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We propose a novel method for defining patterns of contacts present in protein-protein complexes. A new use of the traditional contact maps (more frequently used for representation of the intra-chain contacts) is presented for analysis of inter-chain contacts. Using an algorithm based on image processing techniques, we can compare protein-protein interaction maps and also obtain a dissimilarity score between them. The same algorithm used to compare the maps can align the contacts of all the complexes and be helpful in the determination of a pattern of conserved interactions at the interfaces. We present an example for the application of this method by analyzing the pattern of interaction of bovine pancreatic trypsin inhibitors and trypsins, chymotrypsins, a thrombin, a matriptase, and a kallikrein - all classified as serine proteases. We found 20 contacts conserved in trypsins and chymotrypsins and 3 specific ones are present in all the serine protease complexes studied. The method was able to identify important contacts for the protein family studied and the results are in agreement with the literature.

Online social networks (OSNs) have become popular platforms for people to connect and interact with each other. Among those networks, Pinterest has recently become noteworthy for its growth and promotion of visual over textual content. The purpose of this study is to analyze this image-based network in a gender-sensitive fashion, in order to un- derstand (i) user motivation and usage pattern in the network, (ii) how communications and social interactions happen and (iii) how users describe themselves to others. This work is based on more than 220 million items generated by 683,273 users. We were able to find significant differences w.r.t. all mentioned aspects. We observed that, although the network does not encourage direct social communication, females make more use of lightweight interactions than males. Moreover, females invest more effort in reciprocating social links, are more active and generalist in content generation, and describe themselves using words of affection and positive emotions. Males, on the other hand, are more likely to be specialists and tend to describe themselves in an assertive way. We also observed that each gender has different interests in the network, females tend to make more use of the network's commercial capabilities, while males are more prone to the role of curators of items that reflect their personal taste. It is important to understand gender differences in online social networks, so one can design services and applications that leverage human social interactions and provide more targeted and relevant user experiences.