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Your search keyword '"Mehta, P.P."' showing total 14 results
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14 results on '"Mehta, P.P."'

1. Microfluidics meets 3D cancer cell migration

Author

Mehta, P.P. (author), Rahman, Z. (author), ten Dijke, Peter (author), Boukany, P. (author), Mehta, P.P. (author), Rahman, Z. (author), ten Dijke, Peter (author), and Boukany, P. (author)

Abstract

An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor progression events. Recent microfluidic models have enabled recapitulation of key mechanobiological features present within the TME to investigate collective cancer cell migration and invasion. Microfluidics also allows for functional interrogation and therapeutic manipulation of specific steps to study the dynamic aspects of tumor progression. In this review, we focus on recent developments in cancer cell migration and how microfluidic strategies have evolved to address the physiological complexities of the TME to visualize migration modes adapted by various tumor cells., ChemE/Product and Process Engineering

Published
2022
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3. Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

Author

Burn, E., You, S.C., Sena, A.G., Kostka, K., Abedtash, H., Abrahao, M.T.F., Alberga, A., Alghoul, H., Alser, O., Alshammari, T.M., Aragon, M, Areia, C., Banda, J.M., Cho, J. (Jeiwon), Culhane, A.C., Davydov, A., DeFalco, F.J., Duarte-Salles, T., DuVall, S., Falconer, T., Fernandez-Bertolin, S., Gao, W.H., Golozar, A., Hardin, J., Hripcsak, G. (G.), Huser, V, Jeon, H., Jing, Y.H., Jung, C.Y., Kaas-Hansen, B.S., Kaduk, D., Kent, S., Kim, Y., Kolovos, S., Lane, J.C.E., Lee, H. (Hang), Lynch, K.E., Makadia, R., Matheny, M.E., Mehta, P.P., Morales, D.R., Natarajan, K., Nyberg, F. (Fredrik), Ostropolets, A., Park, RW, Park, J. (Judy), Posada, J.D., Prats-Uribe, A., Rao, G., Reich, C., Rho, Y., Rijnbeek, P.R. (Peter), Schilling, LM, Schuemie, M.J. (Martijn), Shah, NH, Shoaibi, A., Song, S., Spotnitz, M., Suchard, M.A. (Marc), Swerdel, J.N., Vizcaya, D., Volpe, S., Wen, H.N., Williams, A.E., Yimer, B.B., Zhang, L., Zhuk, O., Prieto-Alhambra, D., Ryan, P., Burn, E., You, S.C., Sena, A.G., Kostka, K., Abedtash, H., Abrahao, M.T.F., Alberga, A., Alghoul, H., Alser, O., Alshammari, T.M., Aragon, M, Areia, C., Banda, J.M., Cho, J. (Jeiwon), Culhane, A.C., Davydov, A., DeFalco, F.J., Duarte-Salles, T., DuVall, S., Falconer, T., Fernandez-Bertolin, S., Gao, W.H., Golozar, A., Hardin, J., Hripcsak, G. (G.), Huser, V, Jeon, H., Jing, Y.H., Jung, C.Y., Kaas-Hansen, B.S., Kaduk, D., Kent, S., Kim, Y., Kolovos, S., Lane, J.C.E., Lee, H. (Hang), Lynch, K.E., Makadia, R., Matheny, M.E., Mehta, P.P., Morales, D.R., Natarajan, K., Nyberg, F. (Fredrik), Ostropolets, A., Park, RW, Park, J. (Judy), Posada, J.D., Prats-Uribe, A., Rao, G., Reich, C., Rho, Y., Rijnbeek, P.R. (Peter), Schilling, LM, Schuemie, M.J. (Martijn), Shah, NH, Shoaibi, A., Song, S., Spotnitz, M., Suchard, M.A. (Marc), Swerdel, J.N., Vizcaya, D., Volpe, S., Wen, H.N., Williams, A.E., Yimer, B.B., Zhang, L., Zhuk, O., Prieto-Alhambra, D., and Ryan, P.

Published
2020
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4. Outcomes Following Mitraclip in Advanced Heart Failure Patients: A Meta-Analysis

Author

Belkin, M.N., primary, Nnanabu, J., additional, Mehta, P.P., additional, Feldman, T., additional, Penicka, M., additional, Giannini, C., additional, Fiorelli, F., additional, Braun, D., additional, Swaans, M., additional, Heyden, J. v., additional, Claeys, M., additional, Orban, M., additional, Kalantari, S., additional, Raikhelkar, J., additional, Sarswat, N., additional, Kim, G., additional, Sayer, G., additional, and Uriel, N., additional

Published
2018
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6. Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine

Author

Kung, P.-P., primary, Sinnema, P.-J., additional, Richardson, P., additional, Hickey, M.J., additional, Gajiwala, K.S., additional, Wang, F., additional, Huang, B., additional, McClellan, G., additional, Wang, J., additional, Maegley, K., additional, Bergqvist, S., additional, Mehta, P.P., additional, and Kania, R., additional

Published
2011
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7. Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile

Author

Kung, P.-P., primary, Sinnema, P.-J., additional, Richardson, P., additional, Hickey, M.J., additional, Gajiwala, K.S., additional, Wang, F., additional, Huang, B., additional, McClellan, G., additional, Wang, J., additional, Maegley, K., additional, Bergqvist, S., additional, Mehta, P.P., additional, and Kania, R., additional

Published
2011
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8. Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Author

Kung, P.-P., primary, Sinnema, P.-J., additional, Richardson, P., additional, Hickey, M.J., additional, Gajiwala, K.S., additional, Wang, F., additional, Huang, B., additional, McClellan, G., additional, Wang, J., additional, Maegley, K., additional, Bergqvist, S., additional, Mehta, P.P., additional, and Kania, R., additional

Published
2011
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11. Substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Analysis of fatty acid analogs containing carbonyl groups, nitrogen heteroatoms, and nitrogen heterocycles in an in vitro enzyme assay and subsequent identification of inhibitors of human immunodeficiency virus I replication.

Author

Devadas, B, primary, Lu, T, additional, Katoh, A, additional, Kishore, N.S., additional, Wade, A.C., additional, Mehta, P.P., additional, Rudnick, D.A., additional, Bryant, M.L., additional, Adams, S.P., additional, and Li, Q, additional

Published
1992
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12. The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue

Author

Kishore, N.S., primary, Lu, T.B., additional, Knoll, L.J., additional, Katoh, A., additional, Rudnick, D.A., additional, Mehta, P.P., additional, Devadas, B., additional, Huhn, M., additional, Atwood, J.L., additional, and Adams, S.P., additional

Published
1991
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13. A Synthetic Linear Decapeptide Binds to the Atrial Natriuretic Peptide Receptors and Demonstrates Cyclase Activation and Vasorelaxant Activity*

Author

Bovy, P.R., O'Neal, J.M., Olins, G.M., Patton, D.R., Mehta, P.P., McMahon, E.G., Palomo, M, Schuh, J, and Blehm, D

Abstract

A linear decapeptide, [cyclohexylalanine 106]ANP-(105-114)NH2(1), where ANP is atrial natriuretic peptide, was prepared by solid phase synthesis and purified by reverse-phase liquid chromatography. This novel peptide was found to bind to ANP receptors in rabbit lung membranes, to stimulate cGMP production in various tissues, and to fully relax precontracted rabbit aorta in a dose-dependent fashion. The potency of 1in the various in vitroassays varies between one-twentieth and one-eightieth of the potency of the reference peptide, the 24-mer rat ANP-(103-126). The linear decapeptide 1, which encompasses amino acid residues from the rat ANP sequence (105-114), features a cyclohexylalanine residue instead of the phenylalanine 106 residue in the hormone sequence, a free sulfhydryl function at the N-terminal cysteine 105, and a carboxamide C terminus. Its disulfide dimer 6was active in the rabbit aorta assay while the S-methyl cysteine 7analogue was not active in the same assay at similar concentrations. The decapeptide 1is of particular significance because it is the shortest analogue reported to date endowed with agonistic activity at the guanylate cyclase-coupled ANP receptor. In particular, it is interesting to compare its structure to the structures of other short linear analogues of ANP which are totally devoid of the ability to stimulate particulate guanylate cyclase activity.

Published
1989
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14. Treatment of Superficial Thrombophlebitis: A Randomized, Double-blind Trial of Heparinoid Cream.

Author

Mehta, P.P., Sagar, S., and Kakkar, V.V.

Subjects
*OINTMENTS, *HEPARIN, *THROMBOPHLEBITIS
Abstract

Assesses the efficacy of heparinoid ointment in the treatment of patients with thrombophlebitis in Great Britain. Differences in the mean time required for the relief of symptoms and signs in patients receiving heparinoid and the placebo; Side effects of the treatment; Increase in uptake of radioactive fibrinogen at the site of the thrombophlebitis.

Published
1975
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