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Objectives: The aim of this study is to assess the occurrence, reasons, and consequences of Emergency Peripartum Hysterectomy (EPH) at a particular institution. It seeks to identify risk factors, examine complications, and offer insights for interventions to enhance maternal and fetal outcomes in obstetric emergencies. Methods: The study was conducted at a tertiary care centre and the data analysis covered a period of 1 year. This study retrospectively analyzed Emergency Peripartum Hysterectomy (EPH) cases at a specific institution, reviewing patient demographics, obstetric history, booking status, referral patterns, EPH indications, delivery mode, and maternal-fetal outcomes. Results: The study revealed that the majority of patients (80.3%) belonged to rural backgrounds, with 89.3% being unbooked cases. Furthermore, 64.3% of cases were referred, and 85.7% of patients were in the P2,3,4 group. The most common indication for Emergency Peripartum Hysterectomy (EPH) was uterine rupture (53.6%), with a statistically significant association between the type of hysterectomy and indications for EPH (P value < 0.05). Subtotal hysterectomy was performed in 82.1% of cases, and maternal complications included febrile illness (51.8%) and wound infection (37.5%). Conclusion: This study highlights the imperative to address the elevated incidence of Emergency Peripartum Hysterectomy (EPH) in rural healthcare in India. The findings stress the pressing need for targeted interventions, including improving female literacy, increasing contraception prevalence, and enhancing antenatal care accessibility and quality. Strengthening peripheral healthcare, ensuring timely referrals for high-risk pregnancies, and proper documentation are essential for mitigating maternal morbidity, mortality, and foetal complications. [ABSTRACT FROM AUTHOR]

Introduction: Endometrial cancer (EC) is the most frequent gynaecological cancer in developed countries, and its prevalence is increasing. While the majority of women with endometrial cancer are identified with highly treatable illness and have acceptable outcomes, a considerable minority have severe clinicopathological features that indicate a bad prognosis. Prognostic biomarkers that reliably identify people at highest risk of disease recurrence and mortality can guide management methods to ensure that patients receive evidence-based and individualised care. Materials and Methods: All selected articles were reviewed, and data were compiled in a comprehensive database that included: general information (first author's name, country, journal, year of publication); number of patients and analytical technique used; association of the described biomarkers with different prognostic factors (histological type, histological grade, FIGO stage, myometrial invasion, lymph node status, LVSI, cervical invasion, metastasis, TCGA molecular classification, A meta-analysis on OS was performed for the five most studied biomarkers. Only studies providing an estimate of the hazard ratio (HR) and the associated 95% CI for the parameter here considered were included. Results: Our initial PubMed, Medline, Scopus, Chochrane and DOAJ search yielded 250 hits, which were reduced to 155 following the first screening phase. 39 of them satisfied our criteria and were considered for this review. Biomarker research on prognostic biomarkers in the EC has expanded over time, with Asia (43%) and Europe (41%) being the largest contributors. At the country level, Japan, China, the United States of America, Turkey, and Norway are the leading countries. Conclusion: According to our meta-analysis, ESR1, TP53, and WFDC2 have the ability to predict overall survival in EC. The limitations of the published research are noted in terms of suitable study design, a lack of high-throughput measurements, and statistical flaws, and novel methodologies and possibilities for the identification and validation of clinically relevant EC prognostic biomarkers are presented. [ABSTRACT FROM AUTHOR]

Introduction: Primary gall bladder carcinoma is a rare cancer, however it is one of the most prevalent bile system cancers. Cholelithiasis is the most frequent risk factor for the development of gallbladder carcinoma worldwide, with a varying incidence of gallbladder carcinoma across geographic areas due to cholelithiasis prevalence. Gallbladder cancer is one of the most common cancers in the Gangetic and Brahmaputra valleys of Northern and Eastern India. Gallbladder cancer is identified preoperatively in less than 20% of instances, while the remaining cases are diagnosed intraoperatively or after laparoscopic cholecystectomy in 74-92% of cases. Materials and Methods: A search was conducted using the following terms: gallbladder cancer; gallbladder neoplasms; cholangiocarcinoma; bile duct cancer; PET; positron emission tomography. The search was conducted separately by two authors (SS, BM) using the PRISMA statement's verified techniques. There were no language restrictions. MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, PubMed, Scopus, Doaj, Cochrane and Web of Science were the databases analysed. To identify further relevant studies, the reference lists of all included papers, as well as related review articles, were manually searched. Results: Seven studies examined the role of PET-CT in gallbladder carcinoma though two studies did not report their results specifically. Butte et al investigated 32 patients with incidental gallbladder carcinoma following laparoscopic cholecystectomy. Thirteen patients had negative PET-CT results, 9 refused further resection with only one of the four patients resected having residual disease on operative exploration. PET-CT changed management in 12 out of 32 patients (38%) demonstrating unexpected disseminated disease in 10 patients and localised resectable disease in 2 patients. Conclusion: 230 records were screened, 49 were assessed and 7 studies were included in the systematic review. PET-CT has a low sensitivity for regional lymph node metastases from cholangiocarcinoma and gallbladder cancer but a high specificity. In one study, PET-CT appears to be effective in assessing all nodal basins related to the liver, bile ducts and gallbladder. PET CT has no role in the assessment of hepatic satellite lesions but is useful in defining extraabdominal metastatic disease and recurrent disease and to assess specific areas of concern defined on CT scan and/or magnetic resonance scan. [ABSTRACT FROM AUTHOR]