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2. Complex intracranial aneurysms: a DELPHI study to define associated characteristics

Author

Diana, Francesco, Romoli, Michele, Raz, Eytan, Agid, Ronit, Albuquerque, Felipe C., Arthur, Adam S., Beck, Jürgen, Berge, Jerome, Boogaarts, Hieronymus D., Burkhardt, Jan-Karl, Cenzato, Marco, Chapot, René, Charbel, Fady T., Desal, Hubert, Esposito, Giuseppe, Fifi, Johanna T., Florian, Stefan, Gruber, Andreas, Hassan, Ameer E., Jabbour, Pascal, Jadhav, Ashutosh P., Korja, Miikka, Krings, Timo, Lanzino, Giuseppe, Meling, Torstein R., Morcos, Jaques, Mosimann, Pascal J., Nossek, Erez, Pereira, Vitor Mendes, Raabe, Andreas, Regli, Luca, Rohde, Veit, Siddiqui, Adnan H., Tanikawa, Rokuya, Tjoumakaris, Stavropoula I., Tomasello, Alejandro, Vajkoczy, Peter, Valvassori, Luca, Velinov, Nikolay, Walsh, Daniel, Woo, Henry, Xu, Bin, Yoshimura, Shinichi, van Zwam, Wim H., and Peschillo, Simone

Published
2024
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5. Opportunities and challenges for the development of “core outcome sets” in neuro-oncology

Author

Millward, Christopher P, Armstrong, Terri S, Barrington, Heather, Brodbelt, Andrew R, Bulbeck, Helen, Byrne, Anthony, Dirven, Linda, Gamble, Carrol, Grundy, Paul L, Islim, Abdurrahman I, Javadpour, Mohsen, Keshwara, Sumirat M, Krishna, Sandhya T, Mallucci, Conor L, Marson, Anthony G, McDermott, Michael W, Meling, Torstein R, Oliver, Kathy, Pizer, Barry, Plaha, Puneet, Preusser, Matthias, Santarius, Thomas, Srikandarajah, Nisaharan, Taphoorn, Martin JB, Watts, Colin, Weller, Michael, Williamson, Paula R, Zadeh, Gelareh, Najafabadi, Amir H Zamanipoor, and Jenkinson, Michael D

Subjects
Clinical Trials and Supportive Activities, Rare Diseases, Neurosciences, Clinical Research, Cancer, Brain Disorders, Brain Cancer, Evaluation of treatments and therapeutic interventions, 6.9 Resources and infrastructure (treatment evaluation), Generic health relevance, Adult, Child, Consensus, Delphi Technique, Humans, Meningeal Neoplasms, Meningioma, Research Design, Treatment Outcome, clinical trial, core outcome set, effectiveness, glioma, meningioma, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Core Outcome Sets (COS) define minimum outcomes to be measured and reported in clinical effectiveness trials for a particular health condition/health area. Despite recognition as critical to clinical research design for other health areas, none have been developed for neuro-oncology. COS development projects should carefully consider: scope (how the COS should be used), stakeholders involved in development (including patients as both research partners and participants), and consensus methodologies used (typically a Delphi survey and consensus meeting), as well as dissemination plans. Developing COS for neuro-oncology is potentially challenging due to extensive tumor subclassification (including molecular stratification), different symptoms related to anatomical tumor location, and variation in treatment options. Development of a COS specific to tumor subtype, in a specific location, for a particular intervention may be too narrow and would be unlikely to be used. Equally, a COS that is applicable across a wider area of neuro-oncology may be too broad and therefore lack specificity. This review describes why and how a COS may be developed, and discusses challenges for their development, specific to neuro-oncology. The COS under development are briefly described, including: adult glioma, incidental/untreated meningioma, meningioma requiring intervention, and adverse events from surgical intervention for pediatric brain tumors.

Published
2022

6. Orbitofrontal cortex governs working memory for temporal order

Author

Johnson, Elizabeth L, Chang, William K, Dewar, Callum D, Sorensen, Donna, Lin, Jack J, Solbakk, Anne-Kristin, Endestad, Tor, Larsson, Pal G, Ivanovic, Jugoslav, Meling, Torstein R, Scabini, Donatella, and Knight, Robert T

Subjects
Biological Psychology, Cognitive and Computational Psychology, Psychology, Behavioral and Social Science, Basic Behavioral and Social Science, Neurosciences, Rare Diseases, Humans, Memory, Short-Term, Neuroimaging, Prefrontal Cortex, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

How do we think about time? Converging lesion and neuroimaging evidence indicates that orbitofrontal cortex (OFC) supports the encoding and retrieval of temporal context in long-term memory1, which may contribute to confabulation in individuals with OFC damage2. Here, we reveal that OFC damage diminishes working memory for temporal order, that is, the ability to disentangle the relative recency of events as they unfold. OFC lesions reduced working memory for temporal order but not spatial position, and individual deficits were commensurate with lesion size. Comparable effects were absent in patients with lesions restricted to lateral prefrontal cortex (PFC). Based on these findings, we propose that OFC supports understanding of the order of events. Well-documented behavioral changes in individuals with OFC damage2 may relate to impaired temporal-order understanding.

Published
2022

7. Development of ‘Core Outcome Sets’ for Meningioma in Clinical Studies (The COSMIC Project): protocol for two systematic literature reviews, eDelphi surveys and online consensus meetings

Author

Millward, Christopher P, Armstrong, Terri S, Barrington, Heather, Bell, Sabrina, Brodbelt, Andrew R, Bulbeck, Helen, Crofton, Anna, Dirven, Linda, Georgious, Theo, Grundy, Paul L, Islim, Abdurrahman I, Javadpour, Mohsen, Keshwara, Sumirat M, Koszdin, Shelli D, Marson, Anthony G, McDermott, Michael W, Meling, Torstein R, Oliver, Kathy, Plaha, Puneet, Preusser, Matthias, Santarius, Thomas, Srikandarajah, Nisaharan, Taphoorn, Martin JB, Turner, Carole, Watts, Colin, Weller, Michael, Williamson, Paula R, Zadeh, Gelareh, Najafabadi, Amir H Zamanipoor, Jenkinson, Michael D, Aldape, Kenneth, Au, Karolyn, Barnhartz-Sloan, Jill, Bi, Wenya Linda, Behling, Felix, Brastianos, Priscilla K, Brodie, Chaya, Butowski, Nicholas, Carlotti, Carlos, Castro, Ana, Cohen-Gadol, Aaron, Couce, Marta, Cusimano, Michael D, DiMeco, Francesco, Drummond, Katharine, Dunn, Ian F, Erker, Craig, Felicella, Michelle, Fountain, Daniel M, Galanis, Evanthia, Galldiks, Norbert, Giannini, Caterina, Goldbrunner, Roland, Griffith, Brent, Hashizume, Rintaro, Hanemann, C Oliver, Herold-Mende, Christel, Hnenny, Luke, Horbinski, Craig, Huang, Raymond Y, James, David, Jungk, Christine, Jungwirth, Gerhard, Kaufmann, Timothy J, Krischek, Boris, Kurz, Sylvia, Lachance, Daniel, Lafougère, Christian, Lamszus, Katrin, Lee, Ian, Liu, Jeff C, Makarenko, Serge, Malta, Tathiana, Mamatjan, Yasin, Mansouri, Alireza, Mawrin, Christian, McDermott, Michael, Moliterno-Gunel, Jennifer, Morokoff, Andrew, Munoz, David, Nassiri, Farshad, Noushmehr, Houtan, Ng, Ho-Keung, Perry, Arie, Pirouzmand, Farhad, Poisson, Laila M, Pollo, Bianca, Ragunathan, Aditya, Raleigh, David, Renovanz, Mirjam, Ricklefs, Franz, Sahm, Felix, Saladino, Andrea, Santacroce, Antonio, Schittenhelm, Jens, and Schichor, Christian

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Brain Disorders, Clinical Research, Clinical Trials and Supportive Activities, Cancer, Consensus, Delphi Technique, Humans, Meningeal Neoplasms, Meningioma, Research Design, Systematic Reviews as Topic, Treatment Outcome, EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, Brainstrust, and Brain Tumour Foundation of Canada, clinical trial, core outcome set, meningioma, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

IntroductionMeningioma is the most common primary intracranial tumour in adults. The majority are non-malignant, but a proportion behave more aggressively. Incidental/minimally symptomatic meningioma are often managed by serial imaging. Symptomatic meningioma, those that threaten neurovascular structures, or demonstrate radiological growth, are usually resected as first-line management strategy. For patients in poor clinical condition, or with inoperable, residual or recurrent disease, radiotherapy is often used as primary or adjuvant treatment. Effective pharmacotherapy treatments do not currently exist. There is heterogeneity in the outcomes measured and reported in meningioma clinical studies. Two 'Core Outcome Sets' (COS) will be developed: (COSMIC: Intervention) for use in meningioma clinical effectiveness trials and (COSMIC: Observation) for use in clinical studies of incidental/untreated meningioma.Methods and analysisTwo systematic literature reviews and trial registry searches will identify outcomes measured and reported in published and ongoing (1) meningioma clinical effectiveness trials, and (2) clinical studies of incidental/untreated meningioma. Outcomes include those that are clinician reported, patient reported, caregiver reported and based on objective tests (eg, neurocognitive tests), as well as measures of progression and survival. Outcomes will be deduplicated and categorised to generate two long lists. The two long lists will be prioritised through two, two-round, international, modified eDelphi surveys including patients with meningioma, healthcare professionals, researchers and those in caring/supporting roles. The two final COS will be ratified through two 1-day online consensus meetings, with representation from all stakeholder groups.Ethics and disseminationInstitutional review board (University of Liverpool) approval was obtained for the conduct of this study. Participant eConsent will be obtained prior to participation in the eDelphi surveys and consensus meetings. The two systematic literature reviews and two final COS will be published and freely available.Trial registration numberCOMET study ID 1508.

Published
2022

13. Cavernous malformations of the central nervous system: An international consensus statement

Author

Tasiou, Anastasia, Brotis, Alexandros G., Kalogeras, Adamantios, Tzerefos, Christos, Alleyne, Cargill H., Jr., Andreou, Alexandros, Demetriades, Andreas K., Foroglou, Nikolaos, Friedlander, Robert M., Karlsson, Bengt, Kitchen, Neil, Meling, Torstein R., Mitsos, Aristotelis, Panagiotopoulos, Vasilios, Papasilekas, Themistoklis, Pavesi, Giacomo, Rasulic, Lukas, Santos, Alejandro N., Spetzler, Robert F., Sure, Ulrich, Tjoumakaris, Stavropoula, Tolias, Christos M., Vajkoczy, Peter, and Fountas, Kostas N.

Published
2023
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14. Lesions to the Fronto-Parietal Network Impact Alpha-Band Phase Synchrony and Cognitive Control.

Author

Sadaghiani, Sepideh, Dombert, Pascasie L, Løvstad, Marianne, Funderud, Ingrid, Meling, Torstein R, Endestad, Tor, Knight, Robert T, Solbakk, Anne-Kristin, and D’Esposito, Mark

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Neurosciences, Behavioral and Social Science, Basic Behavioral and Social Science, 2.1 Biological and endogenous factors, Aetiology, Adult, Alpha Rhythm, Cortical Synchronization, Executive Function, Frontal Lobe, Humans, Middle Aged, Neural Pathways, Neuropsychological Tests, Parietal Lobe, Young Adult, cognitive flexibility, dorsolateral prefrontal cortex, fronto-parietal network, lesion, alpha oscillations, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

Long-range phase synchrony in the α-oscillation band (near 10 Hz) has been proposed to facilitate information integration across anatomically segregated regions. Which areas may top-down regulate such cross-regional integration is largely unknown. We previously found that the moment-to-moment strength of high-α band (10-12 Hz) phase synchrony co-varies with activity in a fronto-parietal (FP) network. This network is critical for adaptive cognitive control functions such as cognitive flexibility required during set-shifting. Using electroencephalography (EEG) in 23 patients with focal frontal lobe lesions (resected tumors), we tested the hypothesis that the FP network is necessary for modulation of high-α band phase synchrony. Global phase-synchrony was measured using an adaptation of the phase-locking value (PLV) in a sliding window procedure, which allowed for measurement of changes in EEG-based resting-state functional connectivity across time. As hypothesized, the temporal modulation (range and standard deviation) of high-α phase synchrony was reduced as a function of FP network lesion extent, mostly due to dorsolateral prefrontal cortex (dlPFC) lesions. Furthermore, patients with dlPFC lesions exhibited reduced cognitive flexibility as measured by the Trail-Making Test (set-shifting). Our findings provide evidence that the FP network is necessary for modulatory control of high-α band long-range phase synchrony, and linked to cognitive flexibility.

Published
2019

17. Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part II: Trigeminal and facial nerve schwannomas (CN V, VII)

Author

Bal, Jarnail, Bruneau, Michael, Berhouma, Moncef, Cornelius, Jan F., Cavallo, Luigi M., Daniel, Roy T., Froelich, Sebastien, Jouanneau, Emmanuel, Meling, Torstein R., Messerer, Mahmoud, Roche, Pierre-Hugues, Schroeder, Henry W. S., Tatagiba, Marcos, Zazpe, Idoya, and Paraskevopoulos, Dimitrios

Published
2022
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20. Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part III: Lower cranial nerve schwannomas, jugular foramen (CN IX, X, XI) and hypoglossal schwannoma (XII)

Author

Bal, Jarnail, Bruneau, Michael, Berhouma, Moncef, Cornelius, Jan F., Cavallo, Luigi M., Daniel, Roy T., Froelich, Sebastien, Jouanneau, Emmanuel, Meling, Torstein R., Messerer, Mahmoud, Roche, Pierre-Hugues, Schroeder, Henry, Tatagiba, Marcos, Zazpe, Idoya, and Paraskevopoulos, Dimitrios

Published
2022
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21. Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section. Part I: oculomotor and other rare non-vestibular schwannomas (I, II, III, IV, VI)

Author

Bal, Jarnail, Bruneau, Michael, Berhouma, Moncef, Cornelius, Jan F., Cavallo, Luigi M., Daniel, Roy T., Froelich, Sebastien, Jouanneau, Emmanuel, Meling, Torstein R., Messerer, Mahmoud, Roche, Pierre-Hugues, Schroeder, Henry W. S., Tatagiba, Marcos, Zazpe, Idoya, and Paraskevopoulos, Dimitrios

Published
2022
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22. Update in Cushing disease: What the neurosurgeon has to KNOW, on behalf of the EANS skull base section

Author

Eulate-Beramendi, Sayoa, Casajús, Ainhoa, Ollero, Lola, Niemann, Lynnette K., Fernández-Miranda, Juan Carlos, Bruneau, Michaël, Berhouma, Moncef, Cavallo, Luigi Maria, Cornelius, Jan Frederick, Daniel, Roy T., Froelich, Sebastien, Jouanneau, Emmanuel, Kasper, Ekkehard, Mazzatenta, Diego, Meling, Torstein R., Messerer, Mahmoud, Schroeder, Henry W.S., Tatagiba, Marcos, Visocchi, Massimiliano, Voormolen, Eduard H., and Zazpe, Idoya

Published
2022
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23. Surgical management of giant pituitary neuroendocrine tumors: Meta-analysis and consensus statement on behalf of the EANS skull base section

Author

Cossu, Giulia, Jouanneau, Emmanuel, Cavallo, Luigi M., Froelich, Sebastien, Starnoni, Daniele, Giammattei, Lorenzo, Harel, Ethan, Mazzatenta, Diego, Bruneau, Micheal, Meling, Torstein R., Berhouma, Moncef, Chacko, Ari G., Cornelius, Jan F., Paraskevopoulos, Dimitrios, Schroeder, Henry W.S., Zazpe, Idoya, Manet, Romain, Gardner, Paul A., Dufour, Henry, Cappabianca, Paolo, Daniel, Roy T., and Messerer, Mahmoud

Published
2022
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24. Management of cavernous sinus meningiomas: Consensus statement on behalf of the EANS skull base section

Author

Corniola, Marco V., Roche, Pierre-Hugues, Bruneau, Michaël, Cavallo, Luigi M., Daniel, Roy T., Messerer, Mahmoud, Froelich, Sebastien, Gardner, Paul A., Gentili, Fred, Kawase, Takeshi, Paraskevopoulos, Dimitrios, Régis, Jean, Schroeder, Henry W.S., Schwartz, Theodore H., Sindou, Marc, Cornelius, Jan F., Tatagiba, Marcos, and Meling, Torstein R.

Published
2022
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26. Aggressive pituitary neuroendocrine tumors: current practices, controversies, and perspectives, on behalf of the EANS skull base section

Author

Ng, Sam, Messerer, Mahmoud, Engelhardt, Julien, Bruneau, Michaël, Cornelius, Jan Frederick, Cavallo, Luigi Maria, Cossu, Giulia, Froelich, Sebastien, Meling, Torstein R., Paraskevopoulos, Dimitrios, Schroeder, Henry W. S., Tatagiba, Marcos, Zazpe, Idoya, Berhouma, Moncef, Daniel, Roy T., Laws, Edward R., Knosp, Engelbert, Buchfelder, Michael, Dufour, Henri, Gaillard, Stéphane, Jacquesson, Timothée, and Jouanneau, Emmanuel

Published
2021
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28. Lateral prefrontal cortex lesion impairs regulation of internally and externally directed attention

Author

Kam, Julia WY, Solbakk, Anne-Kristin, Endestad, Tor, Meling, Torstein R, and Knight, Robert T

Subjects
Biomedical and Clinical Sciences, Health Sciences, Behavioral and Social Science, Basic Behavioral and Social Science, Neurosciences, Neurological, Alpha Rhythm, Attention, Brain Diseases, Brain Neoplasms, Electroencephalography, Executive Function, Humans, Prefrontal Cortex, Stroke, Theta Rhythm, Internally directed attention, Externally directed attention, Lateral prefrontal cortex, Electrophysiology, Executive Control, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

Our capacity to flexibly shift between internally and externally directed attention is crucial for successful performance of activities in our daily lives. Neuroimaging studies have implicated the lateral prefrontal cortex (LPFC) in both internally directed processes, including autobiographical memory retrieval and future planning, and externally directed processes, including cognitive control and selective attention. However, the causal involvement of the LPFC in regulating internally directed attention states is unknown. The current study recorded scalp EEG from patients with LPFC lesions and healthy controls as they performed an attention task that instructed them to direct their attention either to the external environment or their internal milieu. We compared frontocentral midline theta and posterior alpha between externally and internally directed attention states. While healthy controls showed increased theta power during externally directed attention and increased alpha power during internally directed attention, LPFC patients revealed no differences between the two attention states in either electrophysiological measure in the analyzed time windows. These findings provide evidence that damage to the LPFC leads to dysregulation of both types of attention, establishing the important role of LPFC in supporting sustained periods of internally and externally directed attention.

Published
2018

29. Dynamic frontotemporal systems process space and time in working memory.

Author

Johnson, Elizabeth L, Adams, Jenna N, Solbakk, Anne-Kristin, Endestad, Tor, Larsson, Pål G, Ivanovic, Jugoslav, Meling, Torstein R, Lin, Jack J, and Knight, Robert T

Subjects
Prefrontal Cortex, Temporal Lobe, Humans, Theta Rhythm, Brain Mapping, Memory, Short-Term, Adult, Female, Male, Memory, Short-Term, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology
Abstract

How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are these regions independent, or do they interact in the service of working memory? We addressed this core issue in behavior by recording directly from frontotemporal sites in humans performing a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. Theta band oscillations drove bidirectional interactions between the PFC and medial temporal lobe (MTL; including the hippocampus). MTL theta oscillations directed the PFC preferentially during the processing of spatiotemporal information, while PFC theta oscillations directed the MTL for all types of information being processed in working memory. These findings reveal an MTL theta mechanism for processing space and time and a domain-general PFC theta mechanism, providing evidence that rapid, dynamic MTL-PFC interactions underlie working memory for everyday experiences.

Published
2018

32. Acute Stenting and Concomitant Tirofiban Administration for the Endovascular Treatment of Acute Ischemic Stroke Related to Intracranial Artery Dissections: A Single Center Experience and Systematic Review of the Literature

Author

Bernava, Gianmarco, Meling, Torstein R., Rosi, Andrea, Hofmeister, Jeremy, Yilmaz, Hasan, Brina, Olivier, Reymond, Philippe, Muster, Michel, Corniola, Marco V., Carrera, Emmanuel, Lovblad, Karl-Olof, Kulcsar, Zsolt, and Machi, Paolo

Published
2021
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34. 3D printing in neurosurgery

Author

Athanasiou, Alkinoos, primary, Meling, Torstein R., additional, Brotis, Alexandros, additional, Moiraghi, Alessandro, additional, Fountas, Konstantinos, additional, Bamidis, Panagiotis D., additional, and Magras, Ioannis, additional

Published
2022
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35. Contributors

Author

Alexiou, Maria V., primary, Antoniou, Panagiotis E., additional, Athanasiou, Alkinoos, additional, Athina, Bakopoulou, additional, Bamidis, Panagiotis D., additional, Bangeas, Petros, additional, Brotis, Alexandros, additional, Christina, Hadjichristou, additional, Daniilidis, Angelos, additional, Demiri, Efterpi, additional, Dionyssiou, Dimitrios, additional, Fountas, Konstantinos, additional, Giannoulis, Kleanthis E., additional, Grimbizis, Grigoris F., additional, Karolos, Ion-Anastasios, additional, Magras, Ioannis, additional, Maria, Bousnaki, additional, Meling, Torstein R., additional, Moiraghi, Alessandro, additional, Petros, Koidis, additional, Pikridas, Christos, additional, Spanos, Constantine P., additional, Spanos, Marianna P., additional, Spyropoulou, Georgia-Alexandra, additional, Theodoridis, Theodoros D., additional, Tooulias, Andreas I., additional, Tsimponis, Antonios, additional, Tsioukas, Vassilios, additional, Tsoulfas, Georgios, additional, and Tzounis, Lazaros, additional

Published
2022
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37. The outcomes measured and reported in intracranial meningioma clinical trials: A systematic review

Author

Millward, Christopher P; https://orcid.org/0000-0001-7727-1157, Keshwara, Sumirat M, Armstrong, Terri S; https://orcid.org/0000-0002-2414-0492, Barrington, Heather; https://orcid.org/0000-0001-9103-2670, Bell, Sabrina, Brodbelt, Andrew R, Bulbeck, Helen, Dirven, Linda; https://orcid.org/0000-0001-9157-9895, Grundy, Paul L, Islim, Abdurrahman I, Javadpour, Mohsen, Koszdin, Shelli D, Marson, Anthony G, McDermott, Michael W, Meling, Torstein R, Oliver, Kathy, Plaha, Puneet, Preusser, Matthias; https://orcid.org/0000-0003-3541-2315, Santarius, Thomas, Srikandarajah, Nisaharan; https://orcid.org/0000-0001-9578-508X, Taphoorn, Martin J B; https://orcid.org/0000-0001-9949-4722, Turner, Carole, Watts, Colin; https://orcid.org/0000-0003-3531-8791, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Williamson, Paula R, Zadeh, Gelareh; https://orcid.org/0000-0002-6637-4502, Zamanipoor Najafabadi, Amir H, Jenkinson, Michael D, Aldape, Kenneth; https://orcid.org/0000-0001-5119-7550, et al, Millward, Christopher P; https://orcid.org/0000-0001-7727-1157, Keshwara, Sumirat M, Armstrong, Terri S; https://orcid.org/0000-0002-2414-0492, Barrington, Heather; https://orcid.org/0000-0001-9103-2670, Bell, Sabrina, Brodbelt, Andrew R, Bulbeck, Helen, Dirven, Linda; https://orcid.org/0000-0001-9157-9895, Grundy, Paul L, Islim, Abdurrahman I, Javadpour, Mohsen, Koszdin, Shelli D, Marson, Anthony G, McDermott, Michael W, Meling, Torstein R, Oliver, Kathy, Plaha, Puneet, Preusser, Matthias; https://orcid.org/0000-0003-3541-2315, Santarius, Thomas, Srikandarajah, Nisaharan; https://orcid.org/0000-0001-9578-508X, Taphoorn, Martin J B; https://orcid.org/0000-0001-9949-4722, Turner, Carole, Watts, Colin; https://orcid.org/0000-0003-3531-8791, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Williamson, Paula R, Zadeh, Gelareh; https://orcid.org/0000-0002-6637-4502, Zamanipoor Najafabadi, Amir H, Jenkinson, Michael D, Aldape, Kenneth; https://orcid.org/0000-0001-5119-7550, and et al

Abstract

Background Meningioma clinical trials have assessed interventions including surgery, radiotherapy, and pharmacotherapy. However, agreement does not exist on what, how, and when outcomes of interest should be measured. To do so would allow comparative analysis of similar trials. This systematic review aimed to summarize the outcomes measured and reported in meningioma clinical trials. Methods Systematic literature and trial registry searches were performed to identify published and ongoing intracranial meningioma clinical trials (PubMed, Embase, Medline, CINAHL via EBSCO, and Web of Science, completed January 22, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were deduplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the “Core Outcome Measures in Effectiveness Trials” (COMET) initiative. Results Thirty published articles and 18 ongoing studies were included, describing 47 unique clinical trials: Phase 2 n = 33, phase 3 n = 14. Common interventions included: Surgery n = 13, radiotherapy n = 8, and pharmacotherapy n = 20. In total, 659 verbatim outcomes were reported, of which 84 were defined. Following de-duplication, 415 unique verbatim outcomes remained and were grouped into 115 standardized outcome terms. These were classified using the COMET taxonomy into 29 outcome domains and 5 core areas. Conclusions Outcome measurement across meningioma clinical trials is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a core outcome set for use in future meningioma clinical trials.

Published
2024

38. The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review

Author

Millward, Christopher P; https://orcid.org/0000-0001-7727-1157, Islim, Abdurrahman I, Armstrong, Terri S; https://orcid.org/0000-0002-2414-0492, Barrington, Heather; https://orcid.org/0000-0001-9103-2670, Bell, Sabrina, Brodbelt, Andrew R, Bulbeck, Helen, Dirven, Linda; https://orcid.org/0000-0001-9157-9895, Grundy, Paul L, Javadpour, Mohsen, Keshwara, Sumirat M, Koszdin, Shelli D, Marson, Anthony G, McDermott, Michael W, Meling, Torstein R, Oliver, Kathy, Plaha, Puneet, Preusser, Matthias; https://orcid.org/0000-0003-3541-2315, Santarius, Thomas, Srikandarajah, Nisaharan; https://orcid.org/0000-0001-9578-508X, Taphoorn, Martin J B; https://orcid.org/0000-0001-9949-4722, Turner, Carole, Watts, Colin; https://orcid.org/0000-0003-3531-8791, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Williamson, Paula R, Zadeh, Gelareh; https://orcid.org/0000-0002-6637-4502, Zamanipoor Najafabadi, Amir H, Jenkinson, Michael D, Aldape, Kenneth; https://orcid.org/0000-0001-5119-7550, et al, Millward, Christopher P; https://orcid.org/0000-0001-7727-1157, Islim, Abdurrahman I, Armstrong, Terri S; https://orcid.org/0000-0002-2414-0492, Barrington, Heather; https://orcid.org/0000-0001-9103-2670, Bell, Sabrina, Brodbelt, Andrew R, Bulbeck, Helen, Dirven, Linda; https://orcid.org/0000-0001-9157-9895, Grundy, Paul L, Javadpour, Mohsen, Keshwara, Sumirat M, Koszdin, Shelli D, Marson, Anthony G, McDermott, Michael W, Meling, Torstein R, Oliver, Kathy, Plaha, Puneet, Preusser, Matthias; https://orcid.org/0000-0003-3541-2315, Santarius, Thomas, Srikandarajah, Nisaharan; https://orcid.org/0000-0001-9578-508X, Taphoorn, Martin J B; https://orcid.org/0000-0001-9949-4722, Turner, Carole, Watts, Colin; https://orcid.org/0000-0003-3531-8791, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Williamson, Paula R, Zadeh, Gelareh; https://orcid.org/0000-0002-6637-4502, Zamanipoor Najafabadi, Amir H, Jenkinson, Michael D, Aldape, Kenneth; https://orcid.org/0000-0001-5119-7550, and et al

Abstract

Background The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies. Methods A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were de-duplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the “Core Outcome Measures in Effectiveness Trials” (COMET) initiative. Results Thirty-three published articles and 1 ongoing study were included describing 32 unique studies: study designs were retrospective n = 27 and prospective n = 5. In total, 268 verbatim outcomes were reported, of which 77 were defined. Following de-duplication, 178 unique verbatim outcomes remained and were grouped into 53 standardized outcome terms. These were classified using the COMET taxonomy into 9 outcome domains and 3 core areas. Conclusions Outcome measurement across observational studies of incidental and untreated intracranial meningioma is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a Core Outcome Set for use in future observational studies.

Published
2024

45. A Spotlight on Cadaveric Dissection in Neurosurgical Training: the Perspective of the EANS Young Neurosurgeons Committee

Author

Torregrossa, Fabio, primary, Peris-Celda, Maria, additional, Spiriev, Toma, additional, Zoia, Cesare, additional, Drosos, Evangelos, additional, Aldea, Cristina, additional, Bartek, Jiri, additional, Bauer, Marlies, additional, Belo, Diogo, additional, Stastna, Daniela, additional, Kaprovoy, Stanislav, additional, Lepic, Milan, additional, Lippa, Laura, additional, Mohme, Malte, additional, Motov, Stefan, additional, Schwake, Michael, additional, Stengel, Felix, additional, Iacopino, Gerardo, additional, Grasso, Giovanni, additional, Gandìa-Gonzàlez, Maria L., additional, Meling, Torstein R., additional, and Raffa, Giovanni, additional

Published
2024
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47. Neurosurgical fellowship in Europe: It's time to cooperate – A call from the EANS Young Neurosurgeons' Committee

Author

Zoia, Cesare, primary, Mantovani, Giorgio, additional, Aldea, Cristina, additional, Bartek, Jiri, additional, Bauer, Marlies, additional, Belo, Diogo, additional, Drosos, Evangelos, additional, Kaprovoy, Stanislav, additional, Stengel, Felix, additional, Lepic, Milan, additional, Lippa, Laura, additional, Mohme, Malte, additional, Motov, Stefan, additional, Schwake, Michael, additional, Spiriev, Toma, additional, Torregrossa, Fabio, additional, Thomé, Claudius, additional, Meling, Torstein R., additional, and Raffa, Giovanni, additional

Published
2024
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50. Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section

Author

Starnoni, Daniele, Giammattei, Lorenzo, Cossu, Giulia, Link, Michael J., Roche, Pierre-Hugues, Chacko, Ari G., Ohata, Kenji, Samii, Majid, Suri, Ashish, Bruneau, Michael, Cornelius, Jan F., Cavallo, Luigi, Meling, Torstein R., Froelich, Sebastien, Tatagiba, Marcos, Sufianov, Albert, Paraskevopoulos, Dimitrios, Zazpe, Idoya, Berhouma, Moncef, Jouanneau, Emmanuel, Verheul, Jeroen B., Tuleasca, Constantin, George, Mercy, Levivier, Marc, Messerer, Mahmoud, and Daniel, Roy Thomas

Published
2020
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