecca, Vito, Sun, Hua, Mashl, R, Davies, Sherri, Jeon, Ryan, Frech, Christian, Randjelovic, Jelena, Rosains, Jacqueline, Galimi, Francesco, Bertotti, Andrea, Lafferty, Adam, OFarrell, Alice, Modave, Elodie, Lambrechts, Diether, Ter Brugge, Petra, Serra, Violeta, Marangoni, Elisabetta, El Botty, Rania, Kim, Hyunsoo, Kim, Jong-Il, Yang, Han-Kwang, Lee, Charles, Dean, Dennis, Davis-Dusenbery, Brandi, Evrard, Yvonne, Doroshow, James, Welm, Alana, Welm, Bryan, Lewis, Michael, Fang, Bingliang, Roth, Jack, Meric-Bernstam, Funda, Herlyn, Meenhard, Davies, Michael, Ding, Li, Li, Shunqiang, Govindan, Ramaswamy, Isella, Claudio, Moscow, Jeffrey, Trusolino, Livio, Byrne, Annette, Jonkers, Jos, Bult, Carol, Medico, Enzo, and Chuang, Jeffrey

Subjects
Animals, DNA Copy Number Variations, Databases, Genetic, Gene Expression Regulation, Neoplastic, Humans, Mice, Neoplasm Metastasis, Polymorphism, Single Nucleotide, Exome Sequencing, Xenograft Model Antitumor Assays
Abstract

Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engraftment and propagation, affecting the accuracy of PDX modeling of human cancer. Here, we exhaustively analyze copy number alterations (CNAs) in 1,451 PDX and matched patient tumor (PT) samples from 509 PDX models. CNA inferences based on DNA sequencing and microarray data displayed substantially higher resolution and dynamic range than gene expression-based inferences, and they also showed strong CNA conservation from PTs through late-passage PDXs. CNA recurrence analysis of 130 colorectal and breast PT/PDX-early/PDX-late trios confirmed high-resolution CNA retention. We observed no significant enrichment of cancer-related genes in PDX-specific CNAs across models. Moreover, CNA differences between patient and PDX tumors were comparable to variations in multiregion samples within patients. Our study demonstrates the lack of systematic copy number evolution driven by the PDX mouse host.

Published
2021

7. The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization

Author

Dudová, Zdenka, Conte, Nathalie, Mason, Jeremy, Stuchlík, Dalibor, Peša, Radim, Halmagyi, Csaba, Perova, Zinaida, Mosaku, Abayomi, Thorne, Ross, Follette, Alex, Pivarč, Ľuboslav, Šašinka, Radim, Usman, Muhammad, Neuhauser, Steven, Begley, Dale A., Krupke, Debra M., Frassà, Massimiliano, Fiori, Alessandro, Corsi, Riccardo, Vezzadini, Luca, Isella, Claudio, Bertotti, Andrea, Bult, Carol, Parkinson, Helen, Medico, Enzo, Meehan, Terrence, and Křenek, Aleš

Published
2022
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8. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine

Author

Sebastian, Carlos, Ferrer, Christina, Serra, Maria, Choi, Jee-Eun, Ducano, Nadia, Mira, Alessia, Shah, Manasvi S., Stopka, Sylwia A., Perciaccante, Andrew J., Isella, Claudio, Moya-Rull, Daniel, Vara-Messler, Marianela, Giordano, Silvia, Maldi, Elena, Desai, Niyati, Capen, Diane E., Medico, Enzo, Cetinbas, Murat, Sadreyev, Ruslan I., Brown, Dennis, Rivera, Miguel N., Sapino, Anna, Breault, David T., Agar, Nathalie Y. R., and Mostoslavsky, Raul

Published
2022
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10. Metabolic enrichment through functional gene rules

Author

Maspero, Davide, Isella, Claudio, Di Filippo, Marzia, Graudenzi, Alex, Bellomo, Sara Erika, Antoniotti, Marco, Mauri, Giancarlo, Medico, Enzo, and Damiani, Chiara

Subjects
Quantitative Biology - Cell Behavior
Abstract

It is well known that tumors originating from the same tissue have different prognosis and sensitivity to treatments. Over the last decade, cancer genomics consortia like the Cancer Genome Atlas (TCGA) have been generating thousands of cross-sectional data, for thousands of human primary tumors originated from various tissues. Thanks to that public database, it is today possible to analyze a broad range of relevant information such as gene sequences, expression profiles or metabolite footprints, to capture tumor molecular heterogeneity and improve patient stratification and clinical management. To this aim, it is common practice to analyze datasets grouped into clusters based on clinical observations and/or molecular features. However, the identification of specific properties of each cluster that may be effectively targeted by therapeutic drugs still represents a challenging task. We define a method to generate an activity score for the metabolic reactions of different clusters of patients based on their transcriptional profile. This approach reduces the number of variables from many genes to few reactions, by aggregating transcriptional information associated to the same enzymatic reaction according to gene-enzyme and enzyme-reaction rules. We also applied the methodology to a dataset of 244 RNAseq transcriptional profiles taken from patients with colorectal cancer (CRC). CRC samples are typically divided into two sub-types: (i) tumors with microsatellite instability (MSI), associated with hyper-mutation and with CpG island methylation phenotype, and (ii) microsatellite stable (MSS) tumors, typically endowed with chromosomal instability. We report some key differences in the central carbon metabolism of the two clusters. We also show how the method can be used to describe the metabolism of individual patients and cluster them exclusively based on metabolic features., Comment: Preprint of proceedings of CIBB 2017

Published
2017

11. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Author

Meehan, Terrence F, Conte, Nathalie, Goldstein, Theodore, Inghirami, Giorgio, Murakami, Mark A, Brabetz, Sebastian, Gu, Zhiping, Wiser, Jeffrey A, Dunn, Patrick, Begley, Dale A, Krupke, Debra M, Bertotti, Andrea, Bruna, Alejandra, Brush, Matthew H, Byrne, Annette T, Caldas, Carlos, Christie, Amanda L, Clark, Dominic A, Dowst, Heidi, Dry, Jonathan R, Doroshow, James H, Duchamp, Olivier, Evrard, Yvonne A, Ferretti, Stephane, Frese, Kristopher K, Goodwin, Neal C, Greenawalt, Danielle, Haendel, Melissa A, Hermans, Els, Houghton, Peter J, Jonkers, Jos, Kemper, Kristel, Khor, Tin O, Lewis, Michael T, Lloyd, KC Kent, Mason, Jeremy, Medico, Enzo, Neuhauser, Steven B, Olson, James M, Peeper, Daniel S, Rueda, Oscar M, Seong, Je Kyung, Trusolino, Livio, Vinolo, Emilie, Wechsler-Reya, Robert J, Weinstock, David M, Welm, Alana, Weroha, S John, Amant, Frédéric, Pfister, Stefan M, Kool, Marcel, Parkinson, Helen, Butte, Atul J, and Bult, Carol J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Good Health and Well Being, Animals, Databases as Topic, Disease Models, Animal, Humans, Mice, Neoplasms, Patients, Xenograft Model Antitumor Assays, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models. PDX-MI defines the minimal information for describing the clinical attributes of a patient's tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use of PDX models in cancer research. Adherence to PDX-MI standards will facilitate accurate search results for oncology models and their associated data across distributed repository databases and promote reproducibility in research studies using these models. Cancer Res; 77(21); e62-66. ©2017 AACR.

Published
2017

13. Detection of gene communities in multi-networks reveals cancer drivers

Author

Cantini, Laura, Medico, Enzo, Fortunato, Santo, and Caselle, Michele

Subjects
Quantitative Biology - Molecular Networks, Physics - Biological Physics, Physics - Data Analysis, Statistics and Probability, Physics - Physics and Society, Quantitative Biology - Genomics, 92D10
Abstract

We propose a new multi-network-based strategy to integrate different layers of genomic information and use them in a coordinate way to identify driving cancer genes. The multi-networks that we consider combine transcription factor co-targeting, microRNA co-targeting, protein-protein interaction and gene co-expression networks. The rationale behind this choice is that gene co-expression and protein-protein interactions require a tight coregulation of the partners and that such a fine tuned regulation can be obtained only combining both the transcriptional and post-transcriptional layers of regulation. To extract the relevant biological information from the multi-network we studied its partition into communities. To this end we applied a consensus clustering algorithm based on state of art community detection methods. Even if our procedure is valid in principle for any pathology in this work we concentrate on gastric, lung, pancreas and colorectal cancer and identified from the enrichment analysis of the multi-network communities a set of candidate driver cancer genes. Some of them were already known oncogenes while a few are new. The combination of the different layers of information allowed us to extract from the multi-network indications on the regulatory pattern and functional role of both the already known and the new candidate driver genes., Comment: minor modifications

Published
2015
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14. A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes

Author

Orzan, Francesca, Pagani, Francesca, Cominelli, Manuela, Triggiani, Luca, Calza, Stefano, De Bacco, Francesca, Medicina, Daniela, Balzarini, Piera, Panciani, Pier Paolo, Liserre, Roberto, Buglione, Michela, Fontanella, Marco Maria, Medico, Enzo, Galli, Rossella, Isella, Claudio, Boccaccio, Carla, Poliani, Pietro Luigi, and on behalf of the Neuro-Oncology group of Spedali Civili of Brescia

Published
2020
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15. MiR-100 is a predictor of endocrine responsiveness and prognosis in patients with operable luminal breast cancer

Author

Petrelli, Annalisa, Bellomo, Sara Erika, Sarotto, Ivana, Kubatzki, Franziska, Sgandurra, Paola, Maggiorotto, Furio, Di Virgilio, Maria Rosaria, Ponzone, Riccardo, Geuna, Elena, Galizia, Danilo, Nuzzo, Anna Maria, Medico, Enzo, Miglio, Umberto, Berrino, Enrico, Venesio, Tiziana, Ribisi, Salvatore, Provero, Paolo, Sapino, Anna, Giordano, Silvia, and Montemurro, Filippo

Published
2020
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16. Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Author

Apicella, Maria, Giannoni, Elisa, Fiore, Stephany, Ferrari, Karin Johanna, Fernández-Pérez, Daniel, Isella, Claudio, Granchi, Carlotta, Minutolo, Filippo, Sottile, Antonino, Comoglio, Paolo Maria, Medico, Enzo, Pietrantonio, Filippo, Volante, Marco, Pasini, Diego, Chiarugi, Paola, Giordano, Silvia, and Corso, Simona

Published
2018
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19. Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts

Author

Corso, Simona, Cargnelutti, Marilisa, Durando, Stefania, Menegon, Silvia, Apicella, Maria, Migliore, Cristina, Capeloa, Tania, Ughetto, Stefano, Isella, Claudio, Medico, Enzo, Bertotti, Andrea, Sassi, Francesco, Sarotto, Ivana, Casorzo, Laura, Pisacane, Alberto, Mangioni, Monica, Sottile, Antonino, Degiuli, Maurizio, Fumagalli, Uberto, Sgroi, Giovanni, Molfino, Sarah, De Manzoni, Giovanni, Rosati, Riccardo, De Simone, Michele, Marrelli, Daniele, Saragoni, Luca, Rausei, Stefano, Pallabazzer, Giovanni, Roviello, Franco, Cassoni, Paola, Sapino, Anna, Bass, Adam, and Giordano, Silvia

Published
2018
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20. Dual VEGFA/BRAF targeting boosts PD‐1 blockade in melanoma through GM‐CSF‐mediated infiltration of M1 macrophages

Author

Comunanza, Valentina, primary, Gigliotti, Chiara, additional, Lamba, Simona, additional, Doronzo, Gabriella, additional, Vallariello, Edoardo, additional, Martin, Valentina, additional, Isella, Claudio, additional, Medico, Enzo, additional, Bardelli, Alberto, additional, Sangiolo, Dario, additional, Di Nicolantonio, Federica, additional, and Bussolino, Federico, additional

Published
2023
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23. Supplementary Table 1 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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24. Supplementary Figure 2 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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25. Supplementary Table 3 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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26. Data from BRAF V600E Is a Determinant of Sensitivity to Proteasome Inhibitors

Author

Zecchin, Davide, primary, Boscaro, Valentina, primary, Medico, Enzo, primary, Barault, Ludovic, primary, Martini, Miriam, primary, Arena, Sabrina, primary, Cancelliere, Carlotta, primary, Bartolini, Alice, primary, Crowley, Emily H., primary, Bardelli, Alberto, primary, Gallicchio, Margherita, primary, and Di Nicolantonio, Federica, primary

Published
2023
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28. Supplementary Figure 1 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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29. Supplementary Figure 3 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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30. Supplementary Figure 5 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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31. Data from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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32. Supplementary Figure 4 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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33. Supplementary Figure 6 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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34. Supplementary Table 2 from A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Author

Bertotti, Andrea, primary, Migliardi, Giorgia, primary, Galimi, Francesco, primary, Sassi, Francesco, primary, Torti, Davide, primary, Isella, Claudio, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, Buscarino, Michela, primary, Petti, Consalvo, primary, Ribero, Dario, primary, Russolillo, Nadia, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Pisacane, Alberto, primary, Molinaro, Luca, primary, Valtorta, Emanuele, primary, Sartore-Bianchi, Andrea, primary, Risio, Mauro, primary, Capussotti, Lorenzo, primary, Gambacorta, Marcello, primary, Siena, Salvatore, primary, Medico, Enzo, primary, Sapino, Anna, primary, Marsoni, Silvia, primary, Comoglio, Paolo M., primary, Bardelli, Alberto, primary, and Trusolino, Livio, primary

Published
2023
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36. Supplementary Table S1 from A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Author

Arena, Sabrina, primary, Corti, Giorgio, primary, Durinikova, Erika, primary, Montone, Monica, primary, Reilly, Nicole M., primary, Russo, Mariangela, primary, Lorenzato, Annalisa, primary, Arcella, Pamela, primary, Lazzari, Luca, primary, Rospo, Giuseppe, primary, Pagani, Massimiliano, primary, Cancelliere, Carlotta, primary, Negrino, Carola, primary, Isella, Claudio, primary, Bartolini, Alice, primary, Cassingena, Andrea, primary, Amatu, Alessio, primary, Mauri, Gianluca, primary, Sartore-Bianchi, Andrea, primary, Mittica, Gloria, primary, Medico, Enzo, primary, Marsoni, Silvia, primary, Linnebacher, Michael, primary, Abrignani, Sergio, primary, Siena, Salvatore, primary, Di Nicolantonio, Federica, primary, and Bardelli, Alberto, primary

Published
2023
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37. Data from PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Author

Meehan, Terrence F., primary, Conte, Nathalie, primary, Goldstein, Theodore, primary, Inghirami, Giorgio, primary, Murakami, Mark A., primary, Brabetz, Sebastian, primary, Gu, Zhiping, primary, Wiser, Jeffrey A., primary, Dunn, Patrick, primary, Begley, Dale A., primary, Krupke, Debra M., primary, Bertotti, Andrea, primary, Bruna, Alejandra, primary, Brush, Matthew H., primary, Byrne, Annette T., primary, Caldas, Carlos, primary, Christie, Amanda L., primary, Clark, Dominic A., primary, Dowst, Heidi, primary, Dry, Jonathan R., primary, Doroshow, James H., primary, Duchamp, Olivier, primary, Evrard, Yvonne A., primary, Ferretti, Stephane, primary, Frese, Kristopher K., primary, Goodwin, Neal C., primary, Greenawalt, Danielle, primary, Haendel, Melissa A., primary, Hermans, Els, primary, Houghton, Peter J., primary, Jonkers, Jos, primary, Kemper, Kristel, primary, Khor, Tin O., primary, Lewis, Michael T., primary, Lloyd, K.C. Kent, primary, Mason, Jeremy, primary, Medico, Enzo, primary, Neuhauser, Steven B., primary, Olson, James M., primary, Peeper, Daniel S., primary, Rueda, Oscar M., primary, Seong, Je Kyung, primary, Trusolino, Livio, primary, Vinolo, Emilie, primary, Wechsler-Reya, Robert J., primary, Weinstock, David M., primary, Welm, Alana, primary, Weroha, S. John, primary, Amant, Frédéric, primary, Pfister, Stefan M., primary, Kool, Marcel, primary, Parkinson, Helen, primary, Butte, Atul J., primary, and Bult, Carol J., primary

Published
2023
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38. Supplementary Table S3 from Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Author

Lazzari, Luca, primary, Corti, Giorgio, primary, Picco, Gabriele, primary, Isella, Claudio, primary, Montone, Monica, primary, Arcella, Pamela, primary, Durinikova, Erika, primary, Zanella, Eugenia R., primary, Novara, Luca, primary, Barbosa, Fabiane, primary, Cassingena, Andrea, primary, Cancelliere, Carlotta, primary, Medico, Enzo, primary, Sartore-Bianchi, Andrea, primary, Siena, Salvatore, primary, Garnett, Mathew J., primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Di Nicolantonio, Federica, primary, Linnebacher, Michael, primary, Bardelli, Alberto, primary, and Arena, Sabrina, primary

Published
2023
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39. Suppl. Video 3 from CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Author

Leuci, Valeria, primary, Donini, Chiara, primary, Grignani, Giovanni, primary, Rotolo, Ramona, primary, Mesiano, Giulia, primary, Fiorino, Erika, primary, Gammaitoni, Loretta, primary, D'Ambrosio, Lorenzo, primary, Merlini, Alessandra, primary, Landoni, Elisa, primary, Medico, Enzo, primary, Capellero, Sonia, primary, Giraudo, Lidia, primary, Cattaneo, Giulia, primary, Iaia, Ilenia, primary, Pignochino, Ymera, primary, Basiricò, Marco, primary, Vigna, Elisa, primary, Pisacane, Alberto, primary, Fagioli, Franca, primary, Ferrone, Soldano, primary, Aglietta, Massimo, primary, Dotti, Gianpietro, primary, and Sangiolo, Dario, primary

Published
2023
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40. Supplementary Table S4 from Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

Author

Galimi, Francesco, primary, Torti, Davide, primary, Sassi, Francesco, primary, Isella, Claudio, primary, Corà, Davide, primary, Gastaldi, Stefania, primary, Ribero, Dario, primary, Muratore, Andrea, primary, Massucco, Paolo, primary, Siatis, Dimitrios, primary, Paraluppi, Gianluca, primary, Gonella, Federica, primary, Maione, Francesca, primary, Pisacane, Alberto, primary, David, Ezio, primary, Torchio, Bruno, primary, Risio, Mauro, primary, Salizzoni, Mauro, primary, Capussotti, Lorenzo, primary, Perera, Timothy, primary, Medico, Enzo, primary, Di Renzo, Maria Flavia, primary, Comoglio, Paolo M., primary, Trusolino, Livio, primary, and Bertotti, Andrea, primary

Published
2023
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41. Supplementary Figure S2 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Apicella, Maria, primary, Durando, Stefania, primary, Migliore, Cristina, primary, Ughetto, Stefano, primary, D’Errico, Laura, primary, Menegon, Silvia, primary, Moya-Rull, Daniel, primary, Cargnelutti, Marilisa, primary, Capelôa, Tânia, primary, Conticelli, Daniela, primary, Giordano, Jessica, primary, Venesio, Tiziana, primary, Balsamo, Antonella, primary, Marchiò, Caterina, primary, Degiuli, Maurizio, primary, Reddavid, Rossella, primary, Fumagalli, Uberto, primary, De Pascale, Stefano, primary, Sgroi, Giovanni, primary, Rausa, Emanuele, primary, Baiocchi, Gian Luca, primary, Molfino, Sarah, primary, Pietrantonio, Filippo, primary, Morano, Federica, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Bencivenga, Maria, primary, Mengardo, Valentina, primary, Rosati, Riccardo, primary, Marrelli, Daniele, primary, Morgagni, Paolo, primary, Rausei, Stefano, primary, Pallabazzer, Giovanni, primary, De Simone, Michele, primary, Ribero, Dario, primary, Marsoni, Silvia, primary, Sottile, Antonino, primary, Medico, Enzo, primary, Cassoni, Paola, primary, Sapino, Anna, primary, Pectasides, Eirini, primary, Thorner, Aaron R., primary, Nag, Anwesha, primary, Drinan, Samantha D., primary, Wollison, Bruce M., primary, Bass, Adam J., primary, and Giordano, Silvia, primary

Published
2023
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42. Suppl. Video 4 from CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Author

Leuci, Valeria, primary, Donini, Chiara, primary, Grignani, Giovanni, primary, Rotolo, Ramona, primary, Mesiano, Giulia, primary, Fiorino, Erika, primary, Gammaitoni, Loretta, primary, D'Ambrosio, Lorenzo, primary, Merlini, Alessandra, primary, Landoni, Elisa, primary, Medico, Enzo, primary, Capellero, Sonia, primary, Giraudo, Lidia, primary, Cattaneo, Giulia, primary, Iaia, Ilenia, primary, Pignochino, Ymera, primary, Basiricò, Marco, primary, Vigna, Elisa, primary, Pisacane, Alberto, primary, Fagioli, Franca, primary, Ferrone, Soldano, primary, Aglietta, Massimo, primary, Dotti, Gianpietro, primary, and Sangiolo, Dario, primary

Published
2023
Full Text
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43. Data from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Apicella, Maria, primary, Durando, Stefania, primary, Migliore, Cristina, primary, Ughetto, Stefano, primary, D’Errico, Laura, primary, Menegon, Silvia, primary, Moya-Rull, Daniel, primary, Cargnelutti, Marilisa, primary, Capelôa, Tânia, primary, Conticelli, Daniela, primary, Giordano, Jessica, primary, Venesio, Tiziana, primary, Balsamo, Antonella, primary, Marchiò, Caterina, primary, Degiuli, Maurizio, primary, Reddavid, Rossella, primary, Fumagalli, Uberto, primary, De Pascale, Stefano, primary, Sgroi, Giovanni, primary, Rausa, Emanuele, primary, Baiocchi, Gian Luca, primary, Molfino, Sarah, primary, Pietrantonio, Filippo, primary, Morano, Federica, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Bencivenga, Maria, primary, Mengardo, Valentina, primary, Rosati, Riccardo, primary, Marrelli, Daniele, primary, Morgagni, Paolo, primary, Rausei, Stefano, primary, Pallabazzer, Giovanni, primary, De Simone, Michele, primary, Ribero, Dario, primary, Marsoni, Silvia, primary, Sottile, Antonino, primary, Medico, Enzo, primary, Cassoni, Paola, primary, Sapino, Anna, primary, Pectasides, Eirini, primary, Thorner, Aaron R., primary, Nag, Anwesha, primary, Drinan, Samantha D., primary, Wollison, Bruce M., primary, Bass, Adam J., primary, and Giordano, Silvia, primary

Published
2023
Full Text
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44. Suppl. Video 1 from CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Author

Leuci, Valeria, primary, Donini, Chiara, primary, Grignani, Giovanni, primary, Rotolo, Ramona, primary, Mesiano, Giulia, primary, Fiorino, Erika, primary, Gammaitoni, Loretta, primary, D'Ambrosio, Lorenzo, primary, Merlini, Alessandra, primary, Landoni, Elisa, primary, Medico, Enzo, primary, Capellero, Sonia, primary, Giraudo, Lidia, primary, Cattaneo, Giulia, primary, Iaia, Ilenia, primary, Pignochino, Ymera, primary, Basiricò, Marco, primary, Vigna, Elisa, primary, Pisacane, Alberto, primary, Fagioli, Franca, primary, Ferrone, Soldano, primary, Aglietta, Massimo, primary, Dotti, Gianpietro, primary, and Sangiolo, Dario, primary

Published
2023
Full Text
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45. Supplementary Figures S1-S6 from A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem–Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy

Author

Luraghi, Paolo, primary, Bigatto, Viola, primary, Cipriano, Elia, primary, Reato, Gigliola, primary, Orzan, Francesca, primary, Sassi, Francesco, primary, De Bacco, Francesca, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Medico, Enzo, primary, Comoglio, Paolo M., primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, and Boccaccio, Carla, primary

Published
2023
Full Text
View/download PDF

46. Supplementary Table S3 from A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

Author

Corso, Simona, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Apicella, Maria, primary, Durando, Stefania, primary, Migliore, Cristina, primary, Ughetto, Stefano, primary, D’Errico, Laura, primary, Menegon, Silvia, primary, Moya-Rull, Daniel, primary, Cargnelutti, Marilisa, primary, Capelôa, Tânia, primary, Conticelli, Daniela, primary, Giordano, Jessica, primary, Venesio, Tiziana, primary, Balsamo, Antonella, primary, Marchiò, Caterina, primary, Degiuli, Maurizio, primary, Reddavid, Rossella, primary, Fumagalli, Uberto, primary, De Pascale, Stefano, primary, Sgroi, Giovanni, primary, Rausa, Emanuele, primary, Baiocchi, Gian Luca, primary, Molfino, Sarah, primary, Pietrantonio, Filippo, primary, Morano, Federica, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Bencivenga, Maria, primary, Mengardo, Valentina, primary, Rosati, Riccardo, primary, Marrelli, Daniele, primary, Morgagni, Paolo, primary, Rausei, Stefano, primary, Pallabazzer, Giovanni, primary, De Simone, Michele, primary, Ribero, Dario, primary, Marsoni, Silvia, primary, Sottile, Antonino, primary, Medico, Enzo, primary, Cassoni, Paola, primary, Sapino, Anna, primary, Pectasides, Eirini, primary, Thorner, Aaron R., primary, Nag, Anwesha, primary, Drinan, Samantha D., primary, Wollison, Bruce M., primary, Bass, Adam J., primary, and Giordano, Silvia, primary

Published
2023
Full Text
View/download PDF

47. Supplementary Data from Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Author

Lazzari, Luca, primary, Corti, Giorgio, primary, Picco, Gabriele, primary, Isella, Claudio, primary, Montone, Monica, primary, Arcella, Pamela, primary, Durinikova, Erika, primary, Zanella, Eugenia R., primary, Novara, Luca, primary, Barbosa, Fabiane, primary, Cassingena, Andrea, primary, Cancelliere, Carlotta, primary, Medico, Enzo, primary, Sartore-Bianchi, Andrea, primary, Siena, Salvatore, primary, Garnett, Mathew J., primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Di Nicolantonio, Federica, primary, Linnebacher, Michael, primary, Bardelli, Alberto, primary, and Arena, Sabrina, primary

Published
2023
Full Text
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48. Supplementary Data from CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Author

Leuci, Valeria, primary, Donini, Chiara, primary, Grignani, Giovanni, primary, Rotolo, Ramona, primary, Mesiano, Giulia, primary, Fiorino, Erika, primary, Gammaitoni, Loretta, primary, D'Ambrosio, Lorenzo, primary, Merlini, Alessandra, primary, Landoni, Elisa, primary, Medico, Enzo, primary, Capellero, Sonia, primary, Giraudo, Lidia, primary, Cattaneo, Giulia, primary, Iaia, Ilenia, primary, Pignochino, Ymera, primary, Basiricò, Marco, primary, Vigna, Elisa, primary, Pisacane, Alberto, primary, Fagioli, Franca, primary, Ferrone, Soldano, primary, Aglietta, Massimo, primary, Dotti, Gianpietro, primary, and Sangiolo, Dario, primary

Published
2023
Full Text
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49. Supplemental Figure 2 from CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes

Author

Leuci, Valeria, primary, Donini, Chiara, primary, Grignani, Giovanni, primary, Rotolo, Ramona, primary, Mesiano, Giulia, primary, Fiorino, Erika, primary, Gammaitoni, Loretta, primary, D'Ambrosio, Lorenzo, primary, Merlini, Alessandra, primary, Landoni, Elisa, primary, Medico, Enzo, primary, Capellero, Sonia, primary, Giraudo, Lidia, primary, Cattaneo, Giulia, primary, Iaia, Ilenia, primary, Pignochino, Ymera, primary, Basiricò, Marco, primary, Vigna, Elisa, primary, Pisacane, Alberto, primary, Fagioli, Franca, primary, Ferrone, Soldano, primary, Aglietta, Massimo, primary, Dotti, Gianpietro, primary, and Sangiolo, Dario, primary

Published
2023
Full Text
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50. Supplementary Experimental Procedures from A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem–Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy

Author

Luraghi, Paolo, primary, Bigatto, Viola, primary, Cipriano, Elia, primary, Reato, Gigliola, primary, Orzan, Francesca, primary, Sassi, Francesco, primary, De Bacco, Francesca, primary, Isella, Claudio, primary, Bellomo, Sara E., primary, Medico, Enzo, primary, Comoglio, Paolo M., primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, and Boccaccio, Carla, primary

Published
2023
Full Text
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