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344 results on '"Melillo, Lorella"'

1. Antiviral prophylaxis to prevent herpes simplex virus (HSV) and varicella zoster virus (VZV) reactivation in adult patients with newly diagnosed acute leukemia: results of a survey submitted to Italian centers belonging to SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group

Author

Forghieri, Fabio, Cordella, Stefano, Marchesi, Francesco, Itri, Federico, Del Principe, Maria Ilaria, Cavalieri, Elena, Pasciolla, Crescenza, Bonanni, Matteo, Criscuolo, Marianna, Fiorentini, Alessandro, Guolo, Fabio, Buquicchio, Caterina, Prezioso, Lucia, Delia, Mario, Melillo, Lorella, Audisio, Ernesta, Zannier, Maria Elena, Cerchione, Claudio, Dargenio, Michelina, Cattaneo, Chiara, Fracchiolla, Nicola Stefano, Pezone, Sara, Perruccio, Katia, Santoni, Adele, Candoni, Anna, Vignetti, Marco, Luppi, Mario, Pagano, Livio, and Busca, Alessandro

Published
2024
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2. A real-world analysis of PD1 blockade from the Rete Ematologica Pugliese (REP) in patients with relapse/refractory Hodgkin’s lymphoma

Author

Gaudio, Francesco, Loseto, Giacomo, Bozzoli, Valentina, Scalzulli, Potito Rosario, Mazzone, Anna Maria, Tonialini, Lorenzo, Fesce, Vincenza, Quintana, Giovanni, De Santis, Gaetano, Masciopinto, Pierluigi, Arcuti, Elena, Clemente, Felice, Scardino, Stefania, Tarantini, Giuseppe, Pastore, Domenico, Melillo, Lorella, Pavone, Vincenzo, Maggi, Alessandro, Carella, Angelo Michele, Di Renzo, Nicola, Guarini, Attilio, and Musto, Pellegrino

Published
2023
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3. Translational Research on Azacitidine Post-Remission Therapy of Acute Myeloid Leukemia in Elderly Patients (QOL-ONE Trans-2).

Author

Oliva, Esther Natalie, Cuzzola, Maria, Porta, Matteo Della, Candoni, Anna, Salutari, Prassede, Palumbo, Giuseppe A., Reda, Gianluigi, Iannì, Giuseppe, Zampini, Matteo, D'Amico, Saverio, Tripepi, Giovanni, Capelli, Debora, Alati, Caterina, Cannatà, Maria Concetta, Niscola, Pasquale, Serio, Bianca, Barillà, Santina, Musto, Pellegrino, Vigna, Ernesto, and Melillo, Lorella Maria Antonia

Subjects
ACUTE myeloid leukemia, OLDER patients, PROGRESSION-free survival, NUCLEOTIDE sequencing, BONE marrow
Abstract

The achievement of complete remission (CR) is crucial for acute myeloid leukemia (AML) patients undertaking curative therapy, but relapse often occurs within months, highlighting the need for strategies to prolong disease-free survival (DFS). Our phase III study compared the efficacy and safety of azacitidine (AZA) to best supportive care (BSC) in elderly AML patients who achieved CR following intensive induction and consolidation therapy. This ancillary study (QOL-ONE Trans-2) evaluated biological changes in bone marrow using Next-Generation Sequencing (NGS). We analyzed baseline, randomization, and 6-month post-remission samples from 24 patients (median age of 71 and 12 males). High-throughput NGS targeted 350 myeloid malignancy-related genes, considering variants with a variant allele frequency ≥ 4%. At diagnosis, all patients had 5 to 17 (median = 10) mutations, with DNMT3A (42%), NPM1 (33%), and TET2 (33%) being most frequent. FANCA mutations in four patients were linked to a higher relapse risk (HR = 4.96, p = 0.02) for DFS at both 2 and 5 years. Further HLA-specific NGS analyses are ongoing to confirm these results and their therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2024
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4. ELN2017 risk stratification improves outcome prediction when applied to the prospective GIMEMA AML1310 protocol

Author

Buccisano, Francesco, Palmieri, Raffaele, Piciocchi, Alfonso, Arena, Valentina, Candoni, Anna, Melillo, Lorella, Calafiore, Valeria, Cairoli, Roberto, de Fabritiis, Paolo, Storti, Gabriella, Salutari, Prassede, Lanza, Francesco, Martinelli, Giovanni, Luppi, Mario, Capria, Saveria, Maurillo, Luca, Del Principe, Maria Ilaria, Paterno, Giovangiacinto, Irno Consalvo, Maria Antonietta, Ottone, Tiziana, Lavorgna, Serena, Voso, Maria Teresa, Fazi, Paola, Vignetti, Marco, Arcese, William, and Venditti, Adriano

Published
2022
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5. Long-term quality of life of patients with acute promyelocytic leukemia treated with arsenic trioxide vs chemotherapy

Author

Efficace, Fabio, Platzbecker, Uwe, Breccia, Massimo, Cottone, Francesco, Carluccio, Paola, Salutari, Prassede, Di Bona, Eros, Borlenghi, Erika, Autore, Francesco, Levato, Luciano, Finizio, Olimpia, Mancini, Valentina, D'Ardia, Stefano, Schlenk, Richard F., Melillo, Lorella, Fumagalli, Monica, Fiedler, Walter, Beltrami, Germana, Fracchiolla, Nicola Stefano, Bernardi, Massimo, Fazi, Paola, Annibali, Ombretta, Mayer, Karin, Voso, Maria Teresa, and Vignetti, Marco

Published
2021
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6. Long-term results of all-trans retinoic acid and arsenic trioxide in non-high-risk acute promyelocytic leukemia: update of the APL0406 Italian-German randomized trial

Author

Cicconi, Laura, Platzbecker, Uwe, Avvisati, Giuseppe, Paoloni, Francesca, Thiede, Christian, Vignetti, Marco, Fazi, Paola, Ferrara, Felicetto, Divona, Mariadomenica, Albano, Francesco, Efficace, Fabio, Sborgia, Marco, Di Bona, Eros, Breccia, Massimo, Borlenghi, Erika, Cairoli, Roberto, Rambaldi, Alessandro, Melillo, Lorella, La Nasa, Giorgio, Fiedler, Walter, Brossart, Peter, Hertenstein, Bernd, Salih, Helmut R., Annibali, Ombretta, Wattad, Mohammed, Lubbert, Michael, Brandts, Christian H., Hanel, Mathias, Rollig, Christoph, Schmitz, Norbert, Link, Hartmut, Frairia, Chiara, Fozza, Claudio, Maria D’Arco, Alfonso, Di Renzo, Nicola, Cortelezzi, Agostino, Fabbiano, Francesco, Dohner, Konstanze, Ganser, Arnold, Dohner, Hartmut, Amadori, Sergio, Mandelli, Franco, Voso, Maria Teresa, Ehninger, Gerhard, Schlenk, Richard F., and Lo-Coco, Francesco

Published
2020
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7. GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

Author

Venditti, Adriano, Piciocchi, Alfonso, Candoni, Anna, Melillo, Lorella, Calafiore, Valeria, Cairoli, Roberto, de Fabritiis, Paolo, Storti, Gabriella, Salutari, Prassede, Lanza, Francesco, Martinelli, Giovanni, Luppi, Mario, Mazza, Patrizio, Martelli, Maria Paola, Cuneo, Antonio, Albano, Francesco, Fabbiano, Francesco, Tafuri, Agostino, Chierichini, Anna, Tieghi, Alessia, Fracchiolla, Nicola Stefano, Capelli, Debora, Foà, Robin, Alati, Caterina, La Sala, Edoardo, Fazi, Paola, Vignetti, Marco, Maurillo, Luca, Buccisano, Francesco, Del Principe, Maria Ilaria, Irno-Consalvo, Maria, Ottone, Tiziana, Lavorgna, Serena, Voso, Maria Teresa, Lo-Coco, Francesco, Arcese, William, and Amadori, Sergio

Published
2019
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9. Febrile events in acute lymphoblastic leukemia: a prospective observational multicentric SEIFEM study (SEIFEM-2012/B ALL)

Author

Di Blasi, Roberta, Cattaneo, Chiara, Lewis, Russell E., Tumbarello, Mario, Angelici, Laura, Dragonetti, Giulia, Busca, Alessandro, Cambò, Benedetta, Candoni, Anna, Cesarini, Monica, Cesaro, Simone, Delia, Mario, Fanci, Rosa, Farina, Francesca, Garzia, Mariagrazia, Giordano, Antonio, Martino, Bruno, Melillo, Lorella, Nadali, Gianpaolo, Perriello, Vincenzo, Picardi, Marco, Quinto, Angela Maria, Salutari, Prassede, Spolzino, Angelica, Vacca, Adriana, Vetro, Calogero, Zancanella, Michelle, Nosari, Annamaria, Aversa, Franco, Pagano, Livio, and on the behalf of the SEIFEM group (Sorveglianza Epidemiologica Infezioni Fungine in Ematologia)

Published
2018
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10. Multicenter Observational Retrospective Study on Febrile Events in Patients with Acute Myeloid Leukemia Treated with Cpx-351 in “Real-Life”: The SEIFEM Experience

Author

Fianchi, Luana, primary, Guolo, Fabio, additional, Marchesi, Francesco, additional, Cattaneo, Chiara, additional, Gottardi, Michele, additional, Restuccia, Francesco, additional, Candoni, Anna, additional, Ortu La Barbera, Elettra, additional, Fazzi, Rita, additional, Pasciolla, Crescenza, additional, Finizio, Olimpia, additional, Fracchiolla, Nicola, additional, Delia, Mario, additional, Lessi, Federica, additional, Dargenio, Michelina, additional, Bonuomo, Valentina, additional, Del Principe, Maria Ilaria, additional, Zappasodi, Patrizia, additional, Picardi, Marco, additional, Basilico, Claudia, additional, Piedimonte, Monica, additional, Minetto, Paola, additional, Giordano, Antonio, additional, Chiusolo, Patrizia, additional, Prezioso, Lucia, additional, Buquicchio, Caterina, additional, Melillo, Lorella Maria Antonia, additional, Zama, Daniele, additional, Farina, Francesca, additional, Mancini, Valentina, additional, Terrenato, Irene, additional, Rondoni, Michela, additional, Urbino, Irene, additional, Tumbarello, Mario, additional, Busca, Alessandro, additional, and Pagano, Livio, additional

Published
2023
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11. Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope

Author

Del Principe, Maria Ilaria, Seidel, Danila, Criscuolo, Marianna, Dargenio, Michelina, Racil, Zdenek, Piedimonte, Monica, Marchesi, Francesco, Nadali, Gianpaolo, Koehler, Philipp, Fracchiolla, Nicola, Cattaneo, Chiara, Klimko, Nikolai, Spolzino, Angelica, Karapinar, Deniz Yilmaz, Demiraslan, Hayati, Duarte, Rafael F., Demeter, Judit, Stanzani, Marta, Melillo, Lorella Maria Antonia, Basilico, Claudia Maria, Cesaro, Simone, Paterno, Giovangiacinto, Califano, Catello, Delia, Mario, Buzzatti, Elisa, Busca, Alessandro, Cornely, Oliver A., Pagano, Livio, Alakel, Nael, Arsenijevi'c, Valentina Arsi'c, Camus, Vincent, Falces-Romero, Iker, Itzhak, Levy, Kouba, Michal, Martino, Rodrigo, Sedlacek, Petr, Weinbergerova, Barbora, Del Principe, Maria Ilaria, Seidel, Danila, Criscuolo, Marianna, Dargenio, Michelina, Racil, Zdenek, Piedimonte, Monica, Marchesi, Francesco, Nadali, Gianpaolo, Koehler, Philipp, Fracchiolla, Nicola, Cattaneo, Chiara, Klimko, Nikolai, Spolzino, Angelica, Karapinar, Deniz Yilmaz, Demiraslan, Hayati, Duarte, Rafael F., Demeter, Judit, Stanzani, Marta, Melillo, Lorella Maria Antonia, Basilico, Claudia Maria, Cesaro, Simone, Paterno, Giovangiacinto, Califano, Catello, Delia, Mario, Buzzatti, Elisa, Busca, Alessandro, Cornely, Oliver A., Pagano, Livio, Alakel, Nael, Arsenijevi'c, Valentina Arsi'c, Camus, Vincent, Falces-Romero, Iker, Itzhak, Levy, Kouba, Michal, Martino, Rodrigo, Sedlacek, Petr, and Weinbergerova, Barbora

Abstract

Background Our multicentre study aims to identify baseline factors and provide guidance for therapeutic decisions regarding Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. Methods HM patients with proven (Magnusiomyces capitatus) M. capitatus or (Magnusiomyces clavatus) M. clavatus (formerly Saprochaete capitata and Saprochaete clavata) infection diagnosed between January 2010 and December 2020 were recorded from the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group and FungiScope (Global Emerging Fungal Infection Registry). Cases of Magnusiomyces fungemia were compared with candidemia. Results Among 90 Magnusiomyces cases (60 [66%] M. capitatus and 30 (34%) M. clavatus), median age was 50 years (range 2-78), 46 patients (51%) were female and 67 (74%) had acute leukaemia. Thirty-six (40%) of Magnusiomyces-associated infections occurred during antifungal prophylaxis, mainly with posaconazole (n = 13, 36%) and echinocandins (n = 12, 34%). Instead, the candidemia rarely occurred during prophylaxis (p < .0001). First-line antifungal therapy with azoles, alone or in combination, was associated with improved response compared to other antifungals (p = .001). Overall day-30 mortality rate was 43%. Factors associated with higher mortality rates were septic shock (HR 2.696, 95% CI 1.396-5.204, p = .003), corticosteroid treatment longer than 14 days (HR 2.245, 95% CI 1.151-4.376, p = .018) and lack of neutrophil recovery (HR 3.997, 95% CI 2.102-7.601, p < .001). The latter was independently associated with poor outcome (HR 2.495, 95% CI 1.192-5.222, p = .015). Conclusions Magnusiomyces-associated infections are often breakthrough infections. Effective treatment regimens of these infections remain to be determined, but neutrophil recovery appears to play an important role in the favourable outcome.

Published
2023

12. Fatigue in newly diagnosed acute myeloid leukaemia: general population comparison and predictive factors.

Author

Oswald, Laura B., Venditti, Adriano, Cella, David, Cottone, Francesco, Candoni, Anna, Melillo, Lorella, Cairoli, Roberto, Storti, Gabriella, Salutari, Prassede, Luppi, Mario, Albano, Francesco, Martelli, Maria Paola, Cuneo, Antonio, Tafuri, Agostino, Trisolini, Silvia Maria, Tieghi, Alessia, Fazi, Paola, Vignetti, Marco, and Efficace, Fabio

Published
2023
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13. Azacitidine Post-Remission Therapy for Elderly Patients with AML: A Randomized Phase-3 Trial (QoLESS AZA-AMLE)

Author

Oliva, Esther Natalie, primary, Candoni, Anna, additional, Salutari, Prassede, additional, Palumbo, Giuseppe A., additional, Reda, Gianluigi, additional, Iannì, Giuseppe, additional, Tripepi, Giovanni, additional, Cuzzola, Maria, additional, Capelli, Debora, additional, Mammì, Corrado, additional, Alati, Caterina, additional, Cannatà, Maria Concetta, additional, Niscola, Pasquale, additional, Serio, Bianca, additional, Musto, Pellegrino, additional, Vigna, Ernesto, additional, Volpe, Antonio, additional, Melillo, Lorella Maria Antonia, additional, Arcadi, Maria Teresa, additional, Mannina, Donato, additional, Zannier, Maria Elena, additional, and Latagliata, Roberto, additional

Published
2023
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15. Multicenter Observational Retrospective Study on Febrile Events in Patients with Acute Myeloid Leukemia Treated with Cpx-351 in 'Real-Life': The SEIFEM Experience

Author

Fianchi, Luana, Guolo, Fabio, Marchesi, Francesco, Cattaneo, Chiara, Gottardi, Michele, Restuccia, Francesco, Candoni, Anna, Ortu La Barbera, Elettra, Fazzi, Rita, Pasciolla, Crescenza, Finizio, Olimpia, Fracchiolla, Nicola, Delia, Mario, Lessi, Federica, Dargenio, Michelina, Bonuomo, Valentina, Del Principe, Maria Ilaria, Zappasodi, Patrizia, Picardi, Marco, Basilico, Claudia, Piedimonte, Monica, Minetto, Paola, Giordano, Antonio, Chiusolo, Patrizia, Prezioso, Lucia, Buquicchio, Caterina, Melillo, Lorella Maria Antonia, Zama, Daniele, Farina, Francesca, Mancini, Valentina, Terrenato, Irene, Rondoni, Michela, Urbino, Irene, Tumbarello, Mario, Busca, Alessandro, and Pagano, Livio

Subjects
febrile events, CPX-351 therapy, secondary acute myeloid leukemia
Published
2023

16. Real-world evidence on the use of daratumumab, bortezomib and dexamethasone (DVd) in lenalidomide-refractory myeloma patients: subgroup analysis of the multicenter retrospective experience by "rete ematologica pugliese".

Author

Mele, Giuseppe, Di Renzo, Nicola, Cascavilla, Nicola, Carella, Angelo Michele, Guarini, Attilio, Mazza, Patrizio, Melillo, Lorella, Pavone, Vincenzo, Tarantini, Giuseppe, Curci, Paola, Falcone, Anna P., Germano, Candida, Mele, Anna, Merchionne, Francesca, Palazzo, Giulia, Palumbo, Gaetano, Quinto, Angela Maria, Reddiconto, Giovanni, Rossini, Bernardo, and Spina, Alessandro

Subjects
DARATUMUMAB, MULTIPLE myeloma, BORTEZOMIB, SUBGROUP analysis (Experimental design)
Abstract

(a) Cohort of Multiple Myeloma patients treated with DVd (Daratumumab + Bortezomib + Dexamethasone): OS in the subgroup of "Lenalidomide-refractory patients" (70.6% of patients). The last treatment received before the DVd regimen was Carfilzomib-Lenalidomide-Dexamethasone (KRd) (39.6%), Lenalidomide-Dexamethasone (Rd) (39.6%), Elotuzumab-Lenalidomide-Dexamethasone (EloRd) (14.6%) and Ixazomib-Lenalidomide-Dexamethasone (IxaRd) (6.2%). (range 1-34) ht 1 Hgb: hemoglobin; LDH: lactate dehydrogenase; 2M: 2microglobulin; DVd: Daratumumab-Bortezomib-Dexamethasone; KRd: Carfilzomib-Lenalidomide-Dexamethasone; Rd: Lenalidomide-Dexamethasone; EloRd: Elotuzumab-Lenalidomide-Dexamethasone; IxaRd: Ixazomib-Lenalidomide-Dexamethasone. (b) Cohort of Multiple Myeloma patients treated with DVd (Daratumumab + Bortezomib + Dexamethasone): TTP in the subgroup of "Lenalidomide-refractory patients" (70.6% of patients). [Extracted from the article]

Published
2023
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17. Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope

Author

Weinbergerová, Barbora, Sedlacek, Petr, Martino, Rodrigo, Kouba, Michal, Itzhak, Levy, Falces-Romero, Iker, Camus, Vincent, Arsenijevi'c, Valentina Arsi'c, Alakel, Nael, Pagano, Livio, Cornely, Oliver A., Busca, Alessandro, Buzzatti, Elisa, Delia, Mario, Califano, Catello, Paterno, Giovangiacinto, Cesaro, Simone, Basilico, Claudia Maria, Melillo, Lorella Maria Antonia, Stanzani, Marta, Demeter, Judit, Duarte, Rafael F., Demiraslan, Hayati, Yilmaz Karapinar, Deniz, Spolzino, Angelica, Klimko, Nikolai, Cattaneo, Chiara, Fracchiolla, Nicola, Koehler, Philipp, Nadali, Gianpaolo, Marchesi, Francesco, Piedimonte, Monica, Rácil, Zdenek, Dargenio, Michelina, Criscuolo, Marianna, Seidel, Danila, and Del Principe, Maria Ilaria

Subjects
Adult, Male, Saprochaete, Antifungal Agents, Adolescent, Hematological Malignancies, Diseases, Dermatology, Clavata, Guidelines, Young Adult, Echinocandins, Trichosporon, Humans, Child, Aged, Capitatus, fungal infection, Candidemia, General Medicine, Hematology, Middle Aged, Prognosis, Settore MED/15, Geotrichum, Management, Settore MED/15 - MALATTIE DEL SANGUE, antifungal treatment, Infectious Diseases, Child, Preschool, Magnusiomyces, Invasive Infections, Female, Fungal-Infection
Abstract

© 2022 Wiley-VCH GmbH.Background: Our multicentre study aims to identify baseline factors and provide guidance for therapeutic decisions regarding Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. Methods: HM patients with proven (Magnusiomyces capitatus) M. capitatus or (Magnusiomyces clavatus) M. clavatus (formerly Saprochaete capitata and Saprochaete clavata) infection diagnosed between January 2010 and December 2020 were recorded from the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group and FungiScope (Global Emerging Fungal Infection Registry). Cases of Magnusiomyces fungemia were compared with candidemia. Results: Among 90 Magnusiomyces cases (60 [66%] M. capitatus and 30 (34%) M. clavatus), median age was 50 years (range 2–78), 46 patients (51%) were female and 67 (74%) had acute leukaemia. Thirty-six (40%) of Magnusiomyces-associated infections occurred during antifungal prophylaxis, mainly with posaconazole (n = 13, 36%) and echinocandins (n = 12, 34%). Instead, the candidemia rarely occurred during prophylaxis (p

Published
2022

18. Evaluation of the Practice of Antifungal Prophylaxis Use in Patients With Newly Diagnosed Acute Myeloid Leukemia: Results From the SEIFEM 2010-B Registry

Author

Pagano, Livio, Caira, Morena, Candoni, Anna, Aversa, Franco, Castagnola, Carlo, Caramatti, Cecilia, Cattaneo, Chiara, Delia, Mario, De Paolis, Maria Rosaria, Di Blasi, Roberta, Di Caprio, Luigi, Fanci, Rosa, Garzia, Mariagrazia, Martino, Bruno, Melillo, Lorella, Mitra, Maria Enza, Nadali, Gianpaolo, Nosari, Annamaria, Picardi, Marco, Potenza, Leonardo, Salutari, Prassede, Trecarichi, Enrico Maria, Tumbarello, Mario, Verga, Luisa, Vianelli, Nicola, and Busca, Alessandro

Published
2012
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20. A High-Risk Profile for Invasive Fungal Infections Is Associated with Altered Nasal Microbiota and Niche Determinants

Author

Costantini, Claudio, primary, Nunzi, Emilia, additional, Spolzino, Angelica, additional, Merli, Francesco, additional, Facchini, Luca, additional, Spadea, Antonio, additional, Melillo, Lorella, additional, Codeluppi, Katia, additional, Marchesi, Francesco, additional, Marchesini, Gessica, additional, Valente, Daniela, additional, Dragonetti, Giulia, additional, Nadali, Gianpaolo, additional, Englmaier, Lukas, additional, Coufalikova, Katerina, additional, Spáčil, Zdeněk, additional, Bellet, Marina Maria, additional, Pariano, Marilena, additional, Renga, Giorgia, additional, Stincardini, Claudia, additional, D’Onofrio, Fiorella, additional, Bozza, Silvia, additional, Pagano, Livio, additional, Aversa, Franco, additional, and Romani, Luigina, additional

Published
2022
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21. Long-Term Follow-Up of Elderly Patients with Acute Myeloid Leukemia Treated with Decitabine: A Real-World Study of the Apulian Hematological Network

Author

Dargenio, Michelina, primary, Tarantini, Giuseppe, additional, Cascavilla, Nicola, additional, Pavone, Enzo, additional, Musto, Pellegrino, additional, Mazza, Patrizio, additional, Melillo, Lorella, additional, Pastore, Domenico, additional, Guarini, Attilio, additional, Buquicchio, Caterina, additional, Fina, Maria Paola, additional, Federico, Vincenzo, additional, Santeramo, Teresa Maria, additional, Urbano, Marina Aurora, additional, Leo, Mariangela, additional, Carluccio, Vera, additional, Carluccio, Paola, additional, Delia, Mario, additional, Carlino, Daniela, additional, Vergine, Carolina, additional, Gagliardi, Vito Pier, additional, Greco, Giuseppina, additional, Sibilla, Silvia, additional, Abbenante, Mariachiara, additional, Rossi, Giovanni, additional, Spinosa, Giuseppina, additional, Mazzone, Annamaria, additional, Aprile, Lara, additional, de Fazio, Vincenza, additional, Pasciolla, Crescenza, additional, Specchia, Giorgina, additional, and Di Renzo, Nicola, additional

Published
2022
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23. Focus on Key Issues in Immune Thrombotic Thrombocytopenic Purpura: Italian Experience of Six Centers

Author

Tiscia, Giovanni, primary, Sartori, Maria Teresa, additional, Giuffrida, Gaetano, additional, Ostuni, Angelo, additional, Cascavilla, Nicola, additional, Nicolosi, Daniela, additional, Battista, Cosima, additional, Santeramo, Teresa Maria, additional, Melillo, Lorella, additional, Giordano, Giulio, additional, Cappucci, Filomena, additional, Fischetti, Lucia, additional, Chinni, Elena, additional, Tarantini, Giuseppe, additional, Cerbo, Anna, additional, Bertomoro, Antonella, additional, Fabris, Fabrizio, additional, and Grandone, Elvira, additional

Published
2021
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24. Results of the 6-Year Follow-up of the Gimema AML1310 Trial: A Risk-Adapted, MRD-Directed Therapy for Young Adults with Newly Diagnosed Acute Myeloid Leukemia

Author

Venditti, Adriano, primary, Piciocchi, Alfonso, additional, Palmieri, Raffaele, additional, Arena, Valentina, additional, Candoni, Anna, additional, Calafiore, Valeria, additional, Melillo, Lorella MA, additional, Cairoli, Roberto, additional, De Fabritiis, Paolo, additional, Storti, Gabriella, additional, Salutari, Prassede, additional, Lanza, Francesco, additional, Martinelli, Giovanni, additional, Luppi, Mario, additional, Capria, Saveria, additional, Maurillo, Luca, additional, Del Principe, Maria Ilaria, additional, Paterno, Giovangiacinto, additional, Buzzatti, Elisa, additional, Voso, Maria Teresa, additional, Ottone, Tiziana, additional, irno Consalvo, Maria, additional, Fazi, Paola, additional, Vignetti, Marco, additional, Arcese, William, additional, Amadori, Sergio, additional, and Buccisano, Francesco, additional

Published
2021
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25. Risk of invasive fungal infection in patients affected by acute promyelocytic leukaemia. A report by the SEIFEM-D registry

Author

Pagano, Livio, Stamouli, Maria, Tumbarello, Mario, Verga, Luisa, Candoni, Anna, Cattaneo, Chiara, Nadali, Gianpaolo, Mitra, Maria Enza, Mancini, Valentina, Nosari, Annamaria, Garzia, Maria Grazia, Delia, Mario, Storti, Sergio, Spadea, Antonio, Caramatti, Cecilia, Perriello, Vincenzo, Sanna, Marco, Vacca, Adriana, De Paolis, Maria Rosaria, Potenza, Leonardo, Salutari, Prassede, Castagnola, Carlo, Fanci, Rosa, Chierichini, Anna, Melillo, Lorella, Picardi, Marco, Facchini, Luca, Martino, Bruno, Di Blasi, Roberta, Cesarini, Monica, Offidani, Massimo, Vianelli, Nicola, Caira, Morena, Lessi, Federica, Ferrari, Antonella, Venditti, Adriano, Pavone, Vincenzo, Lo-Coco, Francesco, Aversa, Franco, and Busca, Alessandro

Published
2015
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26. A Snapshot of the Management of Chronic Lymphocytic Leukemia in Italy. Preliminary Analysis on over 3000 Patients Enrolled in the Gimema CLL2121 Trial

Author

Scarfo, Lydia, Coscia, Marta, Molteni, Alfredo, Rambaldi, Alessandro, Marasca, Roberto, Steffanoni, Sara, Murru, Roberta, Maschio, Nilla, Scortechini, Ilaria, Gambacorti-Passerini, Carlo, Pennese, Elsa, Trentin, Livio, Moia, Riccardo, Farina, Lucia, Innao, Vanessa, Musto, Pellegrino, Sanna, Alessandro, Facchinelli, Davide, Falcucci, Paolo, Pini, Massimo, Laurenti, Luca, Varettoni, Marzia, Angeletti, Ilaria, Orsucci, Lorella, Rago, Angela, D'Arena, Giovanni, Melillo, Lorella Maria Antonia, Maggi, Alessandro, Ilariucci, Fiorella, Massaia, Massimo, Pastore, Domenico, Vallisa, Daniele, Fazi, Paola, Piciocchi, Alfonso, Messina, Monica, Paoloni, Francesca Paola, Foà, Robin, Del Giudice, Ilaria, Rigolin, Gian Matteo, Cuneo, Antonio, and Ghia, Paolo

Published
2023
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27. Novel Gene Mutations Associated with Disease-Free Survival in Elderly Patients with Acute Myeloid Leukemia Receiving First-Line Induction-Consolidation with or without Azacitidine Post-Remission Treatment

Author

Oliva, Esther Natalie, Cuzzola, Maria, Candoni, Anna, Salutari, Prassede, Palumbo, Giuseppe Alberto, Reda, Gianluigi, Ianni', Giuseppe, Tripepi, Giovanni, Capelli, Debora, Alati, Caterina, Cannatà, Maria Concetta, Niscola, Pasquale, Serio, Bianca, Barillà, Santina, Musto, Pellegrino, Vigna, Ernesto, Melillo, Lorella Maria Antonia, Tripepi, Rocco, Delfino, Ilaria Maria, Zannier, Maria Elena, Nannya, Yasuhito, Ogawa, Seishi, and Mammì, Corrado

Published
2023
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28. Gimema Seifem Real-Life Study VS Randomized CPX-351 Registrative Trial for Older Patients with Secondary ACUTE Myeloid Leukemia: An Unanchored Matching-Adjusted Indirect Comparison of Infection Rates and Survival Outcomes

Author

Fianchi, Luana, Piciocchi, Alfonso, Cattaneo, Chiara, Guolo, Fabio, Marchesi, Francesco, Gottardi, Michele, Restuccia, Francesco, Candoni, Anna, Ortu La Barbera, Elettra, Fazzi, Rita, Pasciolla, Crescenza, Finizio, Olimpia, Fracchiolla, Nicola, Delia, Mario, Lessi, Federica, Dargenio, Michelina, Bonuomo, Valentina, Del Principe, Maria Ilaria, Zappasodi, Patrizia, Picardi, Marco, Basilico, Claudia, Piedimonte, Monica, Minetto, Paola, Criscuolo, Marianna, Bonanni, Matteo, Chiusolo, Patrizia, Prezioso, Lucia, Buquicchio, Caterina, Melillo, Lorella Maria Antonia, Zama, Daniele, Farina, Francesca, Giordano, Antonio, Mancini, Valentina, Terrenato, Irene, Rondoni, Michela, Bacigalupo, Andrea, Busca, Alessandro, and Pagano, Livio

Published
2023
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29. Lifestyle Behaviors and Health-Related Quality of Life in Long-Term Survivors of Acute Myeloid Leukemia: An International Survivorship Study By the Gimema, EORTC Quality of Life and Leukemia Groups

Author

Efficace, Fabio, Cannella, Laura, Thomas, Xavier, Yuksel, Meltem Kurt, Trisolini, Silvia Maria, Saveria, Capria, Brini, Alberto, Audisio, Ernesta, Maurillo, Luca, Lemoli, Roberto Massimo, Imovilli, Annalisa, Panovska Stavridis, Irina, Quattrone, Martina, Ciccone, Maria, Filardi, Nunzio, Fracchiolla, Nicola, Vallisa, Daniele, Crugnola, Monica, Melillo, Lorella Maria Antonia, Skerget, Matevz, Vignetti, Marco, and Baron, Frederic

Published
2023
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30. Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

Author

Hasan, Syed Khizer, Mays, Ashley N., Ottone, Tiziana, Ledda, Antonio, La Nasa, Giorgio, Cattaneo, Chiara, Borlenghi, Erika, Melillo, Lorella, Montefusco, Enrico, Cervera, José, Stephen, Christopher, Satchi, Gnanam, Lennard, Anne, Libura, Marta, Byl, Jo Ann W., Osheroff, Neil, Amadori, Sergio, Felix, Carolyn A., Voso, Maria Teresa, Sperr, Wolfgang R., Esteve, Jordi, Sanz, Miguel A., Grimwade, David, and Lo-Coco, Francesco

Published
2008
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31. Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients

Author

Costantini, Claudio, primary, Nunzi, Emilia, additional, Spolzino, Angelica, additional, Palmieri, Melissa, additional, Renga, Giorgia, additional, Zelante, Teresa, additional, Englmaier, Lukas, additional, Coufalikova, Katerina, additional, Spáčil, Zdeněk, additional, Borghi, Monica, additional, Bellet, Marina M., additional, Acerbi, Enzo, additional, Puccetti, Matteo, additional, Giovagnoli, Stefano, additional, Spaccapelo, Roberta, additional, Talesa, Vincenzo N., additional, Lomurno, Giuseppe, additional, Merli, Francesco, additional, Facchini, Luca, additional, Spadea, Antonio, additional, Melillo, Lorella, additional, Codeluppi, Katia, additional, Marchesi, Francesco, additional, Marchesini, Gessica, additional, Valente, Daniela, additional, Dragonetti, Giulia, additional, Nadali, Gianpaolo, additional, Pagano, Livio, additional, Aversa, Franco, additional, and Romani, Luigina, additional

Published
2021
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32. Fatigue in newly diagnosed acute myeloid leukaemia: general population comparison and predictive factors

Author

Oswald, Laura B, primary, Venditti, Adriano, additional, Cella, David, additional, Cottone, Francesco, additional, Candoni, Anna, additional, Melillo, Lorella, additional, Cairoli, Roberto, additional, Storti, Gabriella, additional, Salutari, Prassede, additional, Luppi, Mario, additional, Albano, Francesco, additional, Martelli, Maria Paola, additional, Cuneo, Antonio, additional, Tafuri, Agostino, additional, Trisolini, Silvia Maria, additional, Tieghi, Alessia, additional, Fazi, Paola, additional, Vignetti, Marco, additional, and Efficace, Fabio, additional

Published
2021
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33. Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

Author

Lo-Coco, Francesco, Avvisati, Giuseppe, Vignetti, Marco, Thiede, Christian, Orlando, Sonia Maria, Iacobelli, Simona, Ferrara, Felicetto, Fazi, Paola, Cicconi, Laura, Di Bona, Eros, Specchia, Giorgina, Sica, Simona, Divona, Mariadomenica, Levis, Alessandro, Fiedler, Walter, Cerqui, Elisa, Breccia, Massimo, Fioritoni, Giuseppe, Salih, Helmut R., Cazzola, Mario, Melillo, Lorella, Carella, Angelo M., Brandts, Christian H., Morra, Enrica, von Lilienfeld-Toal, Marie, Hertenstein, Bernd, Wattad, Mohammed, Lübbert, Michael, Hänel, Matthias, Schmitz, Norbert, Link, Hartmut, Kropp, Maria Grazia, Rambaldi, Alessandro, La Nasa, Giorgio, Luppi, Mario, Ciceri, Fabio, Finizio, Olimpia, Venditti, Adriano, Fabbiano, Francesco, Döhner, Konstanze, Sauer, Michaela, Ganser, Arnold, Amadori, Sergio, Mandelli, Franco, Döhner, Hartmut, Ehninger, Gerhard, Schlenk, Richard F., and Platzbecker, Uwe

Published
2013
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34. Bortezomib (Velcade) for progressive myeloma after autologous stem cell transplantation and thalidomide

Author

Musto, Pellegrino, Falcone, Antonietta, Sanpaolo, Grazia, Guglielmelli, Tommasina, Zambello, Renato, Balleari, Enrico, Catalano, Lucio, Spriano, Mauro, Cavallo, Federica, Sala, Antonio La, Mantuano, Saverio, Nobile, Michele, Melillo, Lorella, Scalzulli, Potito Rosario, Dell’Olio, Matteo, Bodenizza, Carlo, Greco, Michele Mario, Carella, Angelo Michele, Jr., Merla, Emanuela, Carella, Angelo Michele, Boccadoro, Mario, Cascavilla, Nicola, and Palumbo, Antonio

Published
2006
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35. GIMEMA AIDA 0493 amended protocol for elderly patients with acute promyelocytic leukaemia. Long-term results and prognostic factors

Author

Latagliata, Roberto, Breccia, Massimo, Fazi, Paola, Vignetti, Marco, Di Raimondo, Francesco, Sborgia, Marco, Vincelli, Donatella, Candoni, Anna, Salvi, Flavia, Rupoli, Serena, Martinelli, Giovanni, Kropp, Maria Grazia, Tonso, Anna, Venditti, Adriano, Melillo, Lorella, Cimino, Giuseppe, Petti, Maria Concetta, Avvisati, Giuseppe, Lo-Coco, Francesco, and Mandelli, Franco

Published
2011
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36. Validation of ELN2017 Risk Stratification in a Post-Hoc Analysis of the Prospective Biomarker-Based Gimema AML1310 Protocol

Author

Palmieri, Raffaele, primary, Buccisano, Francesco, additional, Piciocchi, Alfonso, additional, Arena, Valentina, additional, Candoni, Anna, additional, Melillo, Lorella MA, additional, Calafiore, Valeria, additional, Cairoli, Roberto, additional, De Fabritiis, Paolo, additional, Storti, Gabriella, additional, Salutari, Prassede, additional, Lanza, Francesco, additional, Martinelli, Giovanni, additional, Luppi, Mario, additional, Capria, Saveria, additional, Maurillo, Luca, additional, Del Principe, Maria Ilaria, additional, Paterno, Giovangiacinto, additional, Voso, Maria Teresa, additional, Ottone, Tiziana, additional, Lavorgna, Serena, additional, Fazi, Paola, additional, Vignetti, Marco, additional, Arcese, William, additional, and Venditti, Adriano, additional

Published
2020
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37. Clearance of leukemic blasts by flow cytometry versus minimal residual disease as predictors of clinical outcome in elderly patients with acute myeloid leukemia.

Author

Rossi, Giovanni, primary, Giambra, Vincenzo, additional, Minervini, Maria Marta, additional, de Waure, Chiara, additional, Giacchetta, Irene, additional, la Torre, Antonella, additional, Ciavarella, Michele, additional, Melillo, Lorella M, additional, Scalzulli, Potito Rosario, additional, Carella, Angelo Michele, additional, and Cascavilla, Nicola, additional

Published
2020
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38. Outcome of 122 pregnancies in essential thrombocythemia patients: A report from the Italian registry

Author

Melillo, Lorella, Tieghi, Alessia, Candoni, Anna, Radaelli, Franca, Ciancia, Rosanna, Specchia, Giorgina, Martino, Bruno, Scalzulli, Potito Rosario, Latagliata, Roberto, Palmieri, Fausto, Usala, Emilio, Valente, Daniela, Valvano, Maria Rosa, Cedrone, Michele, Comitini, Giuseppina, Martinelli, Vincenzo, Cascavilla, Nicola, and Gugliotta, Luigi

Published
2009
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41. Clinical and biological features of acute myeloid leukaemia occurring as second malignancy: GIMEMA archive of adult acute leukaemia

Author

Pagano, Livio, Pulsoni, Alessandro, Tosti, Maria Elena, Avvisati, Giuseppe, Mele, Luca, Mele, Alfonso, Martino, Bruno, Visani, Giuseppe, Cerri, Raffaella, Di Bona, Eros, Invernizzi, Rosangela, Nosari, Annamaria, Clavio, Marino, Allione, Bernardino, Coser, Paolo, Candoni, Anna, Levis, Alessandro, Camera, Andrea, Melillo, Lorella, Leone, Giuseppe, and Mandelli, Franco

Published
2001

42. Feasibility of peripheral blood stem cell rescue as intensification in elderly patients with acute myelocytic leukaemia[colon] a pilot study from the Gimema Group

Author

Montillo, Marco, Tedeschi, Alessandra, Pagano, Livio, Venditti, Adriano, Ferrara, Felicetto, Fabris, Piero, Martino, Bruno, Musso, Maurizio, De Rosa, Gennaro, Specchia, Giorgina, Monaco, Michele, Sparaventi, Giovanni, Spadea, Antonio, Palmas, Angelo, Deplano, Wilma, Manna, Annunziata, Melillo, Lorella, Miraglia, Eustachio, Mirto, Salvatore, and Mandelli, Franco

Published
2000

43. 'Real-life' analysis of the role of antifungal prophylaxis in preventing invasive aspergillosis in AML patients undergoing consolidation therapy: Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM) 2016 study

Author

Del Principe, Maria Ilaria, Dragonetti, Giulia, Verga, Luisa, Candoni, Anna, Marchesi, Francesco, Cattaneo, Chiara, Delia, Mario, Potenza, Leonardo, Farina, Francesca, Ballanti, Stelvio, Decembrino, Nunzia, Castagnola, Carlo, Nadali, Gianpaolo, Fanci, Rosa, Orciulo, Enrico, Veggia, Barbara, Offidani, Massimo, Melillo, Lorella, Manetta, Sara, Tumbarello, Mario, Venditti, Adriano, Busca, Alessandro, Aversa, Franco, Pagano, Livio, Picardi, M, Della Pepa, R, Ferrari, A, Piedimonte, M, Fracchiolla, Ns, Sciumè, M, Lessi, F, Prezioso, L, Spolzino, A, Rambaldi, B, Russo, D, Maracci, L, di Ematologia, C, Sarlo, C, Annibali, O, Cefalo, M, Zizzari, A, Di Blasi, R, di Ematologia, I, Zama, D, Mancini, V, Salutari, P, Cesaro, S, Chiara Tisi, M, Garzia, Mg, Vacca, A, Dargenio, M, Invernizzi, R, Perruccio, K, Mitra, Me, Quinto, Am, Chierichini, A, and Spadea, A.

Subjects
0301 basic medicine, Microbiology (medical), Adult, Male, medicine.medical_specialty, Antifungal Agents, AML, SEIFEM, Invasive Aspergillosis, consolidation therapy, antifumgal prophylaxis, antifungal therapy, 030106 microbiology, SEIFEM, antifumgal prophylaxis, Comorbidity, Aspergillosis, 03 medical and health sciences, 0302 clinical medicine, AML, Risk Factors, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Prospective cohort study, Aged, Pharmacology, business.industry, Incidence (epidemiology), Mortality rate, Consolidation Chemotherapy, Induction Chemotherapy, Middle Aged, medicine.disease, antifungal therapy, Leukemia, Myeloid, Acute, Infectious Diseases, Number needed to treat, Cytarabine, Invasive Aspergillosis, Female, business, consolidation therapy, Settore MED/15 - Malattie del Sangue, Invasive Fungal Infections, medicine.drug
Abstract

Background We evaluated the incidence of proven/probable invasive aspergillosis (IA) and the role of antifungal prophylaxis (AP) in a 'real-life' setting of patients with AML receiving intensive consolidation therapy. Methods Cases of IA, observed during consolidation in adult/paediatric patients with AML between 2011 and 2015, were retrospectively collected in a multicentre Italian study. Results Of 2588 patients, 56 (2.2%) developed IA [43 probable (1.7%) and 13 proven (0.5%)]. IA was diagnosed in 34 of 1137 (2.9%) patients receiving no AP and in 22 of 1451 (1.5%) who were given AP (P = 0.01). Number-needed-to-treat calculation indicates that, on average, 71 patients should have received AP (instead of no AP) for one additional patient to not have IA. Initial antifungal therapy was 'pre-emptive' in 36 (64%) patients and 'targeted' in 20 (36%) patients. A good response to first-line therapy was observed in 26 (46%) patients, mainly those who received AP [16 of 22 (73%) versus 10 of 34 (29%); P = 0.001]. The overall mortality rate and the mortality rate attributable to IA by day 120 were 16% and 9%, respectively. In multivariate analysis, age ≥60 years (OR = 12.46, 95% CI = 1.13-136.73; P = 0.03) and high-dose cytarabine treatment (OR = 10.56, 95% CI = 1.95-116.74; P = 0.04) independently affected outcome. Conclusions In our experience, AP appears to prevent IA from occurring during consolidation. However, although the incidence of IA was low, mortality was not negligible among older patients. Further prospective studies should be carried out particularly in elderly patients treated with high-dose cytarabine to confirm our data and to identify subsets of individuals who may require AP.

Published
2019

45. Central nervous system fungal infections in allogeneic stem cell transplantation. Outcome of 24 recent cases and literature review

Author

Candoni, Anna, primary, Facchin, Gabriele, additional, Busca, Alessandro, additional, Lazzarotto, Davide, additional, Cattaneo, Chiara, additional, Nadali, Gianpaolo, additional, Klimko, Nicholai, additional, Del Principe, Maria Ilaria, additional, Castagnola, Carlo, additional, Verga, Luisa, additional, Zannier, Maria Elena, additional, Calore, Elisabetta, additional, Capelli, Debora, additional, Perruccio, Katia, additional, Melillo, Lorella, additional, Fanin, Renato, additional, and Pagano, Livio, additional

Published
2019
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46. Every‐other‐day palonosetron plus aprepitant for prevention of emesis following induction chemotherapy for acute myeloid leukemia: A randomized, controlled study from the “Rete Ematologica Pugliese”

Author

Di Renzo, Nicola, primary, Melillo, Lorella, additional, Porretto, Fernando, additional, Dargenio, Michela, additional, Pavone, Vincenzo, additional, Pastore, Domenico, additional, Mazza, Patrizio, additional, Mannina, Donato, additional, Merenda, Anxur, additional, Cascavilla, Nicola, additional, Greco, Giuseppina, additional, Matera, Rosella, additional, Bonizzoni, Erminio, additional, Celio, Luigi, additional, and Musso, Maurizio, additional

Published
2019
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47. Long-term results of all-trans retinoic acid and arsenic trioxide in non-high-risk acute promyelocytic leukemia: update of the APL0406 Italian-German randomized trial

Author

Cicconi, Laura, primary, Platzbecker, Uwe, additional, Avvisati, Giuseppe, additional, Paoloni, Francesca, additional, Thiede, Christian, additional, Vignetti, Marco, additional, Fazi, Paola, additional, Ferrara, Felicetto, additional, Divona, Mariadomenica, additional, Albano, Francesco, additional, Efficace, Fabio, additional, Sborgia, Marco, additional, Di Bona, Eros, additional, Breccia, Massimo, additional, Borlenghi, Erika, additional, Cairoli, Roberto, additional, Rambaldi, Alessandro, additional, Melillo, Lorella, additional, La Nasa, Giorgio, additional, Fiedler, Walter, additional, Brossart, Peter, additional, Hertenstein, Bernd, additional, Salih, Helmut R., additional, Annibali, Ombretta, additional, Wattad, Mohammed, additional, Lubbert, Michael, additional, Brandts, Christian H., additional, Hanel, Mathias, additional, Rollig, Christoph, additional, Schmitz, Norbert, additional, Link, Hartmut, additional, Frairia, Chiara, additional, Fozza, Claudio, additional, Maria D’Arco, Alfonso, additional, Di Renzo, Nicola, additional, Cortelezzi, Agostino, additional, Fabbiano, Francesco, additional, Dohner, Konstanze, additional, Ganser, Arnold, additional, Dohner, Hartmut, additional, Amadori, Sergio, additional, Mandelli, Franco, additional, Voso, Maria Teresa, additional, Ehninger, Gerhard, additional, Schlenk, Richard F., additional, and Lo-Coco, Francesco, additional

Published
2019
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48. Clinicobiological features and outcome of acute promyelocytic leukemia occurring as a second tumor: the GIMEMA experience

Author

Pulsoni, Alessandro, Pagano, Livio, Lo Coco, Francesco, Avvisati, Giuseppe, Mele, Luca, Di Bona, Eros, Invernizzi, Rosangela, Leoni, Franco, Marmont, Filippo, Mele, Alfonso, Melillo, Lorella, Nosari, Anna Maria, Pogliani, Enrico Maria, Vignetti, Marco, Visani, Giuseppe, Zagonel, Vittorina, Leone, Giuseppe, and Mandelli, Franco

Published
2002
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50. Bloodstream infections caused by Klebsiella pneumoniae in onco-hematological patients: clinical impact of carbapenem resistance in a multicentre prospective survey

Author

Trecarichi, Enrico Maria, Pagano, Livio, Martino, Bruno, Candoni, Anna, Di Blasi, Roberta, Nadali, Gianpaolo, Fianchi, Luana, Delia, Mario, Sica, Simona, Perriello, Vincenzo, Busca, Alessandro, Aversa, Franco, Fanci, Rosa, Melillo, Lorella, Lessi, Federica, Del Principe, Maria Ilaria, Cattaneo, Chiara, and Tumbarello, Mario

Subjects
Male, Drug Resistance, Bacteremia, Drug Resistance, Microbial, Hematology, Antibiotic Prophylaxis, Middle Aged, Settore MED/17 - MALATTIE INFETTIVE, Prognosis, Klebsiella Infections, Cohort Studies, Klebsiella pneumoniae, Settore MED/15 - MALATTIE DEL SANGUE, Microbial, Carbapenems, Italy, Hematologic Neoplasms, Humans, Female, Prospective Studies, Registries, Proportional Hazards Models
Abstract

The aim of this study was to identify risk factors for mortality in patients suffering from hematological malignancies (HMs) with bloodstream infections (BSIs) caused by Klebsiella pneumoniae (KP). We conducted a prospective cohort study on KP BSI in 13 Italian hematological units participating in the HEMABIS registry-SEIFEM group. The outcome measured was death within 21 days of BSI onset. Survivor and non-survivor subgroups were compared and Cox regression analysis was conducted to identify independent predictors of mortality. A total of 278 episodes of KP BSI were included in the study between January 2010 and June 2014. We found that 161 (57.9%) KP isolates were carbapenem resistant (CRKP). The overall 21-day mortality rate was 36.3%. It was significantly higher for patients with CRKP BSI (84/161, 52.2%) than for those with BSI caused by carbapenem susceptible KP (CSKP) (17/117, 14.5%; P 0.001). Septic shock (HR 3.86), acute respiratory failure (HR 2.32), inadequate initial antimicrobial therapy (HR 1.87) and carbapenem resistance by KP isolates (HR 1.85) were independently associated with mortality. A subanalysis was conducted in only 149 patients with CRKP BSI who had received ≥48 hr of adequate antibiotic therapy, and combination therapy was independently associated with survival (HR 0.32). Our study shows that in recent years carbapenem resistance has dramatically increased in HM patients with KP BSI in Italy and is associated with a worse outcome. The optimal management of such infections and the definition of new empirical/targeted antimicrobial strategies in HM patients can still be considered unmet clinical needs. Am. J. Hematol. 91:1076-1081, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

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