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4 results on '"Melchionna, Mario"'

1. SGLT2 breast expression could affect the cardiovascular performance in pre-menopausal women with fatty vs. non fatty breast via over-inflammation and sirtuins’ down regulation

Author

Sardu, Celestino, Gatta, Gianluca, Pieretti, Gorizio, Onofrio, Nunzia D’, Balestrieri, Maria Luisa, Scisciola, Lucia, Cappabianca, Salvatore, Ferraro, Giuseppe, Nicoletti, Giovanni Francesco, Signoriello, Giuseppe, Sportiello, Liberata, Savarese, Gianluigi, Melchionna, Mario, Ciccarelli, Feliciano, La Forgia, Daniele, Paolisso, Giuseppe, and Marfella, Raffaele

Published
2023
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2. Evidence of an anti-inflammatory effect of PCSK9 inhibitors within the human atherosclerotic plaque

Author

Marfella, Raffaele, Prattichizzo, Francesco, Sardu, Celestino, Paolisso, Pasquale, D'Onofrio, Nunzia, Scisciola, Lucia, La Grotta, Rosalba, Frigé, Chiara, Ferraraccio, Franca, Panarese, Iacopo, Fanelli, Mara, Modugno, Piero, Calafiore, Antonio Maria, Melchionna, Mario, Sasso, Ferdinando Carlo, Furbatto, Fulvio, D'Andrea, Davide, Siniscalchi, Mario, Mauro, Ciro, Cesaro, Arturo, Calabrò, Paolo, Santulli, Gaetano, Balestrieri, Maria Luisa, Barbato, Emanuele, Ceriello, Antonio, and Paolisso, Giuseppe

Published
2023
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3. Bio-Physics Approach to Urinary Incontinence Disabilities

Author

Prosperi, Loris, primary, Barassi, Giovanni, additional, Panunzio, Maurizio, additional, Pellegrino, Raffaello, additional, Marinucci, Celeste, additional, Di Iulio, Antonella, additional, Colombo, Antonio, additional, Licameli, Marco, additional, Moccia, Antonio, additional, and Melchionna, Mario, additional

Published
2022
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4. SGLT2 breast expression could affect the cardiovascular performance in pre-menopausal women with fatty vs. non fatty breast via over-inflammation and sirtuins' down regulation

Author

Celestino Sardu, Gianluca Gatta, Gorizio Pieretti, Nunzia D’ Onofrio, Maria Luisa Balestrieri, Lucia Scisciola, Salvatore Cappabianca, Giuseppe Ferraro, Giovanni Francesco Nicoletti, Giuseppe Signoriello, Liberata Sportiello, Gianluigi Savarese, Mario Melchionna, Feliciano Ciccarelli, Daniele La Forgia, Giuseppe Paolisso, Raffaele Marfella, Sardu, Celestino, Gatta, Gianluca, Pieretti, Gorizio, Onofrio, Nunzia D', Balestrieri, Maria Luisa, Scisciola, Lucia, Cappabianca, Salvatore, Ferraro, Giuseppe, Nicoletti, Giovanni Francesco, Signoriello, Giuseppe, Sportiello, Liberata, Savarese, Gianluigi, Melchionna, Mario, Ciccarelli, Feliciano, La Forgia, Daniele, Paolisso, Giuseppe, and Marfella, Raffaele

Subjects
Inflammation, Internal Medicine, Breast density, Sirtuins, Cardiac performance, SGLT2
Abstract

Objectives: To evaluate the expression of sodium-glucose transporter 2 (SGLT2), inflammatory cytokines, and sirtuins in breast fat tissue at baseline, and serum cytokines of fatty vs. non-fatty pre-menopausal women at baseline, and at 12 months of follow-up. To correlate SGLT2/cytokines/sirtuins expression to clinical variables, and their changes (Δ) at follow-up, as intima-media wall thickness (IMT), left ventricle mass (LVM), left ventricle ejection fraction (LVEF), and myocardial performance index (MPI), and its normalization. Background: Pre-menopausal women with the lowest breast fat density (fatty breast) vs. higher breast fat density (non-fatty breast) are a high-risk population for cardiovascular diseases and worse prognosis. Methods: We analyzed SGLT2/cytokines/sirtuins of excised fatty breasts of fatty vs. non-fatty pre-menopausal women. We correlated SGLT2/cytokines/sirtuins to Δ IMT, Δ LVM, Δ LVEF, and Δ MPI, and normal cardiac performance (NCP) at 1 year of follow-up. Results: fatty vs. non-fatty breast over-expressed SGLT2/inflammatory cytokines, with lowest values of sirtuins (p

Published
2023

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