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We present a 48-year-old male patient with a mass in the tail of the pancreas on abdominal ultrasonography. The lesion was suspicious for a well-differentiated pancreatic neuroendocrine tumor and spleen preserved distal pancreatectomy surgery was performed. It was diagnosed as intrapancreatic accessory spleen (IPAS) after pathological examination. Accessory spleen is not an infrequent congenital entity caused by the localization of normal splenic tissue in ectopic regions. As it is known, an accessory spleen is a benign entity and does not require surgical treatment or follow-up when detected. However, it is important to recognize IPAS tissue as it may mimic a pancreatic neoplasia when it is located in the pancreas. In this article, we discuss the differential diagnostic possibilities of the IPAS entity.

Ağır konjenital nötropeniler (AKN), nadir görülen olgun nötrofillerin eksikliği ile karakterize primer bir immün yetersizlik hastalığıdır. Klinik özellikler arasında doğumdan itibaren azalmış mutlak nötrofil sayısı, tekrarlayan ve yaşamı tehdit eden enfeksiyonlar vardır. Ayıca miyelodisplastik sendrom, akut miyeloblastik lösemi riskinde artış vardır. Dört yaş kız çocuğu sık tekrarlayan ağız içi yaraları, tonsillofarenjit, yumuşak doku ve akciğer enfeksiyonları ile başvurdu. Hastanın şikâyetleri nedeniyle bir kez yoğun bakımda olmak üzere birçok kez hastaneye yatışları olmuş. Tekrarlayan enfeksiyonlar nedeniyle bir yılda yaklaşık 15 kez intravenöz veya oral antibiyotik ihtiyacı olduğu öğrenildi. Hasta ateş, halsizlik ve frontal bölgede şişlik, kızarıklık şikâyetleri ile kliniğimize başvurdu. Öyküsünde, bir yıl önce de frontal bölgede apse gelişen hastaya drenaj ve antibiyotik tedavisi uygulandığı öğrenildi. Anne baba arasında akrabalık mevcuttu. Ailede benzer şikâyetleri olan bireyler yoktu. Hastamızın genetik analizinde HAX1 (HCLS1 ilişkili protein X-1) geninde homozigot mutasyon saptandı ve AKN tip 3 tanısı konuldu. Anne ve baba da aynı heterozigot mutasyon vardı. Özellikle tekrarlayan enfeksiyonlar ve nötropeni tespit edilen hastalarda nadir görülen bir hastalık olan Kostmann sendromunun ayırıcı tanıda düşünülmesi gerektiğini vurgulamak amacıyla bu vakayı sunduk, Severe congenital neutropenia (SCN) is a primary immune deficiency disease characterized by a rare deficiency of mature neutrophils. Clinical features include recurrent and life-threatening infections and a reduced absolute neutrophil count from birth. There is also an increased risk of myelodysplastic syndrome and acute myeloblastic leukemia. A four-year-old girl has recurrent oral aft, tonsillopharyngitis, soft tissue, and lung infections. Due to the complaints of the patient, she was hospitalized several times, once in intensive care. She needed intravenous or oral antibiotics about 15 times a year due to recurrent infections. The patient applied to our clinic with fever, fatigue, swelling, and redness in the frontal region. In her history has the patient was administered drainage and antibiotic therapy one year ago due to an abscess in the frontal region. There was a kinship between the parents. There were no individuals with similar complaints in the family. In our patient’s genetic analysis, there was a homozygous mutation in the HAX1 (HCLS1-associated protein X-1) gene, and SCN type 3 was diagnosed. The heterozygous same mutation was present in the mother and father.We reported this case to emphasize that Kostmann Syndrome as a rare disease in children with recurrent infections and neutropenia.

Introduction: Intestinal ischemia/reperfusion (I/R) is a serious life-threatening clinical case. Overproduction of reactive oxygen species (ROS) associated with oxidative stress plays a key role in I/R pathophysiology. Objective: The aim of this study is to evaluate dynamic thiol / disulfide hemostasis in intestinal I/R in rats. Materials and Methods: 24 Winstar albino rats were divided into 3 groups (8 animals in each group: (1) sham (operation without ischemia), (2) ischemia (90 minutes ischemia), (3) ischemia/reperfusion (after ischemia for 30 minutes reperfusion for 60 minutes). At the end of the process, liver samples were evaluated pathologically. Also, in plasma samples, native thiol, disulphide and total thiol levels were measured. Results: Native thiol levels in ischemia and I/R group were found to be significantly lower compared to the sham group (P

Oculocutaneous albinism (OCA) is a disorder of melanin biosynthesis characterized by hypopigmentation of the skin, hair, and retinal pigment epithelium. We present the clinical and laboratory features of two siblings, born to consanguineous Turkish parents, who were diagnosed with autosomal recessive OCA type 7. We detected a homozygous mutation in the C10ORF11 gene (p.A23Rfs * 39) in both patients. Interestingly, the medical history revealed that both patients had suffered from recurrent respiratory tract infections since birth. The patients were investigated for suspected immunodeficiency and the results of the immune screening assays were normal. We believe these patients are noteworthy to report since presentation with infections has not been described in the prior descriptions of OCA type 7. As of this current writing, infectious problems have stopped in one of our cases since the age of five and a half years. Keywords: Oculocutaneous albinism type 7, recurrent infection, immune system, genetic analysis, C10ORF11 gene

The aim of this study was to determine the clinicopathological features of papillary thyroid carcinomas (PTC) without extrathyroidal extension (ETE) and with lymph node metastasis (LNM). PTC1 cm increased the risk of LNM by 2.161 times compared to papillary thyroid microcarcinoma. The risk increased by 3.774 times in males and 1.553 times in the presence of multifocality. Presence of vascular invasion (VI) increased the risk of LNM by 3.093 times in patients without capsular invasion (CI). Clinicians should be careful about possible LNM in patients with large primary tumor diameter, multifocal tumors, CI and VI.

Kısadere, İhsan (Balikesir Author), Introduction: Evaluation of health status and physical condition of Kyrgyz Judo Athletes before the Olympic Games. Objective: To evaluate changes in hematological, biochemical and blood gas values of athletes during the training period. Methods: Eight elite athletes (n=8 men), participated to the study. Before and after the exercise periods (baseline, 3rd month and 6th month), blood samples were taken, to determine plasma red blood cell (RBC), white blood cell (WBC), blood clot cell (PLT), granulocyte (NOTR) and agranulocyte (LNF) counts, hemoglobin (HGB) and hematocrit (HCT) values, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and venous blood pH, PO2, PCO2, SAT O-2, HCO3, BE, Na, K, Cl values. In addition, serum glucose (Glu), total protein (TP), total cholesterol ( TC), HDL cholesterol, triglyceride (Trig), blood urea nitrogen (BUN), creatinine (Creat), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK) values were measured. Results: Although, the athletes' WBC and LNF counts increased significantly (p0.05) was found in the other hematological parameters. Blood pH, pCO(2), HCO3 and BE values decreased (P, Kyrgyz Turkish Manas University KTMU-BAP 2015.FBE.06 Olympic Sports Directorate of the Ministry of Sports of Kyrgyzstan

Physical urticaria is a heterogeneous group of inducible conditions in which symptoms are induced by exogenous physical triggers such as cold, water, heat, and mechanical stimuli, acting on the skin. Our case involves a sixteen-year-old female patient who presented with erythema, small wheals and pruritus on her skin after contact with water and cold. After conducting water and ice cube provocation tests in addition to her medical history and physical examination, the patient was diagnosed with aquagenic urticaria (AU) and cold urticaria (CU). Her complaints had started 20 days before presentation. Regardless of the temperature and the source of water, her symptoms increased after contact with water, and the physical examination disclosed thoracic scoliosis. Symptoms were significantly relieved after one month of antihistamine and liquid petrolatum treatment. However, the patient developed complaints of urticaria, itching and angioedema in the contact areas of the body after contact with cold air, cold water, and cold objects in the winter season. She was tested with ice cubes and the result was positive. We started treatment with omalizumab, and her symptoms improved at the eighth week of this treatment. Here we present an adolescent female patient diagnosed with CU and AU.

Background Cystic fibrosis (CF) is a lethal recessive genetic disease caused by loss of function associated with mutations in the CF trans-membrane conductance regulator. It is highly prevalent (approximately 1 in 3,500) in Caucasians. The aim of this study was to compare demographic and clinical features, diagnostic tests, treatments, and complications of patients with CF whose newborn screening (NBS) with twice-repeated immune reactive trypsinogen testing was positive, normal, and not performed. Methods In this study, 359 of all 1,488 CF patients recorded in the CF Registry of Turkey in 2018, who had been born through the process of NBS, were evaluated. Demographic and clinical features were compared in patients diagnosed with positive NBS (Group 1), normal (Group 2), or without NBS (Group 3). Results In Group 1, there were 299 patients, in Group 2, there were 40 patients, and in Group 3, there were 20 patients. Among all patients, the median age at diagnosis was 0.17 years. The median age at diagnosis was higher in Groups 2 and 3 than in Group 1 (P = 0.001). Fecal elastase results were higher in Group 2 (P = 0.033). The weight z-score was lower and chronic Staphylococcus aureus infection was more common in Group 3 (P = 0.017, P = 0.004, respectively). Conclusions Frequency of growth retardation and chronic S. aureus infection can be reduced with an early diagnosis using NBS. In the presence of clinical suspicion in patients with normal NBS, further analyses such as genetic testing should be performed, especially to prevent missing patients with severe mutations.

© 2022 Wiley Periodicals LLC.Background: Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease. Methods: Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data. Results: There were 1170 people with CF in 2017 and 1637 in 2019 CF registry. Eight hundred and fourteen people were registered in both 2017 and 2019 of whom z-scores of heights and BMI were significantly higher in 2019 (p = 0.002, p =0.039, respectively). Inhaled hypertonic saline, bronchodilator, and azithromycin usages were significantly higher in 2019 (p =0.001, p = 0.001, p = 0.003, respectively). The percent predicted of forced expiratory volume in 1 sec and forced vital capacity were similar in 2017 and 2019 (88% and 89.5%, p = 0.248 and 84.5% and 87%, p =0.332, respectively). Liver diseases and osteoporosis were significantly higher, and pseudo-Bartter syndrome (PBS) was significantly lower in 2019 (p = 0.011, p = 0.001, p = 0.001, respectively). Conclusions: The z-scores of height and BMI were higher, the use of medications that protect and improve lung functions was higher and incidence of PBS was lower in 2019. It was predicted that registry system increased the care of people with CF regarding their follow-up. The widespread use of national CF registry system across the country may be beneficial for the follow-up of people with CF.

SUMMARY OBJECTIVE: In this retrospective study, we aimed to determine factors associated with bleeding complications in patients on long-term warfarin, undergoing inguinal hernia repair using low-molecular-weight heparin (LMWH) bridging. METHODS: Two-year hospital records yielded 44 inguinal hernia repair patients on long-term warfarin (26 men, 4 women, aged 57.4 [38–72] years). All patients were managed with LMWH bridging. Patient and operative characteristics, LMWH bridging characteristics, and international normalized ratio (INR) values were compared between patients with and without postoperative bleeding complications. RESULTS: Indication for warfarin use was heart valve disease (n=15), atrial fibrillation (n=7), deep venous thrombosis (n=3), cerebrovascular event (n=3), and pulmonary embolism (n=2). Four of the operations were urgent, while the remaining were elective. There were four ecchymosis cases and three hematoma cases in a total of seven patients. Baseline (2.94±0.26 versus 2.16±0.38, p

BackgroundHallux valgus, one of the most common deformities of the great toe, may cause pain, dysfunction, and impaired gait pattern. In this retrospective study we report the results of a new type of distal metatarsal osteotomy combined with distal soft-tissue release in patients with mild-to-moderate hallux valgus deformity.MethodsThis new technique was used in the management of 32 feet of 31 patients (eight men and 23 women) with mild-to-moderate hallux valgus. Hallux valgus angle, intermetatarsal angle, and distal metatarsal articular angle were measured on preoperative, early postoperative (6–8 weeks), and late (1 year) postoperative radiographs. American Orthopaedic Foot and Ankle Society hallux metatarsophalangeal score was calculated. Sesamoid position, by considering medial sesamoid position, and metatarsal shortness were also measured.ResultsStatistically significant differences were detected between the preoperative and late postoperative measurements of the hallux valgus angle, distal metatarsal articular angle, intermetatarsal angle, and sesamoid position parameters in patients operated on with this technique. Improvement was 14° for the hallux valgus angle, 4° for the distal metatarsal articular angle, and 4° for the intermetatarsal angle. Sesamoid position was also improved, and the mean American Orthopaedic Foot and Ankle Society score was significantly improved. Metatarsal shortness greater than 2 mm was observed in two patients without resulting in any clinical discomfort.ConclusionsThis new technique was easy, safe, and promising in patients diagnosed as having mild-to-moderate hallux valgus deformity.

Background In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine (RAI) for hyperthyroidism years ago. Methods Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated with fine-needle aspiration biopsy (FNAB) were included in the study. Results There were 27 patients (22 female and 5 male) with a mean age of 59.3 ± 13.5. The indication for RAI treatment was Graves in 5 (18.6%), toxic nodular or multinodular goiter in 16 (69.2%), and unknown in 6 (22.2%) patients. A total of 48 thyroid nodules were evaluated with FNAB and cytological diagnosis were benign in 24 (50.0%), nondiagnostic in 15 (31.2%), atypia of undetermined significance in 5 (10.4%), suspicous for malignancy in 2 (4.2%), and malignant in 2 (4.2%) nodules. Thyroidectomy was performed in 10 patients, 5 were benign (50.0%), and 5 (50.0%) were malignant histopathologically. Ultrasonography features of 31 cytologically/histopathologically benign and five cytologically/histopathologically malignant nodules were compared. Prevalence of isoechoic nodules was higher in benign nodules (P = .025). Macrocalcification was observed in 4 (80.0%) of malignant and 10 (32.3%) of benign nodules (P = .042). Conclusion In patients with a history of RAI treatment for hyperthyroidism, thyroid nodules with suspicious ultrasonography features, particulary hypoechoic appearence and macrocalcification, should be evaluated with FNAB irrespective of the time elapsed after RAI treatment.

This study investigated the relationship between the types of pollen in the air and sensitization to pollen in a skin prick test in allergic children. The pollen in the atmosphere of Elazig city was measured between June 2013 and June 2014. The study included 520 children with allergic complaints. In the atmosphere of Elazig city, pollen belonging to a total of 38 taxa was identified, including 20 woody plants and 18 herbaceous plants. The annual pollen integral of 108,313 pollen day/m3 from the 38 taxa was identified. The most common pollen detected was woody plants (76.4%), weeds (14.1%), Poaceae (Gramineae) (9.1%), and unidentified plants (0.4%). The skin prick test in allergic children found that they were most commonly sensitized to mixture of grasses and cereals (43.8%), weed (14.1%), tree mixture I (10.1%), and tree mixture II (7.9%). There was no direct relationship between the frequency of pollen types in the atmosphere and the sensitization frequency to pollen, as identified by the skin prick test in allergic patients. We believe that the data from this study will provide new information to other researchers and clinicians in the evaluation of allergic diseases.

Objectives Moving from the point that there might be an association between the neuroanatomy of obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder, we decided to examine the volumes of hippocampus and amygdala of patients with obsessive-compulsive personality disorder, which was previously evaluated in OCD patients by us. Methods Volumes of the hippocampus, and amygdala were measured by magnetic resonance imaging (MRI) in patients with obsessive-compulsive personality disorder and healthy control subjects. Manual tracing was used. Results We detected that the mean left and right sides of hippocampus and amygdala volumes of the patients with obsessive-compulsive personality disorder were smaller than those of the healthy controls. Conclusion Consequently, our present results suggest that hippocampal and amygdalar structural abnormalities may be related to the neuroanatomy of obsessive-compulsive personality disorder. However, it is required novel studies with larger sample.

Background: The association between vitamin D receptor (VDR) polymorphisms and the risk of asthma remains unclear. This study aimed to investigate the effect of VDR gene polymorphisms and VDR mRNA expression levels on respiratory function, nitric oxide levels in expiratory air, and serum vitamin D levels in children with asthma. Materials and Methods: The study included 80 healthy children (control group) and 100 asthmatic children (asthma group) between the age of 5 and 18 years. The VDR genotypes (ApaI, TaqI, and FokI) and VDR mRNA levels were determined in all groups. Results: There was no statistically significant difference in vitamin D levels between the asthma group and the control group (P > 0.05). A significant association was found between both genotype (CC) of the TaqI polymorphism [odds ratio (OR) = 0.2, 95% confidence interval (CI) (0.07–0.5), P = 0.003] and genotype (CA) of ApaI polymorphisms [OR = 0.2, 95% CI (0.07–0.8), P = 0.02], and asthma risk. In addition, when single-nucleotide polymorphism allelic frequencies between asthma and control groups were compared there is no significant association (P > 0.05). When compared to control group, VDR mRNA expression in asthma group decreased in genotypes CC and CA of ApaI and in genotypes TT and TC of TaqI (P

Objectives Obsessive compulsive personality disorder (OCPD) is currently thought to bear a close relationship with obsessive-compulsive disorder (OCD), and other compulsive disorders such as eating disorder and autistic spectrum disorder, as well as with the personality disorders, focusing on some important dimensions like phenomenology, heritability, environmental risk factors, comorbidity, course of illness, neurocognitive endophenotypes, and treatment response. In the present study, when we have taken into consideration the knowledge aforementioned, we aimed to examine OFC and thalamus volumes in patients with OCPD. Methods We comparatively measured orbito-frontal cortex (OFC) and thalamus volumes of patients with OCPD and healthy control subjects. Results Patients with OCPD had considerably smaller left and right OFC volumes compared to those of healthy control subjects. We also found that thalamus volumes of patients were statistically significantly greater than those of healthy comparisons for both sides of region of interest. Conclusions We consider that volumetric alterations determined in the present study may be involved in the pathophysiology of the OCPD, considering that OCPD might be related to OCD spectrum disorders neuroanatomically.

Aim: For adrenal lesions which are functional and bigger than four centimeters, the optional therapy is surgery. Laparoscopy for the surgery of adrenal masses is increasingly used today. In the past, total adrenalectomy was performed for any adrenal lesions without any exception; however, bilateral involvement of tumors like pheochromocytoma causes trouble and forced surgeons to try partial adrenalectomy. Recently, partial adrenalectomy is a routine surgical procedure for bilateral lesions and also becoming common for unilateral lesions. We aimed to present short-term results for patients who undergo laparoscopic total or partial adrenalectomy.Material and Method: We collect data retrospectively for 33 patients who were operated on in our clinic for adrenal mass between January 2010 and December 2014. 3 patients were excluded from the study. All data were gained from personal patient medical records. Follow-up records were noted with one-by-one interviews by questioning steroid usage and symptoms of adrenal insufficiency.Results: Patients were divided into two groups as total adrenalectomy group with 19 patients and partial adrenalectomy group with 11 patients. All patients who underwent total adrenalectomy have unilateral lesions, while 4 for 11 partial adrenalectomy patients have bilateral adrenal masses. Adrenal insufficiency developed in 3 patients for total adrenalectomy, 1 patient for unilateral partial adrenalectomy, and 1 patient for bilateral partial adrenalectomy.Conclusion: Partial adrenalectomy appears to be protective for adrenal insufficiency for bilateral cases with a ratio of 75%. there was no significant difference between the total or partial unilateral adrenalectomy group, considering postoperative complications, recurrence rates, and insufficiency. As a result, laparoscopic partial adrenalectomy has similar results with less morbidity for unilateral lesions and an alternative method with less adrenal insufficiency for bilateral lesions. Laparoscopic partial adrenalectomy could be performed safely after the learning period was completed and should be considered for adrenal surgeries., Amaç: Adrenal kitleler fonksiyonel ve 4 cm üzerindeyse ilk tercih adrenalektomidir. Günümüzde adrenal kitlelerin cerrahisi için laparoskopi yaygın olarak kullanılmaktadır. Tarihsel olarak adrenal kitleler için total adrenalektomi uygulanmıştır. Fakat bilateral tutulumu olan feokromasitoma gibi olgular nedeniyle ilk kez parsiyel adrenalektomi gündeme gelmiştir. Günümüzde bilateral olgularda parsiyel adrenalektomi rutin olarak uygulanmakta iken tek taraflı benign lezyonlarda da uygulanması giderek yaygınlaşmaktadır. Bu çalışmada laparoskopik total ve parsiyel adrenalektomi yapmış olduğumuz olguları kısa dönem sonuçlarını sunmayı amaçlıyoruz.Gereç ve Yöntem: Çalışma Ocak 2010-Aralık 2014 tarihleri arasında adrenal kitle nedenli opere edilen hastaların verileri retrospektif olarak taranması ile yapılmıştır. Belitilen tarihler arasında 33 hastanın sürrenal adenoma nedenli ameliyata alındığı görülmüştür. Çalışmaya dahil edilme kriterlerine uymayan 3 hasta çalışma dışında bırakılmıştır. Çalışmaya dahil edilen 30 hastanın demografik verileri ve yapılan cerrrahi türü hasta dosyalarından öğrenilmiştir. Hastalar kontrole çağırılarak adrenal yetmezlik gelişip gelişmediği ve steroid replasman tedavisi alıp almadıkları sorgulanmıştır.Bulgular: Çalışmaya alınan 30 hastanın 19’u total adrenalektomi yapıldığı, 11’i parsiyel adrenalektomi yapıldığı görüldü. Total adrenalektomilerinin hepsi unilateral iken parsiyel yapılan ameliyatların 7’si unilateral parsiyel 4’ü bilateral parsiyel adrenalektomi yapılmış olduğu görüldü. Total adrenalektomi yapılan hastaların postoperatif dönemde 3’ünde adrenal yetmezlik gelişirken unilateral parsiyel ve bilateral parsiyel adrenalektomi yapılan hasta gruplarınında birer hastada adrenal yetmezlik geliştiği görüldü.Sonuçlar: Parsiyel adrenalektomi bilateral olgularda %75 oranında adrenal yetmezlikten korumuştur. Tek taraflı lezyonlarda da nüks, yetmezlik ve peroperatif komplikasyonlar açısından parsiyel ile total arasında fark yoktur. LPA öğrenme eğrisi tamamlandıktan sonra güvenle uygulanabilir. Bilateral adrenalektomi yapılan hastaların çoğunu yetmezlikten korur. Tek taraflı lezyonlarda uygulaması kolay ve hastaya bir zarar vermediği gibi muhtemel faydaları olaçağına inanıyoruz.

Inclusion of baked-milk products to the diet appears to markedly accelerate tolerance to unheated milk compared to a strict avoidance diet.: The present study aims to investigate the predictors of baked-milk tolerance in children with Immunoglobulin E (IgE)-mediated cow's milk (CM) allergy.The study included 80 patients diagnosed with IgE-mediated CM allergy upon oral food challenge (OFC) testing at our clinic. Patients who developed and did not develop reactions during OFC with baked milk were compared considering clinical and laboratory parameters.Eighty patients with CM allergy comprised 48 male and 32 female infants with an average age of 7.25 ± 2.45 (3-13) months. We found that 62.5% of them showed tolerance to baked milk in the OFC test performed with cakes containing 2.6-g milk protein. When the patients who tolerated and could not tolerate baked-milk products were compared for test results, we detected a statistically significant intergroup difference regarding diameter of wheal in skin prick test (SPT) performed with muffin slurry, levels of specific Immunoglobulin E (sIgE) in CM, sheep's milk (SM), goat's milk (GM), casein, and the amount of unheated milk consumed until a reaction developed in the OFC test performed with unheated milk (P0.05).We defined novel decision points based on CM, SM, GM, casein sIgE levels, wheal diameter in SPT with muffin slurry, and the amount of milk ingested during OFC performed with unheated milk that may be useful in predicting outcomes of baked-milk ingestion.

Harmanci, Koray/0000-0002-8494-648X; Sismanlar Eyuboglu, Tugba/0000-0001-7284-4999; Aslan, Ayse Tana/0000-0002-5360-8517 WOS: 000535323700001 PubMed: 32453906 Background A better understanding of cystic fibrosis transmembrane conductance regulator biology has led to the development of modulator drugs such as ivacaftor, lumacaftor-ivacaftor, tezacaftor-ivacaftor, and elexacaftor-tezacaftor-ivacaftor. This cross-sectional study evaluated cystic fibrosis (CF) patients eligible for modulator drugs. Methods Data for age and genetic mutations from the Cystic Fibrosis Registry of Turkey collected in 2018 were used to find out the number of patients who are eligible for modulator therapy. Results Of registered 1488 CF patients, genetic analysis was done for 1351. The numbers and percentages of patients and names of the drugs, that the patients are eligible for, are as follows: 122 (9.03%) for ivacaftor, 156 (11.54%) for lumacaftor-ivacaftor, 163 (11.23%) for tezacaftor-ivacaftor, and 57 (4.21%) for elexacaftor-tezacaftor-ivacaftor. Among 1351 genotyped patients total of 313 (23.16%) patients are eligible for currently licensed modulator therapies (55 patients were shared by ivacaftor and tezacaftor-ivacaftor, 108 patients were shared by lumacaftor-ivacaftor and tezacaftor-ivacaftor, and 22 patients were shared by tezacaftor-ivacaftor and elexacaftor-tezacaftor-ivacaftor groups). Conclusions The present study shows that approximately one-fourth of the registered CF patients in Turkey are eligible for modulator drugs. As, frequent mutations that CF patients have in Turkey are different from North American and European CF patients, developing modulator drugs effective for those mutations is necessary. Furthermore, as modulator drugs are very expensive currently, financial support of the government in developing countries like Turkey is noteworthy.

BACKGROUND Regular exercise activities affect blood cells. OBJECTIVE The purpose of this study was to evaluate the seasonal evaluation of some hematological and biochemical parameters of the Olympic Greco-Roman wrestlers. METHODS A total of three measurements were performed on wrestlers: immediately before the training period, three months and six months after the training session. Hematological and biochemical parameters were analyzed by taking sufficient blood samples from the athletes before and after exercise. RESULTS The total leukocyte, lymphocyte, and neutrophil values were found to be significantly higher (p< 0.05) in all three measures (beginning, 3rd and 6th months) in comparison with the values before exercise. When biochemical analyses were examined, blood glucose levels were significantly decreased after exercise in all three measures compared to before exercise. Post-exercise HDL cholesterol concentrations significantly increased (p< 0.05) while LDL cholesterol concentrations significantly decreased (p< 0.05). CONCLUSION On all three measures fatigue exercise has significantly increased the total leukocyte, lymphocyte and neutrophil values of wrestlers, while other, hematological parameters were not affected evenly. Fatigue exercise also significantly reduced blood glucose levels and LDL cholesterol concentrations, while HDL cholesterol concentrations were increased. The six-month period training did not have a significant effect on both hematologic and biochemical parameters in all three measurements.

PubMed ID: 30461227, Background and objectives: The accurate identification of hyper functioning parathyroid gland is needed for definitive surgical treatment in primary hyperparathyroidism. Ultrasonography and 99mTechnetium sestamibi scintigraphy are the two most used methods with varying sensitivities. This study aimed to assess the value of parathyroid hormone (PTH) assay in preoperative ultrasound guided fine needle aspiration (FNA)-PTH washout fluid to verify the correct localisation of lesions with negative or inconclusive scintigraphy results. Methods: We evaluated data of 28 lesions in 21 patients who underwent US-guided parathyroid fine-needle aspiration (FNA) with PTH washout, retrospectively. The PTH washout results and the reports of parathyroid surgery and imaging studies were reviewed. Results: Of operated 28 lesions 23 had positive and 5 had negative washout results. The median FNA-PTH washout was 2315.5 pg/ ml (min–max: 12.3-6978 pg/ ml). The calculated sensitivity of FNA-PTH washout was 85.7% and the specifity was 28.6%. The positive and negative predictive values were 78.3% and 40.0%, respectively. Conclusions: FNA-PTH can be used to establish the nature of the lesion, discriminate parathyroid gland from thyroid lesions or cervical lymph nodes, improving the surgical outcomes. It can be used to localise parathyroid lesions preoperatively when negative or discordant ultrasound and scintigraphy findings are obtained. © 2018 Wiley Periodicals, Inc.

Objectives Pycnogenol® (PYC®), a standardized extract from the bark of Pinus maritima, consists of different phenolic compounds. PYC® has shown to have protective effects on chronic diseases such as diabetes, asthma, cancer, and immune disorders. The aim of this study was to determine the effects of PYC® against the DNA damage and biochemical changes in blood, liver, and lung tissues of ischemia-reperfusion (IR)-induced Wistar albino rats. Materials and Methods A sham group, IR injury-induced group, and IR+PYC® group were formed. Ischemia was induced and sustained for 45 min, then the ischemic liver was reperfused, which was sustained for a further 120 min at the end of this period. After anesthesia and before the IR inducement, 100 mg/kg PYC® was given to the IR+PYC® group through intraperitoneal injections. The total oxidant (TOS) and total antioxidant status (TAS), total thiol levels (TTL), advanced oxidation protein products (AOPP), and biochemical parameters [myeloperoxidase (MPO), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH)] in the rats were analyzed using spectrophotometric methods and DNA damage was assessed using single-cell gel electrophoresis. Results The levels of TOS, TTL, MPO, AOPP, ALT, AST, and LDH were significantly decreased in the IR+PYC® group compared with the IR group (p

In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated.In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. The lesion slides were scanned. The WSI was rendered digital. The histopathological slide images scanned with USG images were matched. With the İmage J program, the areas of cell types and morphological changes were measured.In parathyroid neoplasms, hypoechoic areas were found to be matched with 21% [55.3%] chief cell, 2 [5.0%] oncocytic cell and 8%[20.0%] cystic morphology. Of the 57 patients, 26 [45.61%] had a cystic area. It was seen that hyperechogenic areas match more connective tissue areas than chef cell [p 0.05]. There was less clear cell in hyperechogenic areas than iso-hyperechogenic areas [p 0.05]. The ratio of fat tissue echogenicity was lower in hypoechoic areas than hyperechoic [p 0.05]. There was a positive correlation between PTH and the entire tissue area [r = 0.377, p = 0.004]. A positive directional moderate linear relationship was found between blood calcium level and parathyroid adenoma [rho = 0.530, p = 0.009] and percentage [rho = 0.416, p = 0.048]. When atypical adenomas and adenoma cases were compared, no significant difference was found between the cystic and chief cell areas [p 0.05].The hypoechogenicity seen in USG was observed to be compatible with chief cell, hyperechogenic areas in USG were compatible with connective tissue and fat tissue. As the cystic area increased, blood calcium levels were higher in adenomas. We think that the results of this study will be guiding to evaluate the reflections of the detailed morphometric studies.

Introduction: Delusional disorder shares some clinical characteristics of OCD and hypochondriasis. Delusions compared to obsessions in the OCD and compared to bodily preoccupations in the hypochondriasis are more established beliefs. Aim: To measure pituitary volumes in patients with delusional disorder and hypothesized that volumes would be reduced in those patients by a mechanism that we could not account for before for patients with OCD and hypochondriasis. Methods: Eighteen patients with delusional disorder and healthy controls were included into the study. Pituitary gland volumes were measured. Results: When using independent t test, the mean total pituitary volume was 777.22±241.28 mm3 in healthy controls, while it was 532.11±125.65 mm3 in patients with delusional disorder. The differences in regard to pituitary gland volumes between patients with delusional disorder and healthy control subjects were statistically meaningful (p