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4 results on '"Melinda Tiao"'

1. Review of methods to improve the performance of linear array-based photoacoustic tomography

Author

Yuehang Wang, Ye Zhan, Melinda Tiao, and Jun Xia

Subjects
photoacoustic tomography, linear array ultrasound transducer, spatial resolution, Technology, Optics. Light, QC350-467
Abstract

As a hybrid imaging modality that combines optical excitation with acoustic detection, photoacoustic tomography (PAT) has become one of the fastest growing biomedical imaging modalities. Among various types of transducer arrays used in a PAT system configuration, the linear array is the most commonly utilized due to its convenience and low-cost. Although linear array-based PAT has been quickly developed within the recent decade, there are still two major challenges that impair the overall performance of the PAT imaging system. The first challenge is that the three-dimensional (3D) imaging capability of a linear array is limited due to its poor elevational resolution. The other challenge is that the geometrical shape of the linear array constrains light illumination. To date, substantial efforts have been made to address the aforementioned challenges. This review will present current technologies for improving the elevation resolution and light delivery of linear array-based PAT systems.

Published
2020
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3. A new photoacoustic breast cancer tomography system that images the patient in standing pose

Author

Huijuan Zhang, Ermelinda Bonaccio, X. Cynthia Fan, Nikhila Nyayapathi, Jun Xia, Melinda Tiao, and Kazuaki Takabe

Subjects
Materials science, medicine.diagnostic_test, business.industry, Breast imaging, Ultrasound, Subtraction, Magnetic resonance imaging, Laser, law.invention, Transducer, law, Maximum intensity projection, medicine, Tomography, business, Biomedical engineering
Abstract

We have developed a photoacoustics-based imaging system that combines optical contrasts with acoustic detection, to obtain a snapshot of the angiographic features in human breast. The system uses near-infrared (NIR) light at 1064 nm wavelength for excitation and hemoglobin in blood as endogenous contrast agent. The light source is a 10 ns Nd:YAG laser with 10-Hz pulse repetition rate. Tumor-angiogenesis, the increase in neovasculature in rapidly growing tumors, is a known biomarker for malignancy. By mapping total hemoglobin levels, we are able to pinpoint the tumor location based on vessel density. For acoustic detection, two 128-element linear-array transducers with 2.25 MHz central frequency are employed. Photoacoustic data is acquired by scanning the breast mildly compressed in the craniocaudal plane, similar to a mammogram, with a scan time of less than 1 minute. The system simultaneously acquires ultrasound (US) data, which can be correlated easily with the photoacoustic data obtained as well as clinical ultrasound images. The photoacoustic images can also be correlated with maximum intensity projection (MIP) subtraction images of contrast MRI (magnetic resonance imaging) 6 minutes post-injection of Gadolinium, and the same vessels could be identified. With our dual transducer geometry, we are able to visualize through 7 cm of breast tissue, a first in this field. The resolution was measured to be 0.97 mm in lateral and 1.05 mm in elevational directions. Our system offers high spatial resolution, fast imaging capability, and convenient correlation with all existing imaging modalities, along with better sensitivity towards dense breast tissue.

Published
2020

4. Dual Scan Mammoscope (DSM)-A New Portable Photoacoustic Breast Imaging System With Scanning in Craniocaudal Plane

Author

Rachel Su Ann Lim, Kazuaki Takabe, Wenhan Zheng, Huijuan Zhang, Melinda Tiao, X. Cynthia Fan, Nikhila Nyayapathi, Jun Xia, Ermelinda Bonaccio, Kwang W. Oh, and Yuehang Wang

Subjects
Computer science, Breast imaging, 0206 medical engineering, Transducers, Biomedical Engineering, Breast Neoplasms, 02 engineering and technology, Imaging modalities, Photoacoustic Techniques, medicine, Mammography, Humans, Breast, Early Cancer Detection, Image resolution, medicine.diagnostic_test, 020601 biomedical engineering, Ultrasonic imaging, Transducer, Photoacoustic tomography, Female, Tomography, Tomography, X-Ray Computed, Human breast, Biomedical engineering
Abstract

Objective: We present a new photoacoustic tomography system that provides visualization of angiographic features in a human breast with mammogram-like images. Methods: The system images a mildly compressed breast, from both top and bottom, using two 128-element, 2.25 MHz linear transducer arrays and line optical fiber bundles. The mild compression is achieved using plastic films, which is a more comfortable experience for the patient compared to rigid metal plates used in a traditional mammogram. Results: We could image a D cup-sized breast of 7 cm thickness within 1 minute and achieve a spatial resolution of around 1 mm in all directions. Conclusion: Our system possesses the benefits of portability, speedy scanning, and patient comfort. The craniocaudal-view images can be easily correlated with existing imaging modalities for data interpretation. Significance: Early cancer detection plays a critical role in overall cancer survival rate. Our system may address the limitations of mammogram and offer a radiation-free screening technique for patients with dense breasts.

Published
2019

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