1. Lupeol inhibits pesticides induced hepatotoxicity via reducing oxidative stress and inflammatory markers in rats
- Author
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Melis Coremen, Ismet Burcu Turkyilmaz, Huseyin Us, Ayca Sezen Us, Sefa Celik, Aysen E. Ozel, Omur Karabulut Bulan, and Refiye Yanardag
- Subjects
Male ,General Medicine ,Toxicology ,Antioxidants ,Rats ,Oxidative Stress ,Liver ,Animals ,Chemical and Drug Induced Liver Injury ,Pesticides ,Rats, Wistar ,Pentacyclic Triterpenes ,Biomarkers ,Food Science - Abstract
The present study was aimed at investigating the toxicity of various pesticides on rat liver. It also aimed to show whether this toxicity could be avoided using lupeol. Adult male Wistars albino rats were randomly divided into nine groups. Control groups were given saline, corn oil, and lupeol; pesticide groups were given malathion, chlorpyrifos, and tebuconazole; in the other three treatments, same doses of pesticides and lupeol were given to the rats for ten days. Histopathological examination showed severe degenerative changes in the pesticide groups. Serum AChE activities, liver GSH, total antioxidant capacity levels, AChE, CAT, SOD, GPx, GR, Na
- Published
- 2022
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