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1. Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19

Author

Radke, Josefine, Meinhardt, Jenny, Aschman, Tom, Chua, Robert Lorenz, Farztdinov, Vadim, Lukassen, Sören, Ten, Foo Wei, Friebel, Ekaterina, Ishaque, Naveed, Franz, Jonas, Huhle, Valerie Helena, Mothes, Ronja, Peters, Kristin, Thomas, Carolina, Schneeberger, Shirin, Schumann, Elisa, Kawelke, Leona, Jünger, Julia, Horst, Viktor, Streit, Simon, von Manitius, Regina, Körtvélyessy, Péter, Vielhaber, Stefan, Reinhold, Dirk, Hauser, Anja E., Osterloh, Anja, Enghard, Philipp, Ihlow, Jana, Elezkurtaj, Sefer, Horst, David, Kurth, Florian, Müller, Marcel A., Gassen, Nils C., Melchert, Julia, Jechow, Katharina, Timmermann, Bernd, Fernandez-Zapata, Camila, Böttcher, Chotima, Stenzel, Werner, Krüger, Elke, Landthaler, Markus, Wyler, Emanuel, Corman, Victor, Stadelmann, Christine, Ralser, Markus, Eils, Roland, Heppner, Frank L., Mülleder, Michael, Conrad, Christian, and Radbruch, Helena

Published
2024
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3. Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19

Author

Mothes, Ronja, Pascual-Reguant, Anna, Koehler, Ralf, Liebeskind, Juliane, Liebheit, Alina, Bauherr, Sandy, Philipsen, Lars, Dittmayer, Carsten, Laue, Michael, von Manitius, Regina, Elezkurtaj, Sefer, Durek, Pawel, Heinrich, Frederik, Heinz, Gitta A., Guerra, Gabriela M., Obermayer, Benedikt, Meinhardt, Jenny, Ihlow, Jana, Radke, Josefine, Heppner, Frank L., Enghard, Philipp, Stockmann, Helena, Aschman, Tom, Schneider, Julia, Corman, Victor M., Sander, Leif E., Mashreghi, Mir-Farzin, Conrad, Thomas, Hocke, Andreas C., Niesner, Raluca A., Radbruch, Helena, and Hauser, Anja E.

Published
2023
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4. Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses

Author

Krasemann, Susanne, Dittmayer, Carsten, von Stillfried, Saskia, Meinhardt, Jenny, Heinrich, Fabian, Hartmann, Kristin, Pfefferle, Susanne, Thies, Edda, von Manitius, Regina, Aschman, Tom Alex David, Radke, Josefine, Osterloh, Anja, Schmid, Simone, Buhl, Eva Miriam, Ihlow, Jana, Dubois, Frank, Arnhold, Viktor, Elezkurtaj, Sefer, Horst, David, Hocke, Andreas, Timm, Sara, Bachmann, Sebastian, Corman, Victor, Goebel, Hans-Hilmar, Matschke, Jakob, Stanelle-Bertram, Stephanie, Gabriel, Gülsah, Seilhean, Danielle, Adle-Biassette, Homa, Ondruschka, Benjamin, Ochs, Matthias, Stenzel, Werner, Heppner, Frank L., Boor, Peter, Radbruch, Helena, Laue, Michael, and Glatzel, Markus

Published
2022
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5. Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells

Author

Lehmann, Malte, Allers, Kristina, Heldt, Claudia, Meinhardt, Jenny, Schmidt, Franziska, Rodriguez-Sillke, Yasmina, Kunkel, Désirée, Schumann, Michael, Böttcher, Chotima, Stahl-Hennig, Christiane, Elezkurtaj, Sefer, Bojarski, Christian, Radbruch, Helena, Corman, Victor M., Schneider, Thomas, Loddenkemper, Christoph, Moos, Verena, Weidinger, Carl, Kühl, Anja A., and Siegmund, Britta

Published
2021
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8. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Author

Meinhardt, Jenny, Radke, Josefine, Dittmayer, Carsten, Franz, Jonas, Thomas, Carolina, Mothes, Ronja, Laue, Michael, Schneider, Julia, Brünink, Sebastian, Greuel, Selina, Lehmann, Malte, Hassan, Olga, Aschman, Tom, Schumann, Elisa, Chua, Robert Lorenz, Conrad, Christian, Eils, Roland, Stenzel, Werner, Windgassen, Marc, Rößler, Larissa, Goebel, Hans-Hilmar, Gelderblom, Hans R., Martin, Hubert, Nitsche, Andreas, Schulz-Schaeffer, Walter J., Hakroush, Samy, Winkler, Martin S., Tampe, Björn, Scheibe, Franziska, Körtvélyessy, Péter, Reinhold, Dirk, Siegmund, Britta, Kühl, Anja A., Elezkurtaj, Sefer, Horst, David, Oesterhelweg, Lars, Tsokos, Michael, Ingold-Heppner, Barbara, Stadelmann, Christine, Drosten, Christian, Corman, Victor Max, Radbruch, Helena, and Heppner, Frank L.

Published
2021
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10. The central nervous system’s proteogenomic and spatial imprint upon systemic viral infections with SARS-CoV-2

Author

Radke, Josefine, primary, Meinhardt, Jenny, additional, Aschman, Tom, additional, Chua, Robert Lorenz, additional, Farztdinov, Vadim, additional, Lukkassen, Sören, additional, Ten, Foo Wei, additional, Friebel, Ekaterina, additional, Ishaque, Naveed, additional, Franz, Jonas, additional, Huhle, Valerie Helena, additional, Mothes, Ronja, additional, Peters, Kristin, additional, Thomas, Carolina, additional, Streit, Simon, additional, Manitius, Regina von, additional, Körtvélyessy, Péter, additional, Vielhaber, Stefan, additional, Reinhold, Dirk, additional, Hauser, Anja, additional, Osterloh, Anja, additional, Enghard, Philipp, additional, Ihlow, Jana, additional, Elezkurtaj, Sefer, additional, Horst, David, additional, Kurth, Florian, additional, Müller, Marcel A., additional, Gassen, Nils C., additional, Schneider, Julia, additional, Jechow, Katharina, additional, Timmermann, Bernd, additional, Fernandez-Zapata, Camila, additional, Böttcher, Chotima, additional, Stenzel, Werner, additional, Wyler, Emanuel, additional, Corman, Victor, additional, Stadelmann-Nessler, Christine, additional, Ralser, Markus, additional, Eils, Roland, additional, Heppner, Frank L., additional, Mülleder, Michael, additional, Conrad, Christian, additional, and Radbruch, Helena, additional

Published
2023
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11. Neuropathologische Veränderungen bei schwerem COVID-19

Author

Meinhardt, Jenny

Subjects
neuropathology, SARS-CoV-2, Neuro-COVID-19, COVID-19, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Einleitung Eine Infektion mit dem neuartigen Erreger SARS-CoV-2 verursacht COVID-19 und geht in mehr als einem Drittel der Fälle mit einem breiten Spektrum neurologischer Symptome einher, deren Ätiopathogenesen bisher nicht vollumfänglich geklärt sind. Riech- und Geschmacksstörungen, insbesondere die Anosmie und Ageusie, sind für einen Teil der Patienten*innen sogar die führenden Symptome einer SARS-CoV-2-Infektion. Die Rezeptionszone des olfaktorischen Systems wird als Riechschleimhaut bezeichnet und bedeckt die obere Nasenmuschel direkt unterhalb der Siebplatte. In Anbetracht des direkten Kontaktes von neuralen/neuronalen Zellen mit der Umwelt stellt die Riechschleimhaut eine Schnittstelle und somit eine potentielle Eintrittspforte von SARS-CoV-2 in das ZNS dar. Methodik In der vorliegenden Arbeit erfolgte eine systematische postmortem Untersuchung des ZNS sowie peripherer Gewebeproben aus dem Respirationstrakt von Personen, die infolge einer SARS-CoV-2-Infektion verstorben sind. Mittels der Korrelation klinischer Daten und (neuro-)pathologischer Untersuchungen wurden SARS-CoV-2-spezifische Veränderungen des ZNS ermittelt. Zur Quantifizierung pro- und antiinflammatorischer Zytokine im Liquor der Verstorbenen wurde ein humaner Zytokin Array (Bio-techne) durchgeführt. Der Nachweis von SARS-CoV-2-RNA sowie subgenomischer (sg)RNA, als Surrogat aktiver Virusreplikation, erfolgte mittels quantitativer Echtzeit-Polymerase-Kettenreaktion (qPCR). Zur Charakterisierung des Tropismus von SARS-CoV-2 wurde die RNAscope® in situ Hybridisierung (ISH), Immunhistochemie (IHC) und Elektronenmikroskopie genutzt. Ergebnisse Akute thromboembolische ischämische Infarkte (n=13/86; 15%) und frische Blutungen (n=13/86; 15%) sowie eine starke angeborene Immunantwort, vermittelt durch HLA-DR+ Mikroglia mit korrelierender Erhöhung proinflammatorischer Mediatoren wie IL-6, IL-18, CCL2 und sICAM-1 im Liquor, sind die führenden Veränderungen im ZNS. Die höchste Viruslast ließ sich mittels qPCR in der Riechschleimhaut detektieren. SgRNA fand sich am häufigsten in der Riechschleimhaut (n=18/57) und Uvula (n=8/45); es ergab sich kein Nachweis von sgRNA im ZNS. Die Viruslast korreliert invers mit der Erkrankungsdauer der Patienten*innen (r=-0,5; P=0,006). Im Riechepithel - hier in Kolokalisation mit neuralen/neuronalen Zellen - sowie in den cerebralen Gefäßendothelzellen fand sich eine distinkte Immunreaktivität für SARS-CoV Spike-Protein. Mittels RNAscope® ISH gelang es SARS-CoV-2 RNA innerhalb des Riechepithels darzustellen. Ultrastrukturell konnten wir elektronenmikroskopische Aufnahmen intakter Coronaviruspartikel in der Riechschleimhaut anfertigen. Schlussfolgerung Die Ergebnisse weisen darauf hin, dass SARS-CoV-2 die Nervenzellen der Riechschleimhaut als Eintrittspforte in das Gehirn benutzen kann. Eine SARS-CoV-2-Infektion führt im ZNS zu einer Immunantwort mit Aktivierung von HLA-DR+ Mikroglia und erhöhten Spiegeln von Entzündungsmediatoren., Introduction The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19) which is accompanied by a broad spectrum of neurological manifestations in more than one-third of COVID-19 cases. ­­­For the latter, olfactory and gustatory disturbances such as anosmia and ageusia, are often leading symptoms of SARS-CoV-2 infection. The reception area of the human olfactory system is known as the olfactory mucosa and covers the upper turbinate directly underneath the cribriform plate. Given the close proximity of neural/neuronal cells and the environment the olfactory mucosa as a neural-mucosal interface may represent a potential port of CNS entry for SARS-CoV-2. Methods Here, we systematically investigated postmortem tissue of the CNS and respiratory tract from individuals with COVID-19. Based on the correlation of clinical data and (neuro-)pathological examinations, SARS-CoV-2-specific morphological changes were determined. To quantify pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of the deceased, a human cytokine array (Bio-techne) was performed. Detection of SARS-CoV-2 RNA, including subgenomic (sg)RNA as a surrogate of active virus replication, was performed using quantitative real-time PCR (qPCR). By various means, such as RNAscope® in situ hybridization (ISH), immunohistochemistry and electron microscopy, we further characterized the CNS tropism of SARS-CoV-2 and the consequences thereof. Results Acute thromboembolic ischemic infarcts (n=13/86; 15%) and a strong innate immune response, mediated by HLA-DR+ microglia with a linked increase in proinflammatory mediators such as IL-6, IL-18, CCL2 and sICAM-1 in the CSF, are leading alterations in the CNS. The highest levels of viral RNA for SARS-CoV-2 were found within the olfactory mucosa. SgRNA was most frequently found in the olfactory mucosa (n=18/57) and uvula (n=8/45), although there was no evidence of sgRNA in the CNS. An inverse correlation between the duration of illness and viral load could be determined (r=-0,5; P=0,006). Besides, a distinct immunoreactivity for SARS-CoV Spike (S) protein was found in the olfactory epithelium – here co-localizing with neural/neuronal cells - and within cerebral endothelial cells. Using RNAscope® ISH, SARS-CoV-2 RNA was successfully detected within the olfactory epithelium. We were also able to illustrate intact coronavirus particles in the olfactory mucosa ultrastructurally. Conclusion The results indicate that SARS-CoV-2 can enter the nervous system by crossing the neural-mucosal interface in the olfactory mucosa. SARS-CoV-2 infection results in an innate immune response with activation of HLA-DR+ microglia and increased levels of inflammatory mediators in the CNS.

Published
2023
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12. Loss of IDH mutation or secondary tumour manifestation? Evolution of an IDH‐mutant and 1p/19q‐codeleted oligodendroglioma after 15 years of continuous temozolomide treatment and radiotherapy: A case report

Author

Ehret, Felix, primary, Hansch, Alexander, additional, Meinhardt, Jenny, additional, Hain, Elisabeth Gertrud, additional, Misch, Martin, additional, Onken, Julia, additional, Roohani, Siyer, additional, Koch, Arend, additional, Schweizer, Leonille, additional, Radke, Josefine, additional, and Kaul, David, additional

Published
2022
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13. First report from the German COVID-19 autopsy registry

Author

von Stillfried, Saskia, primary, Bülow, Roman David, additional, Röhrig, Rainer, additional, Boor, Peter, additional, Böcker, Jana, additional, Schmidt, Jens, additional, Tholen, Pauline, additional, Majeed, Raphael, additional, Wienströer, Jan, additional, Weis, Joachim, additional, Bremer, Juliane, additional, Knüchel, Ruth, additional, Breitbach, Anna, additional, Cacchi, Claudio, additional, Freeborn, Benita, additional, Wucherpfennig, Sophie, additional, Spring, Oliver, additional, Braun, Georg, additional, Römmele, Christoph, additional, Märkl, Bruno, additional, Claus, Rainer, additional, Dhillon, Christine, additional, Schaller, Tina, additional, Sipos, Eva, additional, Hirschbühl, Klaus, additional, Wittmann, Michael, additional, Kling, Elisabeth, additional, Kröncke, Thomas, additional, Heppner, Frank L., additional, Meinhardt, Jenny, additional, Radbruch, Helena, additional, Streit, Simon, additional, Horst, David, additional, Elezkurtaj, Sefer, additional, Quaas, Alexander, additional, Göbel, Heike, additional, Hansen, Torsten, additional, Titze, Ulf, additional, Lorenzen, Johann, additional, Reuter, Thomas, additional, Woloszyn, Jaroslaw, additional, Baretton, Gustavo, additional, Hilsenbeck, Julia, additional, Meinhardt, Matthias, additional, Pablik, Jessica, additional, Sommer, Linna, additional, Holotiuk, Olaf, additional, Meinel, Meike, additional, Mahlke, Nina, additional, Esposito, Irene, additional, Crudele, Graziano, additional, Seidl, Maximilian, additional, Amann, Kerstin U., additional, Coras, Roland, additional, Hartmann, Arndt, additional, Eichhorn, Philip, additional, Haller, Florian, additional, Lange, Fabienne, additional, Schmid, Kurt Werner, additional, Ingenwerth, Marc, additional, Rawitzer, Josefine, additional, Theegarten, Dirk, additional, Birngruber, Christoph G., additional, Wild, Peter, additional, Gradhand, Elise, additional, Smith, Kevin, additional, Werner, Martin, additional, Schilling, Oliver, additional, Acker, Till, additional, Gattenlöhner, Stefan, additional, Stadelmann, Christine, additional, Metz, Imke, additional, Franz, Jonas, additional, Stork, Lidia, additional, Thomas, Carolina, additional, Zechel, Sabrina, additional, Ströbel, Philipp, additional, Wickenhauser, Claudia, additional, Fathke, Christine, additional, Harder, Anja, additional, Ondruschka, Benjamin, additional, Dietz, Eric, additional, Edler, Carolin, additional, Fitzek, Antonia, additional, Fröb, Daniela, additional, Heinemann, Axel, additional, Heinrich, Fabian, additional, Klein, Anke, additional, Kniep, Inga, additional, Lohner, Larissa, additional, Möbius, Dustin, additional, Püschel, Klaus, additional, Schädler, Julia, additional, Schröder, Ann-Sophie, additional, Sperhake, Jan-Peter, additional, Aepfelbacher, Martin, additional, Fischer, Nicole, additional, Lütgehetmann, Marc, additional, Pfefferle, Susanne, additional, Glatzel, Markus, additional, Krasemann, Susanne, additional, Matschke, Jakob, additional, Jonigk, Danny, additional, Werlein, Christopher, additional, Schirmacher, Peter, additional, Domke, Lisa Maria, additional, Hartmann, Laura, additional, Klein, Isabel Madeleine, additional, Schwab, Constantin, additional, Röcken, Christoph, additional, Friemann, Johannes, additional, Langer, Dorothea, additional, Roth, Wilfried, additional, Strobl, Stephanie, additional, Rudelius, Martina, additional, Stock, Konrad Friedrich, additional, Weichert, Wilko, additional, Delbridge, Claire, additional, Kasajima, Atsuko, additional, Kuhn, Peer-Hendrik, additional, Slotta-Huspenina, Julia, additional, Weirich, Gregor, additional, Barth, Peter, additional, Wardelmann, Eva, additional, Evert, Katja, additional, Büttner, Andreas, additional, Manhart, Johannes, additional, Nigbur, Stefan, additional, Bittmann, Iris, additional, Fend, Falko, additional, Bösmüller, Hans, additional, Granai, Massimo, additional, Klingel, Karin, additional, Warm, Verena, additional, Steinestel, Konrad, additional, Umathum, Vincent Gottfried, additional, Rosenwald, Andreas, additional, Kurz, Florian, additional, and Vogt, Niklas, additional

Published
2022
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14. Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure : a nationwide register study report

Author

von Stillfried, Saskia, Bülow, Roman David, Wienströer, Jan, Pfefferle, Susanne, Glatzel, Markus, Krasemann, Susanne, Matschke, Jakob, Jonigk, Danny, Werlein, Christopher, Schirmacher, Peter, Domke, Lisa Maria, Hartmann, Laura, Klein, Isabel Madeleine, Weis, Joachim, Schwab, Constantin, Röcken, Christoph, Friemann, Johannes, Langer, Dorothea, Roth, Wilfried, Strobl, Stephanie, Rudelius, Martina, Stock, Konrad Friedrich, Weichert, Wilko, Delbridge, Claire, Bremer, Juliane, Kasajima, Atsuko, Kuhn, Peer-Hendrik, Slotta-Huspenina, Julia, Weirich, Gregor, Barth, Peter, Wardelmann, Eva, Schnepper, Alexander, Evert, Katja, Büttner, Andreas, Manhart, Johannes, Knüchel, R., Nigbur, Stefan, Bittmann, Iris, Fend, Falko, Bösmüller, Hans, Granai, Massimo, Klingel, Karin, Warm, Verena, Steinestel, Konrad, Umathum, Vincent Gottfried, Rosenwald, Andreas, Breitbach, Anna, Kurz, Florian, Vogt, Niklas, Cacchi, Claudio, Freeborn, Benita, Wucherpfennig, Sophie, Spring, Oliver, Braun, Georg, Röhrig, Rainer, Römmele, Christoph, Märkl, Bruno, Claus, Rainer, Dhillon, Christine, Schaller, Tina, Sipos, Eva, Hirschbühl, Klaus, Wittmann, Michael, Kling, Elisabeth, Kröncke, Thomas, Meybohm, Patrick, Heppner, Frank L., Meinhardt, Jenny, Radbruch, Helena, Streit, Simon, Horst, David, Elezkurtaj, Sefer, Quaas, Alexander, Göbel, Heike, Hansen, Torsten, Titze, Ulf, Boor, Peter, Lorenzen, Johann, Reuter, Thomas, Woloszyn, Jaroslaw, Baretton, Gustavo, Hilsenbeck, Julia, Meinhardt, Matthias, Pablik, Jessica, Sommer, Linna, Holotiuk, Olaf, Meinel, Meike, DeRegCOVID Collaborators, Mahlke, Nina, Esposito, Irene, Crudele, Graziano, Seidl, Maximilian, Amann, Kerstin U., Coras, Roland, Hartmann, Arndt, Eichhorn, Philip, Haller, Florian, Lange, Fabienne, Böcker, Jana, Schmid, Kurt Werner, Ingenwerth, Marc, Rawitzer, Josefine, Theegarten, Dirk, Birngruber, Christoph G., Wild, Peter, Gradhand, Elise, Smith, Kevin, Werner, Martin, Schilling, Oliver, Schmidt, Jens, Acker, Till, Gattenlöhner, Stefan, Stadelmann, Christine, Metz, Imke, Franz, Jonas, Stork, Lidia, Thomas, Carolina, Zechel, Sabrina, Ströbel, Philipp, Wickenhauser, Claudia, Tholen, Pauline, Fathke, Christine, Harder, Anja, Ondruschka, Benjamin, Dietz, Eric, Edler, Carolin, Fitzek, Antonia, Fröb, Daniela, Heinemann, Axel, Heinrich, Fabian, Klein, Anke, Majeed, Raphael, Kniep, Inga, Lohner, Larissa, Möbius, Dustin, Püschel, Klaus, Schädler, Julia, Schröder, Ann-Sophie, Sperhake, Jan-Peter, Aepfelbacher, Martin, Fischer, Nicole, and Lütgehetmann, Marc

Subjects
ddc:610
Published
2022

15. Loss of IDH mutation or secondary tumour manifestation? Evolution of an IDH-mutant and 1p/19q-codeleted oligodendroglioma after 15 years of continuous temozolomide treatment and radiotherapy: A case report.

Author

Ehret, Felix, Hansch, Alexander, Meinhardt, Jenny, Hain, Elisabeth Gertrud, Misch, Martin, Onken, Julia, Roohani, Siyer, Koch, Arend, Schweizer, Leonille, Radke, Josefine, and Kaul, David

Subjects
TEMOZOLOMIDE, ISOCITRATE dehydrogenase, RADIOTHERAPY, MOLECULAR pathology, TUMORS
Published
2023
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16. Local CCL18 and CCL21 expand lung fibrovascular niches and recruit lymphocytes, leading to tertiary lymphoid structure formation in prolonged COVID-19

Author

Mothes, Ronja, primary, Pascual-Reguant, Anna, additional, Koehler, Ralf, additional, Liebeskind, Juliane, additional, Liebheit, Alina, additional, Bauherr, Sandy, additional, Dittmayer, Carsten, additional, Laue, Michael, additional, von Manitius, Regina, additional, Elezkurtaj, Sefer, additional, Durek, Pawel, additional, Heinrich, Frederik, additional, Heinz, Gitta Anne, additional, Guerra, Gabriela Maria, additional, Obermayer, Benedikt, additional, Meinhardt, Jenny, additional, Ihlow, Jana, additional, Radke, Josefine, additional, Heppner, Frank L., additional, Enghard, Philipp, additional, Stockmann, Helena, additional, Aschman, Tom, additional, Schneider, Julia, additional, Corman, Victor, additional, Sander, Leif Erik, additional, Mashreghi, Mir-Farzin, additional, Conrad, Thomas, additional, Hocke, Andreas, additional, Niesner, Raluca A., additional, Radbruch, Helena, additional, and Hauser, Anja E., additional

Published
2022
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17. Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died

Author

Aschman, Tom, primary, Schneider, Julia, additional, Greuel, Selina, additional, Meinhardt, Jenny, additional, Streit, Simon, additional, Goebel, Hans-Hilmar, additional, Büttnerova, Ivana, additional, Elezkurtaj, Sefer, additional, Scheibe, Franziska, additional, Radke, Josefine, additional, Meisel, Christian, additional, Drosten, Christian, additional, Radbruch, Helena, additional, Heppner, Frank L., additional, Corman, Victor Max, additional, and Stenzel, Werner, additional

Published
2021
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20. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Author

Meinhardt, Jenny, primary, Radke, Josefine, additional, Dittmayer, Carsten, additional, Franz, Jonas, additional, Thomas, Carolina, additional, Mothes, Ronja, additional, Laue, Michael, additional, Schneider, Julia, additional, Brünink, Sebastian, additional, Greuel, Selina, additional, Lehmann, Malte, additional, Hassan, Olga, additional, Aschman, Tom, additional, Schumann, Elisa, additional, Chua, Robert Lorenz, additional, Conrad, Christian, additional, Eils, Roland, additional, Stenzel, Werner, additional, Windgassen, Marc, additional, Rößler, Larissa, additional, Goebel, Hans-Hilmar, additional, Gelderblom, Hans R., additional, Martin, Hubert, additional, Nitsche, Andreas, additional, Schulz-Schaeffer, Walter J., additional, Hakroush, Samy, additional, Winkler, Martin S., additional, Tampe, Björn, additional, Scheibe, Franziska, additional, Körtvélyessy, Péter, additional, Reinhold, Dirk, additional, Siegmund, Britta, additional, Kühl, Anja A., additional, Elezkurtaj, Sefer, additional, Horst, David, additional, Oesterhelweg, Lars, additional, Tsokos, Michael, additional, Ingold-Heppner, Barbara, additional, Stadelmann, Christine, additional, Drosten, Christian, additional, Corman, Victor Max, additional, Radbruch, Helena, additional, and Heppner, Frank L., additional

Published
2020
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21. COVID-19: B-Cell Depletion and Sepsis Related Changes in Bone Marrow and Spleen

Author

Ihlow, Jana, primary, von-Bruenneck, Ann-Christin, additional, Michaelis, Edward Georg, additional, Greuel, Selina, additional, Heynol, Verena, additional, Lehmann, Annika, additional, Radbruch, Helena, additional, Meinhardt, Jenny, additional, Corman, Victor Max, additional, Miller, Florian, additional, Herbst, Hermann, additional, Westermann, Jörg, additional, Bullinger, Lars, additional, Horst, David, additional, and Elezkurtaj, Sefer, additional

Published
2020
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23. Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients

Author

Meinhardt, Jenny, primary, Radke, Josefine, additional, Dittmayer, Carsten, additional, Mothes, Ronja, additional, Franz, Jonas, additional, Laue, Michael, additional, Schneider, Julia, additional, Brünink, Sebastian, additional, Hassan, Olga, additional, Stenzel, Werner, additional, Windgassen, Marc, additional, Rößler, Larissa, additional, Goebel, Hans-Hilmar, additional, Martin, Hubert, additional, Nitsche, Andreas, additional, Schulz-Schaeffer, Walter J., additional, Hakroush, Samy, additional, Winkler, Martin S., additional, Tampe, Björn, additional, Elezkurtaj, Sefer, additional, Horst, David, additional, Oesterhelweg, Lars, additional, Tsokos, Michael, additional, Heppner, Barbara Ingold, additional, Stadelmann, Christine, additional, Drosten, Christian, additional, Corman, Victor Max, additional, Radbruch, Helena, additional, and Heppner, Frank L., additional

Published
2020
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24. Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells.

Author

Lehmann, Malte, Allers, Kristina, Heldt, Claudia, Meinhardt, Jenny, Schmidt, Franziska, Rodriguez-Sillke, Yasmina, Kunkel, Désirée, Schumann, Michael, Böttcher, Chotima, Stahl-Hennig, Christiane, Elezkurtaj, Sefer, Bojarski, Christian, Radbruch, Helena, Corman, Victor M., Schneider, Thomas, Loddenkemper, Christoph, Moos, Verena, Weidinger, Carl, Kühl, Anja A., and Siegmund, Britta

Published
2021
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25. Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+T cells

Author

Lehmann, Malte, Allers, Kristina, Heldt, Claudia, Meinhardt, Jenny, Schmidt, Franziska, Rodriguez-Sillke, Yasmina, Kunkel, Désirée, Schumann, Michael, Böttcher, Chotima, Stahl-Hennig, Christiane, Elezkurtaj, Sefer, Bojarski, Christian, Radbruch, Helena, Corman, Victor M., Schneider, Thomas, Loddenkemper, Christoph, Moos, Verena, Weidinger, Carl, Kühl, Anja A., and Siegmund, Britta

Abstract

The SARS-CoV-2 pandemic has so far claimed over three and a half million lives worldwide. Though the SARS-CoV-2 mediated disease COVID-19 has first been characterized by an infection of the upper airways and the lung, recent evidence suggests a complex disease including gastrointestinal symptoms. Even if a direct viral tropism of intestinal cells has recently been demonstrated, it remains unclear, whether gastrointestinal symptoms are caused by direct infection of the gastrointestinal tract by SARS-CoV-2 or whether they are a consequence of a systemic immune activation and subsequent modulation of the mucosal immune system. To better understand the cause of intestinal symptoms we analyzed biopsies of the small intestine from SARS-CoV-2 infected individuals. Applying qRT-PCR and immunohistochemistry, we detected SARS-CoV-2 RNA and nucleocapsid protein in duodenal mucosa. In addition, applying imaging mass cytometry and immunohistochemistry, we identified histomorphological changes of the epithelium, which were characterized by an accumulation of activated intraepithelial CD8+T cells as well as epithelial apoptosis and subsequent regenerative proliferation in the small intestine of COVID-19 patients. In summary, our findings indicate that intraepithelial CD8+T cells are activated upon infection of intestinal epithelial cells with SARS-CoV-2, providing one possible explanation for gastrointestinal symptoms associated with COVID-19.

Published
2021
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26. First report from the German COVID-19 autopsy registry

Author

Saskia von Stillfried, Roman David Bülow, Rainer Röhrig, Peter Boor, Jana Böcker, Jens Schmidt, Pauline Tholen, Raphael Majeed, Jan Wienströer, Joachim Weis, Juliane Bremer, Ruth Knüchel, Anna Breitbach, Claudio Cacchi, Benita Freeborn, Sophie Wucherpfennig, Oliver Spring, Georg Braun, Christoph Römmele, Bruno Märkl, Rainer Claus, Christine Dhillon, Tina Schaller, Eva Sipos, Klaus Hirschbühl, Michael Wittmann, Elisabeth Kling, Thomas Kröncke, Frank L. Heppner, Jenny Meinhardt, Helena Radbruch, Simon Streit, David Horst, Sefer Elezkurtaj, Alexander Quaas, Heike Göbel, Torsten Hansen, Ulf Titze, Johann Lorenzen, Thomas Reuter, Jaroslaw Woloszyn, Gustavo Baretton, Julia Hilsenbeck, Matthias Meinhardt, Jessica Pablik, Linna Sommer, Olaf Holotiuk, Meike Meinel, Nina Mahlke, Irene Esposito, Graziano Crudele, Maximilian Seidl, Kerstin U. Amann, Roland Coras, Arndt Hartmann, Philip Eichhorn, Florian Haller, Fabienne Lange, Kurt Werner Schmid, Marc Ingenwerth, Josefine Rawitzer, Dirk Theegarten, Christoph G. Birngruber, Peter Wild, Elise Gradhand, Kevin Smith, Martin Werner, Oliver Schilling, Till Acker, Stefan Gattenlöhner, Christine Stadelmann, Imke Metz, Jonas Franz, Lidia Stork, Carolina Thomas, Sabrina Zechel, Philipp Ströbel, Claudia Wickenhauser, Christine Fathke, Anja Harder, Benjamin Ondruschka, Eric Dietz, Carolin Edler, Antonia Fitzek, Daniela Fröb, Axel Heinemann, Fabian Heinrich, Anke Klein, Inga Kniep, Larissa Lohner, Dustin Möbius, Klaus Püschel, Julia Schädler, Ann-Sophie Schröder, Jan-Peter Sperhake, Martin Aepfelbacher, Nicole Fischer, Marc Lütgehetmann, Susanne Pfefferle, Markus Glatzel, Susanne Krasemann, Jakob Matschke, Danny Jonigk, Christopher Werlein, Peter Schirmacher, Lisa Maria Domke, Laura Hartmann, Isabel Madeleine Klein, Constantin Schwab, Christoph Röcken, Johannes Friemann, Dorothea Langer, Wilfried Roth, Stephanie Strobl, Martina Rudelius, Konrad Friedrich Stock, Wilko Weichert, Claire Delbridge, Atsuko Kasajima, Peer-Hendrik Kuhn, Julia Slotta-Huspenina, Gregor Weirich, Peter Barth, Eva Wardelmann, Katja Evert, Andreas Büttner, Johannes Manhart, Stefan Nigbur, Iris Bittmann, Falko Fend, Hans Bösmüller, Massimo Granai, Karin Klingel, Verena Warm, Konrad Steinestel, Vincent Gottfried Umathum, Andreas Rosenwald, Florian Kurz, Niklas Vogt, Weis, Joachim, Glatzel, Markus, Krasemann, Susanne, Matschke, Jakob, Jonigk, Danny, Werlein, Christopher, Schirmacher, Peter, Domke, Lisa Maria, Hartmann, Laura, Klein, Isabel Madeleine, Schwab, Constantin, Bremer, Juliane, Röcken, Christoph, Friemann, Johannes, Langer, Dorothea, Roth, Wilfried, Strobl, Stephanie, Rudelius, Martina, Stock, Konrad Friedrich, Weichert, Wilko, Delbridge, Claire, Kasajima, Atsuko, Knüchel-Clarke, Ruth, Kuhn, Peer-Hendrik, Slotta-Huspenina, Julia, Weirich, Gregor, Barth, Peter, Wardelmann, Eva, Evert, Katja, Büttner, Andreas, Manhart, Johannes, Nigbur, Stefan, Bittmann, Iris, Breitbach, Anna, Fend, Falko, Bösmüller, Hans, Granai, Massimo, Klingel, Karin, Warm, Verena, Steinestel, Konrad, Umathum, Vincent Gottfried, Rosenwald, Andreas, Kurz, Florian, Vogt, Niklas, Cacchi, Claudio, Freeborn, Benita, Wucherpfennig, Sophie, Spring, Oliver, Braun, Georg, Römmele, Christoph, Märkl, Bruno, Claus, Rainer, Dhillon, Christine, Schaller, Tina, Sipos, Eva, Hirschbühl, Klaus, Wittmann, Michael, Kling, Elisabeth, Kröncke, Thomas, Heppner, Frank L., Meinhardt, Jenny, Radbruch, Helena, Streit, Simon, Horst, David, Elezkurtaj, Sefer, Quaas, Alexander, Göbel, Heike, Hansen, Torsten, Titze, Ulf, Lorenzen, Johann, Reuter, Thomas, Woloszyn, Jaroslaw, Baretton, Gustavo, Hilsenbeck, Julia, Meinhardt, Matthias, Pablik, Jessica, Sommer, Linna, Holotiuk, Olaf, Meinel, Meike, Mahlke, Nina, Böcker, Jana, Esposito, Irene, Crudele, Graziano, Seidl, Maximilian, Amann, Kerstin U., Coras, Roland, Hartmann, Arndt, Eichhorn, Philip, Haller, Florian, Lange, Fabienne, Schmid, Kurt Werner, Schmidt, Jens, Ingenwerth, Marc, Rawitzer, Josefine, Theegarten, Dirk, Birngruber, Christoph G., Wild, Peter, Gradhand, Elise, Smith, Kevin, Werner, Martin, Schilling, Oliver, Acker, Till, Tholen, Pauline, Gattenlöhner, Stefan, Stadelmann, Christine, Metz, Imke, Franz, Jonas, Stork, Lidia, Thomas, Carolina, Zechel, Sabrina, Ströbel, Philipp, Wickenhauser, Claudia, Fathke, Christine, Majeed, Raphael, Harder, Anja, Ondruschka, Benjamin, Dietz, Eric, Edler, Carolin, Fitzek, Antonia, Fröb, Daniela, Heinemann, Axel, Heinrich, Fabian, Klein, Anke, Kniep, Inga, Wienströer, Jan, Lohner, Larissa, Möbius, Dustin, Püschel, Klaus, Schädler, Julia, Schröder, Ann-Sophie, Sperhake, Jan-Peter, Aepfelbacher, Martin, Fischer, Nicole, Lütgehetmann, Marc, and Pfefferle, Susanne

Subjects
Oncology, Health Policy, Internal Medicine, Medizin, ddc:610
Abstract

The lancet / Regional health. Europe 15, 100330 (2022). doi:10.1016/j.lanepe.2022.100330, Published by Elsevier, [Amsterdam]

Published
2022

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