169 results on '"Mehta, S. R."'
Search Results
2. Blood pressure and clinical outcomes in patients with diabetes and stable coronary artery disease in THEMIS
- Author
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Pareek, M, primary, Bhatt, D L, additional, Zheng, L, additional, Lee, J J, additional, Leiter, L A, additional, Simon, T, additional, Mehta, S R, additional, Harrington, R A, additional, Fox, K, additional, Himmelmann, A, additional, Vidal-Petiot, E, additional, and Steg, P G, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Supplement to: Early versus delayed invasive intervention in acute cor-onary syndromes.
- Author
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Mehta, S R, Granger, C B, and Boden, W E
- Published
- 2009
4. Supplement to: Effects of CYP2C19 genotype on outcomes of clopidogrel treatment.
- Author
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Paré, G, Mehta, S R, and Yusuf, S
- Published
- 2010
5. Comparison of the anticoagulant intensities of fondaparinux and enoxaparin in the organization to assess strategies in acute ischemic syndromes (OASIS)-5 trial
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ANDERSON, J. A. M., HIRSH, J., YUSUF, S., JOHNSTON, M., AFZAL, R., MEHTA, S. R., FOX, K. A. A., BUDAJ, A., and EIKELBOOM, J. W.
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- 2010
- Full Text
- View/download PDF
6. Intra-hepatic insulin exposure but not percent extraction of newly-secreted insulin is increased in subjects with non-alcoholic fatty liver disease (NAFLD): A64
- Author
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Mehta, S R, Godsland, I F, Barton, N, Bell, J D, Thomas, E L, Fitzpatrick, J, Durighel, G, McCarthy, J, Taylor-Robinsonz, S D, and Johnston, D G
- Published
- 2008
7. Lymphoma and the Kidney: A Kidney Biopsy Teaching Case
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L'Imperio, V, Rossi, M, Abdul, A, Mehta, S, Shaver, A, Fogo, A, L'Imperio V., Rossi M., Abdul A., Mehta S. R., Shaver A. C., Fogo A. B., L'Imperio, V, Rossi, M, Abdul, A, Mehta, S, Shaver, A, Fogo, A, L'Imperio V., Rossi M., Abdul A., Mehta S. R., Shaver A. C., and Fogo A. B.
- Abstract
Lymphomatous infiltration of kidney parenchyma is a frequent complication of systemic hematologic malignancies and often shows subtle clinical presentation. Diffuse large B-cell lymphoma represents the most frequent form involving the kidney, with advanced stage at diagnosis, poor outcome, and risk for central nervous system relapse if not adequately treated. Kidney biopsy can provide specific and early detection of these cases, helping in the differential diagnosis with more frequent entities. Finally, further hematologic workup (bone marrow biopsy, complete blood cell count, and positron emission tomography) can distinguish secondary involvement of the kidney from the rarer kidney-limited forms, especially in patients without a previous diagnosis of lymphoma. Making a prompt and correct diagnosis directs the management of these cases and may improve the outcome, as described in the present report.
- Published
- 2020
8. Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope (R) registry 2008-2019
- Author
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Jenks, J. D., Seidel, D., Cornely, O. A., Chen, S., van Hal, S., Kauffman, C., Miceli, M. H., Heinemann, M., Christner, M., Jover Saenz, A., Burchardt, A., Kemmerling, B., Herbrecht, R., Steinmann, J., Shoham, S., Graeber, S., Pagano, L., Deeren, D., Aslam, S., Taplitz, R., Revankar, S. G., Baddley, J., Mehta, S. R., Reed, S., Slavin, M. A., Hoenigl, M., Jenks, J. D., Seidel, D., Cornely, O. A., Chen, S., van Hal, S., Kauffman, C., Miceli, M. H., Heinemann, M., Christner, M., Jover Saenz, A., Burchardt, A., Kemmerling, B., Herbrecht, R., Steinmann, J., Shoham, S., Graeber, S., Pagano, L., Deeren, D., Aslam, S., Taplitz, R., Revankar, S. G., Baddley, J., Mehta, S. R., Reed, S., Slavin, M. A., and Hoenigl, M.
- Abstract
Objectives: Lomentospora prolificans is an emerging cause of serious invasive fungal infections. Optimal treatment of these infections is unknown, although voriconazole-containing treatment regimens are considered the treatment of choice. The objective of this study was to evaluate the role of combination antifungal therapy for L. prolificans infections. Methods: We performed a retrospective review of medical records of patients with invasive L. prolificans infection diagnosed between 1 January 2008 and 9 September 2019 that were documented in the FungiScope (R) registry of rare invasive fungal infections. We compared clinical outcomes between antifungal treatment strategies. Results: Over the study period, 41 individuals with invasive L. prolificans infection from eight different countries were documented in the FungiScope (R) registry. Overall, 17/40 (43%) had treatment response/ stable disease and 21/40 (53%) had a fatal outcome attributed to invasive fungal infection. Combination antifungal therapy was associated with increased 28-day survival (15/24 survived versus 4/16 receiving monotherapy; p 0.027) and the combination voriconazole plus terbinafine trended to be associated with higher rates of treatment success (10/16, 63%, 95% CI 35%-85%) compared with other antifungal treatment regimens (7/24, 29%, 95% CI 13%-51%, p 0.053). In Kaplan-Meier survival analysis there was a higher survival probability in individuals receiving the voriconazole/terbinafine combination compared with other antifungal regimens (median survival 150 days versus 17 days). Conclusions: While overall mortality was high, combination antifungal treatment, and in particular combination therapy with voriconazole plus terbinafine may be associated with improved treatment outcomes compared with other antifungal regimens for the treatment of invasive L. prolificans infections. (C) 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserv
- Published
- 2020
9. Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008–2019
- Author
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Jenks, J. D., Seidel, D., Cornely, O. A., Chen, S., van Hal, S., Kauffman, C., Miceli, M. H., Heinemann, M., Christner, M., Jover Saenz, A., Burchardt, A., Kemmerling, B., Herbrecht, R., Steinmann, J., Shoham, S., Graber, S., Pagano, Livio, Deeren, D., Aslam, S., Taplitz, R., Revankar, S. G., Baddley, J., Mehta, S. R., Reed, S., Slavin, M. A., Hoenigl, M., Pagano L. (ORCID:0000-0001-8287-928X), Jenks, J. D., Seidel, D., Cornely, O. A., Chen, S., van Hal, S., Kauffman, C., Miceli, M. H., Heinemann, M., Christner, M., Jover Saenz, A., Burchardt, A., Kemmerling, B., Herbrecht, R., Steinmann, J., Shoham, S., Graber, S., Pagano, Livio, Deeren, D., Aslam, S., Taplitz, R., Revankar, S. G., Baddley, J., Mehta, S. R., Reed, S., Slavin, M. A., Hoenigl, M., and Pagano L. (ORCID:0000-0001-8287-928X)
- Abstract
Objectives: Lomentospora prolificans is an emerging cause of serious invasive fungal infections. Optimal treatment of these infections is unknown, although voriconazole-containing treatment regimens are considered the treatment of choice. The objective of this study was to evaluate the role of combination antifungal therapy for L. prolificans infections. Methods: We performed a retrospective review of medical records of patients with invasive L. prolificans infection diagnosed between 1 January 2008 and 9 September 2019 that were documented in the FungiScope® registry of rare invasive fungal infections. We compared clinical outcomes between antifungal treatment strategies. Results: Over the study period, 41 individuals with invasive L. prolificans infection from eight different countries were documented in the FungiScope® registry. Overall, 17/40 (43%) had treatment response/stable disease and 21/40 (53%) had a fatal outcome attributed to invasive fungal infection. Combination antifungal therapy was associated with increased 28-day survival (15/24 survived versus 4/16 receiving monotherapy; p 0.027) and the combination voriconazole plus terbinafine trended to be associated with higher rates of treatment success (10/16, 63%, 95% CI 35%–85%) compared with other antifungal treatment regimens (7/24, 29%, 95% CI 13%–51%, p 0.053). In Kaplan–Meier survival analysis there was a higher survival probability in individuals receiving the voriconazole/terbinafine combination compared with other antifungal regimens (median survival 150 days versus 17 days). Conclusions: While overall mortality was high, combination antifungal treatment, and in particular combination therapy with voriconazole plus terbinafine may be associated with improved treatment outcomes compared with other antifungal regimens for the treatment of invasive L. prolificans infections.
- Published
- 2020
10. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
- Author
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Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, Haddad, T, Rohr, K, Levinson, L, Gaona, R, Uretsky, B, Maheshwari, H, Lee, D, Kinnaman, S, Singal, R, Geohas, J, Gigliotti, O, Raisinghani, A, Khurana, C, Hella, B, Kelberman, M, Voyce, S, Singh, S, Lo, E, Singh, P, Goodfellow, R, Fischer, S, Lorraine, R, Turner, T, Shanes, J, Busch, R, Broker, R, Zaniewski, M, Pounds, K, Debs-Perez, G, Ong, S, Frandsen, B, Fullington, D, Jaffrani, N, Khan, A, Lee, M, Pouzar, J, Revtyak, G, Gonzalez, J, Nakhle, S, Murillo, A, Young, D, Makam, S, Syed, M, Woolf, K, Grena, P, Alfata, S, Mahal, S, Hoffman, D, Kizhakekuttu, T, Deering, J, Bhavsar, J, Mikesell, S, Wilson, W, Wilson, V, El, S, Spinale, F, Kannarkat, V, Rao, S, Hanson, L, Bertsch, J, Gonzalez-Ortiz, E, Severino, N, Willis, J, Schock, J, Bakhtari, L, Gazmuri, R, Ansari, S, Hall, J, Mehta, A, Shealy, N, Zarich, S, Singh, D, Vora, K, Andrawis, N, Molter, D, Maron, D, Cardona, J, D'Agostino, R, Arshad, T, Samaan, R, Jones, D, Presser, D, Heath, J, Green, S, Bittar, G, Henry, S, Korn, D, Schmedtje, J, Nadar, V, Graham, B, Labroo, A, Clavijo, L, Roseman, H, Ledesma, G, Rosen, R, Dor, I, Kirby, W, Sutton, J, Eder, F, Iteld, B, Gomez-Cortes, J, Buchbinder, M, Kasper, J, Terrelonge, A, Torres, G, Jagielo, T, Alvarez, J, Handelsman, Y, Guillen, M, Richwine, R, Lewy-Alterbaum, L, Corder, C, Arvind, M, Bolshoun, D, Mikhail, M, Minton, S, Alvarado, O, Abbott, J, Cauthen, B, Welter, R, Mintz, R, Cox, J, Quick, A, Weiss, M, Dy, J, Zebrack, J, Gandelman, G, Hegde, V, Silver, M, Degregorio, M, Lawson, W, Paa, C, Bortnick, A, Krolick, M, Sotolongo, R, Cheirif, J, Kumar, P, Jetty, P, Patel, A, Kruk, M, Kobielusz-Gembala, I, Rewerska, B, Madrzejewski, A, Milewski, K, Cygler, J, Petryka-Mazurkiewicz, J, Jastrzebski, W, Korecki, J, Fil, W, Prokopczuk, J, Bochenek, A, Wujkowski, M, Witek, R, Konczakowski, P, Miekus, P, Szczasny, M, Musial, W, Cymerman, K, Lampart, J, Mikosinski, J, Szynal, S, Fares, I, Opolski, G, Mazur, S, Wozakowska-Kaplon, B, Bijata-Bronisz, R, Wierucki, L, Losa, B, Drelich, G, Konieczny, M, Starczewski, P, Pawlowicz, L, Jesionowski, P, Jurowiecki, J, Gniot, J, Czyzycki, M, Stania, K, Kucharczyk-Bauman, I, Busz-Papiez, B, Karczmarczyk, A, Sudnik, W, Koszek, A, Kolodziej, P, Skwarna, B, Jaramillo, N, Jankowski, M, Czochra, W, Kinasz, L, Miklaszewicz, B, Stasinska, T, Pluta, W, Basiak, M, Rusicka, T, Niedbal-Yahfouf, I, Popenda, G, Korzeniak, R, Mirek, A, Mariankowski, R, Wojnowski, L, Korol, M, Baszak, J, Podolec, P, Piesiewicz, W, Zurakowski, A, Luengas, C, Skura, M, Pilecki, P, Majchrzak, P, Krzyzagorska, E, Drozd, M, Kaczmarek, B, Sliwinska, T, Zelazowska, K, Sztembis, R, Landa, K, Matyszczak-Toniak, L, Strojek, K, Piepiorka, M, Malinowski, R, Gorska, M, Stolarczyk-Sowa, E, Romanowski, L, Zinka, E, Reszka, Z, Skierkowska, J, Uzunow, A, Laskowska-Derlaga, E, Puntus, E, Kosmacheva, E, Koziolova, N, Pavlov, P, Supryadkina, T, Didenko, Y, Kopylov, P, Kazakov, A, Aksentiev, S, Vishneva, E, Repin, A, Smolenskaya, O, Mantserova, O, Khrustalev, O, Privalova, E, Konstantinov, V, Boldueva, S, Ezhov, A, Chernyavsky, A, Kamalov, G, Galyavich, A, Zubeeva, G, Nechaeva, G, Shustov, S, Dzhaiani, N, Treshkur, T, Osokina, N, Panov, A, Shutemova, E, Makukhin, V, Kropotina, T, Tsyba, L, Karpov, Y, Sizova, J, Ballyuzek, M, Tarasov, N, Demchenko, E, Barbarash, O, Moiseev, V, Markov, V, Kuznetsov, V, Viktorova, I, Sergienko, I, Ermoshkina, L, Khasanov, N, Khlevchuk, T, Baglikov, A, Shalaev, S, Zonova, E, Reznik, E, Haisheva, L, Morugova, T, Lomakin, N, Vishnevsky, A, Shvarts, Y, Magnitskaya, O, Mikhailusova, M, Pavlysh, E, Libov, I, Zateyschikova, A, Kostenko, V, Edin, A, Khovaeva, Y, Zakharov, K, Stryuk, R, Khirmanov, V, Kanorskiy, S, Yakushin, S, Barabashkina, A, Li, H, Zhao, Q, Zhang, J, Ma, J, He, Y, Luo, M, Zhang, A, Zhang, N, Chai, Y, Ma, G, Wang, H, Liu, Z, He, L, Song, Z, Dong, X, Tao, L, Li, Z, Su, X, Kong, X, Niu, H, Ge, J, Luo, Z, Huang, W, Peng, D, Yuan, Z, Milanova, M, Tenev, D, Gogov, A, Karageorgiev, D, Kolchev, T, Rusev, N, Georgieva, N, Kondov, R, Rusinov, V, Petrov, I, Stanchev, G, Konteva, M, Dincheva, A, Yaneva, Z, Vatova, R, Ilieva, K, Runev, N, Kolomanov, B, Iliev, N, Tisheva, S, Chompalova, B, Tokmakova, M, Raev, D, Byanov, K, Markov, D, Mihov, L, Mihov, A, Milcheva, N, Minchev, M, Mollov, M, Borisov, B, Tihchev, T, Karakolev, V, Dimov, B, Georgiev, S, Smilov, L, Koo, B, Ahn, T, Hong, S, Yoon, J, Oh, S, Jeong, M, Kim, D, Chang, K, Kim, W, Hahn, J, Cha, K, Lee, J, Choi, S, Nam, C, Chae, I, Park, Y, Tahk, S, Shin, W, Chae, J, Kim, B, Bae, J, Park, W, Rha, S, Choi, Y, Hwang, J, Park, H, Baracioli, L, Guimaraes, F, Vasconcellos, E, Saraiva, J, Pereira, A, Santos, Q, Rossi, P, Maia, L, Madeira, M, Pereira, M, Botelho, R, Reis, G, Eliaschewitz, F, Borges, J, Nascimento, C, Fortes, J, de Souza, W, Pimentel, P, Hissa, M, Franchetti, M, Precoma, D, Ortiz, C, Hernandes, M, Saporito, W, dos Santos, F, Kormann, A, Neuenschwander, F, Dutra, O, Rassi, N, Tanajura, L, Souza, J, Junior, D, Leaes, P, Forte, A, Bonansea, T, Marin, J, Machado, B, Cerqueira, M, Silva, F, Michalaros, Y, Manenti, E, Cercato, C, Figueiredo, E, Liu, M, Wang, Y, Lee, T, Fang, C, Wu, Y, Ueng, K, Sheu, H, Lai, W, Hsieh, I, Chen, Z, Chiang, C, Shyu, K, Hsia, C, Mar, G, Chan, S, Wu, C, Tseng, W, Yeh, H, Wang, J, Hou, C, Sorokina, I, Dolzhenko, M, Horoshko, O, Karpenko, O, Rudenko, L, Vakaliuk, I, Kulyk, A, Levchenko, O, Prokhorov, O, Reshotko, D, Sorokivskyy, M, Velichko, N, Maslovskyi, V, Teliatnikova, Z, Dotsenko, S, Krakhmalova, O, Kraiz, I, Zharinova, V, Bula, L, Kaydashev, I, Molodtsov, V, Rasputina, L, Pidlisna, V, Lysunets, O, Kravchenko, A, Glushko, L, Khomazyuk, T, Svyshchenko, Y, Parkhomenko, O, Mankovsky, B, Abrahamovych, O, Yagensky, A, Stanislavchuk, M, Vasilyeva, L, Sokolova, L, Sychov, O, Tseluyko, V, Kyrychenko, I, Rishko, M, Furkalo, S, Gallo, R, Bertrand, O, Constance, C, Sussex, B, Zadra, R, Kouz, S, Chehayeb, R, Pandey, A, Dion, D, Bailey, G, Hill, L, Ramanathan, K, Dorsch, M, Nanji, A, Babapulle, M, Montigny, M, Gosselin, G, Dehghani, P, Rupka, D, Le May, M, Pichette, F, St-Maurice, F, Teefy, P, Mansour, S, Kassam, S, Cheung, S, Siega, A, O'Keefe, D, Sabbah, E, Bell, A, Chouinard, G, Wong, B, Miller, M, Gaudet, D, Lachance, P, Bata, I, Petrella, R, Gossard, D, Dumas, R, Ing, D, Boyrazian, H, Bessoudo, R, Huynh, T, Hart, R, Belle-Isle, J, Shukla, D, Kelly, A, Mazza, G, Cha, J, Henein, S, Frechette, A, Vizel, S, Liutkus, J, O'Mahony, M, Halperin, F, Kooy, J, Graham, J, Bailey, A, Wojcik, R, Wilderman, I, Turi, T, Motyovszki, A, Merkely, B, Kiss, R, Kiraly, C, Andrassy, P, Sarszegi, Z, Fulop, T, Zilahi, Z, Edes, I, Papp, A, Muller, G, Czigany, A, Zolyomi, S, Koranyi, L, Takacs, J, Juhasz, F, Benczur, B, Kancz, S, Foldi, A, Nagy, A, Bakai, J, Greschik, I, Puski, L, Nagy, L, Kirschner, R, Kuchar, R, Hajek, P, Busak, L, Michalik, D, Matyasek, I, Marusincova, I, Kucera, D, Jerabek, O, Honkova, M, Dedek, V, Rihacek, I, Kos, P, Slaby, J, Machkova, M, Zidkova, E, Elbl, L, Grunfeldova, H, Carda, J, Mrozek, V, Maly, J, Milkovic, R, Malecha, J, Skalicka, H, Oral, I, Krcova, E, Lisa, L, Belohlavek, J, Miklik, R, Cermak, O, Bednarova, J, Peroutka, Z, Spinar, J, Wilke, A, Appel, K, Taggeselle, J, Forster, A, Toursarkissian, N, Schmidt, E, Bott, J, Al-Zoebi, A, Hennig, D, Schon, N, Sauter, J, Simonis, G, Nischik, R, Rieker, W, Schenkenberger, I, Behnke, T, Klausmann, G, Jeserich, M, Trenk, D, Weigmann, I, Reuter, H, Rummel, R, von Munchhausen, C, von Engelhardt, C, Horibe, E, Shibasaki, T, Sato, T, Kakuta, T, Michishita, I, Tan, M, Ishiki, R, Aoyama, T, Higashiue, S, Niijima, Y, Idogaki, A, Hasegawa, T, Kiyosue, A, Tomobuchi, Y, Kawamitsu, K, Kawasaki, S, Hata, Y, Fukui, K, Seki, K, Takenaka, T, Abe, M, Utsu, N, Oono, A, Mitsuo, K, Sueyoshi, A, Hirohata, A, Tsujimoto, M, Ueda, O, Takase, S, Suzuki, M, Sakuragi, S, Yamamoto, F, Fujimoto, N, Kakinoki, S, Sugiura, T, Sugino, H, Nakamura, T, Kadokami, T, Uehara, H, Ono, M, Yokoya, K, Koike, A, Komatsu, S, Sonoda, M, Ueno, H, Doi, T, Takagi, Y, Fujimoto, K, Eki, Y, Okubo, M, Sasaki, K, van Eck, M, Ronner, E, The, S, van de Wal, R, Nierop, P, de Nooijer, C, Werner, H, Westendorp, I, van der Zwaan, C, Crijns, H, Cornel, J, Strikwerda, S, Bos, R, de Melker, E, Kuijper, A, Louwerenburg, H, Plomp, J, Dantzig, J, Prins, F, van Kesteren, H, Willems, F, Amoroso, G, Carnero, G, Duronto, E, Besada, D, Chacon, C, Zangroniz, P, Solis, S, Liberman, A, Sernia, V, Alvarisqueta, A, Maffei, L, Vilamajo, O, Garcia, C, Sicer, M, Muntaner, J, Bordonava, A, Albisu, J, Zanini, A, Rista, L, Hominal, M, Estrada, J, Prado, A, Gosparini, D, Schiavi, B, Castillo, A, Martinez, G, Lopez, V, Rosas, E, Lopez, G, Cantu, E, de los Rios Ibarra, M, Padilla, F, Carrasco, J, Carrillo, L, Garcia, J, Askar, A, Salinas, C, Gamba, M, Sanchez, C, Cantu, A, Sanchez, R, Madrigal, J, Urbano, R, Romo, A, Gonzalez Juanatey, J, Racugno, P, Fillat, A, de la Torre Hernandez, J, Pelaez, J, Cortada, J, Pavia, P, Navarro, M, Asenjo, R, Diaz, F, Peligero, E, Manterola, F, Ortiz, A, Mediavilla Garcia, J, Ortuno, F, Vera, T, Gonzalez, A, Vinas, J, Fernandez Portales, F, Mayordomo, P, Ojeda, F, Dominguez, A, Gonzalez, R, Guerrero, D, Ruiz Nodar, J, Marimon, X, Margaez, J, Aguilera, R, Diaz Fernandez, J, Zamorano Gomez, J, Gonzalez, V, del Blanco, B, Perez, I, Moreno, M, Ereno, A, Garcia Lledo, J, Prieto, J, Villablanca, A, Raffo, C, Pincetti, C, Conejeros, C, Roman, O, Varleta, P, Goldberg, C, Sandoval, J, Arriagada, G, Corbalan, R, Leon, L, Potthoff, S, Cobos, J, Figueroa, C, Makotoko, E, Fourie, N, Burgess, L, Nortje, H, Theron, R, Pillai, P, Ranjith, N, Trokis, J, Pillay, S, Reddy, J, Nunkoo, T, Kapp, C, Urbach, D, Distiller, L, Horak, A, van Zyl, L, Coetzee, K, Punt, Z, Bayat, J, Dawood, S, Mitha, I, Padayachee, T, Hoosen, F, Dalby, A, Prabhavathi, Gowdaiah, P, Mehta, V, Chag, M, Gadkari, M, Ramamurthee, K, Das, A, Sawhney, J, Sathe, P, Adhyapak, S, Nguyen, T, Pham, V, Do, H, Nguyen, A, Nguyen, H, Truong, B, Jamil-Copley, S, Lang, C, 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Angoulvant, D, Ferrario, E, Elbaz, M, Dubreuil, O, Fontaine, C, Sorbets, E, Omer, H, Al-Saif, S, Al-Faleh, H, Al-Shehri, A, El-Amin, O, Alshehri, H, Bazari, R, Hei, P, Ying, M, Chan, M, Wong, M, Ma, R, Siu, S, Tsang, C, Ferrario, M, Assanelli, E, Senni, M, Piatti, P, Calabro, P, Urbinati, S, Michisanti, M, Varbella, F, de Cosmo, S, Trevisan, R, Bellotti, S, Di Pasquale, G, Bongo, A, Uguccioni, M, Mannucci, E, Mauro, C, Ragonese, M, Fresco, C, Turturo, M, Marcucci, R, Lievano Triana, M, Arana, C, Accini, J, Botero, R, Muzyk-Osikowicz, M, Dada, F, Vallejo, G, Manzur, F, Isaza, D, Molina, D, Mesa, J, Quintero, A, Nyman, K, Makela, J, Strand, J, Nieminen, S, Taurio, J, Kuusela, M, Valle, T, Pietila, M, Kekki, S, Strandberg, T, Klutstein, M, Greenberg, G, Rozenman, Y, Chorin, E, Roguin, A, Lewis, B, Bashkin, A, Tan, E, Prado, J, Ferrolino, A, Babilonia, N, Barbas, B, Matiga, G, Coching, R, Drexel, H, Brath, H, Schnack, C, Hanusch, U, Fliesser-Gorzer, E, Paulweber, B, Ebenbichler, C, Prager, R, Huber, K, Wolzt, M, Auer, J, Berger, R, Schernthaner, G, Stanciulescu, G, Creteanu, M, Spiridon, M, Dobreanu, V, Vinereanu, D, Iosipescu, L, Istratoaie, O, Coman, I, Militaru, C, Cinteza, M, Nicolau, J, Kerr Saraiva, J, Widimsky, P, Kristensen, S, Hartikainen, J, Darius, H, Tse, H, Pais, P, Lev, E, de Luca, L, Ramos Lopez, G, Kontny, F, Zateyshchikov, D, Ruda, M, Elamin, O, Kovar, F, Bueno, H, Leonsson-Zachrisson, M, Bhatt D. L., Steg P. G., Mehta S. R., Leiter L. A., Simon T., Fox K., Held C., Andersson M., Himmelmann A., Ridderstrale W., Chen J., Song Y., Diaz R., Goto S., James S. K., Ray K. K., Parkhomenko A. N., Kosiborod M. N., McGuire D. K., Harrington R. A., Santos V., Jain A., Lendel I., Russo M., Haught W. H., Bouza M., Gogia H., Banerjee S., Kichura G., Kantaros L., Padron F., Passi R., Stone J., Pursley M., D'Urso M., Gardner T., Bennett J., Nour K., Saini S., Zhang W., Kumbhani D., Thomas D., Angiolillo D., Bertolet B., Roman-Miranda A., Black R., Manshadi R., Vaca C., Blanco A., Napoli M., Brabham D., Akyea-Djamson A., Desai P., Prasada S., Khaira A., Forgosh L., Lieber I., Umpierrez G., Singal D., Londono J., Fraser N., Ruiz J., Vega D., Rodriguez L., Brown C., Syed F., Aggarwala G., Eaves W., Foster M., Gupta D., Avino D., Asfour W., Tonnessen G., Zhao X. -Q., Singh N., Brockmyre A., Lepor N., Shammas N., Blick D., Hearne S., Prodafikas J., Carell E., Izzo M., Karim A., Zakhary B., Atieh M., Leichter S., Meadows C., Hotchkiss D., Abu-Fadel M., Wiseman A., Bander J., Shah M., Ganim R., Sopko K., Khan M., Lloret R., Weirick T., Mehta R., Thadani U., Bhargava A., Kosiborod M., Moya J., Staniloae C., Guerra Y. D., Chhabra A., Kosmicki D., Shaheen W., Mohammed A., Bitters J. C., Pattanayak J., Javier J., Srivastava S., Phillips R., Al-Amin J., Lillestol M., Simpson P., Hazan L., Amin A., Shah G., Korpas D., Platt B., Dickert J., Puente O., Hiotis L., Doyle T., Rajan R., Meholick A., Gring C., Hage-Korban E., Feldman R., Colfer H., Butman S., Hart T., Huling R., Eshaghian S., Quintana O., Cheung D., Handel F., Rodriguez M., Suh D., Gordon P., Pressman G., Bauer M., French W., Barettella M., Chatrathi S., Suresh D., Goldberg R., Huth M., Younis L., Rahman A., Mascolo R., Welch M., Suneja R., Smith S., Shurmur S., Agaiby J., Jingo A., Johnston J., Beth M., Vlastaris A., Kemp S., Taheri H., Pereira E., Deyoung M., Hawa Z., Smith R., Galski T., Garas S., Reddy M., Sharma S., Hargrove J., Treasure C., Emerson R., Haddad T., Rohr K., Levinson L., Gaona R., Uretsky B., Maheshwari H., Lee D., Kinnaman S., Singal R., Geohas J., Gigliotti O., Raisinghani A., Khurana C., Hella B., Kelberman M., Voyce S., Singh S., Lo E., Singh P., Goodfellow R., Fischer S., Lorraine R., Turner T., Shanes J., Busch R., Broker R., Zaniewski M., Pounds K., Debs-Perez G., Ong S., Frandsen B., Fullington D., Jaffrani N., Khan A., Lee M., Pouzar J., Revtyak G., Gonzalez J., Nakhle S., Murillo A., Young D., Makam S., Syed M., Woolf K., Grena P., Alfata S., Mahal S., Hoffman D., Kizhakekuttu T., Deering J., Bhavsar J., Mikesell S., Wilson W., Wilson V., El S., Spinale F., Kannarkat V., Rao S., Hanson L., Bertsch J., Gonzalez-Ortiz E., Severino N., Willis J., Schock J., Bakhtari L., Gazmuri R., Ansari S., Hall J., Mehta A., Shealy N., Zarich S., Singh D., Vora K., Andrawis N., Molter D., Maron D., Cardona J., D'Agostino R., Arshad T., Samaan R., Jones D., Presser D., Heath J., Green S., Bittar G., Henry S., Korn D., Schmedtje J., Nadar V., Graham B., Labroo A., Clavijo L., Roseman H., Ledesma G., Rosen R., Dor I., Kirby W., Sutton J., Eder F., Iteld B., Gomez-Cortes J., Buchbinder M., Kasper J., Terrelonge A., Torres G., Jagielo T., Alvarez J., Handelsman Y., Guillen M., Richwine R., Lewy-Alterbaum L., Corder C., Arvind M., Bolshoun D., Mikhail M., Minton S., Alvarado O., Abbott J., Cauthen B., Welter R., Mintz R., Cox J., Quick A., Weiss M., Dy J., Zebrack J., Gandelman G., Hegde V., Silver M., DeGregorio M., Lawson W., Paa C., Bortnick A., Krolick M., Sotolongo R., Cheirif J., Kumar P., Jetty P., Patel A., Kruk M., Kobielusz-Gembala I., Rewerska B., Madrzejewski A., Milewski K., Cygler J., Petryka-Mazurkiewicz J., Jastrzebski W., Korecki J., Fil W., Prokopczuk J., Bochenek A., Wujkowski M., Witek R., Konczakowski P., Miekus P., Szczasny M., Musial W., Cymerman K., Lampart J., Mikosinski J., Szynal S., Fares I., Opolski G., Mazur S., Wozakowska-Kaplon B., Bijata-Bronisz R., Wierucki L., Losa B., Drelich G., Konieczny M., Starczewski P., Pawlowicz L., Jesionowski P., Jurowiecki J., Gniot J., Czyzycki M., Stania K., Kucharczyk-Bauman I., Busz-Papiez B., Karczmarczyk A., Sudnik W., Koszek A., Kolodziej P., Skwarna B., Jaramillo N., Jankowski M., Czochra W., Kinasz L., Miklaszewicz B., Stasinska T., Pluta W., Basiak M., Rusicka T., Niedbal-Yahfouf I., Popenda G., Korzeniak R., Mirek A., Mariankowski R., Wojnowski L., Korol M., Baszak J., Podolec P., Piesiewicz W., Zurakowski A., Luengas C., Skura M., Pilecki P., Majchrzak P., Krzyzagorska E., Drozd M., Kaczmarek B., Sliwinska T., Zelazowska K., Sztembis R., Landa K., Matyszczak-Toniak L., Strojek K., Piepiorka M., Malinowski R., Gorska M., Stolarczyk-Sowa E., Romanowski L., Zinka E., Reszka Z., Skierkowska J., Uzunow A., Laskowska-Derlaga E., Puntus E., Kosmacheva E. D., Koziolova N., Pavlov P., Supryadkina T., Didenko Y., Kopylov P., Kazakov A., Aksentiev S., Vishneva E., Repin A., Smolenskaya O., Mantserova O., Khrustalev O., Privalova E., Konstantinov V., Boldueva S., Ezhov A., Chernyavsky A., Kamalov G., Galyavich A., Zubeeva G., Nechaeva G., Shustov S., Dzhaiani N., Treshkur T., Osokina N., Panov A., Shutemova E., Makukhin V., Kropotina T., Tsyba L., Karpov Y., Sizova J. M., Ballyuzek M., Tarasov N., Demchenko E., Barbarash O., Moiseev V., Markov V., Kuznetsov V., Viktorova I., Sergienko I., Ermoshkina L., Khasanov N., Khlevchuk T., Baglikov A., Shalaev S., Zonova E., Reznik E., Haisheva L., Morugova T., Lomakin N., Vishnevsky A., Shvarts Y., Magnitskaya O., Mikhailusova M., Pavlysh E., Libov I., Zateyschikova A., Kostenko V., Edin A., Khovaeva Y., Zakharov K., Stryuk R., Khirmanov V., Kanorskiy S., Yakushin S., Barabashkina A., Li H., Zhao Q., Zhang J., Ma J., He Y., Luo M., Zhang A., Zhang N., Chai Y., Ma G., Wang H., Liu Z., He L., Song Z., Dong X., Tao L., Li Z., Su X., Kong X., Niu H., Ge J., Luo Z., Huang W., Peng D., Yuan Z., Milanova M., Tenev D., Gogov A., Karageorgiev D., Kolchev T., Rusev N., Georgieva N., Kondov R., Rusinov V., Petrov I., Stanchev G., Konteva M., Dincheva A., Yaneva Z., Vatova R., Ilieva K., Runev N., Kolomanov B., Iliev N., Tisheva S., Chompalova B., Tokmakova M., Raev D., Byanov K., Markov D., Mihov L., Mihov A., Milcheva N., Minchev M., Mollov M., Borisov B., Tihchev T., Karakolev V., Dimov B., Georgiev S., Smilov L., Koo B. K., Ahn T., Hong S. J., Yoon J., Oh S. K., Jeong M. H., Kim D. -I., Chang K., Kim W., Hahn J. -Y., Cha K. S., Lee J. -H., Choi S. -W., Nam C. -W., Chae I. -H., Park Y. H., Tahk S. -J., Shin W. -Y., Chae J. -K., Kim B. J., Bae J. -W., Park W. J., Rha S. W., Choi Y. J., Hwang J. -Y., Park H. S., Baracioli L., Guimaraes F., Vasconcellos E., Saraiva J., Pereira A., Santos Q., Rossi P., Maia L., Madeira M., Pereira M., Botelho R., Reis G., Eliaschewitz F., Borges J., Nascimento C., Fortes J. A., de Souza W., Pimentel P., Hissa M., Franchetti M., Precoma D., Ortiz C., Hernandes M., Saporito W., dos Santos F. R., Kormann A., Neuenschwander F., Dutra O., Rassi N., Tanajura L., Souza J., Junior D. S., Leaes P., Forte A., Bonansea T. C., Marin J., Machado B., Cerqueira M. J., Silva F., Michalaros Y., Manenti E., Cercato C., Figueiredo E., Liu M. -E., Wang Y. -C., Lee T. -M., Fang C., Wu Y. -W., Ueng K. -C., Sheu H. -H., Lai W. T., Hsieh I. -C., Chen Z. -C., Lee M. -J., Chiang C., Shyu K. -G., Hsia C. -H., Mar G. -Y., Chan S. -H., Wu C. -C., Tseng W. -K., Chang K. -C., Yeh H. -I., Wang J. -H., Hou C., Sorokina I., Dolzhenko M., Horoshko O., Karpenko O., Rudenko L., Vakaliuk I., Kulyk A., Levchenko O., Prokhorov O., Reshotko D., Sorokivskyy M., Velichko N., Maslovskyi V., Teliatnikova Z., Dotsenko S., Krakhmalova O., Kraiz I., Zharinova V., Bula L., Kaydashev I., Molodtsov V., Rasputina L., Pidlisna V., Lysunets O., Kravchenko A., Glushko L., Khomazyuk T., Svyshchenko Y., Parkhomenko O., Mankovsky B., Abrahamovych O., Yagensky A., Stanislavchuk M., Vasilyeva L., Sokolova L., Sychov O., Tseluyko V., Kyrychenko I., Rishko M., Furkalo S., Gallo R., Bertrand O., Mehta S., Constance C., Sussex B., Zadra R., Kouz S., Chehayeb R., Pandey A., Dion D., Bailey G., Hill L., Ramanathan K., Dorsch M., Nanji A., Babapulle M., Montigny M., Gosselin G., Dehghani P., Rupka D., Le May M., Pichette F., St-Maurice F., Teefy P., Mansour S., Kassam S., Cheung S., Siega A. D., O'Keefe D., Sabbah E., Bell A., Chouinard G., Wong B., Miller M., Gaudet D., Lachance P., Bata I., Petrella R., Gossard D., Dumas R., Ing D., Boyrazian H., Bessoudo R., Huynh T. T., Hart R., Belle-Isle J., Shukla D., Kelly A., Mazza G., Cha J., Henein S., Frechette A., Vizel S., Liutkus J. F., O'Mahony M., Halperin F., Kooy J., Graham J., Bailey A., Wojcik R., Wilderman I., Turi T., Motyovszki A., Merkely B., Kiss R. G., Kiraly C., Andrassy P., Sarszegi Z., Fulop T., Zilahi Z., Edes I., Papp A., Muller G., Czigany A., Zolyomi S., Koranyi L., Takacs J., Juhasz F., Benczur B., Kancz S., Foldi A., Nagy A. C., Bakai J., Greschik I., Puski L., Nagy L., Kirschner R., Kuchar R., Hajek P., Busak L., Michalik D., Matyasek I., Marusincova I., Kucera D., Jerabek O., Honkova M., Dedek V., Rihacek I., Kos P., Slaby J., Machkova M., Zidkova E., Elbl L., Grunfeldova H., Carda J., Mrozek V., Maly J., Milkovic R., Malecha J., Skalicka H., Oral I., Krcova E., Lisa L., Belohlavek J., Miklik R., Cermak O., Bednarova J., Peroutka Z., Spinar J., Wilke A., Appel K. -F., Taggeselle J., Forster A., Toursarkissian N., Schmidt E., Bott J., Al-Zoebi A., Hennig D., Schon N., Sauter J., Simonis G., Nischik R., Rieker W., Schenkenberger I., Behnke T., Klausmann G., Jeserich M., Trenk D., Weigmann I., Reuter H., Rummel R., von Munchhausen C., von Engelhardt C., Horibe E., Shibasaki T., Sato T., Kakuta T., Michishita I., Tan M., Ishiki R., Aoyama T., Higashiue S., Niijima Y., Idogaki A., Hasegawa T., Kiyosue A., Tomobuchi Y., Kawamitsu K., Kawasaki S., Hata Y., Fukui K., Seki K., Takenaka T., Abe M., Utsu N., Oono A., Mitsuo K., Sueyoshi A., Hirohata A., Tsujimoto M., Ueda O., Takase S., Suzuki M., Sakuragi S., Yamamoto F., Fujimoto N., Kakinoki S., Sugiura T., Sugino H., Nakamura T., Kadokami T., Uehara H., Ono M., Yokoya K., Koike A., Komatsu S., Sonoda M., Ueno H., Doi T., Takagi Y., Fujimoto K., Eki Y., Okubo M., Sasaki K., van Eck M., Ronner E., The S., van de Wal R., Nierop P., de Nooijer C., Werner H., Westendorp I., van der Zwaan C., Crijns H., Cornel J. H., Strikwerda S., Bos R., de Melker E., Kuijper A., Louwerenburg H., Plomp J., Dantzig J. -M., Prins F., van Kesteren H., Willems F., Amoroso G., Carnero G., Duronto E., Besada D., Chacon C., Zangroniz P., Solis S., Liberman A., Sernia V., Alvarisqueta A., Maffei L., Vilamajo O. G., Garcia C., Sicer M., Muntaner J., Bordonava A., Albisu J., Zanini A., Rista L., Hominal M., Estrada J. N., Prado A., Gosparini D. M., Schiavi B., Castillo A. G., Ruiz J. G., Martinez G. R., Lopez V. G., Rosas E. L., Lopez G. R., Cantu E. G., de los Rios Ibarra M., Padilla F. P., Carrasco J. P., Carrillo L. V., Garcia J. D., Askar A. N., Salinas C. A., Gamba M. A., Sanchez C. G., Cantu A. G., Sanchez R. V., Madrigal J. C., Urbano R. H., Romo A. I., Gonzalez Juanatey J. R., Racugno P., Fillat A. C., de la Torre Hernandez J. M., Pelaez J. A., Cortada J. B., Pavia P. G., Navarro M. J., Asenjo R. M., Diaz F. F., Peligero E. B., Manterola F. A., Ortiz A. F., Mediavilla Garcia J. D., Ortuno F. M., Vera T. R., Gonzalez A. S., Vinas J. A., Fernandez Portales F. J., Mayordomo P. S., Ojeda F. B., Dominguez A. R., Gonzalez R. S., Guerrero D. B., Ruiz Nodar J. M., Marimon X. G., Margaez J. G., Aguilera R. M., Diaz Fernandez J. F., Zamorano Gomez J. L., Gonzalez V. B., del Blanco B. G., Perez I. P., Moreno M. R., Ereno A. R., Garcia Lledo J. A., Prieto J., Villablanca A., Raffo C., Pincetti C., Conejeros C., Roman O., Varleta P., Goldberg C., Sandoval J., Arriagada G., Corbalan R., Leon L., Potthoff S., Cobos J., Figueroa C., Makotoko E., Fourie N., Burgess L., Nortje H., Theron R., Pillai P., Ranjith N., Trokis J., Pillay S., Reddy J., Nunkoo T., Kapp C., Urbach D., Distiller L., Horak A., van Zyl L., Coetzee K., Punt Z., Bayat J., Dawood S., Mitha I., Padayachee T., Hoosen F., Dalby A., Gowdaiah P., Mehta V., Chag M., Gadkari M., Ramamurthee K., Das A., Sawhney J. S., Sathe P., Adhyapak S., Nguyen T., Pham V., Do H., Nguyen A., Nguyen H., Truong B., Jamil-Copley S., Lang C., Pell A., Zaman A., Storey R., Swanson N., Sharman D., Braganza D., Hammond P., Moriarty A., Bain S., Pye M., Sharp A., Blagden M., Randeva H., Myhill T., Viswanathan G., Keeling P., Clifford P., Saxena M., Lyons K., McMurray J., Jaafar F., Murphy C., Cartwright S., Abouglila K., Antalik L., Krajci P., Urban M., Fazekas F., Pella D., Koleny D., Vykoukalova T., Macek V., Vinanska D., Jamriskova L., Such S., Fulop P., Farsky S., Bugan V., Strbova J., Micko K., Palka Jr J., Sivak V., Kristensen D., Refsgaard J., Holmvang L., Dixen U., Nielsen H., Egstrup K., Jensen L. O., Sykulski R., Rasmussen O., Andries A., Luckow A., Nielsen G., Sorensen T., Wongvipaporn C., Chamnarnphol N., Srimahachota S., Sansanayudh N., Kuanprasert S., Tresukosol D., Sookananchai B., Kanadasi M., Ozcan T., Kucuk M., Ongen Z., Okuyan E., Arat A., Acikel S., Yalcin A., Guray U., Ceyhan C., Ozer N., Arslan S., Angeras O., Johnston N., Weiderman A. -C., Bandh S., Hansen O., Larnefeldt H., Kusiak D., Lindholm C. -J., Hedman A., Erlinge D., Curiac D., Lundman P., Zucconi-Mazzini R., Aladellie L., Jensen J., Verwerft J., Vrolix M., Faes D., Striekwold H., Sinnaeve P., Timmermans P., Guedes A., Delforge M., Nimmegeers J., Stammen F., Buysschaert I., Hoffer E., Hollanders G., Vervoort G., Coussement P., de Maeseneire S., Janssens L., Gravdal S. A., Risberg K., Gullestad L., Hofseth O. D., Nilsen D., Lappegard K. T., van den Heuvel C., Gibbs C., Khusrawi A., Arora S., Tomala T., Kjaernli T., Berg-Johansen J., Hagemeier R., Skjelvan G., Colquhoun D., Amerena J., Morbey C., Hammett C., Dart A., Lehman R., Hamilton A., Worthley M., Purnell P., Whelan A., MacIsaac R., Arya K., Linjawi S., Proietto J., Prasad L., Rodriguez A., Godoy A., Rodriguez V., Berrospi P., Chavez C., Negron S., Heredia J., Medina F., Manrique H., Cabrera W., Cordova F., Quinteros T., Haro J. M., Regalado S., Guitton J., Arbanil H., Pansieri M., Decoulx E., Goube P., de Labriolle A., Labeque J. N., Range G., Cottin Y., Montalescot G., Cayla G., Danchin N., Angoulvant D., Ferrario E., Elbaz M., Dubreuil O., Fontaine C., Sorbets E., Omer H., Al-Saif S., Al-Faleh H., Al-Shehri A., El-Amin O., Alshehri H., Bazari R., Hei P., Ying M., Chan M., Wong M., Ma R., Siu S. C., Tsang C. C., Ferrario M., Assanelli E., Senni M., Piatti P., Calabro P., Urbinati S., Michisanti M., Varbella F., de Cosmo S., Trevisan R., Bellotti S., Di Pasquale G., Bongo A. S., Uguccioni M., Mannucci E., Mauro C., Ragonese M., Fresco C., Turturo M., Marcucci R., Lievano Triana M. J., Arana C., Accini J., Botero R., Muzyk-Osikowicz M., Dada F. T., Vallejo G. S., Manzur F., Isaza D., Molina D., Mesa J. G., Quintero A., Nyman K., Makela J., Strand J., Nieminen S., Taurio J., Kuusela M., Valle T., Pietila M., Kekki S., Strandberg T., Klutstein M., Greenberg G., Rozenman Y., Chorin E., Roguin A., Lewis B., Bashkin A., Tan E., Prado J. P., Ferrolino A., Babilonia N., Barbas B., Matiga G., Coching R. M., Drexel H., Brath H., Schnack C., Hanusch U., Fliesser-Gorzer E., Paulweber B., Ebenbichler C., Prager R., Huber K., Wolzt M., Auer J., Berger R., Schernthaner G. -H., Stanciulescu G., Creteanu M., Spiridon M., Dobreanu V., Vinereanu D., Iosipescu L. C., Istratoaie O., Coman I., Militaru C., Cinteza M., Sinnaeve P. R., Nicolau J. C., Kerr Saraiva J. F., Widimsky P., Kristensen S. D., Hartikainen J., Darius H., Tse H. F., Pais P., Lev E., de Luca L., Ramos Lopez G. A., Kontny F., Babilonia N. A., Zateyshchikov D. A., Ruda M., Elamin O., Kovar F., Dalby A. J., Bueno H., Chiang C. -E., Parkhomenko A., Nguyen T. Q., and Leonsson-Zachrisson M.
- Abstract
Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pinteraction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo
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- 2019
11. Confidence bounds on structural reliability
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Mehta, S. R, Cruse, T. A, and Mahadevan, S
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Structural Mechanics - Abstract
Different approaches for quantifying physical, statistical, and model uncertainties associated with the distribution parameters which are aimed at determining structural reliability are described. Confidence intervals on the distribution parameters of the input random variables are estimated using four algorithms to evaluate uncertainty of the response. Design intervals are evaluated using either Monte Carlo simulation or an iterative approach. A first order approach can be used to compute a first approximation of the design interval, but its accuracy is not satisfactory. The regression approach which combines the iterative approach with Monte Carlo simulation is capable of providing good results if the performance function can be accurately represented using regression analysis. It is concluded that the design interval-based approach seems to be quite general and takes into account distribution and model uncertainties.
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- 1993
12. COMMUNICATION AND DEVELOPMENT: CONCEPTS AND METHODS
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Mehta, S. R.
- Published
- 1987
13. Punch Biopsy Of The Peritoneum
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Sarin, L. R., Mehta, S. R., and Sarin, J. C.
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- 1961
14. Falciparum malaria
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Chandar, Vipan, Mehta, S. R., Sharma, P. D., Sarkar, P. K., and Sharma, B. R.
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- 1989
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15. An unusual cause of headache in pregnancy
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Htay, T, primary, Bedford, J, additional, Harvie, M, additional, Dassan, P, additional, and Mehta, S R, additional
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- 2015
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16. Participatory approaches to sustainable rural development K. Vijayaragavan
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Mehta, S. R.
- Published
- 2000
17. Reply to Sachdev et al
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Karris, M. Y., primary, Beekmann, S. E., additional, Mehta, S. R., additional, and Polgreen, P. M., additional
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- 2014
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18. Are We Prepped for Preexposure Prophylaxis (PrEP)? Provider Opinions on the Real-World Use of PrEP in the United States and Canada
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Karris, M. Y., primary, Beekmann, S. E., additional, Mehta, S. R., additional, Anderson, C. M., additional, and Polgreen, P. M., additional
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- 2013
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19. Corporate Social Responsibility (CSR) and Universities:Towards an Integrative Approach
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Mehta, S. R., primary
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- 2011
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20. Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary intervention: insights from the PCI-CURE study
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Jolly, S. S., primary, Pogue, J., additional, Haladyn, K., additional, Peters, R. J.G., additional, Fox, K. A.A., additional, Avezum, A., additional, Gersh, B. J., additional, Rupprecht, H. J., additional, Yusuf, S., additional, and Mehta, S. R., additional
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- 2008
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21. Book Reviews
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Sahai, Jugendra, primary, Hegde, Sasheej, additional, Jain, Shobhita, additional, Rajimwale, Kirti, additional, Mehta, S. R., additional, Sandhu, Jasmeet, additional, Prasad, Rajeshwar, additional, Advani, Mohan, additional, Kaur, Malkit, additional, Gupta, G. V., additional, and Goel, Dharmendra, additional
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- 2000
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22. Impact fracture behavior of injection molded long glass fiber reinforced polypropylene
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Skourlis, T. P., primary, Mehta, S. R., additional, Chassapis, C., additional, and Manoochehri, S., additional
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- 1998
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23. Prognostic significance of thrombocytopenia during hirudin and heparin therapy in acute coronary syndrome without ST elevation: Organization to Assess Strategies for Ischemic Syndromes (OASIS-2)study.
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Eikelboom, J W, Anand, S S, Mehta, S R, Weitz, J I, Yi, C, and Yusuf, S
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- 2001
24. Safety outcomes in meta-analyses of phase 2 vs phase 3 randomized trials: Intracranial hemorrhage in trials of bolus thrombolytic therapy.
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Eikelboom JW, Mehta SR, Pogue J, Yusuf S, Eikelboom, J W, Mehta, S R, Pogue, J, and Yusuf, S
- Abstract
Context: Recent studies have reported disagreement between meta-analysis of small trials and subsequent large trials addressing the same question. However, disagreement for uncommon but serious adverse safety outcomes has not been examined.Objective: To explore disagreement for serious adverse safety (intracranial hemorrhage [ICH]) and efficacy outcomes between meta-analysis of phase 2 (small) vs meta-analysis of phase 3 (large) randomized controlled trials comparing the efficacy of bolus thrombolytic therapy with infusion for acute myocardial infarction (AMI).Data Sources: Electronic databases (MEDLINE, Cochrane Database of Clinical Trials) between January 1980 and December 1999 using the search terms thrombolysis, thrombolytic therapy, and myocardial infarction; conference proceedings; and reference lists.Study Selection: Fifteen randomized trials comparing thrombolytic agents administered by bolus injection with standard infusion therapy in patients with AMI.Data Extraction: Data on ICH, other causes of stroke, total mortality, and reinfarction were independently extracted from each study by 2 observers.Data Synthesis: Meta-analysis of 9 phase 2 trials (n = 3956) revealed a lower risk of ICH with bolus thrombolytic therapy (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.27-1.01), which was not statistically significant. Meta-analysis of 6 phase 3 trials (n = 62 673) indicated a significant increase in risk of ICH (OR, 1.25; 95% CI, 1.06-1.49). These results were significantly different (P =.01). There was no disagreement for efficacy outcomes. Phase 2 trials included younger and heavier patients with lower baseline blood pressures, and were more often open-label. Subgroup analyses suggested that each of these factors was associated with a lower estimate of risk of ICH with bolus agents.Conclusions: Our results suggest that when therapeutic interventions are associated with a potential for uncommon but serious adverse safety outcomes, there may be differences between small phase 2 and large phase 3 trials that result in their disagreement for safety but not necessarily efficacy outcomes. Further investigation of the frequency and causes of disagreement between small and large trials for safety outcomes is warranted. [ABSTRACT FROM AUTHOR]- Published
- 2001
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25. Routine Spironolactone in Acute Myocardial Infarction.
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jolly, S. S., d 'Entremont, M.-A., Pitt, B., Lee, S. F., Mian, R., Tyrwhitt, J., Kedev, S., Montalescot, G., Cornel, J. H., Stanković, G., Moreno, R., Storey, R. F., Henry, T. D., Mehta, S. R., Bossard, M., Kala, P., Bhindi, R., Zafrovska, B., Devereaux, P. J., and Eikelboom
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MYOCARDIAL infarction , *CONGESTIVE heart failure , *PERCUTANEOUS coronary intervention , *MINERALOCORTICOID receptors , *HEART failure - Abstract
Background Mineralocorticoid receptor antagonists have been shown to reduce mortality in patients after myocardial infarction with congestive heart failure. Whether routine use of spironolactone is beneficial after myocardial infarction is uncertain. Methods In this multicenter trial with a 2-by-2 factorial design, we randomly assigned patients with myocardial infarction who had undergone percutaneous coronary intervention to receive either spironolactone or placebo and either colchicine or placebo. The results of the spironolactone trial are reported here. The two primary outcomes were a composite of death from cardiovascular causes or new or worsening heart failure, evaluated as the total number of events; and a composite of the first occurrence of myocardial infarction, stroke, new or worsening heart failure, or death from cardiovascular causes. Safety was also assessed. Results We enrolled 7062 patients at 104 centers in 14 countries; 3537 patients were assigned to receive spironolactone and 3525 to receive placebo. At the time of our analyses, the vital status was unknown for 45 patients (0.6%). For the first primary outcome, there were 183 events (1.7 per 100 patient-years) in the spironolactone group as compared with 220 events (2.1 per 100 patient-years) in the placebo group over a median follow-up period of 3 years (hazard ratio adjusted for competing risk of death from noncardiovascular causes, 0.91; 95% confidence interval [CI], 0.69 to 1.21; P=0.51). With respect to the second primary outcome, an event occurred in 280 of 3537 patients (7.9%) in the spironolactone group and 294 of 3525 patients (8.3%) in the placebo group (hazard ratio adjusted for competing risk, 0.96; 95% CI, 0.81 to 1.13; P=0.60). Serious adverse events were reported in 255 patients (7.2%) in the spironolactone group and 241 (6.8%) in the placebo group. Conclusions Among patients with myocardial infarction, spironolactone did not reduce the incidence of death from cardiovascular causes or new or worsening heart failure or the incidence of a composite of death from cardiovascular causes, myocardial infarction, stroke, or new or worsening heart failure. [ABSTRACT FROM AUTHOR]
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- 2025
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26. Colchicine in Acute Myocardial Infarction.
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Jolly, S. S., d'Entremont, M.-A., Lee, S. F., Mian, R., Tyrwhitt, J., Kedev, S., Montalescot, G., Cornel, H., Stanković, G., Moreno, R., Storey, R. F., Henry, T. D., Mehta, S. R., Bossard, M., Kala, P., Layland, J., Zafirovska, B., Devereaux, PJ., Eikelboom, J., and Cairns, J. A.
- Subjects
- *
MYOCARDIAL infarction , *C-reactive protein , *FACTORIAL experiment designs , *STROKE , *COLCHICINE - Abstract
Background Inflammation is associated with adverse cardiovascular events. Data from recent trials suggest that colchicine reduces the risk of cardiovascular events. Methods In this multicenter trial with a 2-by-2 factorial design, we randomly assigned patients who had myocardial infarction to receive either colchicine or placebo and either spironolactone or placebo. The results of the colchicine trial are reported here. The primary efficacy outcome was a composite of death from cardiovascular causes, recurrent myocardial infarction, stroke, or unplanned ischemia-driven coronary revascularization, evaluated in a time-to-event analysis. C-reactive protein was measured at 3 months in a subgroup of patients, and safety was also assessed. Results A total of 7062 patients at 104 centers in 14 countries underwent randomization; at the time of analysis, the vital status was unknown for 45 patients (0.6%), and this information was most likely missing at random. A primary-outcome event occurred in 322 of 3528 patients (9.1%) in the colchicine group and 327 of 3534 patients (9.3%) in the placebo group over a median follow-up period of 3 years (hazard ratio, 0.99; 95% confidence interval [CI], 0.85 to 1.16; P=0.93). The incidence of individual components of the primary outcome appeared to be similar in the two groups. The least-squares mean difference in C-reactive protein levels between the colchicine group and the placebo group at 3 months, adjusted according to the baseline values, was −1.28 mg per liter (95% CI, −1.81 to −0.75). Diarrhea occurred in a higher percentage of patients with colchicine than with placebo (10.2% vs. 6.6%; P<0.001), but the incidence of serious infections did not differ between groups. Conclusions Among patients who had myocardial infarction, treatment with colchicine, when started soon after myocardial infarction and continued for a median of 3 years, did not reduce the incidence of the composite primary outcome (death from cardiovascular causes, recurrent myocardial infarction, stroke, or unplanned ischemia-driven coronary revascularization) [ABSTRACT FROM AUTHOR]
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- 2025
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27. The Mode of Production, Social Classes and the State Bipul Kumar Bhadra
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Mehta, S. R.
- Published
- 1991
28. Haptoglobins in Haemoglobinopathy: A Genetic and Clinical Study.
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Mehta, S. R. and Jensen, W. N.
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- 1960
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29. Long-term growth of human B cells and their use in a microassay for B-cell growth factor.
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Maizel, A L, Morgan, J W, Mehta, S R, Kouttab, N M, Bator, J M, and Sahasrabuddhe, C G
- Abstract
Normal human B lymphocytes, prepared from peripheral venous blood, have been stimulated with intact anti-IgM (mu chain specific) bound to an insoluble matrix. The activation event, in a subfraction of human B cells, was associated with subsequent receptivity to the mitogenic effects of exogenously added B-cell growth factor. The ability of the cell population to specifically absorb the B-cell growth factor was dependent upon the time of stimulation with the anti-IgM. Continuous replenishment of the growth factor resulted in the ability to maintain long-term growth-factor-dependent human B-cell populations. These cultured B lymphocytes were shown to specifically absorb the B-cell growth factor, suggesting the presence of membrane receptors for it. The cultured B lymphocytes were routinely maintained in logarithmic-phase growth, in the presence of growth factor, with a population doubling time of 36 hr. These cultured B cells have been utilized in a microassay for the assessment of B-cell growth factor activity that is accurate, sensitive, and precise.
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- 1983
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30. Effect of interleukin 1 on human thymocytes and purified human T cells.
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Maizel, A L, Mehta, S R, Ford, R J, and Lachman, L B
- Abstract
Human Interleukin 1 (IL-1) purified by molecular weight fractionation, isoelectric focusing, and gel electrophoresis has been tested on human thymocytes and highly purified human T cells. IL-1 prepared in this manner could not support the long-term growth of T cells yet would augment lectin-stimulated mitogenesis. The IL-1 preparations were shown to possess the lectin-augmenting activity at dilutions containing less than 1 ng of the measurable protein. These data are in agreement with the model that IL-1 stimulates production of IL-2 from lectin-stimulated lymphocytes.
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- 1981
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31. A surface-wave approach to high-gain antenna design for data acquisition by UHF radio telemetry
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Mehta, S R and Taylor, B G
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Engineering - Published
- 1976
32. Comparison of fondaparinux and enoxaparin in acute coronary syndromes
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Yusuf, S., Mehta, S. R., Bassand, J. P., Budaj, A., Chrolavicius, S., Fox, K. A. A., Granger, C. B., Joyner, C., Peters, R. J. G., Wallentin, L., Avezum, A., Boden, W., Cardona, E., Ceremuzynski, L., Col, J., Commerford, P. J., Diaz, R., Faxon, D., Flather, M., Fodor, G., Franzosi, M. G., Granger, C., Halon, D., Hunt, D., Karatzas, N., Keltai, M., Kenda, M., Kim, J. H., Lanas, F., Lau, C. P., Lewis, B. S., Morais, J., Moccetti, T., Pais, P., Paolasso, E., Parkhomenko, A., Petrauskiene, B., Piegas, L., Pipilis, A., Robaayah, D., Ruda, M., Rumboldt, Z., Rupprecht, H. J., Sitkei, E., Steg, P. G., Swahn, E., Theroux, P., Valentin, V., Varigos, J., Weitz, J., White, H., Widimsky, P., Xavier, D., Zhu, J. R., Ameriso, S., Bonilla, C., Braekken, S., Chan, Y. K., Chen, W., Chenniappan, M., Cohen, E., Cottin, Y., Csiba, L., Czepiel, A., Raedt, H., Finet, G., Gardinale, E., Gaxiola, E., Gorecki, A., Gregor, P., Happola, O., Heras, M., Himbert, D., Irkin, O., Isaaz, K., Iyengar, S. S., Kalvach, P., Kevers, L., Klosiewicz-Wasek, B., Laine, M., Leys, D., Lundstrom, E., Lusic, I., Lutay, Y., Maggioni, A., Massaro, A., Mayosi, B. M., Moulin, T., Narendra, J., Naslund, U., Peeters, A., Penicka, M., Perakis, A., Petersen, P., Polic, S., Radhakrishnan, S., Renkin, J., Stockins, B., Sundararajan, R., Thygesen, K., Turazza, F., Belle, E., Vik-Mo, H., Zaborski, J., Sleight, P., Anderson, J. L., Johnstone, D. E., Hirsh, J., Demets, D., Holmes, D. R., Meeks, B., Afzal, R., Pogue, J., Boccalon, S., Chrysler, K., Cracknell, B., Horsman, C., Hoskin, T., Jedrzejowski, B., Johnson, J., Kotlan, S., Lawrence, M., Smiley, M., Stevens, C., Yallup, R., Connolly, S., Demers, C., Devereaux, P. J., Healey, J., Lonn, E., Magloire, P., Mckelvie, R., Morillo, C., Natarajan, M., Rokoss, M., Teo, K., Valettas, N., Velianou, J., Albisu, J. P., Amuchastegui, M., Bello, F. A., Bluguermann, J. J., Bono, J. O., Caccavo, A., Carlevaro, O. O., Cassettari, A., Cuneo, C., Farras, H. A., Fuselli, J., Garrido, M., Guerrero, R., Hasbani, E., Hominal, M. A., Hrabar, A., Marquez, L. L., Luciardi, H. L., Riera, L. M., Marzetti, E. M., Memoli, R., Nordaby, R., Orlandini, A. D., Perez, M., Piasentin, J. A., Ramos, H. R., Risolo, A. M., Sala, J., Salomone, O., Schygiel, P. O., Ubaldini, J., Vico, M., Amerena, J., Arnolda, L., Aroney, G., Boyd, P., Cahill, P., Chew, D., Counsell, J. T., Cross, D., Edington, J., Fitzpatrick, D., Hicks, P., Horowitz, J. D., Horrigan, M. C. G., New, G., Owensby, D., Schoeman, M., Thompson, P., Tulloch, G., Waites, J., Whelan, A., Ziffer, R., Huber, K., Jordanova, N., Al Shawafi, K., Convens, C., Coussement, P., Meester, A., El Allaf, D., Janssens, L., Marcovitch, O., Muyldermans, L., Roosen, J., Soeur, F., Lierde, J., Vrolix, M., Leaes, P., Carvalho, A. C., Schramm, E. C., Mora, R. D., Amino, J. D., Dutra, O., Manenti, E. R. F., Gun, C., Saraiva, J. F. K., Hayashi, E. K., Lichter, A., Lima, A., Marin-Neto, J. A., Teixeira, S. P. M., Abrantes, J. A. M., Baracioli, L. M., Nicolau, J. C., Maia, L. N., Jaeger, C. P., Esteves, J. P., Rabelo, A., Ramos, R. F., Reis, G., Rossi, P., Dos Santos, F. R., Teixeira, M. S., Silveira, D. S., Lemos, Mabt, Timerman, A., Greque, G. V., Vaz, R., Bhargava, R., Brons, S., Colclough, M., Constance, C., Costi, P., Dacyk, A., Davies, T., Diodati, J., Dupuis, R., Elliott, H., Fell, D. A., Fung, A. Y., Gladstone, P. J. S., Gosselin, G., Grondin, F., Huynh, T., Janzen, I., Kalaparambath, T., Kornder, J., Kouz, S., Kuritzky, R., Labelle-Stimac, S., Lamothe, M., Lauzon, C., Lemay, M., Ma, P., Maccallum, G. C., Mccallum, A., Mitchell, D., Montigny, M., Nguyen, N., Pearce, M., Pistawka, K. J., Rebane, T., Roy, M., Senaratne, M., Smith, J., Stimac, J., Traboulsi, M., Vizel, S., Weeks, A., Zadra, R., Zimmerman, R. H., Alcaino, M. E., Castro, P., Chen, J., Chen, J. L., Fan, W., Ge, J., Hu, D., Huang, J., Jingxuan, G., Ke, Y., Ma, H., Wu, Y., Yingxian, S., Yu, B., Zhu, W., Bakula, M., Bergovec, M., Lukin, A., Milicevic, G., Padovan, M., Raguz, M., Aschermann, M., Belohlavek, J., Bocek, P., Branny, M., Budesinsky, T., Groch, L., Holm, F., Jansky, P., Jelinek, P., Jirka, V., Kaislerova, M., Konecny, P., Lisa, L., Maly, M., Marcinek, G., Oscipovsky, M., Stumar, J., Vacha, M., Nielsen, T., Vigholt, E., Laanmets, P., Soopold, U., Voitk, J., Naveri, H., Niemela, M., Peuhkurinen, K., Tuomainen, P., Ylitalo, A., Py, A., Amat, G., Bessede, G., Boschat, J., Carrie, D., Charbonnier, B., Coliet, J. P., Dambrine, P., Dubois-Rande, J. L., Ferrari, E., Fouche, R., Grollier, G., Jaboureck, O., Ketelers, R., Khalife, K., Leroy, F., Lognone, T., Macquin-Mavier, I., Montalescot, G., Pacouret, G., Poulard, J. E., Puel, J., Richard, M., Schiele, F., Bischoff, K. O., Buerke, M., Buerke, U., Dominick, K., Drexler, H., Feiler, A., Guelker, H., Haltern, G., Katus, H. A., Klauss, V., Klutmann, M., Koeth, O., Meinhardt, G., Muenzel, T. M., Nitschke, T., Offterdinger, M., Rieber, J., Schieffer, B., Stangl, K., Stangl, V., Vom Dahl, J., Witzenbichler, B., Zeymer, U., Alexopoulos, D., Blassopoulou, N., Christon, A., Fotiadis, I., Foussas, S., Grapsas, N., Moschos, N., Papasteriadis, E., Symeonidis, D., Tyrologos, A., Leung, W. S., Li, S. K., Arabadzisz, H., Csikazs, J., Dancs, T., Davidovits, Z., Edes, I., Farkas, E., Herczeg, B., Janos, S., Janosi, A., Kadar, A., Kis, E., Kristof, E., Lupkovics, G., Mark, L., Nagy, A., Nagy, L., Poor, F., Regos, L., Sebo, J., Tomcsanyi, J., Toth, K., Bharani, A., Chidambaram, N., Haridas, K. K., Jain, A., Jain, P. R. K., Jaison, T. M., Kerkar, P. G., Naik, S., Nambiar, A., Panwar, R. B., Parikh, K., Puri, V. K., Rajesh, T., Ramesh, M., Singh, B., Thanikachalam, S., Tongia, R. K., Varma, S., Barbiero, M., Bardelli, G., Bernardi, D., Bolognese, L., Capponi, L., Ferrari, G., Fanelli, R., Frediani, L., Galli, M., Izzo, A., Lombardi, A., Maresta, A., Martinoni, A., Melloni, C., Meneghetti, P., Mennuni, M., Moretti, L., Orlandi, M., Pancaldi, L. G., Petronzelli, S., Piovaccari, G., Salvioni, A., Severini, D., Terrosu, P., Zanini, R., Erglis, A., Kalnins, U., Verboenko, J., Zakke, I., Kugiene, R., Zaliunas, R., Bin Othman, A., Chee, K. H., Hian, S. K., Gutierrez, A. C., Diaz, A. C., Garcia-Castillo, A., Guerrero, M. C., Morales, C. L., Ramos-Lopez, G., Baldew, S. C., Basart, D. C. G., Clappers, N., Daniels, M. C. G., Weerd, G. J., Den Hartog, F. R., Hendriks, Ihgm, Herrman, J. P. R., Kofflard, M., Krasznai, K., Michels, H. R., Stoel, I., Ten Berg, J. M., Umans, Vawn, Beek, G. J., Daele, Merm, Den Berg, B. J., Hessen, M. W. J., Kalmthout, P. M., Rossum, P., Verheugt, F. W. A., Viergever, E. P., Withagen, Ajam, Achremczyk, P., Arasimowicz, P., Baranowska, T., Biegayto, J., Bronisz, M., Buszman, P., Dalkowski, M., Dluzniewski, M., Gessek, J., Goch, J. H., Janik, K., Janion, M., Kawecki, D., Kleinrok, A., Komorowski, P., Krasowski, W., Krauze-Wielicka, M., Malinowski, S., Nowak, T., Nowakowski, P., Ogorek, M., Piepiorka, M., Pluta, W., Puzio, E., Puzniak, M., Rekosz, J., Rybka, P., Sendrowski, D., Siminiak, T., Skura, M., Stopinski, M., Szetemej, R., Szolkiewicz, M., Szpajer, M., Trusz-Gluza, M., Waszyrowski, T., Wita, K., Wodniecki, J., Wojewoda, P., Zambrzycki, J., Zielinski, Z., Cardoso, P., Carrageta, D. M., Ferreira, D., Gomes, M. V., Santos, L., Arkhipov, M., Belousov, Y., Charchoglyan, R., Gordeev, I. G., Gratsiansky, N. A., Grinshtein, Y., Khrustalev, O., Kokorin, V. A., Komarov, A., Kozulin, V., Minushkina, L. O., Panchenko, E., Panov, A., Petrik, E. S., Shakhnovich, R. M., Shalaev, S. V., Sukhinina, T. S., Trifonov, I. R., Zateyshchikov, D. A., Khoo, B. C. H., Tan, H. C., Tan, R. S., Hricak, V., Motovska, Z., Poliacik, P., Kanic, V., Kovacic, D., Kranjec, I., Voga, G., Bayat, J., Essop, M. R., Maritz, F., Marx, J. D., Ntsekhe, M., Pretorius, M. P., Ranjith, N., Theron, H., Chae, I. H., Chae, S. C., Choe, K. H., Chung, N. S., Jeong, M. H., Kim, C. J., Kim, H. S., Kim, W., Rhim, C. Y., Shin, E. K., Shin, G. J., Alameda, M., Alonso-Orcajo, N., Bethencourt, A., Calvo, F., Avellaneda, J. L. C., Delgado, V., Diaz-Castro, O., Esplugas, E., Faus, R., Antonio Fernandez-Ortiz, Frutos, A., Goirena, P., Iglesias, F. C., Llorian, A. R., Macaya, C., Mancisidor, X., Melgares, R., Pascual, C., Ruiz-Nodar, J. M., Simon, J. M., Agewall, S., Ahlstrom, P., Ali, M., Andersson, L., Bandh, S., Digerfeldt, C., Ericsson, H., Forsgren, M., Jabro, J., Janzon, M., Joborn, H., Johnston, N., Karlsson, J. E., Larsson, L. E., Linderfalk, C., Lonnberg, I., Mooe, T., Oldgren, J., Pihl, E., Risenfors, M., Sjolund, E., Soderberg, I., Stjerna, A., Svennberg, L., Wodlin, P., Pagnamenta, A., Pieper, M., Rossi, M. G., Weber, K., Peng, M. C., Cheng, J. J., Chiang, F. T., Kuo, C. T., Tseng, C. D., Andreyeshcheva, I., Dzyak, G. V., Fedtchouk, L., Gontar, A., Karpenko, O., Kononenko, L., Koval, E. A., Kovalsky, I., Kraitz, I., Netiazhenko, V., Polyvoda, S., Prokopenko, Y., Prudkiy, I., Rudenko, L., Serediuk, N., Zolotaykina, V., Adgey, J., Ahsan, A., Brack, M., Bridges, A. B., Burton, J., Findlay, I., Fluck, D. S., Radford, L., Robson, R. H., Senior, R., Starkey, I. R., Alexander, J., Baber, Z., Campbell, M., Caputo, R., Chandna, H., Chandrashekhar, Y., Chu, A., Deraad, R. E., Druken, B., Goyal, A., Holly, D., Kemp, A., Kotlaba, D., Levine, M. J., Miller, G. P., Nygaard, T., Parikh, D. K., Ramos, C., Rivera, E., Rodriguez, R., Sangani, B., Walder, J. S., and Oasis
33. Characterization of the cell surface receptors for human B cell growth factor of 12,000 molecular weight.
- Author
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Mehta, S R, primary, Grant, S R, additional, and Maizel, A L, additional
- Published
- 1986
- Full Text
- View/download PDF
34. Purification of human B cell growth factor.
- Author
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Mehta, S R, primary, Conrad, D, additional, Sandler, R, additional, Morgan, J, additional, Montagna, R, additional, and Maizel, A L, additional
- Published
- 1985
- Full Text
- View/download PDF
35. ChemInform Abstract: LITHIATION OF METHYLENEDIOXYBENZENE DERIVATIVES
- Author
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RANADE, A. C., primary, MALI, R. S., additional, BHIDE, S. R., additional, and MEHTA, S. R., additional
- Published
- 1976
- Full Text
- View/download PDF
36. Human T lymphocyte/monocyte interaction in response to lectin: kinetics of entry into the S-phase.
- Author
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Maizel, A L, primary, Mehta, S R, additional, Hauft, S, additional, Franzini, D, additional, Lachman, L B, additional, and Ford, R J, additional
- Published
- 1981
- Full Text
- View/download PDF
37. ChemInform Abstract: ANTIIMPLANTATION AGENTS: PART III ‐ 1,2‐DIARYL‐4,5‐POLYMETHYLENEPYRROLES AND 1,2‐DIARYL‐4‐OXO‐ AND 1,2‐DIARYL‐4‐HYDROXY‐4,5,6,7‐TETRAHYDROINDOLES
- Author
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NAGARAJAN, K., primary, TALWALKER, P. K., additional, SHAH, R. K., additional, MEHTA, S. R., additional, and NAYAK, G. V., additional
- Published
- 1985
- Full Text
- View/download PDF
38. ChemInform Abstract: RK. VON 1,3,3-TRIMETHYL-2-METHYLEN-INDOLIN (FISCHER-BASE) MIT SULFONYL-CHLORIDEN
- Author
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NAGARAJAN, K., primary and MEHTA, S. R., additional
- Published
- 1971
- Full Text
- View/download PDF
39. Reserve angiography and revascularisation for high risk patients with ongoing ischaemia.
- Author
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Mehta, S. R., Cannon, C. P., and Fox, K. A.
- Subjects
- *
HEART diseases , *THERAPEUTICS , *CORONARY disease , *MYOCARDIAL infarction , *ANGINA pectoris , *ANGIOGRAPHY , *MYOCARDIAL revascularization - Abstract
Asks whether a routine or a selective invasive strategy is more effective in treating acute coronary syndrome. Controversy over the optimal treatment for patients with unstable angina or non-ST segment elevation myocardial infarction; Definition of a routine invasive strategy, which involves immediate coronary angiography followed by revascularisation; Explanation of a selective invasive strategy, which involves pharmacological treatment followed by angiography and revascularisation only if necessary; View that high risk patients with unstable angina or non-ST segment elevation myocardial infarction benefit from immediate coronary angiography.
- Published
- 2005
- Full Text
- View/download PDF
40. Participatory Approaches to Sustainable Rural Development (Book).
- Author
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Mehta, S. R.
- Abstract
Reviews the book "Participatory Approaches to Sustainable Rural Development," edited by K. Vijayaragavan.
- Published
- 2000
41. Lithiation of Methylenedioxybenzene Derivatives
- Author
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RANADE, A. C., MALI, R. S., BHIDE, S. R., and MEHTA, S. R.
- Published
- 1976
- Full Text
- View/download PDF
42. Ticagrelor in Patients with Stable Coronary Disease and Diabetes.
- Author
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Steg, P. G., Bhatt, D. L., Simon, T., Fox, K., Mehta, S. R., Harrington, R. A., Held, C., Andersson, M., Himmelmann, A., Ridderstrale, W., Leonsson-Zachrisson, M., Liu, Y., Opolski, G., Zateyshchikov, D., Ge, J., Nicolau, J. C., Corbalan, R., Cornel, J. H., Widimsky, P., and Leiter, L. A.
- Abstract
BACKGROUND Patients with stable coronary artery disease and diabetes mellitus who have not had a myocardial infarction or stroke are at high risk for cardiovascular events. Whether adding ticagrelor to aspirin improves outcomes in this population is unclear. METHODS In this randomized, double-blind trial, we assigned patients who were 50 years of age or older and who had stable coronary artery disease and type 2 diabetes mellitus to receive either ticagrelor plus aspirin or placebo plus aspirin. Patients with previous myocardial infarction or stroke were excluded. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke. The primary safety outcome was major bleeding as defined by the Thrombolysis in Myocardial Infarction (TIMI) criteria. RESULTS A total of 19,220 patients underwent randomization. The median follow-up was 39.9 months. Permanent treatment discontinuation was more frequent with ticagrelor than placebo (34.5% vs. 25.4%). The incidence of ischemic cardiovascular events (the primary efficacy outcome) was lower in the ticagrelor group than in the placebo group (7.7% vs. 8.5%; hazard ratio, 0.90; 95% confidence interval [Cl], 0.81 to 0.99; P=0.04), whereas the incidence of TIMI major bleeding was higher (2.2% vs. 1.0%; hazard ratio, 2.32; 95% Cl, 1.82 to 2.94; P<0.001), as was the incidence of intracranial hemorrhage (0.7% vs. 0.5%; hazard ratio, 1.71; 95% Cl, 1.18 to 2.48; P=0.005). There was no significant difference in the incidence of fatal bleeding (0.2% vs. 0.1%; hazard ratio, 1.90; 95% Cl, 0.87 to 4.15; P=0.11). The incidence of an exploratory composite outcome of irreversible harm (death from any cause, myocardial infarction, stroke, fatal bleeding, or intracranial hemorrhage) was similar in the ticagrelor group and the placebo group (10.1% vs. 10.8%; hazard ratio, 0.93; 95% Cl, 0.86 to 1.02). CONCLUSIONS In patients with stable coronary artery disease and diabetes without a history of myocardial infarction or stroke, those who received ticagrelor plus aspirin had a lower incidence of ischemic cardiovascular events but a higher incidence of major bleeding than those who received placebo plus aspirin. (Funded by AstraZeneca; THEMIS ClinicalTrials.gov number, NCT01991795.) [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
43. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.
- Author
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Mehta, Shamir R, Yusuf, Salim, Peters, Ron J G, Bertrand, Michel E, Lewis, Basil S, Natarajan, Madhu K, Malmberg, Klas, Rupprecht, Hans-Jurgen, Zhao, Feng, Chrolavicius, Susan, Copland, Ingrid, Fox, Keith A A, Mehta, S R, Yusuf, S, Peters, R J, Bertrand, M E, Lewis, B S, Natarajan, M K, Malmberg, K, and Rupprecht, H
- Subjects
- *
DRUG therapy for angina pectoris , *CHEMOPREVENTION , *CORONARY heart disease treatment , *THERAPEUTICS - Abstract
Background: Despite the use of aspirin, there is still a risk of ischaemic events after percutaneous coronary intervention (PCI). We aimed to find out whether, in addition to aspirin, pretreatment with clopidogrel followed by long-term therapy after PCI is superior to a strategy of no pretreatment and short-term therapy for only 4 weeks after PCI.Methods: 2658 patients with non-ST-elevation acute coronary syndrome undergoing PCI in the CURE study had been randomly assigned double-blind treatment with clopidogrel (n=1313) or placebo (n=1345). Patients were pretreated with aspirin and study drug for a median of 6 days before PCI during the initial hospital admission, and for a median of 10 days overall. After PCI, most patients (>80%) in both groups received open-label thienopyridine for about 4 weeks, after which study drug was restarted for a mean of 8 months. The primary endpoint was a composite of cardiovascular death, myocardial infarction, or urgent target-vessel revascularisation within 30 days of PCI. The main analysis was by intention to treat.Findings: There were no drop-outs. 59 (4.5%) patients in the clopidogrel group had the primary endpoint, compared with 86 (6.4%) in the placebo group (relative risk 0.70 [95% CI 0.50-0.97], p=0.03). Long-term administration of clopidogrel after PCI was associated with a lower rate of cardiovascular death, myocardial infarction, or any revascularisation (p=0.03), and of cardiovascular death or myocardial infarction (p=0.047). Overall (including events before and after PCI) there was a 31% reduction cardiovascular death or myocardial infarction (p=0.002). There was less use of glycoprotein IIb/IIIa inhibitor in the clopidogrel group (p=0.001). At follow-up, there was no significant difference in major bleeding between the groups (p=0.64).Interpretation: In patients with acute coronary syndrome receiving aspirin, a strategy of clopidogrel pretreatment followed by long-term therapy is beneficial in reducing major cardiovascular events, compared with placebo. [ABSTRACT FROM AUTHOR]- Published
- 2001
- Full Text
- View/download PDF
44. Blood transfusion and ischaemic outcomes according to anemia and bleeding in patients with non-ST-segment elevation acute coronary syndromes: Insights from the TAO randomized clinical trial.
- Author
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Deharo P, Ducrocq G, Bode C, Cohen M, Cuisset T, Mehta SR, Pollack CV, Wiviott SD, Rao SV, Jukema JW, Erglis A, Moccetti T, Elbez Y, and Steg PG
- Subjects
- Blood Transfusion, Eptifibatide, Hemorrhage chemically induced, Hemorrhage diagnosis, Hemorrhage epidemiology, Humans, Treatment Outcome, Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome therapy, Anemia diagnosis, Anemia epidemiology, Anemia therapy, Percutaneous Coronary Intervention
- Abstract
Background: The benefits and risks of blood transfusion in patients with acute myocardial infarction who are anemic or who experience bleeding are debated. We sought to study the association between blood transfusion and ischemic outcomes according to haemoglobin nadir and bleeding status in patients with NST-elevation myocardial infarction (NSTEMI)., Methods: The TAO trial randomized patients with NSTEMI and coronary angiogram scheduled within 72h to heparin plus eptifibatide versus otamixaban. After exclusion of patients who underwent coronary artery bypass surgery, patients were categorized according to transfusion status considering transfusion as a time-varying covariate. The primary ischemic outcome was the composite of all-cause death or MI within 180 days of randomization. Subgroup analyses were performed according to pre-transfusion hemoglobin nadir and bleeding status., Results: 12,547 patients were enrolled. Among these, blood transfusion was used in 489 (3.9%) patients. Patients who received transfusion had a higher rate of death or MI (29.9% vs. 8.1%, p<0.01). This excess risk persisted after adjustment on GRACE score and nadir of hemoglobin (HR 3.36 95%CI 2.63-4.29 p<0.01). Subgroup analyses showed that blood transfusion was associated with a higher risk in patients without overt bleeding (adjusted HR 6.25 vs. 2.85; p-interaction 0.001) as well as in those with hemoglobin nadir > 9.0 g/dl (HR 4.01; p-interaction<0.0001)., Conclusion: In patients with NSTEMI, blood transfusion was associated with an overall increased risk of ischaemic events. However, this was mainly driven by patients without overt bleeding and those hemoglobin nadir > 9.0g/dl. This suggests possible harm of transfusion in those groups., Competing Interests: Disclosures PG Steg Research grants: Amarin, Bayer, Sanofi, and Servier Clinical trials (Steering committee or CEC or DMC), speaker or consultant : Amarin, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Idorsia, Mylan, Novo-Nordisk, Novartis, Pfizer, Sanofi, Servier. CV Pollack Consultant for Sanofi. J W Jukema : JW Jukema/his department has received research grants from and/or was speaker (with or without lecture fees) on a.o.(CME accredited) meetings sponsored by Amgen, Athera, Astra-Zeneca, Biotronik, Boston Scientific, Dalcor, Daiichi Sankyo, Lilly, Medtronic, Merck-Schering-Plough, Pfizer, Roche, Sanofi Aventis, The Medicine Company, the Netherlands Heart Foundation, CardioVascular Research the Netherlands (CVON), the Netherlands Heart Institute and the European Community Framework KP7 Programme. M Cohen : speaker Sanofi, Consultant to and research support from AstraZeneca. SD Wiviott: Sanofi Aventis, AstraZeneca, Merck, Eli Lilly/Daiichi Sankyo, Boehringer Ingelheim. SR Mehta: Research grants AstraZeneca and Boston scientific; M Sabatine : to be suppressed Sunil V Rao A.Erglis , C Bode, T Cuisset, T Moccetti, G Ducrocq Y Elbez None., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
45. Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008-2019.
- Author
-
Jenks JD, Seidel D, Cornely OA, Chen S, van Hal S, Kauffman C, Miceli MH, Heinemann M, Christner M, Jover Sáenz A, Burchardt A, Kemmerling B, Herbrecht R, Steinmann J, Shoham S, Gräber S, Pagano L, Deeren D, Aslam S, Taplitz R, Revankar SG, Baddley J, Mehta SR, Reed S, Slavin MA, and Hoenigl M
- Subjects
- Adult, Aged, Drug Therapy, Combination, Female, Humans, Invasive Fungal Infections blood, Male, Microbial Sensitivity Tests, Middle Aged, Registries, Retrospective Studies, Scedosporium drug effects, Treatment Outcome, Antifungal Agents therapeutic use, Invasive Fungal Infections drug therapy, Terbinafine therapeutic use, Voriconazole therapeutic use
- Abstract
Objectives: Lomentospora prolificans is an emerging cause of serious invasive fungal infections. Optimal treatment of these infections is unknown, although voriconazole-containing treatment regimens are considered the treatment of choice. The objective of this study was to evaluate the role of combination antifungal therapy for L. prolificans infections., Methods: We performed a retrospective review of medical records of patients with invasive L. prolificans infection diagnosed between 1 January 2008 and 9 September 2019 that were documented in the FungiScope® registry of rare invasive fungal infections. We compared clinical outcomes between antifungal treatment strategies., Results: Over the study period, 41 individuals with invasive L. prolificans infection from eight different countries were documented in the FungiScope® registry. Overall, 17/40 (43%) had treatment response/stable disease and 21/40 (53%) had a fatal outcome attributed to invasive fungal infection. Combination antifungal therapy was associated with increased 28-day survival (15/24 survived versus 4/16 receiving monotherapy; p 0.027) and the combination voriconazole plus terbinafine trended to be associated with higher rates of treatment success (10/16, 63%, 95% CI 35%-85%) compared with other antifungal treatment regimens (7/24, 29%, 95% CI 13%-51%, p 0.053). In Kaplan-Meier survival analysis there was a higher survival probability in individuals receiving the voriconazole/terbinafine combination compared with other antifungal regimens (median survival 150 days versus 17 days)., Conclusions: While overall mortality was high, combination antifungal treatment, and in particular combination therapy with voriconazole plus terbinafine may be associated with improved treatment outcomes compared with other antifungal regimens for the treatment of invasive L. prolificans infections., (Copyright © 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
46. Validation of the GeneXpert® CT/NG Assay for use with Male Pharyngeal and Rectal Swabs.
- Author
-
Geiger R, Smith DM, Little SJ, and Mehta SR
- Abstract
Objectives: The GeneXpert
® CT/NG (Cepheid, Sunnyvale, CA) assay is a point-of-care (POC) molecular diagnostic assay designed to rapidly test for the presence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC). However, the test is only approved for vaginal swabs, urine, and endocervical swabs. Here, we performed an evaluation of the GeneXpert® CT/NG assay to detect the presence of CT and GC on male pharyngeal and rectal swabs., Methods: Men who have sex with men participating in an HIV and Sexually Transmitted Infection (STI) screening program providing consent were enrolled into the study. Participants were asked to self-collect two pharyngeal and two rectal swabs. One set was tested on site using GeneXpert® and the other was sent to a reference lab for molecular testing using the APTIMA® system (Hologic, San Diego, CA)., Results: A total of 570 swabs were collected from 144 patients. GeneXpert® detected 13/15 rectal swabs testing CT positive by the APTIMA® assay (relative sensitivity=88.2%), 1/2 pharyngeal swabs testing CT positive (relative sensitivity=50%), and 7/9 pharyngeal swabs testing NG positive (relative sensitivity =77.8%). No discordance was observed for rectal NG swabs., Conclusions: Although less sensitive than the APTIMA® assay for the molecular detection of NG and CT, GeneXpert® 's potential as a rapid POC diagnostic still make it a viable diagnostic test for STI screening. Molecular POC diagnostics, such as this, will allow more thorough screening of at risk individuals, and enhance the ability of clinics to provide same-day diagnosis and treatment.- Published
- 2016
47. Butyricimonas virosa bacteraemia identified by MALDI-TOF.
- Author
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Mehta SR, Estrada J, Basallo C, Farala A, and Fierer J
- Published
- 2015
- Full Text
- View/download PDF
48. A case cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in human immunodeficiency virus infection.
- Author
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Chaillon A, Gianella S, Massanella Luna M, Little SJ, Richman DD, and Mehta SR
- Subjects
- Adult, Alleles, Disease Progression, HIV Infections genetics, HIV Infections transmission, HIV-1 genetics, HLA Antigens genetics, Homosexuality, Male, Humans, Male, Young Adult, HIV Infections immunology, HIV Infections virology, HIV-1 physiology, HLA Antigens immunology
- Abstract
We present a detailed analysis of sexual HIV transmission from one source partner to two recipients. The HLA haplotypes between the source partner and one recipient were very similar with 7 out of 8 HLA alleles from four loci (HLA A, B, C and DRB) shared, while the other recipient shared only one allele. The immunologic outcomes between the two recipients differed dramatically, despite the absence of apparent virologic differences in their inoculums. We suggest that non-viral factors, which might be related to differences in the HLA profile, played a role in determining different CD4+ T-cells dynamics for these two recipients., (© 2013 Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
49. Clopidogrel in acute coronary syndromes: where are we now?
- Author
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Bainey KR, Lai TF, and Mehta SR
- Subjects
- ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1 genetics, Acute Coronary Syndrome genetics, Biological Availability, Clinical Protocols, Clinical Trials as Topic, Clopidogrel, Cytochrome P-450 Enzyme System genetics, Drug Interactions, Humans, Platelet Activation drug effects, Polymorphism, Genetic, Survival Analysis, Ticlopidine pharmacokinetics, Ticlopidine pharmacology, Ticlopidine therapeutic use, Treatment Outcome, Acute Coronary Syndrome drug therapy, Acute Coronary Syndrome mortality, Purinergic P2Y Receptor Antagonists pharmacokinetics, Purinergic P2Y Receptor Antagonists pharmacology, Purinergic P2Y Receptor Antagonists therapeutic use, Ticlopidine analogs & derivatives
- Published
- 2011
- Full Text
- View/download PDF
50. Radiotherapy: Basic Concepts and Recent Advances.
- Author
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Mehta SR, Suhag V, Semwal M, and Sharma N
- Abstract
Radiation therapy (RT) is a clinical modality dealing with the use of ionizing radiations to treat malignant neoplasias (and occasionally benign diseases). Since its inception, the goal of RT has been to cure cancer locally without excessive side effects. The most important factors affecting the results of RT are the tumor type, its location and regional extent, the anatomic area of involvement and the geometric accuracy with which a calculated radiation dose is delivered. Although higher doses of radiation can produce better tumor control, the dosage which can be given is limited by the possibility of normal tissue damage. Approximately 60-65% of all cancer patients require RT as the sole treatment modality and / or in combination with surgery or chemotherapeutic drugs. There is a huge gap between demand and supply of radiotherapy facilities and infrastructure. Most of the oncocentres are located in urban areas in private sector and are beyond the reach of the common man.
- Published
- 2010
- Full Text
- View/download PDF
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