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138 results on '"Meivelu Moovendhan"'

2. Acrylamide exposure: Dietary risks of oral carcinoma in non-smokers

Author

Gokul Sudhakaran, Kuppusamy Sathishkumar, and Meivelu Moovendhan

Subjects
Acrylamide, Cancer, Diet, Smoking, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Acrylamide, classified as a probable human carcinogen, is primarily found in plant-derived foods like potatoes, grains, and coffee, with heightened formation during high-temperature cooking. Exposure occurs through food and cigarette smoke. Rodent studies indicate an increased cancer risk, with acrylamide converting into glycidamide, causing DNA damage. Its hydrophilic nature allows penetration into various body tissues. Though evidence linking dietary acrylamide intake to head and neck cancer risk is inconclusive, potential exceptions exist. Further research, particularly on non-smokers, is recommended. Minimizing exposure via dietary and cooking modifications is crucial. Additional studies on human acrylamide and oral cancer risk are needed for effective public health strategies.

Published
2024
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9. Anticancer Activity of Rhizophora mucronata Leaves Extract on Sprague–Dawley Rats: In Vivo Model

Author

Asbin Mary X, Syed Ali Mohamed Yacoob, Anuradha Venkatraman, Ruban Packiasamy, Meivelu Moovendhan, Murugesan Gnanadesigan, and Yogananth Nagarajan

Subjects
Toxicology. Poisons, RA1190-1270
Abstract

Medicinal plants are now used to treat cancer due to the presence of bioactive compounds. Apart from the plants, mangroves also possess rich bioactive compounds with high medicinal activity. Based on the ethnobotanical attributes of Rhizophora mucronata, we are keen to work with its anticancer activity. The aim of the study is to assess the anticancer activity of methanolic extract of Rhizophora mucronata leaves against breast cancer. Its safety profile for anticancer investigations was therefore confirmed through an acute toxicity assessment. In accordance with OECD guiding principles, the study was approved to evaluate the toxicity, including acute and subacute effects and anticancer activities of methanolic extract of Rhizophora mucronata leaves on Sprague–Dawley rats. In acute toxicity trials, the dose of 1000 mg/kg body weight was determined to be safe and nontoxic even at high dose levels and did not result in any indicators of toxicity or death in the tested groups compared to controls for 14 days. In contrast, rats in a subacute toxicity study were given consistent doses of 100 mg/kg, 200 mg/kg, and 300 mg/kg for a total of 28 days along with a control group. Haematological, biochemical, and histological tests conducted in advance revealed that methanolic extract of Rhizophora mucronata leaves (MERML) at repeated doses of 200 mg/kg and 300 mg/kg was normal and had no significant effects on the treated groups. Rhizophora mucronata extract (250 mg/kg) was successfully used in in vivo trials to stop the growth of breast cancer cells in groups that had been given DMBA. Based on these findings, it has been concluded that methanolic extract of Rhizophora mucronata leaves (MERML) was safe at both higher and lower dosages and could be assessed for pharmacological study.

Published
2023
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43. Sustainable approach to manage the vulnerable rodents using eco-friendly green rodenticides formulation through nanotechnology principles – A review

Author

S. Karthick Raja Namasivayam, Subramanian Srinivasan, Krishnappa Samrat, Bala Priyalakshmi, Ramkumar Dinesh Kumar, Arvind Bharani, Ramkumar Ganesh Kumar, M. Kavisri, and Meivelu Moovendhan

Subjects
Environmental Engineering, General Chemical Engineering, Environmental Chemistry, Safety, Risk, Reliability and Quality
Published
2023
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47. Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model

Author

null Ajay Guru, null Gokul Sudhakaran, null S. Karthick Raja Namasivayam, null Boopathi Seenivasan, null Mukesh Pasupulieti, null Jesu Arockiaraj, and null Meivelu Moovendhan

Subjects
Bioengineering, General Medicine, Molecular Biology, Applied Microbiology and Biotechnology, Biochemistry, Biotechnology
Published
2023
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