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Emotional memory can persist strikingly long, but it is believed that not all its elements are protected against the fading effects of time. So far, studies of emotional episodic memory have mostly investigated retention up to 24h postencoding and revealed that central emotional features (items) are usually strengthened, while contextual binding of the event is reduced. However, even though it is known for neutral memories that central versus contextual elements evolve differently with longer passage of time, the time-dependent evolution of emotional memories remains unclear. Hypothetically, compared to neutral memories, emotional item memory becomes increasingly stronger, accompanied by accelerated decay of--already fragile--links with their original encoding contexts, resulting in progressive reductions in contextual dependency. Here, we tested these predictions in a large-scale study. Participants encoded emotional and neutral episodes, and were assessed 30 minutes (N = 40), 1 day (N = 40), 1 week (N = 39), or 2 weeks (N = 39) later on item memory, contextual dependency, and subjective quality of memory. The results show that, with the passage of time, emotional memories were indeed characterized by increasingly stronger item memory and weaker contextual dependency. Interestingly, analyses of the subjective quality of memories revealed that stronger memory for emotional items with time was expressed in familiarity, whereas increasingly smaller contextual dependency for emotional episodes was reflected in recollection. Together, these findings uncover the timedependent transformation of emotional episodic memories, thereby shedding light on the ways healthy and maladaptive human memories may develop. [ABSTRACT FROM AUTHOR]

The transition from secondary to tertiary education varies from country to country. In many countries, secondary school is concluded with high-stakes, national exams, or high-stakes entry tests are used for admissions to tertiary education. In other countries, secondary-school grade point average (GPA) is the determining factor. In the Netherlands, both play a role. With administrative data of close to 180,000 students, we investigated whether national exam scores or secondary school GPA was a better predictor of tertiary first-year retention. For both university education and higher professional education, secondary school GPA was the better prediction of retention, to the extent that national exams did not explain any additional variance. Moreover, for students who failed their exam, being held back by the secondary school for an additional year and entering tertiary education one year later, GPA in the year of failure remained as predictive as for students who had passed their exams and started tertiary education immediately. National exam scores, on the other hand, had no predictive value at all for these students. It is concluded that secondary school GPA measures aspects of student performance that is not included in high-stakes national exams, but that are predictive of subsequent success in tertiary education. [ABSTRACT FROM AUTHOR]

According to Vygotsky’s cultural-historical activity theory, pretend play can be an important context for the development of children’s social competence. The aim of this meta-analysis was to synthesize the current evidence about the relation between pretend play and social competence in early childhood (age 3–8 years). A systematic literature search of PsycINFO, ERIC, and Web of Science identified a total of 34 relevant empirical studies. The included studies were systematically coded and categorized for pretend play and social competence. Overall, the findings of this meta-analysis reveal a positive relation between pretend play and social competence, irrespective of how the latter was measured. The relation between pretend play and social competence was slightly negatively impacted by children’s age, suggesting that the relation weakens as children get older. Studies measuring the amount of pretend play found lower correlations between pretend play and social competence than studies measuring the quality of pretend play. Most included studies adopted a cross-sectional design, so claims about causal effects could not be supported. Future research is required to determine the direction of causality and potential mechanisms that may explain the relation between pretend play and social competence. [ABSTRACT FROM AUTHOR]

When reading, orthographic information is extracted not only from the word the reader is looking at, but also from adjacent words in the parafovea. Here we examined, using the recently introduced OB1‐reader computational model, how orthographic information can be processed in parallel across multiple words and how orthographic information can be integrated across time and space. Although OB1‐reader is a model of text reading, here we used it to simulate single‐word recognition experiments in which parallel processing has been shown to play a role by manipulating the surrounding context in flanker and priming paradigms. In flanker paradigms, observers recognize a central word flanked by other letter strings located left and right of the target and separated from the target by a space. The model successfully accounts for the finding that such flankers can aid word recognition when they contain bigrams of the target word, independent of where those flankers are in the visual field. In priming experiments, in which the target word is preceded by a masked prime, the model accounts for the finding that priming occurs independent of whether the prime and target word are in the same location or not. Crucial to these successes is the key role that spatial attention plays within OB1‐reader, as it allows the model to receive visual input from multiple locations in parallel, while limiting the kinds of errors that can potentially occur under such spatial pooling of orthographic information. [ABSTRACT FROM AUTHOR]

Our visual brain makes use of recent experience to interact with the visual world, and efficiently select relevant information. This is exemplified by speeded search when target- and distractor features repeat across trials versus when they switch, a phenomenon referred to as intertrial priming. Here, we present fAIM, a computational model that demonstrates how priming can be explained by a simple feature-weighting mechanism integrated into an established model of bottom-up vision. In fAIM, such modulations in feature gains are widespread and not just restricted to one or a few features. Consequentially, priming effects result from the overall tuning of visual features to the task at hand. Such tuning allows the model to reproduce priming for different types of stimuli, including for typical stimulus dimensions such as ‘color’ and for less obvious dimensions such as ‘spikiness’ of shapes. Moreover, the model explains some puzzling findings from the literature: it shows how priming can be found for target-distractor stimulus relations rather than for their absolute stimulus values per se, without an explicit representation of relations. Similarly, it simulates effects that have been taken to reflect a modulation of priming by an observers’ goals—without any representation of goals in the model. We conclude that priming is best considered as a consequence of a general adaptation of the brain to visual input, and not as a peculiarity of visual search. [ABSTRACT FROM AUTHOR]

A hotly debated issue in reading research concerns the extent to which readers process parafoveal words, and how parafoveal information might influence foveal word recognition. We investigated syntactic word processing both in sentence reading and in reading isolated foveal words when these were flanked by parafoveal words. In Experiment 1 we found a syntactic parafoveal preview benefit in sentence reading, meaning that fixation durations on target words were decreased when there was a syntactically congruent preview word at the target location (n) during the fixation on the pre-target (n-1). In Experiment 2 we used a flanker paradigm in which participants had to classify foveal target words as either noun or verb, when those targets were flanked by syntactically congruent or incongruent words (stimulus on-time 170 ms). Lower response times and error rates in the congruent condition suggested that higher-order (syntactic) information can be integrated across foveal and parafoveal words. Although higher-order parafoveal-on-foveal effects have been elusive in sentence reading, results from our flanker paradigm show that the reading system can extract higher-order information from multiple words in a single glance. We propose a model of reading to account for the present findings. [ABSTRACT FROM AUTHOR]

Visual attention is guided by the history of selections in previous trials, an effect usually referred to as intertrial priming. The aim of the present study was to investigate whether such priming in visual search is due to a strengthening of the target signal, or the suppression of the distractor signal. In two experiments, we examined the deviation of saccade endpoints in situations in which the target and distractors were presented in relative close proximity. We found both negative and positive priming, irrespective of whether the repeating feature was relevant or irrelevant. This finding is in contrast to previous results with this paradigm, based on which we concluded that visual priming is strictly the result of boosting perceptual target signals. Based on the differences between these experiments, we conclude that the number of distractors is essential in observing negative priming. We propose that negative priming is solely observed when multiple distractors result in either strong inhibition of distractor features, or strong adaptation to them. Whereas positive priming seems to be a robust mechanism, negative priming is only present if there are multiple distractors. [ABSTRACT FROM AUTHOR]

Studies on intertrial priming have shown that in visual search experiments, the preceding trial automatically affects search performance: facilitating it when the target features repeat and giving rise to switch costs when they change--so-called (short-term) intertrial priming. These effects also occur at longer time scales: When 1 of 2 possible target colors is more frequent during an experiment block, this results in a prolonged and persistent facilitation for the color that was biased, long after the frequency bias is gone--so-called long-term priming. In this study, we explore the robustness of such long-term priming. In Experiment 1, participants were fully informed of the bias and instructed to prioritize the other unbiased color. Despite these instructions, long-term priming of the biased color persisted in this block, suggesting that guidance by long-term priming is an implicit effect. In Experiment 2, long-term priming was built up in 1 experimental session and was then assessed in a second session a week later. Long-term priming persisted across this week, emphasizing that long-term priming is truly a phenomenon of long-term memory. The results support the view that priming results from the automatic and implicit retrieval of memory traces of past trials. [ABSTRACT FROM AUTHOR]

Visual attention is strongly affected by the past: both by recent experience and by long-term regularities in the environment that are encoded in and retrieved from memory. In visual search, intertrial repetition of targets causes speeded response times ( short-term priming). Similarly, targets that are presented more often than others may facilitate search, even long after it is no longer present ( long-term priming). In this study, we investigate whether such short-term priming and long-term priming depend on dissociable mechanisms. By recording eye movements while participants searched for one of two conjunction targets, we explored at what stages of visual search different forms of priming manifest. We found both long- and short- term priming effects. Long-term priming persisted long after the bias was present, and was again found even in participants who were unaware of a color bias. Short- and long-term priming affected the same stage of the task; both biased eye movements towards targets with the primed color, already starting with the first eye movement. Neither form of priming affected the response phase of a trial, but response repetition did. The results strongly suggest that both long- and short-term memory can implicitly modulate feedforward visual processing. [ABSTRACT FROM AUTHOR]

Our brains are highly responsive to novelty. However, how novelty is processed in the brain, and what neurotransmitter systems play a role therein, remains elusive. Here, we systematically review studies on human participants that have looked at the neuromodulatory basis of novelty detection and processing. While theoretical models and studies on nonhuman animals have pointed to a role of the dopaminergic, cholinergic, noradrenergic and serotonergic systems, the human literature has focused almost exclusively on the first two. Dopamine was found to affect electrophysiological responses to novelty early in time after stimulus presentation, but evidence on its effects on later processing was found to be contradictory: While neuropharmacological studies mostly yielded null effects, gene studies did point to an important role for dopamine. Acetylcholine seems to dampen novelty signals in the medial temporal lobe, but boost them in frontal cortex. Findings on 5-HT (serotonin) were found to be mostly contradictory. Two large gaps were identified in the literature. First, few studies have looked at neuromodulatory influences on behavioral effects of novelty. Second, no study has looked at the involvement of the noradrenergic system in novelty processing. [ABSTRACT FROM AUTHOR]

Retrospectively cueing an item retained in visual working memory during maintenance is known to improve its retention. However, studies have provided conflicting results regarding the costs of such retro-cues for the noncued items, leading to different theories on the mechanisms behind visual working memory maintenance and retro-cueing. Here we tested an alternative explanation of the conflicting results regarding retro-cue costs-namely, that they are caused at least partly by differences in retro-cue reliability. We manipulated the ratio of valid-cue trials to invalid-cue trials within blocks. We used a continuous-report procedure that allowed fitting a model that provided recall probability and precision estimates for the memory representations. Reconciling previous contradictory findings, benefits for valid cues were observed in all conditions, but invalid cueing costs were found only when the retro-cue had a high reliability (i.e., was 80 % valid), but not when it had a lower reliability (i.e., 50 % valid). This was found for both the recall probability and the precision of visual working memory representations. Our results suggest that the cognitive mechanisms underlying retro-cue effects are strategically adjusted by participants, depending on the perceived retro-cue reliability. [ABSTRACT FROM AUTHOR]

Inefficient targeting of students at risk of dropping out might explain why dropout-reducing efforts often have no or mixed effects. In this study, we present a new method which uses a series of machine learning algorithms to efficiently identify students at risk and makes the sensitivity/precision trade-off inherent in targeting students for dropout prevention explicit. Data of a Dutch vocational education institute is used to show how out-of-sample machine learning predictions can be used to formulate invitation rules in a way that targets students at risk more effectively, thereby facilitating early detection for effective dropout prevention. [ABSTRACT FROM AUTHOR]

Memory affects visual search, as is particularly evident from findings that when target features are repeated from one trial to the next, selection is faster. Two views have emerged on the nature of the memory representations and mechanisms that cause these intertrial priming effects: independent feature weighting versus episodic retrieval of previous trials. Previous research has attempted to disentangle these views focusing on short term effects. Here, we illustrate that the episodic retrieval models make the unique prediction of long-term priming: biasing one target type will result in priming of this target type for a much longer time, well after the bias has disappeared. We demonstrate that such long-term priming is indeed found for the visual feature of color, but only in conjunction search and not in singleton search. Two follow-up experiments showed that it was the kind of search (conjunction versus singleton) and not the difficulty, that determined whether long-term priming occurred. Long term priming persisted unaltered for at least 200 trials, and could not be explained as the result of explicit strategy. We propose that episodic memory may affect search more consistently than previously thought, and that the mechanisms for intertrial priming may be qualitatively different for singleton and conjunction search. [ABSTRACT FROM AUTHOR]

Introduction Bipolar disorder (BD) is a psychiatric disorder accompanied by deficits in declarative memory. Given the importance of the hippocampus in declarative memory, it is not surprising that BD patients have been reported to show hippocampal abnormalities. Objectives Review evidence about structural and functional hippocampal abnormalities in BD. Methods Systematic review of studies comparing BD patients and healthy controls with respect to hippocampal structure or function. Results Twenty-five studies were included, together involving 1043 patients, 21 of which compared patients to controls. Decrease in hippocampal volume was found in four of 18 studies using adult samples, and two of three samples using adolescents. Four studies revealed localized hippocampal deficits. Meta-analysis revealed a significant but small effect with lower hippocampal volumes when comparing all BD patients with controls. Lithium treatment was associated with larger hippocampal volumes across studies. The three functional studies yielded contradictory evidence. Limitations Studies were only cross-sectional in nature and all used MRI or fMRI to investigate hippocampal volume or function. Heterogeneous patients groups and different methodologies for hippocampal segmentation, may have contributed to difficulties when comparing the different studies. Conclusions There seems to be a small reduction in hippocampal volume in BD, which perhaps is more pronounced in early-onset BD and is counteracted by a neuroprotective effect of lithium treatment. However, how these structural abnormalities relate to functional deficits is largely unclear. Given the few functional neuroimaging studies and given the lack of congruence in these results, further investigation of especially hippocampal function in BD is recommended. [ABSTRACT FROM AUTHOR]

Visual search requires the maintenance of a search template in visual working memory in order to guide attention towards the target. This raises the question whether a search template is essentially the same as a visual working memory representation used in tasks that do not require attentional guidance, or whether it is a qualitatively different representation. Two experiments tested this by comparing electrophysiological markers of visual working memory maintenance between simple recognition and search tasks. For both experiments, responses were less rapid and less accurate in search task than in simple recognition. Nevertheless, the contralateral delay activity (CDA), an index of quantity and quality of visual working memory representations, was equal across tasks. On the other hand, the late positive complex (LPC), which is sensitive to the effort invested in visual working memory maintenance, was greater for the search task than the recognition task. Additionally, when the same target cue was repeated across trials (Experiment 2), the amplitude of visual working memory markers (both CDA and LPC) decreased, demonstrating learning of the target at an equal rate for both tasks. Our results suggest that a search template is qualitatively the same as a representation used for simple recognition, but greater effort is invested in its maintenance. [ABSTRACT FROM AUTHOR]

Intertrial priming in visual search is the finding that repeating target and distractor features from one trial to the next speeds up search, relative to when these features change. Recently, Becker () reported evidence that it is not so much the repetition of absolute feature values that causes priming, but repetition of the relation between target and distractors. For example, in search for a unique size, the size of the search elements may change from trial to trial, but this does not hurt performance as long as the target remains consistently larger (or smaller) than the distractors. Becker () concluded that such findings are difficult to reconcile with existing theory. Here, we replicate the findings in the dimensions of size, color, and luminance and show that these effects are not due to the magnitude of feature changes or to search strategies, as may be induced by blocking versus mixing different types of intertrial changes experienced by observers. However, we show that repeating a feature from one trial to the next does convey a benefit above and beyond repeating the target-distractor relation. We argue that both effects can be readily accounted for within current models of visual search. Priming of relations results when one assumes the existence of cardinal feature channels, as do most models of visual search. Additional priming of specific values results when one assumes broadly distributed, overlapping feature channels. [ABSTRACT FROM AUTHOR]

Abstract: Earlier studies have suggested that information from a prime stimulus can be integrated with target information even when the two stimuli appear at different spatial locations. Here, we examined such location invariance in a masked repetition priming paradigm with single letter and word stimuli. In order to neutralize effects of acuity and spatial attention on prime processing, subliminal prime stimuli always appeared on fixation. Target location varied randomly from trial to trial along the horizontal meridian at one of seven possible locations for letter stimuli (−7° to +7°) and three positions for word stimuli (−4°, 0°, +4°). Speed of responding to letter and word targets was affected by target location, and by priming, but the size of repetition priming effects did not vary as a function of target location. These results suggest that masked repetition priming is mediated by representations that integrate information about object identity independently of object location. [Copyright &y& Elsevier]

The effects of novelty on low-level visual perception were investigated in two experiments using a two-alternative forcedchoice tilt detection task. A target, consisting of a Gabor patch, was preceded by a cue that was either a novel or a familiar fractal image. Participants had to indicate whether the Gabor stimulus was vertically oriented or slightly tilted. In the first experiment tilt angle was manipulated; in the second contrast of the Gabor patch was varied. In the first, we found that sensitivity was enhanced after a novel compared to a familiar cue, and in the second we found sensitivity to be enhanced for novel cues in later experimental blocks when participants became more and more familiarized with the familiar cue. These effects were not caused by a shift in the response criterion. This shows for the first time that novel stimuli affect lowlevel characteristics of perception. We suggest that novelty can elicit a transient attentional response, thereby enhancing perception. [ABSTRACT FROM AUTHOR]

Visual search is speeded when the target is repeated from trial to trial compared to when it changes, suggesting that selective attention learns from previous events. Such intertrial effects are stronger when there is more competition for selection, for example in ambiguous displays where the target is accompanied by a salient distractor. Here we investigate whether this is because the competition strengthens the learning itself, or because it allows for a learned representation to exert a greater effect. The results point to the latter. Observers looked for a colour-defined target that could repeat or change from trial to trial. A salient distractor could be present on the current trial, the previous trial, both, or neither. Intertrial effects were greater when a distractor was present on the current trial, suggesting that a primed target representation is more beneficial under conditions of competition. In contrast, distractor presence on the previous trial had no effects whatsoever, indicating that the learning process itself is not affected by competition. This suggests that the source of the learning resides at postselection stages, whereas the effects may occur at the perceptual level. [ABSTRACT FROM AUTHOR]

Abstract: Objective: Although electroconvulsive therapy (ECT) is generally considered effective against depression, it remains controversial because of its association with retrograde memory loss. Here, we assessed memory after ECT in circumstances most likely to yield strong retrograde amnesia. Method: A cohort of patients undergoing ECT for major depression was tested before and after ECT, and again at 3-months follow-up. Included were 21 patients scheduled to undergo bilateral ECT for severe major depression and 135 controls matched for gender, age, education, and media consumption. Two memory tests were used: a verbal learning test to assess anterograde memory function, and a remote memory test that assessed memory for news during the course of one year. Results: Before ECT the patients'' scores were lower than those of controls. They were lower again after treatment, suggesting retrograde amnesia. At follow-up, however, memory for events before treatment had returned to the pre-ECT level. Memory for events in the months after treatment was as good as that of controls. Limitations: The sample size in this study was not large. Moreover, memory impairment did not correlate with level of depression, which may be due to restriction of range. Conclusions: Our results are consistent with the possibility that ECT as currently practiced does not cause significant lasting retrograde amnesia, but that amnesia is mostly temporary and related to the period of impairment immediately following ECT. [Copyright &y& Elsevier]

We present a model of the eye movement system in which the programming of an eye movement is the result of the competitive integration of information in the superior colliculi (SC). This brain area receives input from occipital cortex, the frontal eye fields, and the dorsolateral prefrontal cortex, on the basis of which it computes the location of the next saccadic target. Two critical assumptions in the model are that cortical inputs are not only excitatory, but can also inhibit saccades to specific locations, and that the SC continue to influence the trajectory of a saccade while it is being executed. With these assumptions, we account for many neurophysiological and behavioral findings from eye movement research. Interactions within the saccade map are shown to account for effects of distractors on saccadic reaction time (SRT) and saccade trajectory, including the global effect and oculomotor capture. In addition, the model accounts for express saccades, the gap effect, saccadic reaction times for antisaccades, and recorded responses from neurons in the SC and frontal eye fields in these tasks. [ABSTRACT FROM AUTHOR]

Background: A large body of evidence suggests impaired context processing in schizophrenia. Here we propose that this impairment arises from defective integration of mediotemporal 'what' and 'where' routes, carrying object and spatial information to the hippocampus. Methodology and Findings: We have previously shown, in a mediotemporal lobe (MTL) model, that the abnormal connectivity between MTL regions observed in schizophrenia can explain the episodic memory deficits associated with the disorder. Here we show that the same neuropathology leads to several context processing deficits observed in patients with schizophrenia: 1) failure to choose subordinate stimuli over dominant ones when the former fit the context, 2) decreased contextual constraints in memory retrieval, as reflected in increased false alarm rates and 3) impaired retrieval of contextual information in source monitoring. Model analyses show that these deficits occur because the 'schizophrenic MTL' forms fragmented episodic representations, in which objects are overrepresented at the expense of spatial contextual information. Conclusions and Significance: These findings highlight the importance of MTL neuropathology in schizophrenia, demonstrating that it may underlie a broad spectrum of deficits, including context processing and memory impairments. It is argued that these processing deficits may contribute to central schizophrenia symptoms such as contextually inappropriate behavior, associative abnormalities, conversational drift, concreteness and delusions. [ABSTRACT FROM AUTHOR]

Abstract: Why does the brain contain more than one memory system? Genetic algorithms can play a role in elucidating this question. Here, model animals were constructed containing a dorsal striatal layer that controlled actions, and a ventral striatal layer that controlled a dopaminergic learning signal. Both layers could gain access to three modeled memory stores, but such access was penalized as energy expenditure. Model animals were then selected on their fitness in simulated operant conditioning tasks. Results suggest that having access to multiple memory stores and their representations is important in learning to regulate dopamine release, as well as in contextual discrimination. For simple operant conditioning, as well as stimulus discrimination, hippocampal compound representations turned out to suffice, a counterintuitive result given findings that hippocampal lesions tend not to affect performance in such tasks. We argue that there is in fact evidence to support a role for compound representations and the hippocampus in even the simplest conditioning tasks. [Copyright &y& Elsevier]

What is the time course of visual attention? Attentional blink studies have found that the 2nd of 2 targets is often missed when presented within about 500 ms from the 1st target, resulting in theories about relatively long-lasting capacity limitations or bottlenecks. Earlier studies, however, reported quite the opposite finding: Attention is transiently enhanced, rather than reduced, for several hundreds of milliseconds after a relevant event. The authors present a general theory, as well as a working computational model, that integrate these findings. There is no central role for capacity limitations or bottlenecks. Central is a rapidly responding gating system (or attentional filter) that seeks to enhance relevant and suppress irrelevant information. When items sufficiently match the target description, they elicit transient excitatory feedback activity (a "boost" function), meant to provide access to working memory. However, in the attentional blink task, the distractor after the target is accidentally boosted, resulting in subsequent strong inhibitory feedback response (a "bounce"), which, in effect, closes the gate to working memory. The theory explains many findings that are problematic for limited-capacity accounts, including a new experiment showing that the attentional blink can be postponed. [ABSTRACT FROM AUTHOR]

Visual search is speeded when the target-defining property (a feature- or dimension difference relative to the distractors) is repeated relative to when it changes, a phenomenon referred to as intertrial priming. Feature priming is usually weaker than dimension priming, and sometimes even absent. Four experiments tested the hypothesis that feature priming effects are especially weakened when the visual search task also involves dimension changes, the idea being that feature changes become less salient or less relevant relative to the bigger dimension changes. Feature changes were embedded in blocks that only contained feature changes, or in blocks that also carried dimension changes. However, regardless of type of search task, and level of display ambiguity, the dimensional context had little to no effect on the magnitude of feature priming. There were only reliable effects of ambiguity, in line with recent proposals (Meeter & Olivers, 2006). [ABSTRACT FROM AUTHOR]

Computational modeling of the brain holds great promise as a bridge from brain to behavior. To fulfill this promise, however, it is not enough for models to be 'biologically plausible': models must be structurally accurate. Here, we analyze what this entails for so-called psychobiological models, models that address behavior as well as brain function in some detail. Structural accuracy may be supported by (1) a model's a priori plausibility, which comes from a reliance on evidence-based assumptions, (2) fitting existing data, and (3) the derivation of new predictions. All three sources of support require modelers to be explicit about the ontology of the model, and require the existence of data constraining the modeling. For situations in which such data are only sparsely available, we suggest a new approach. If several models are constructed that together form a hierarchy of models, higher-level models can be constrained by lower-level models, and low-level models can be constrained by behavioral features of the higher-level models. Modeling the same substrate at different levels of representation, as proposed here, thus has benefits that exceed the merits of each model in the hierarchy on its own. [ABSTRACT FROM AUTHOR]

Abstract: We tested a recent hypothesis suggesting that the eye deviates away from a location when top-down preparation can influence target selection. Participants had to make an eye movement to a peripheral target. Before the upcoming target, a central cue indicated the likely target location. Results show that when the target was presented at a location different from that indicated by the cue, eye movements to the target deviated away from the cued location. Because central cues are under top-down control, the present results are in line with a determining role of top-down preparation on saccade direction. These results contrast with the findings reported in a similar paradigm executed with hand movements, in which the movements were mostly initiated in the direction of the cued location. Therefore, we conclude that inhibitory effects typically observed when executing eye movements may not be observed when executing hand movements in similar conditions. [Copyright &y& Elsevier]

Abstract: It is generally agreed that saccade deviations away from a distractor location represent inhibition in the oculomotor system. By systematically manipulating the location of a distractor we tested whether the inhibition of the distractor is coded coarsely or fine-grained. Results showed that the location of a distractor had an effect on the saccade trajectories, suggesting that the amount of inhibition observed depends on the location of the distractor. More specifically, the vertical distance of the distractor from fixation seems to be a determining factor. These findings have important implications for models that account for inhibition in the target selection process and the areas that could underlie inhibitory influences on the superior colliculus (SC), like the frontal eye fields (FEF) and the dorsolateral prefrontal cortex (dlPFC). Finally, the initial direction and the endpoint of a saccade were found to be strongly correlated, which contradicts recent models proposing that the initial saccade direction and saccade endpoint are unrelated. [Copyright &y& Elsevier]

Abstract: In the last two decades, research has shown that eye movement trajectories can be modified by situational determinants. These modifications can inform us about the mechanisms that control eye movements and they can yield information about the oculomotor, memory and attention system that is not easily obtained via other sources. Eye movement trajectories can deviate either towards or away from elements in the visual field. We review the conditions in which these deviations are found and the mechanisms underlying trajectory deviations. It is argued that deviations towards an element are caused by the unresolved competition in the oculomotor system between elements in a visual scene. Deviations away from an element are mainly observed in situations in which top-down preparation can influence the target selection process, but the exact cause of such deviations remains unclear. [Copyright &y& Elsevier]

5-Hydroxytryptamine (5-HT) transmission has been implicated in memory and in depression. Both 5-HT depletion and specific 5-HT agonists lower memory performance, while depression is also associated with memory deficits. The precise neuropharmacology and neural mechanisms underlying these effects are unknown. We used neural network simulations to elucidate the neuropharmacology and network mechanisms underlying 5-HT effects on memory. The model predicts that these effects are largely dependent on transmission over the 5-HT1A and 5-HT3 receptors, which regulate the selectivity of retrieval. It also predicts differential memory deficit profiles for 5-HT depletion and overactivation. The latter predictions were confirmed in studies with healthy and depressed participants undergoing acute tryptophan depletion or ipsipirone challenge. The results suggest that the memory impairments in depressed subjects may be related to 5-HT undertransmission, and support the notion that 5-HT1A agonists ameliorate memory deficits in depression.Neuropsychopharmacology (2006) 31, 712–720. doi:10.1038/sj.npp.1300869; published online 31 August 2005 [ABSTRACT FROM AUTHOR]

Sequential effects are ubiquitous in experimental psychology. Within visual search, performance is often speeded when participants search for the same target twice in a row, as opposed to two different targets. Here, we investigate such intertrial priming. Two experiments show that factors influencing search processes affect the presence and size of intertrial priming: It is larger when there are fewer elements in the visual display, and larger when there is a salient distractor present than when the target is the only salient element in the display. A control experiment showed that these increased priming effects were not due to longer baseline RTs. These findings, it is argued, are inconsistent with theories that explain intertrial priming as resulting from either only faster visual selection, or from episodic retrieval of responses. Instead, we propose that ambiguity in the stimulus or task underlies the occurrence of intertrial priming. [ABSTRACT FROM AUTHOR]

Visual search is speeded when the target-defining property (a feature- or dimension difference relative to the distractors) is repeated relative to when it changes. It is thought that automatic and implicit intertrial priming mechanisms underlie this effect. However, intertrial priming has been found to be less robust in compound search tasks (in which the response property is unrelated to the target-defining property) than in present/absent search tasks (in which the response is directly related to the presence of a target-defining property). This study explored the hypothesis that intertrial priming is dependent on the level of ambiguity in a task, with the present/absent task being inherently more ambiguous than the compound search task. The first three of five experiments further established the dissociation between the tasks and excluded alternative explanations. Intertrial priming was strong in present/absent and go/no-go tasks, but absent in compound and compound/absent tasks. The last two experiments supported the ambiguity hypothesis by introducing more uncertainty in the compound task, after which intertrial priming returned. [ABSTRACT FROM AUTHOR]

A connectionist model is presented, the TraceLink model, that implements an autonomous “off-line” consolidation process. The model consists of three subsystems: (1) a trace system (neocortex), (2) a link system (hippocampus and adjacent regions), and (3) a modulatory system (basal forebrain and other areas). The model is able to account for many of the characteristics of anterograde and retrograde amnesia, including Ribot gradients, transient global amnesia, patterns of shrinkage of retrograde amnesia, and correlations between anterograde and retrograde amnesia or the absence thereof (e.g., in isolated retrograde amnesia). In addition, it produces normal forgetting curves and can exhibit permastore. It also offers an explanation for the advantages of learning under high arousal for long-term retention. [ABSTRACT FROM AUTHOR]

Memory loss in retrograde amnesia has long been held to be larger for recent periods than for remote periods, a pattern usually referred to as the Ribot gradient. One explanation for this gradient is consolidation of long-term memories. Several computational models of such a process have shown how consolidation can explain characteristics of amnesia, but they have not elucidated how consolidation must be envisaged. Here findings are reviewed that shed light on how consolidation may be implemented in the brain. Moreover, consolidation is contrasted with alternative theories of the Ribot gradient. Consolidation theory, multiple trace theory, and semantization can all handle some findings well but not others. Conclusive evidence for or against consolidation thus remains to be found. [ABSTRACT FROM AUTHOR]

This research explored the absolute accuracy of judgments of learning (JOLs), wherein absolute accuracy pertains to how well the magnitude of the participant's predictions of recall correspond to his or her subsequent recall. The Anchoring Hypothesis proposes that the magnitude of JOLs does not change systematically with item difficulty; analogous to a broken clock that is correct twice a day, the absolute magnitude of JOLs may be accurate by chance and not because of any inherent predictive ability. Alternatively, the Monitoring Hypothesis proposes that the magnitude of JOLs does vary systematically with item difficulty. The Dual-Factors hypothesis proposes that the absolute accuracy of JOLs is affected by some combination of monitoring and anchoring. In four experiments, participants studied a list of paired-associates with a high, medium or low normative proportion of recall, then made JOLs for every item, and subsequently had a recall test. The absolute accuracy of JOLs was investigated both for immediate JOLs and for delayed JOLs. The results were consistent with the Monitoring Hypothesis for delayed JOLs and with the Dual-Factors Hypothesis for immediate JOLs. [ABSTRACT FROM AUTHOR]

Although semantic dementia is primarily characterised by deficits in semantic memory, episodic memory is also impaired. Patients show poor recall of old autobiographical and semantic memories, with better retrieval of recent experiences; they can form new memories, and normal performance on pictorial recognition memory has been demonstrated. As these abnormalities in episodic memory are virtually a mirror image of those seen in the amnesic syndromes, semantic dementia poses a challenge to extant models of remote memory and amnesia. Here, we show that one such model, TraceLink, can reproduce some of the principal findings on episodic memory in semantic dementia. A loss of nodes and connections within the trace system, which can be identified with the temporal neocortical memory storage sites implicated in semantic dementia, simulates without further assumptions the findings reported above. [ABSTRACT FROM AUTHOR]

The hippocampal region, a group of brain structures important for learning and memory, has been the focus of a large number of computational models. These tend to fall into two groups: (1) models of the role of the hippocampal region in incremental learning, which focus on the development of new representations that are sensitive to stimulus regularities and environmental context; (2) models that focus on the role of the hippocampal region in the rapid storage and retrieval of episodic memories. Rather than being in conflict, it is becoming apparent that both approaches are partially correct and might reflect the different functions of substructures of the hippocampal region. Future computational models will help to elaborate how these different substructures interact. [Copyright &y& Elsevier]

We compared judgments of learning (JOLs) that were made either (a) after 1 study trial, (b) 2 study trials, or (c) in-between the 1st and 2nd study trials. In regard to the absolute accuracy of JOLs at predicting subsequent recall, we replicated previous findings of an underconfidence-with-practice effect for immediate JOLs and report for the first time a new finding of an underconfidence-with-practice effect for delayed JOLs (i.e., delayed JOLs after one trial overestimated the likelihood of subsequent recall, whereas delayed JOLs after two trials underestimated that likelihood). Also, although delayed JOLs always had a greater relative accuracy than did immediate JOLs, the relative accuracy of immediate and delayed JOLs was approximately the same after 1 versus 2 study trials. These results demonstrate that additional study trials affect the absolute accuracy of all JOLs but not the relative accuracy of any JOLs. Thus an increase in the number of study trials produced an increasing bias to be underconfident about the subsequent likelihood of recall but did not affect people’s ordering of which items had been more (versus less) well-learned. [Copyright &y& Elsevier]

Consolidation has been implemented in two ways: as straight rehearsal of patterns or as pseudorehearsal, in which pseudoitems are created by sampling attractors or input-output combinations from the network. Although both implementations have been investigated by several authors, few have explored how it is decided which pattern or pseudoitem is consolidated. Controlling consolidation is not trivial, as it is susceptible to a corruption. In runaway consolidation, one or two patterns monopolize all consolidation resources and come to dominate the entire network. Runaway consolidation is analysed, and three solutions are explored. Suppressing transmission in the connections in which consolidation takes place is shown to work best. Placing bounds on connections or unlearning attractors also alleviates runaway consolidation, though less effectively so. [ABSTRACT FROM AUTHOR]

Inclusive education policies stimulate children with special educational needs, including autism, to attend regular education. We aimed to explore change over time in school placement and transitions of autistic children since the introduction of an inclusive education policy in the Netherlands (2014) and to examine the role of individual child characteristics. This study used longitudinal data from 2013 to 2021 on autistic children (N = 1463, aged 5–16 years). We expected an increase in regular school placements and transitions to regular schools. Surprisingly, the proportion of children with autism in regular schools slightly decreased. Special school placement was more likely for boys and autistic children with lower intelligence scores, co-occurring conditions or behavioral and peer relation problems. Younger autistic children and those with lower intelligence scores more often transferred from a regular to a special school. The opposite transition was more common in older autistic children and those with higher intelligence scores. The likelihood of special-to-regular transitions did not change, but regular-to-special transitions were more prevalent during the years just after the policy change than in later years. The inclusive policy had little impact on the school placement, and at most led to a delayed drop in referrals to special schools. [ABSTRACT FROM AUTHOR]

The notion that the brain achieves visual word recognition by encoding the relative positions of letters with open-bigram representations (e.g., 'h-e', 'h-r' and 'e-r' driving recognition of 'her') has been successful in accounting for many behaviors and phenomena. However, one characteristic of open-bigrams has remained unexplored: How is the activation of a bigram modulated by the distance between its constituents in the visual field? On the one hand, contiguous letters (e.g., 'at' in 'father') may allow for a clearer percept of the bigram. On the other hand, an increasing distance between letters (e.g., 'ae' in 'father') should create more certainty about their relative positions, which is precisely what the bigram is meant to convey. This matter was investigated with two experiments in which participants indicated whether target pairs of letters occurred in random letter strings. They were instructed that letter order mattered (i.e., 'a-b' does not occur in 'kbac'), while letter contiguity did not (i.e., 'a-b' occurs in 'akcb'). Controlling for crowding and eccentricity, bigrams were recognized faster upon decreasing the letter distance. However, when switching the target letter order (meaning the string should be met by a 'no' response), shorter letter distances yielded slower responses and more false positives. Neither relative position-coding models nor absolute position-coding models accommodate both these patterns at once. We discuss how a complete account of our effects may instead combine elements from both model types. [ABSTRACT FROM AUTHOR]

This study examines teacher discretion effects in Dutch secondary education for the period 2007–2012. Stark discontinuities are observed in the exam grade distribution for high-stakes retaking students and are located at important graduation thresholds. This phenomenon is systematically related to the level of discretion when grading the exam, with results suggesting that approximately 11% of all graduating retakers did so because of teacher discretion. This yields unequal graduation opportunities that are the result of school- and subject choice patterns, since teacher discretion is structurally and selectively exerted at the school-level with the objective to let students on the margin graduate. [ABSTRACT FROM AUTHOR]

Early Warning Systems (EWS) in higher education accommodate student counsellors by identifying at‐risk students and allow them to intervene in a timely manner to prevent student dropout. This study evaluates an EWS that shares student‐specific risk information with student counsellors, which was implemented at a large Dutch university. A randomised field experiment was conducted to estimate the effect of EWS‐assisted counselling on first‐year student dropout and academic performance. The results show that the EWS accurately predicts at‐risk students. Yet, EWS‐assisted counselling did not reduce dropout, nor improved academic performance. Solving the underlying problem of poor academic performance might require additional actionable feedback and recommended counselling practices. [ABSTRACT FROM AUTHOR]

For over a century, stability of spatial context across related episodes has been considered a source of memory interference, impairing memory retrieval. However, contemporary memory integration theory generates a diametrically opposite prediction. Here, we aimed to resolve this discrepancy by manipulating local context similarity across temporally disparate but related episodes and testing the direction and underlying mechanisms of memory change. A series of experiments show that contextual stability produces memory integration and marked reciprocal strengthening. Variable context, conversely, seemed to result in competition such that new memories become enhanced at the expense of original memories. Interestingly, these patterns were virtually inverted in an additional experiment where context was reinstated during recall. These observations 1) identify contextual similarity across original and new memories as an important determinant in the volatility of memory, 2) present a challenge to classic and modern theories on episodic memory change, and 3) indicate that the sensitivity of context-induced memory changes to retrieval conditions may reconcile paradoxical predictions of interference and integration theory. [ABSTRACT FROM AUTHOR]

The current multilevel meta-analyses and systematic review encompass 47 longitudinal studies of motivation and academic achievement in primary and secondary education. Our inclusion criteria extended beyond studies centred on self-belief type of motivation constructs, as we also selected studies using other motivation constructs (e.g. achievement goals). The findings offered mixed support for the reciprocity. The pooled effect of achievement on motivation was nearly twice as strong (β = 0.176) as that of motivation on achievement (β = 0.096). The effect of achievement on motivation held across different motivation constructs, albeit exhibiting more robust reciprocity for self-belief constructs (β = 0.227) than for other constructs (β = 0.091). The effect of motivation on achievement was exclusively found for self-belief (β = 0.157) and not for non-self-belief motivation. Overall, the medium-to-high heterogeneity between studies and within studies suggests that pivotal factors in the motivation–achievement dynamics may not have been captured yet. [ABSTRACT FROM AUTHOR]

Individuals with autism increasingly enroll in universities, but little is known about predictors for their success. This study developed predictive models for the academic success of autistic bachelor students (N = 101) in comparison to students with other health conditions (N = 2465) and students with no health conditions (N = 25,077). We applied propensity score weighting to balance outcomes. The research showed that autistic students' academic success was predictable, and these predictions were more accurate than predictions of their peers' success. For first-year success, study choice issues were the most important predictors (parallel program and application timing). Issues with participation in pre-education (missingness of grades in pre-educational records) and delays at the beginning of autistic students' studies (reflected in age) were the most influential predictors for the second-year success and delays in the second and final year of their bachelor's program. In addition, academic performance (average grades) was the strongest predictor for degree completion in 3 years. These insights can enable universities to develop tailored support for autistic students. Using early warning signals from administrative data, institutions can lower dropout risk and increase degree completion for autistic students. Laymen Summary: What is already known about the topic? Autistic youths increasingly enter universities. We know from existing research that autistic students are at risk of dropping out or studying delays. Using machine learning and historical information of students, researchers can predict the academic success of bachelor students. However, we know little about what kind of information can predict whether autistic students will succeed in their studies and how accurate these predictions will be. What does this article add? In this research, we developed predictive models for the academic success of 101 autistic bachelor students. We compared these models to 2,465 students with other health conditions and 25,077 students without health conditions. The research showed that the academic success of autistic students was predictable. Moreover, these predictions were more precise than predictions of the success of students without autism. For the success of the first bachelor year, concerns with aptitude and study choice were the most important predictors. Participation in pre-education and delays at the beginning of autistic students' studies were the most influential predictors for second-year success and delays in the second and final year of their bachelor's program. In addition, academic performance in high school was the strongest predictor for degree completion in 3 years. Implications for practice, research, or policy These insights can enable universities to develop tailored support for autistic students. Using early warning signals from administrative data, institutions can lower dropout risk and increase degree completion for autistic students. [ABSTRACT FROM AUTHOR]

During reading, word recognition speed is influenced by the amount of orthographic overlap with surrounding words. The nature of this phenomenon is not understood: some theories attribute it to low-level visual operations (i.e., parafoveal feature detectors influencing foveal letter detectors), whereas other theories assume that orthographic processing (i.e., letter position coding and word activation) occurs across multiple words in parallel. To arbitrate between these theories, we used electroencephalography to reveal the time course of orthographic spatial integration in a lexical decision task. Foveal target words were flanked on each side by parafoveal words, manipulated across three conditions: repetition flankers (e.g. rock rock rock), unrelated flankers (step rock step) and a no-flanker condition. Linear mixed-effect models were constructed to analyze EEG data on a trial-by-trial basis. Word recognition was worse in the unrelated flanker condition than in the repetition and no-flanker conditions. This behavioral pattern was accompanied by increased negativity in the N250 and N400 windows, associated with the activation of sub-lexical and lexico-semantic representations, respectively. Crucially, the absence of effects prior to 200 ms post-stimulus onset provides evidence against the involvement of low-level visual processes. We conclude that orthographic spatial integration is driven by parallel processing of multiple words, which leads to the activation of a larger set of sub-lexical nodes and more difficult processing at the lexical level when those words are orthographically unrelated. • Words are recognized faster when they share many letters with surrounding words. • EEG measurements suggest that this effect unfolds 200 ms after stimulus onset. • The locus of effects contradicts the involvement of low-level visual processing. • Instead, the phenomenon appears to be driven by parallel orthographic processing. [ABSTRACT FROM AUTHOR]