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2 results on '"Mehrjardi A.Z."'

1. Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomas.

Author

Martinez, A., Ponzoni, M., Agostinelli, C., Hebeda, K.M., Matutes, E., Peccatori, J., Campidelli, C., Espinet, B., Perea, G., Acevedo, A., Mehrjardi, A.Z., Martinez-Bernal, M., Gelemur, M., Zucca, E., Pileri, S., Campo, E., Lopez-Guillermo, A., Rozman, M., Martinez, A., Ponzoni, M., Agostinelli, C., Hebeda, K.M., Matutes, E., Peccatori, J., Campidelli, C., Espinet, B., Perea, G., Acevedo, A., Mehrjardi, A.Z., Martinez-Bernal, M., Gelemur, M., Zucca, E., Pileri, S., Campo, E., Lopez-Guillermo, A., and Rozman, M.

Abstract

1 februari 2012, Item does not contain fulltext, Bone marrow involvement by lymphoma is considered a systemic dissemination of the disease arising elsewhere, although some tumors may arise primarily in the bone marrow microenvironment. Primary bone marrow lymphoma (PBML) is a rare entity whose real boundaries and clinicobiological significance are not well defined. Criteria to diagnose PBML encompass isolated bone marrow infiltration, with no evidence of nodal or extranodal involvement, including the bone, and the exclusion of leukemia/lymphomas that are considered to primarily involve the bone marrow. Twenty-one out of 40 lymphomas retrospectively reviewed by the International Extranodal Lymphoma Study Group from 12 institutions in 7 different countries over a 25-year period fulfilled the inclusion criteria. These cases comprised 4 follicular lymphomas (FLs), 15 diffuse large B-cell lymphomas (DLBCLs), and 2 peripheral T-cell lymphomas, not otherwise specified. The FL cases showed paratrabecular infiltration, BCL2 protein and CD10 expression, and BCL2 gene rearrangement. DLBCL showed nodular infiltration in 6 cases and was diffuse in 9 cases; it also showed positivity for BCL2 protein (9/10) and IRF4 (6/8). Median age was 65 years with male predominance. All but 3 FL patients were symptomatic. Most cases presented with cytopenias and high lactate dehydrogenase. Four patients (3 FL cases and 1 DLBCL case) had leukemic involvement. Most DLBCL patients received CHOP-like or R-CHOP-like regimens. The outcome was unfavorable, with a median overall survival of 1.8 years. In conclusion, PBML is a very uncommon lymphoma with particular clinical features and heterogenous histology. Its recognition is important to establish accurate diagnosis and adequate therapy.

Published
2012

2. Primary bone marrow lymphoma: an uncommon extranodal presentation of aggressive non-hodgkin lymphomas

Author

Martinez A., Ponzoni M., Hebeda K. M., Matutes E., Peccatori J., Espinet B., Perea G., Acevedo A., Mehrjardi A. Z., Martinez Bernal M., Gelemur M., Zucca E., Campo E., López Guillermo A., Rozman M., on behalf of the International Extranodal Lymphoma Study Group, AGOSTINELLI, CLAUDIO, CAMPIDELLI, CRISTINA, PILERI, STEFANO, Martinez, A, Ponzoni, Maurilio, Agostinelli, C, Hebeda, Km, Matutes, E, Peccatori, J, Campidelli, C, Espinet, B, Perea, G, Acevedo, A, Mehrjardi, Az, Martinez Bernal, M, Gelemur, M, Zucca, E, Pileri, S, Campo, E, Lopez Guillermo, A, Rozman, M., Martinez A., Ponzoni M., Agostinelli C., Hebeda K.M., Matutes E., Peccatori J., Campidelli C., Espinet B., Perea G., Acevedo A., Mehrjardi A.Z., Martinez-Bernal M., Gelemur M., Zucca E., Pileri S., Campo E., López-Guillermo A., Rozman M., and on behalf of the International Extranodal Lymphoma Study Group

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Follicular lymphoma, Aggressive Non-Hodgkin Lymphoma, NHL, Pathology and Forensic Medicine, immune system diseases, hemic and lymphatic diseases, medicine, Humans, Bone marrow, Extranodal lymphoma, Bone lymphoma, Extranodal Involvement, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Lymphoma, Non-Hodgkin, Aggressive non-Hodgkin lymphoma, Peripheral T-cell lymphoma, Diffuse large B-cell lymphoma, Middle Aged, medicine.disease, Translational research Tissue engineering and pathology [ONCOL 3], Lymphoma, Leukemia, medicine.anatomical_structure, Surgery, Female, Anatomy, business, Bone Marrow Neoplasms
Abstract

Item does not contain fulltext Bone marrow involvement by lymphoma is considered a systemic dissemination of the disease arising elsewhere, although some tumors may arise primarily in the bone marrow microenvironment. Primary bone marrow lymphoma (PBML) is a rare entity whose real boundaries and clinicobiological significance are not well defined. Criteria to diagnose PBML encompass isolated bone marrow infiltration, with no evidence of nodal or extranodal involvement, including the bone, and the exclusion of leukemia/lymphomas that are considered to primarily involve the bone marrow. Twenty-one out of 40 lymphomas retrospectively reviewed by the International Extranodal Lymphoma Study Group from 12 institutions in 7 different countries over a 25-year period fulfilled the inclusion criteria. These cases comprised 4 follicular lymphomas (FLs), 15 diffuse large B-cell lymphomas (DLBCLs), and 2 peripheral T-cell lymphomas, not otherwise specified. The FL cases showed paratrabecular infiltration, BCL2 protein and CD10 expression, and BCL2 gene rearrangement. DLBCL showed nodular infiltration in 6 cases and was diffuse in 9 cases; it also showed positivity for BCL2 protein (9/10) and IRF4 (6/8). Median age was 65 years with male predominance. All but 3 FL patients were symptomatic. Most cases presented with cytopenias and high lactate dehydrogenase. Four patients (3 FL cases and 1 DLBCL case) had leukemic involvement. Most DLBCL patients received CHOP-like or R-CHOP-like regimens. The outcome was unfavorable, with a median overall survival of 1.8 years. In conclusion, PBML is a very uncommon lymphoma with particular clinical features and heterogenous histology. Its recognition is important to establish accurate diagnosis and adequate therapy. 01 februari 2012

Published
2012

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