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2. A lipidomic based metabolic age score captures cardiometabolic risk independent of chronological age

Author

Wang, Tingting, Beyene, Habtamu B., Yi, Changyu, Cinel, Michelle, Mellett, Natalie A., Olshansky, Gavriel, Meikle, Thomas G., Wu, Jingqin, Dakic, Aleksandar, Watts, Gerald F., Hung, Joseph, Hui, Jennie, Beilby, John, Blangero, John, Kaddurah-Daouk, Rima, Salim, Agus, Moses, Eric K., Shaw, Jonathan E., Magliano, Dianna J., Huynh, Kevin, Giles, Corey, and Meikle, Peter J.

Published
2024
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3. Development and validation of a plasmalogen score as an independent modifiable marker of metabolic health: population based observational studies and a placebo-controlled cross-over study

Author

Beyene, Habtamu B., Huynh, Kevin, Wang, Tingting, Paul, Sudip, Cinel, Michelle, Mellett, Natalie A., Olshansky, Gavriel, Meikle, Thomas G., Watts, Gerald F., Hung, Joseph, Hui, Jennie, Beilby, John, Blangero, John, Moses, Eric K., Shaw, Jonathan E., Magliano, Dianna J., Giles, Corey, and Meikle, Peter J.

Published
2024
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7. Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

Author

Mak, Blossom, Lin, Hui-Ming, Kwan, Edmond M., Fettke, Heidi, Tran, Ben, Davis, Ian D., Mahon, Kate, Stockler, Martin R., Briscoe, Karen, Marx, Gavin, Zhang, Alison, Crumbaker, Megan, Tan, Winston, Huynh, Kevin, Meikle, Thomas G., Mellett, Natalie A., Hoy, Andrew J., Du, Pan, Yu, Jianjun, Jia, Shidong, Joshua, Anthony M., Waugh, David J., Butler, Lisa M., Kohli, Manish, Meikle, Peter J., Azad, Arun A., and Horvath, Lisa G.

Published
2022
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8. Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase

Author

Lin, Hui-Ming, Mak, Blossom, Yeung, Nicole, Huynh, Kevin, Meikle, Thomas G., Mellett, Natalie A., Kwan, Edmond M., Fettke, Heidi, Tran, Ben, Davis, Ian D., Mahon, Kate L., Zhang, Alison, Stockler, Martin R., Briscoe, Karen, Marx, Gavin, Crumbaker, Megan, Stricker, Phillip D., Du, Pan, Yu, Jianjun, Jia, Shidong, Scheinberg, Tahlia, Fitzpatrick, Michael, Bonnitcha, Paul, Sullivan, David R., Joshua, Anthony M., Azad, Arun A., Butler, Lisa M., Meikle, Peter J., and Horvath, Lisa G.

Published
2021
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13. Development and Validation of a Plasmalogen Score as an Independent Modifiable Marker of Metabolic Health: Population Based Observational Studies and a Placebo-Controlled Cross-Over Study

Author

Beyene, Habtamu B., primary, Huynh, Kevin, additional, Wang, Tingting, additional, Paul, Sudip, additional, Cinel, Michelle, additional, Mellet, Natalie A., additional, Olshansky, Gavriel, additional, Meikle, Thomas G., additional, Watts, Gerald F., additional, Hung, Joseph, additional, Hui, Jennie, additional, Beilby, John, additional, Blangero, John, additional, Moses, Eric K., additional, Shaw, Jonathan E., additional, Magliano, Dianna J., additional, Giles, Corey, additional, and Meikle, Peter J., additional

Published
2024
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18. Additional file 1 of Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

Author

Mak, Blossom, Lin, Hui-Ming, Kwan, Edmond M., Fettke, Heidi, Tran, Ben, Davis, Ian D., Mahon, Kate, Stockler, Martin R., Briscoe, Karen, Marx, Gavin, Zhang, Alison, Crumbaker, Megan, Tan, Winston, Huynh, Kevin, Meikle, Thomas G., Mellett, Natalie A., Hoy, Andrew J., Du, Pan, Yu, Jianjun, Jia, Shidong, Joshua, Anthony M., Waugh, David J., Butler, Lisa M., Kohli, Manish, Meikle, Peter J., Azad, Arun A., and Horvath, Lisa G.

Abstract

Additional file 1. Supplementary information for ���Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer���. Supplementary information, figures and tables for ���Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer���.

Published
2022
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20. Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer

Author

Lin, Hui-Ming, primary, Yeung, Nicole, additional, Hastings, Jordan F., additional, Croucher, David R., additional, Huynh, Kevin, additional, Meikle, Thomas G., additional, Mellett, Natalie A., additional, Kwan, Edmond M., additional, Davis, Ian D., additional, Tran, Ben, additional, Mahon, Kate L., additional, Zhang, Alison, additional, Stockler, Martin R., additional, Briscoe, Karen, additional, Marx, Gavin, additional, Bastick, Patricia, additional, Crumbaker, Megan L., additional, Joshua, Anthony M., additional, Azad, Arun A., additional, Meikle, Peter J., additional, and Horvath, Lisa G., additional

Published
2021
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27. Protein-Eye View of the in Meso Crystallization Mechanism

Author

van ‘t Hag, Leonie, primary, de Campo, Liliana, additional, Tran, Nhiem, additional, Sokolova, Anna, additional, Trenker, Raphael, additional, Call, Matthew E., additional, Call, Melissa J., additional, Garvey, Christopher J., additional, Leung, Anna E., additional, Darwish, Tamim A., additional, Krause-Heuer, Anwen, additional, Knott, Robert, additional, Meikle, Thomas G., additional, Drummond, Calum J., additional, Mezzenga, Raffaele, additional, and Conn, Charlotte E., additional

Published
2019
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30. Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis

Author

Zabara, Alexandru, primary, Meikle, Thomas G., additional, Trenker, Raphael, additional, Yao, Shenggen, additional, Newman, Janet, additional, Peat, Thomas S., additional, Separovic, Frances, additional, Conn, Charlotte E., additional, Call, Melissa J., additional, Call, Matthew E., additional, Landau, Ehud M., additional, and Drummond, Calum J., additional

Published
2017
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31. Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR

Author

Meikle, Thomas G., Keizer, David W., Babon, Jeffrey J., Drummond, Calum J., Separovic, Frances, Conn, Charlotte E., and Yao, Shenggen

Abstract

Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is of significant interest in many applications including cellular energy turnover underlying ATP synthesis, transmembrane mobility, and transport. Lipidic inverse bicontinuous cubic phases (LCPs) are unique membrane structures formed via the spontaneous self-assembly of certain lipids in an aqueous environment. They feature two networks of water channels, separated by a single lipid bilayer which approximates the geometry of a triply periodic minimal surface. When composed of monoolein, the LCP bilayer features two glycerol hydroxyl groups at the lipid–water interface which undergo exchange with water. Depending on the conditions of the aqueous solution used in the formation of LCPs, both resonances of the glycerol hydroxyl groups may be observed by solution 1H NMR. In this study, PFG-NMR and 1D EXSY were employed to gain insight into chemical exchange between the monoolein hydroxyl groups and water in LCPs. Results including the relative population of hydroxyl protons in exchange with water for a number of LCPs at different hydration levels and the exchange rate constants at 35 wt % hydration are reported. Several technical aspects of PFG-NMR and EXSY-NMR for the characterization of chemical exchange in LCPs are discussed, including an alternative way to analyze PFG-NMR data of exchange systems which overcomes the inherent low sensitivity at high diffusion encoding.

Published
2021
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34. Interactions between inverse bicontinuous cubic phase materials and encapsulated biomolecules

Author

Meikle, Thomas G. and Meikle, Thomas G.

Abstract

The inverse bicontinuous lipidic cubic phase provides a robust, thermodynamically stable membrane mimetic, with the ability to encapsulate a wide range of biomolecules, including amino acids, peptides and proteins. The unique structural architecture and desirable properties of cubic phase lipids have led to their use in wide range of applications, including as a crystallization matrix for membrane proteins, as well as a hosting environment for therapeutic compounds, enabling the design of drug delivery materials. Within the cubic phase-biomolecule system, a complex structural relationship exists between the chemical structure of the lipid, the overall mesostructure of the system, and the structure and properties of encapsulated compounds. At present this relationship is poorly defined, slowing the further development and implementation of these materials. To investigate the structural relationship between lipidic bicontinuous cubic phase bilayers and encapsulated biomolecules, a number of different cubic phase-biomolecule systems have been examined. The encapsulated biomolecules range in complexity from free amino acids to large integral membrane proteins, and give this work relevance to a number of different end use applications, including the delivery and release of small molecule drugs and peptides, as well as the in meso crystallization of integral membrane proteins. We have examined the effects of encapsulating L-histidine and L-phenylalanine within a range of different cubic phase lipids on the mesostructure of the cubic phase. Subsequently, the translational diffusion of these compounds was measured using PFG-NMR, and a linear relationship was discovered with the diameter of the nanoscale water channels. It was demonstrated that a simple mathematical model can be used to predict in vitro release rates of small molecules based solely upon NMR determined in meso diffusion coefficients. Encapsulation of the transmembrane, anti-microbial peptide gramicidin A’ in

Published
2016

35. How Peptide Molecular Structure and Charge Influence the Nanostructure of Lipid Bicontinuous Cubic Mesophases: Model Synthetic WALP Peptides Provide Insights

Author

van ‘t Hag, Leonie, primary, Li, Xu, additional, Meikle, Thomas G., additional, Hoffmann, Søren V., additional, Jones, Nykola C., additional, Pedersen, Jan Skov, additional, Hawley, Adrian M., additional, Gras, Sally L., additional, Conn, Charlotte E., additional, and Drummond, Calum J., additional

Published
2016
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36. Measuring translational diffusion of 15N-enriched biomolecules in complex solutions with a simplified 1H-15N HMQC-filtered BEST sequence.

Author

Yao, Shenggen, Meikle, Thomas G., Sethi, Ashish, Separovic, Frances, Babon, Jeffrey J., and Keizer, David W.

Subjects
*BIOMOLECULES, *DIFFUSION, *PROTEINS, *PEPTIDES, *MOLECULAR structure
Abstract

Pulsed-field gradient nuclear magnetic resonance has seen an increase in applications spanning a broad range of disciplines where molecular translational diffusion properties are of interest. The current study introduces and experimentally evaluates the measurement of translational diffusion coefficients of 15N-enriched biomolecules using a 1H-15N HMQC-filtered band-selective excitation short transient (BEST) sequence as an alternative to the previously described SOFAST-XSTE sequence. The results demonstrate that accurate translational diffusion coefficients of 15N-labelled peptides and proteins can be obtained using this alternative 1H-15N HMQC-filtered BEST sequence which is implementable on NMR spectrometers equipped with probes fitted with a single-axis field gradient, including most cryoprobes dedicated to bio-NMR. The sequence is of potential use for direct quantification of protein or peptide translational diffusion within complex systems, such as in mixtures of macromolecules, crowded solutions, membrane-mimicking media and in bicontinuous cubic phases, where conventional sequences may not be readily applicable due to the presence of intense signals arising from sources other than the protein or peptide under investigation. [ABSTRACT FROM AUTHOR]

Published
2018
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39. Diffusion of Peptides and Small Molecules Encapsulated in Lipidic Cubic Phases by Band-Selective Excitation Short Transient 1 H PGSE NMR.

Author

Yao S, Meikle TG, Keizer DW, and Separovic F

Abstract

In model membrane systems, such as lipidic cubic phases (LCPs), 1 H NMR spectra are dominated by resonances from water and lipid molecules. The measurement of translational diffusion of peptides/molecules encapsulated in LCPs using conventional 1 H pulsed-gradient spin-echo (PGSE) NMR is, therefore, immensely difficult due to the dynamic range caused by the intense resonance(s) from the surrounding environment. The present study reports the use of a band-selective short transient PGSE sequence, avoiding the perturbation of both hydration water and lipids, for measuring the diffusion of molecules encapsulated within the lipid bilayer and the aqueous channels of LCPs.

Published
2024
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40. Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR.

Author

Meikle TG, Keizer DW, Babon JJ, Drummond CJ, Separovic F, Conn CE, and Yao S

Abstract

Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is of significant interest in many applications including cellular energy turnover underlying ATP synthesis, transmembrane mobility, and transport. Lipidic inverse bicontinuous cubic phases (LCPs) are unique membrane structures formed via the spontaneous self-assembly of certain lipids in an aqueous environment. They feature two networks of water channels, separated by a single lipid bilayer which approximates the geometry of a triply periodic minimal surface. When composed of monoolein, the LCP bilayer features two glycerol hydroxyl groups at the lipid-water interface which undergo exchange with water. Depending on the conditions of the aqueous solution used in the formation of LCPs, both resonances of the glycerol hydroxyl groups may be observed by solution 1 H NMR. In this study, PFG-NMR and 1D EXSY were employed to gain insight into chemical exchange between the monoolein hydroxyl groups and water in LCPs. Results including the relative population of hydroxyl protons in exchange with water for a number of LCPs at different hydration levels and the exchange rate constants at 35 wt % hydration are reported. Several technical aspects of PFG-NMR and EXSY-NMR for the characterization of chemical exchange in LCPs are discussed, including an alternative way to analyze PFG-NMR data of exchange systems which overcomes the inherent low sensitivity at high diffusion encoding.

Published
2021
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