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Fasioloides magna is a trematode parasitizing in the liver parenchyma of ruminants. Its life cycle is associated with the humid environment and includes intermediate freshwater snail hosts from family Lymnaeidae. According to the ability of host to form a certain type of a pseudocyst during fascioloidosis, they can be,divided in three groups, specific definitive hosts (red deers, fallow deers, roe deers), nonspecific definitive hosts (cattle, wild boars and elks) and atypical hosts (sheeps and goats). Beside the natural infections also the experimental infections of other potential host species has been realized (chamois, llama and bighorn sheep and traditional laboratory animals such as mice, guinea pigs, rats and rabbits). In the context of different diseases, many changes in infected organism can occur. These can be qualitatively and quantitatively evaluated. Similarly, during fascioloidosis the changes associated with the presence of the parasite in the host's body is possible to monitor, e.g. antibody production, increase in the number of eosinophils, release of eggs in faeces, internal bleeding, or the level liver damage. The liver damage is corresponding primarily to biochemical parameters of blood, not only the liver enzymes, but also other blood components, like blood proteins, lipids,...

Fascioloides magna (giant liver fluke) and Fasciola hepatica (liver fluke) are veterinary and medically important endoparasites belonging to the class Trematoda, subclass Digenea. They are the causative agents of the diseases fascioloidosis (F. magna) and fascioliasis (F. hepatica). They can infect a wide range of definitive hosts to which they cause serious health problems often leading to death. The typical final hosts of F. magna are primarily members of free living cervids, but this fluke can also occasionally occurs in domestic bovids. In contrast to this, F. hepatica is mostly parasite of domestic animals and rarely of cervids. The typical localization of both trematodes inside the definitive host is primarily the liver tissue - F. magna liver pseudocyst and F. hepatica bile ducts. In the liver tissue both flukes cause significant damage. Each species of host developed specific defense system to the invasion, some of them are quite resistant to the infection, some of them susceptive. Key words: Fluke, Fascioloides magna, Fasciola hepatica, definitive hosts, experimental hosts, pathogenicity, interaction.