Search

Your search keyword '"Mellai, Marta"' showing total 189 results
Start Over Author "Mellai, Marta"
189 results on '"Mellai, Marta"'

2. Pilot, open-label, randomized controlled clinical trial evaluating 4 oral hygiene regimens using a manual toothbrush, toothpaste, and mouthwash.

Author

Rosu, Serban, Benatti, Paola, Bianco, Salvatore, Franco Barattini, Dionisio, Nobile, Vincenzo, Mellai, Marta, and Cattaneo, Dario

Subjects
DATA analysis, PATIENT safety, RESEARCH funding, STATISTICAL sampling, PILOT projects, PREBIOTICS, ORAL hygiene, RANDOMIZED controlled trials, HUMAN microbiota, DESCRIPTIVE statistics, TREATMENT effectiveness, LONGITUDINAL method, TOOTHBRUSHES, DENTIFRICES, LACTOBACILLUS, STATISTICS, DENTAL plaque, PATIENT satisfaction, GINGIVAL hyperplasia, MOUTHWASHES
Abstract

In this prospective pilot study, 84 patients with a history of poor oral hygiene were enrolled in an open-label, interventional, randomized controlled clinical trial. The aim was to provide preliminary clinical data on a new line of oral hygiene products containing a prebiotic and a paraprobiotic based on Lactobacillus plantarum. The recruitment rate and patient satisfaction were analyzed to estimate resources for the future primary study, and descriptive data on rebalancing of the oral microbiota were collected. The population was divided into 5 groups based on the products assigned to the patients: 1, delicate mint toothpaste (n = 20); 2, mint toothpaste (n = 12); 3, mint mouthwash (n = 20); 4, delicate mint toothpaste, mint mouthwash, and an antimicrobial toothbrush (n = 20): and 5, continued use of their usual oral care products and routine (control group; n = 12). The study duration was 28 days. All patients tolerated the products well, and there were no adverse events. The recruitment capability and procedures allowed for a realistic estimation for the future main trial. The products did not cause any changes in tooth color. The participants in group 4, who completed the treatment consisting of delicate mint toothpaste, mint mouthwash, and an antimicrobial toothbrush, reported the greatest reduction in gingival sensitivity (P ≤ 0.000; Wilcoxon signed rank test). Analysis with the Wilcoxon signed rank test revealed that all products induced a statistically significant decrease in plague (P ≤ 0.002) and a reduction in gingival sensitivity (delicate mint toothpaste, P ≤ 0.005; mint toothpaste, P ≤ 0.015; and mint mouthwash, P 5 0.015). All products were effective in stabilizing the oral microbiota. The tested products showed an optimal safety profile and a statistically significant efficacy in reducing gingival sensitivity and plague. They also stabilized the biodiversity of the oral microbiota, making it less susceptible to microbial fluctuations than the control group. Trial registration: ClinicalTrials.gov (NCT05999175). [ABSTRACT FROM AUTHOR]

Published
2024

3. Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment

Author

Mellai, Marta, Casalone, Cristina, Corona, Cristiano, Crociara, Paola, Favole, Alessandra, Cassoni, Paola, Schiffer, Davide, Boldorini, Renzo, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, and Birbrair, Alexander, editor

Published
2020
Full Text
View/download PDF

4. A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of Opuntia ficus - indica Prebiotic Supplementation in Subjects with Gut Dysbiosis.

Author

Mellai, Marta, Allesina, Marta, Edoardo, Benedetto, Cascella, Federica, Nobile, Vincenzo, Spina, Amelia, Amone, Fabio, Zaccaria, Vincenzo, Insolia, Violetta, Perri, Anna, Lofaro, Danilo, and Puoci, Francesco

Abstract

Gut dysbiosis refers to an imbalance in gut microbiota composition and function. Opuntia ficus-indica extract has been shown to modulate gut microbiota by improving SCFA production in vivo and gastrointestinal discomfort (GD) in humans. The aim of this study was to demonstrate the efficacy of OdiliaTM on gastrointestinal health by changing the microbial diversity of species involved in inflammation, immunity, oxidation, and the brain–gut–muscle axis. A randomized, double-blind clinical trial was conducted in 80 adults with gut dysbiosis. The intervention consisted of a 300 mg daily intake of OdiliaTM (n = 40) or maltodextrin as a placebo (n = 40), administered for 8 weeks. Intervention effect was evaluated using 16S metagenomics and GIQLI/GSAS scores at baseline, at 4 and 8 weeks. Eight weeks of OdiliaTM supplementation positively modulates gut microbiota composition with a significant reduction in the Firmicutes to Bacteroidetes ratio (p = 0.0012). Relative abundances of beneficial bacteria (Bacteroides and Clostridium_XIVa) were significantly increased (p < 0.001), in contrast to a significant reduction in pro-inflammatory bacteria (p < 0.001). Accordingly, GIQLI and GSAS scores revealed successful improvement in GD. OdiliaTM may represent an effective and well-tolerated treatment in subjects with gut dysbiosis. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Distinct Signatures of Tumor-Associated Microbiota and Metabolome in Low-Grade vs. High-Grade Dysplastic Colon Polyps: Inference of Their Role in Tumor Initiation and Progression

Author

Clavenna, Michela Giulia, primary, La Vecchia, Marta, additional, Sculco, Marika, additional, Joseph, Soni, additional, Barberis, Elettra, additional, Amede, Elia, additional, Mellai, Marta, additional, Brossa, Silvia, additional, Borgonovi, Giulia, additional, Occhipinti, Pietro, additional, Boldorini, Renzo, additional, Robotti, Elisa, additional, Azzimonti, Barbara, additional, Bona, Elisa, additional, Pasolli, Edoardo, additional, Ferrante, Daniela, additional, Manfredi, Marcello, additional, Aspesi, Anna, additional, and Dianzani, Irma, additional

Published
2023
Full Text
View/download PDF

22. Spatial Relationships of MR Imaging and Positron Emission Tomography with Phenotype, Genotype and Tumor Stem Cell Generation in Glioblastoma Multiforme

Author

Schiffer, Davide, primary, Valentini, Consuelo, additional, Melcarne, Antonio, additional, Mellai, Marta, additional, Prodi, Elena, additional, Carrara, Giovanna, additional, Denysenko, Tetyana, additional, Junemann, Carola, additional, Casalone, Cristina, additional, Corona, Cristiano, additional, Caldera, Valentina, additional, Annovazzi, Laura, additional, Piazzi, Angela, additional, Cassoni, Paola, additional, Senetta, Rebecca, additional, Fania, Piercarlo, additional, and Cistaro, Angelina, additional

Published
2014
Full Text
View/download PDF

29. A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

Author

Liguori, Maria, Sawcer, Stephen, Setakis, Efrosini, Compston, Alastair, Giordano, Mara, D'Alfonso, Sandra, Mellai, Marta, Malferrari, Giulia, Trojano, Maria, Livrea, Paolo, De Robertis, Francesca, Massacesi, Luca, Repice, Anna, Ballerini, Clara, Biagioli, Tiziana, Bomprezzi, Roberto, Cannoni, Stefania, Ristori, Giovanni, Salvetti, Marco, Grimaldi, Luigi M.E., Biunno, Ida, Comi, Giancarlo, Leone, Maurizio, Ferro, Isabella, Naldi, Paola, Milanese, Clara, Gellera, Cinzia, Loredana, La Mantia, Savettieri, Giovanni, Salemi, Giuseppe, Aridon, Paolo, Caputo, Domenico, Rosa Guerini, Franca, Ferrante, Pasquale, and Momigliano-Richiardi, Patricia

Published
2003
Full Text
View/download PDF

32. Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain–Blood Barrier and Glioblastoma Stem Cells

Author

Salaroglio, Iris Chiara, primary, Abate, Carmen, additional, Rolando, Barbara, additional, Battaglia, Luigi, additional, Gazzano, Elena, additional, Colombino, Elena, additional, Costamagna, Costanzo, additional, Annovazzi, Laura, additional, Mellai, Marta, additional, Berardi, Francesco, additional, Capucchio, Maria Teresa, additional, Schiffer, Davide, additional, and Riganti, Chiara, additional

Published
2019
Full Text
View/download PDF

37. SEL1L plays a major role in human malignant gliomas.

Author

Mellai, Marta, Annovazzi, Laura, Boldorini, Renzo, Bertero, Luca, Cassoni, Paola, De Blasio, Pasquale, Biunno, Ida, and Schiffer, Davide

Subjects
CYTOLOGY, GENETIC techniques, VASCULAR endothelial cells, MOLECULAR genetics, BIOMARKERS, GENE amplification, ALEMTUZUMAB
Abstract

Suppressor of Lin‐12‐like (C. elegans) (SEL1L) participates in the endoplasmic reticulum‐associated protein degradation pathway, malignant transformation and stem cell biology. We explored the role of SEL1L in 110 adult gliomas, of different molecular subtype and grade, in relation to cell proliferation, stemness, glioma‐associated microglia/macrophages (GAMs), prognostic markers and clinical outcome. SEL1L protein expression was assessed by immunohistochemistry and Western blotting. Genetic and epigenetic alterations were detected by molecular genetics techniques. SEL1L was overexpressed in anaplastic gliomas (World Health Organization [WHO] grade III) and in glioblastoma (GB, WHO grade IV) with the highest labelling index (LI) in the latter. Immunoreactivity was significantly associated with histological grade (p = 0.002) and cell proliferation index Ki‐67/MIB‐1 (p = 0.0001). In GB, SEL1L co‐localised with stemness markers Nestin and Sox2. Endothelial cells and vascular pericytes of proliferative tumour blood vessels expressed SEL1L suggesting a role in tumour neo‐vasculature. GAMs consistently expressed SEL1L. SEL1L overexpression was significantly associated with TERT promoter mutations (p = 0.0001), EGFR gene amplification (p = 0.0013), LOH on 10q (p = 0.0012) but was mutually exclusive with IDH1/2 mutations (p = 0.0001). SEL1L immunoreactivity correlated with tumour progression and cell proliferation, conditioning poor patient survival and response to therapy. This study emphasises SEL1L as a potential biomarker for the most common subgroup of TERT mutant/EGFR amplified/IDH‐WT GBs. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

40. Solid Lipid Nanoparticles Carrying Temozolomide for Melanoma Treatment. Preliminary In Vitro and In Vivo Studies

Author

Clemente, Nausicaa, primary, Ferrara, Benedetta, additional, Gigliotti, Casimiro, additional, Boggio, Elena, additional, Capucchio, Maria, additional, Biasibetti, Elena, additional, Schiffer, Davide, additional, Mellai, Marta, additional, Annovazzi, Laura, additional, Cangemi, Luigi, additional, Muntoni, Elisabetta, additional, Miglio, Gianluca, additional, Dianzani, Umberto, additional, Battaglia, Luigi, additional, and Dianzani, Chiara, additional

Published
2018
Full Text
View/download PDF

42. Comparison among conventional and advanced MRI, 18F-FDG PET/CT, phenotype and genotype in glioblastoma

Author

Valentini, Maria Consuelo, primary, Mellai, Marta, additional, Annovazzi, Laura, additional, Melcarne, Antonio, additional, Denysenko, Tetyana, additional, Cassoni, Paola, additional, Casalone, Cristina, additional, Maurella, Cristiana, additional, Grifoni, Silvia, additional, Fania, Piercarlo, additional, Cistaro, Angelina, additional, and Schiffer, Davide, additional

Published
2017
Full Text
View/download PDF

43. Oligoastrocytoma : a Vanishing Tumor Entity

Author

Mellai, Marta

Subjects
Medical / Oncology
Abstract

Oligoastrocytoma (OA) was a glioma recognized in the current World Health Organization (WHO) classification of the central nervous system (CNS) tumors as a mixed tumor with an astrocytic and an oligodendroglial component. Its definability was, however, poor so that its prevalence varies in the various collections. A series of contributions of the literature and the “International Society of Neuropathology (ISN) – Haarlem Consensus” recently denied its existence as a tumor entity on the basis of 1p/19q, isocitrate dehydrogenase (IDH) and α-thalassemia/mental retardation syndrome X-linked (ATRX) status. Most tumors previously diagnosed as OAs were, therefore, reclassified as either oligodendrogliomas or astrocytomas.

Published
2016

46. Solid Lipid Nanoparticles Loaded with Antitumor Lipophilic Prodrugs Aimed to Glioblastoma Treatment: Preliminary Studies on Cultured Cells

Author

Annovazzi, Laura, primary, Schiffer, Davide, additional, Mellai, Marta, additional, Gallarate, Marina, additional, Battaglia, Luigi, additional, Chirio, Daniela, additional, Peira, Elena, additional, Muntoni, Elisabetta, additional, Chegaev, Konstantin, additional, Barge, Alessandro, additional, Lanotte, Michele, additional, Panciani, Pierpaolo, additional, Capucchio, Maria Teresa, additional, Valazza, Alberto, additional, Biasibetti, Elena, additional, and Riganti, Chiara, additional

Published
2017
Full Text
View/download PDF

47. Solid lipid nanoparticles by coacervation loaded with a methotrexate prodrug: preliminary study for glioma treatment

Author

Battaglia, Luigi, primary, Muntoni, Elisabetta, additional, Chirio, Daniela, additional, Peira, Elena, additional, Annovazzi, Laura, additional, Schiffer, Davide, additional, Mellai, Marta, additional, Riganti, Chiara, additional, Salaroglio, Iris Chiara, additional, Lanotte, Michele, additional, Panciani, Pierpaolo, additional, Capucchio, Maria Teresa, additional, Valazza, Alberto, additional, Biasibetti, Elena, additional, and Gallarate, Marina, additional

Published
2017
Full Text
View/download PDF

48. An additional hypothesis to the origin of perinecrotic niches in glioblastoma

Author

Schiffer, Davide, Annovazzi, Laura, Mellai, Marta, and Mazzucco, Marta

Subjects
ddc: 610, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Introduction: Microenvironment exerts its effects at the most on perivascular and perinecrotic niches where glioblastoma stem cells (GSCs) are believed to be located in glioblastoma multiforme (GBM). The histological definition of the niches is not univocal. The perinecrotic ones develop around circumscribed[for full text, please go to the a.m. URL], 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results